DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) - Rat Genome Database

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Gene: DYRK2 (dual specificity tyrosine phosphorylation regulated kinase 2) Pan paniscus
Analyze
Symbol: DYRK2
Name: dual specificity tyrosine phosphorylation regulated kinase 2
RGD ID: 12018619
Description: ENCODES a protein that exhibits ATP binding (inferred); magnesium ion binding (inferred); manganese ion binding (inferred); INVOLVED IN DNA damage response (inferred); intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (inferred); negative regulation of calcineurin-NFAT signaling cascade (inferred); PARTICIPATES IN p53 signaling pathway; ASSOCIATED WITH gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN ribonucleoprotein complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: dual specificity tyrosine-phosphorylation-regulated kinase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21026,689,217 - 26,704,660 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11226,685,982 - 26,701,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01221,241,325 - 21,260,321 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11221,751,119 - 21,766,602 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1221,757,436 - 21,767,505 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DYRK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21026,689,217 - 26,704,660 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11226,685,982 - 26,701,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01221,241,325 - 21,260,321 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11221,751,119 - 21,766,602 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1221,757,436 - 21,767,505 (-)Ensemblpanpan1.1panPan2
DYRK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381267,648,745 - 67,665,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1267,648,338 - 67,665,406 (+)EnsemblGRCh38hg38GRCh38
GRCh371268,042,525 - 68,059,186 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361266,328,779 - 66,342,711 (+)NCBINCBI36Build 36hg18NCBI36
Build 341266,329,020 - 66,340,410NCBI
Celera1267,706,515 - 67,720,446 (+)NCBICelera
Cytogenetic Map12q15NCBI
HuRef1265,093,416 - 65,107,347 (+)NCBIHuRef
CHM1_11268,010,112 - 68,024,043 (+)NCBICHM1_1
T2T-CHM13v2.01267,628,264 - 67,644,920 (+)NCBIT2T-CHM13v2.0
Dyrk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910118,691,507 - 118,725,144 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10118,691,508 - 118,706,114 (-)EnsemblGRCm39 Ensembl
GRCm3810118,855,602 - 118,889,245 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10118,855,603 - 118,870,209 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710118,296,405 - 118,305,959 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610118,262,342 - 118,271,896 (-)NCBIMGSCv36mm8
Celera10121,236,125 - 121,244,887 (-)NCBICelera
Cytogenetic Map10D2NCBI
cM Map1066.75NCBI
Dyrk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8756,235,276 - 56,265,741 (-)NCBIGRCr8
mRatBN7.2754,348,724 - 54,381,363 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl754,349,610 - 54,380,106 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx756,256,148 - 56,268,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0758,459,275 - 58,471,695 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0758,237,109 - 58,249,529 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0761,785,423 - 61,816,775 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl761,786,309 - 61,798,729 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0761,775,902 - 61,807,168 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4758,114,127 - 58,126,547 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1758,138,697 - 58,149,260 (-)NCBI
Celera751,116,337 - 51,128,757 (-)NCBICelera
Cytogenetic Map7q22NCBI
Dyrk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545814,193,303 - 14,218,957 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545814,199,912 - 14,201,712 (+)NCBIChiLan1.0ChiLan1.0
DYRK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1109,982,245 - 9,994,327 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl109,980,080 - 9,991,934 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha109,915,768 - 9,929,155 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01010,099,203 - 10,112,645 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1010,098,813 - 10,108,970 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1109,974,467 - 9,987,896 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01010,221,581 - 10,234,975 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01010,343,266 - 10,356,687 (+)NCBIUU_Cfam_GSD_1.0
Dyrk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494548,553,639 - 48,567,246 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365455,542,803 - 5,554,136 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365455,542,873 - 5,555,469 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DYRK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl532,047,643 - 32,064,222 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1532,047,614 - 32,064,231 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.25110,120,816 - 110,124,970 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DYRK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11163,294,035 - 63,308,008 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1163,294,444 - 63,304,080 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037182,403,669 - 182,420,416 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dyrk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624802650,119 - 660,005 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624802643,783 - 660,603 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000065377   ⟹   ENSPPAP00000042447
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1221,757,436 - 21,767,505 (-)Ensembl
RefSeq Acc Id: XM_034935481   ⟹   XP_034791372
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21026,689,217 - 26,704,660 (-)NCBI
NHGRI_mPanPan11226,685,982 - 26,701,425 (-)NCBI
Mhudiblu_PPA_v01221,241,325 - 21,260,321 (-)NCBI
RefSeq Acc Id: XM_034935482   ⟹   XP_034791373
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21026,689,217 - 26,704,364 (-)NCBI
NHGRI_mPanPan11226,685,982 - 26,701,129 (-)NCBI
Mhudiblu_PPA_v01221,241,325 - 21,260,295 (-)NCBI
RefSeq Acc Id: XM_034935483   ⟹   XP_034791374
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21026,689,217 - 26,702,795 (-)NCBI
NHGRI_mPanPan11226,685,982 - 26,699,608 (-)NCBI
Mhudiblu_PPA_v01221,241,325 - 21,258,491 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034791372 (Get FASTA)   NCBI Sequence Viewer  
  XP_034791373 (Get FASTA)   NCBI Sequence Viewer  
  XP_034791374 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000042447.1
Reference Protein Sequences
RefSeq Acc Id: XP_034791372   ⟸   XM_034935481
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CSN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034791373   ⟸   XM_034935482
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CSN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034791374   ⟸   XM_034935483
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CSN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000042447   ⟸   ENSPPAT00000065377
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043797 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000065377.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.10.30 UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro DYRK UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene DYRK2 ENTREZGENE
PANTHER DUAL SPECIFICITY PROTEIN KINASE UniProtKB/TrEMBL
  DUAL SPECIFICITY TYROSINE-PHOSPHORYLATION-REGULATED KINASE 2 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9CSN8 ENTREZGENE, UniProtKB/TrEMBL