SCN11A (sodium voltage-gated channel alpha subunit 11) - Rat Genome Database

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Gene: SCN11A (sodium voltage-gated channel alpha subunit 11) Pan paniscus
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Symbol: SCN11A
Name: sodium voltage-gated channel alpha subunit 11
RGD ID: 12018943
Description: ENCODES a protein that exhibits metal ion transmembrane transporter activity (inferred); monoatomic cation channel activity (inferred); sodium channel activity (inferred); INVOLVED IN establishment of localization in cell (ortholog); optic nerve development (ortholog); sodium ion transport (ortholog); ASSOCIATED WITH autosomal dominant distal hereditary motor neuronopathy 14 (ortholog); Brugada syndrome (ortholog); Charcot-Marie-Tooth disease (ortholog); FOUND IN axon (ortholog); axonal growth cone (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: sodium channel protein type 11 subunit alpha; sodium channel, voltage-gated, type XI, alpha subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,797,256 - 38,904,450 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,802,018 - 38,909,202 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,741,485 - 38,948,400 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1339,024,090 - 39,131,293 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,024,921 - 39,128,015 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
action potential  (IEA)
action potential initiation  (IEA)
acute inflammatory response  (IEA)
artery development  (IEA)
axonogenesis  (IEA)
behavioral response to acetic acid induced pain  (IEA)
behavioral response to formalin induced pain  (IEA)
behavioral response to pain  (IEA)
calcitonin gene-related peptide receptor signaling pathway  (IEA)
calcium ion transmembrane transport  (IEA)
cAMP/PKA signal transduction  (IEA)
cell motility  (IEA)
cellular response to cold  (IEA)
chemosensory behavior  (IEA)
chronic inflammatory response  (IEA)
circadian rhythm  (IEA)
detection of mechanical stimulus involved in sensory perception  (IEA)
detection of mechanical stimulus involved in sensory perception of pain  (IEA)
detection of temperature stimulus involved in sensory perception of pain  (IEA)
establishment of localization in cell  (IEA,ISO)
G protein-coupled receptor signaling pathway  (IEA)
inflammatory response  (IEA)
inorganic cation transmembrane transport  (IEA)
mast cell degranulation  (IEA)
membrane depolarization during action potential  (IEA)
micturition  (IEA)
monoatomic ion transmembrane transport  (IEA)
neuronal action potential  (IEA)
optic nerve development  (ISO)
reflex  (IEA)
regulation of membrane potential  (IEA)
response to auditory stimulus  (IEA)
response to cold  (IEA)
response to heat  (IEA)
response to high light intensity  (IEA)
response to nitric oxide  (IEA)
response to pain  (IEA)
response to prostaglandin E  (IEA)
response to toxic substance  (IEA)
response to xenobiotic stimulus  (IEA)
sensory perception of itch  (IEA)
sensory perception of pain  (IEA)
skeletal muscle organ development  (IEA)
small intestine smooth muscle contraction  (IEA)
sodium ion transmembrane transport  (IEA)
sodium ion transport  (IEA,ISO)
thermosensory behavior  (IEA)
thigmotaxis  (IEA)
transmembrane transport  (IEA)
transmission of nerve impulse  (IEA)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
SCN11A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2238,797,256 - 38,904,450 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1338,802,018 - 38,909,202 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0338,741,485 - 38,948,400 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1339,024,090 - 39,131,293 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl339,024,921 - 39,128,015 (-)Ensemblpanpan1.1panPan2
SCN11A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38338,845,764 - 39,051,944 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl338,845,764 - 39,052,157 (-)EnsemblGRCh38hg38GRCh38
GRCh37338,887,255 - 39,093,435 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,862,264 - 38,967,056 (-)NCBINCBI36Build 36hg18NCBI36
Build 34338,862,263 - 38,967,056NCBI
Celera338,826,267 - 38,932,035 (-)NCBICelera
Cytogenetic Map3p22.2NCBI
HuRef338,929,417 - 39,033,960 (-)NCBIHuRef
CHM1_1338,838,871 - 38,943,183 (-)NCBICHM1_1
T2T-CHM13v2.0338,857,981 - 39,064,106 (-)NCBIT2T-CHM13v2.0
Scn11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399119,582,829 - 119,654,522 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9119,582,825 - 119,654,522 (-)EnsemblGRCm39 Ensembl
GRCm389119,753,763 - 119,825,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9119,753,759 - 119,825,456 (-)EnsemblGRCm38mm10GRCm38
MGSCv379119,662,881 - 119,734,574 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369119,602,461 - 119,672,558 (-)NCBIMGSCv36mm8
Celera9120,223,700 - 120,294,696 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map971.33NCBI
Scn11a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88128,374,441 - 128,444,718 (-)NCBIGRCr8
mRatBN7.28119,495,550 - 119,567,044 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8119,496,769 - 119,567,044 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8125,078,222 - 125,148,530 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08123,277,258 - 123,347,562 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08121,110,473 - 121,180,436 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08128,450,793 - 128,527,510 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8128,450,801 - 128,521,109 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08127,654,010 - 127,724,293 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48124,724,493 - 124,794,654 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18124,744,232 - 124,814,391 (-)NCBI
Celera8118,645,022 - 118,713,950 (-)NCBICelera
Cytogenetic Map8q32NCBI
Scn11a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542724,989,615 - 25,109,550 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542724,917,709 - 25,109,499 (+)NCBIChiLan1.0ChiLan1.0
SCN11A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1238,559,804 - 8,651,448 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl238,559,952 - 8,651,500 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha238,599,916 - 8,691,489 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0238,852,382 - 8,933,244 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl238,852,696 - 8,935,541 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1238,662,540 - 8,754,003 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0238,803,937 - 8,896,178 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0238,797,979 - 8,889,539 (-)NCBIUU_Cfam_GSD_1.0
Scn11a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118195,023,309 - 195,117,394 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647328,162,528 - 28,248,474 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647328,162,528 - 28,248,474 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SCN11A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1323,602,977 - 23,692,220 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11323,602,378 - 23,692,281 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21325,889,505 - 25,951,832 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SCN11A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.115466,295 - 575,460 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl15467,210 - 575,110 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660639,093,710 - 9,305,205 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Scn11a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247312,065,228 - 2,203,215 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000034747   ⟹   ENSPPAP00000012085
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl339,024,921 - 39,128,015 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000034752   ⟹   ENSPPAP00000012090
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl339,028,763 - 39,128,015 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000034754   ⟹   ENSPPAP00000012092
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl339,028,772 - 39,128,015 (-)Ensembl
RefSeq Acc Id: XM_055109673   ⟹   XP_054965648
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2238,797,256 - 38,904,450 (-)NCBI
NHGRI_mPanPan1338,802,018 - 38,909,202 (-)NCBI
Protein Sequences
Protein RefSeqs XP_054965648 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012085.1
  ENSPPAP00000012090.1
  ENSPPAP00000012092.1
Ensembl Acc Id: ENSPPAP00000012092   ⟸   ENSPPAT00000034754
Ensembl Acc Id: ENSPPAP00000012090   ⟸   ENSPPAT00000034752
Ensembl Acc Id: ENSPPAP00000012085   ⟸   ENSPPAT00000034747
RefSeq Acc Id: XP_054965648   ⟸   XM_055109673
- UniProtKB: A0A2R9A8W6 (UniProtKB/TrEMBL)
Protein Domains
Ion transport   Sodium ion transport-associated


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029217 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034747.1 UniProtKB/TrEMBL
  ENSPPAT00000034752.1 UniProtKB/TrEMBL
  ENSPPAT00000034754.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.120.350 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  iswi atpase UniProtKB/TrEMBL
InterPro Ion_trans_dom UniProtKB/TrEMBL
  Na_channel_asu UniProtKB/TrEMBL
  Na_chnl_inactivation_gate UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
  VGCC_Ca_Na UniProtKB/TrEMBL
  Volt_channel_dom_sf UniProtKB/TrEMBL
NCBI Gene SCN11A ENTREZGENE
PANTHER PTHR10037 UniProtKB/TrEMBL
  PTHR10037:SF210 UniProtKB/TrEMBL
Pfam Ion_trans UniProtKB/TrEMBL
  Na_trans_assoc UniProtKB/TrEMBL
PRINTS NACHANNEL UniProtKB/TrEMBL
Superfamily-SCOP Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R9A456_PANPA UniProtKB/TrEMBL
  A0A2R9A8W6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A8X1_PANPA UniProtKB/TrEMBL