ISCA2 (iron-sulfur cluster assembly 2) - Rat Genome Database

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Gene: ISCA2 (iron-sulfur cluster assembly 2) Pan paniscus
Analyze
Symbol: ISCA2
Name: iron-sulfur cluster assembly 2
RGD ID: 12017070
Description: ENCODES a protein that exhibits 2 iron, 2 sulfur cluster binding (inferred); 4 iron, 4 sulfur cluster binding (inferred); identical protein binding (inferred); INVOLVED IN iron-sulfur cluster assembly (inferred); obsolete protein maturation by [4Fe-4S] cluster transfer (inferred); PARTICIPATES IN mitochondrial iron-sulfur cluster protein biogenesis pathway; ASSOCIATED WITH Developmental Disabilities (ortholog); genetic disease (ortholog); intellectual disability (ortholog); FOUND IN mitochondrial [4Fe-4S] assembly complex (inferred); mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: iron-sulfur cluster assembly 2 homolog; iron-sulfur cluster assembly 2 homolog, mitochondrial
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,577,491 - 75,580,448 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,794,022 - 74,795,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,046,821 - 55,048,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,894,694 - 73,896,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,894,694 - 73,896,444 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ISCA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21575,577,491 - 75,580,448 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11474,794,022 - 74,795,673 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01455,046,821 - 55,048,602 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11473,894,694 - 73,896,444 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1473,894,694 - 73,896,444 (+)Ensemblpanpan1.1panPan2
ISCA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381474,493,765 - 74,497,106 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1474,493,756 - 74,497,106 (+)EnsemblGRCh38hg38GRCh38
GRCh371474,960,468 - 74,963,809 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361474,030,221 - 74,031,923 (+)NCBINCBI36Build 36hg18NCBI36
Build 341474,030,220 - 74,031,922NCBI
Celera1454,998,835 - 55,000,656 (+)NCBICelera
Cytogenetic Map14q24.3NCBI
HuRef1455,128,867 - 55,130,715 (+)NCBIHuRef
CHM1_11474,899,959 - 74,901,807 (+)NCBICHM1_1
T2T-CHM13v2.01468,702,736 - 68,706,077 (+)NCBIT2T-CHM13v2.0
Isca2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391284,820,007 - 84,821,863 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1284,820,025 - 84,821,862 (+)EnsemblGRCm39 Ensembl
GRCm381284,773,230 - 84,775,089 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1284,773,251 - 84,775,088 (+)EnsemblGRCm38mm10GRCm38
MGSCv371286,114,220 - 86,116,039 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361285,663,018 - 85,664,836 (+)NCBIMGSCv36mm8
Celera1286,229,524 - 86,231,343 (+)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1239.38NCBI
Isca2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86110,149,593 - 110,151,103 (+)NCBIGRCr8
mRatBN7.26104,418,509 - 104,420,019 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1467,719,052 - 67,719,919 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl6104,418,454 - 104,420,045 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6104,587,949 - 104,589,458 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06104,887,108 - 104,888,617 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06104,256,458 - 104,257,967 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06108,488,678 - 108,490,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6108,488,678 - 108,490,188 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06117,059,002 - 117,060,512 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.46108,815,061 - 108,816,650 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera6102,243,383 - 102,244,893 (+)NCBICelera
Cytogenetic Map6q31NCBI
Isca2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555231,008,246 - 1,010,041 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555231,008,246 - 1,010,030 (-)NCBIChiLan1.0ChiLan1.0
ISCA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1847,650,864 - 47,657,896 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl847,650,938 - 47,652,292 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha847,334,798 - 47,342,174 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0847,877,829 - 47,885,208 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl847,877,883 - 47,884,270 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1847,548,997 - 47,556,348 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0847,570,242 - 47,577,621 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0847,968,246 - 47,975,623 (+)NCBIUU_Cfam_GSD_1.0
Isca2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864028,390,176 - 28,392,252 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364883,676,677 - 3,678,949 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364883,676,752 - 3,678,741 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ISCA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl797,740,491 - 97,743,911 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1797,740,479 - 97,746,491 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27103,582,734 - 103,584,760 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ISCA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12451,700,941 - 51,702,680 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2451,700,991 - 51,702,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605339,935,914 - 39,937,682 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Isca2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473427,165,007 - 27,166,595 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473427,165,000 - 27,166,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003824167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000026295   ⟹   ENSPPAP00000005897
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1473,894,694 - 73,896,444 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000026299   ⟹   ENSPPAP00000005899
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1473,894,744 - 73,895,803 (+)Ensembl
RefSeq Acc Id: XM_003824167   ⟹   XP_003824215
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21575,577,491 - 75,580,448 (+)NCBI
NHGRI_mPanPan11474,794,022 - 74,795,673 (+)NCBI
Mhudiblu_PPA_v01455,046,821 - 55,048,602 (+)NCBI
PanPan1.11473,894,694 - 73,896,444 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003824215 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000005897.1
  ENSPPAP00000005899.1
RefSeq Acc Id: XP_003824215   ⟸   XM_003824167
- Sequence:
Ensembl Acc Id: ENSPPAP00000005897   ⟸   ENSPPAT00000026295
Ensembl Acc Id: ENSPPAP00000005899   ⟸   ENSPPAT00000026299
Protein Domains
FeS cluster biogenesis


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000023891 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000026295.1 UniProtKB/TrEMBL
  ENSPPAT00000026299.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.300.12 UniProtKB/TrEMBL
InterPro FeS_biogenesis UniProtKB/TrEMBL
  FeS_cluster_insertion UniProtKB/TrEMBL
  FeS_cluster_insertion_CS UniProtKB/TrEMBL
  HesB-like_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100980907 UniProtKB/TrEMBL
NCBI Gene ISCA2 ENTREZGENE
PANTHER IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
  IRON-SULFUR CLUSTER ASSEMBLY 2 HOMOLOG, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam Fe-S_biosyn UniProtKB/TrEMBL
PROSITE HESB UniProtKB/TrEMBL
Superfamily-SCOP SSF89360 UniProtKB/TrEMBL
UniProt A0A2R8ZLR8_PANPA UniProtKB/TrEMBL
  A0A2R8ZSR6_PANPA UniProtKB/TrEMBL