NUDT12 (nudix hydrolase 12) - Rat Genome Database

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Gene: NUDT12 (nudix hydrolase 12) Pan paniscus
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Symbol: NUDT12
Name: nudix hydrolase 12
RGD ID: 12012987
Description: ENCODES a protein that exhibits magnesium ion binding (ortholog); RNA NAD-cap (NMN-forming) hydrolase activity (ortholog); zinc ion binding (ortholog); INVOLVED IN circadian regulation of gene expression (ortholog); mRNA catabolic process (ortholog); NAD catabolic process (ortholog); PARTICIPATES IN niacin metabolic pathway; ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: NAD-capped RNA hydrolase NUDT12; peroxisomal NADH pyrophosphatase NUDT12
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2498,832,811 - 98,846,787 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1596,986,459 - 97,000,835 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0598,903,740 - 98,917,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15104,603,701 - 104,617,927 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5104,601,373 - 104,617,925 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleus  (IEA)
peroxisome  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
NUDT12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2498,832,811 - 98,846,787 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1596,986,459 - 97,000,835 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0598,903,740 - 98,917,763 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15104,603,701 - 104,617,927 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5104,601,373 - 104,617,925 (-)Ensemblpanpan1.1panPan2
NUDT12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385103,548,855 - 103,562,789 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5103,548,855 - 103,562,790 (-)EnsemblGRCh38hg38GRCh38
GRCh375102,884,556 - 102,898,490 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365102,912,455 - 102,926,389 (-)NCBINCBI36Build 36hg18NCBI36
Build 345102,912,455 - 102,926,389NCBI
Celera598,832,394 - 98,846,327 (-)NCBICelera
Cytogenetic Map5q21.2NCBI
HuRef598,066,154 - 98,080,094 (-)NCBIHuRef
CHM1_15102,317,764 - 102,331,705 (-)NCBICHM1_1
T2T-CHM13v2.05104,057,169 - 104,071,102 (-)NCBIT2T-CHM13v2.0
Nudt12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391759,307,104 - 59,320,317 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1759,306,613 - 59,320,367 (-)EnsemblGRCm39 Ensembl
GRCm381759,000,107 - 59,013,367 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1758,999,618 - 59,013,372 (-)EnsemblGRCm38mm10GRCm38
MGSCv371759,140,824 - 59,152,745 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361758,686,732 - 58,698,653 (-)NCBIMGSCv36mm8
Celera1763,340,740 - 63,352,661 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1730.64NCBI
Nudt12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr89106,188,930 - 106,202,340 (-)NCBIGRCr8
mRatBN7.2998,741,627 - 98,755,039 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl998,742,360 - 98,755,039 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx9107,157,934 - 107,170,738 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.09112,285,705 - 112,298,509 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.09110,629,306 - 110,642,104 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.09105,680,603 - 105,693,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl9105,680,670 - 105,693,357 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.09105,282,066 - 105,294,901 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4997,551,943 - 97,565,919 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1997,763,808 - 97,773,230 (-)NCBI
Celera996,183,688 - 96,196,456 (-)NCBICelera
Cytogenetic Map9q36NCBI
Nudt12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541810,459,638 - 10,474,124 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541810,459,644 - 10,474,124 (+)NCBIChiLan1.0ChiLan1.0
NUDT12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.137,693,903 - 7,708,930 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl37,696,505 - 7,724,769 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha39,096,599 - 9,111,624 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.037,580,872 - 7,595,974 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl37,580,961 - 7,595,765 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.137,523,258 - 7,538,243 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.037,541,652 - 7,556,628 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.037,701,088 - 7,716,081 (+)NCBIUU_Cfam_GSD_1.0
Nudt12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213162,779,449 - 162,793,749 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936523964,813 - 979,250 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936523964,858 - 979,118 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NUDT12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2109,045,592 - 109,059,616 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12109,044,946 - 109,059,721 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22113,204,432 - 113,216,169 (-)NCBISscrofa10.2Sscrofa10.2susScr3
NUDT12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1236,980,848 - 6,995,193 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl236,978,704 - 6,994,660 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660367,322,532 - 7,336,519 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nudt12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474321,701,158 - 21,717,123 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474321,702,453 - 21,716,805 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000050220   ⟹   ENSPPAP00000027380
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5104,601,373 - 104,615,084 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000050221   ⟹   ENSPPAP00000027381
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5104,603,701 - 104,617,925 (-)Ensembl
RefSeq Acc Id: XM_003828308   ⟹   XP_003828356
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2498,832,811 - 98,846,786 (-)NCBI
NHGRI_mPanPan1596,986,459 - 97,000,832 (-)NCBI
Mhudiblu_PPA_v0598,903,740 - 98,917,762 (-)NCBI
PanPan1.15104,603,701 - 104,617,925 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008953678   ⟹   XP_008951926
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2498,832,811 - 98,846,779 (-)NCBI
NHGRI_mPanPan1596,986,459 - 97,000,833 (-)NCBI
Mhudiblu_PPA_v0598,903,740 - 98,917,753 (-)NCBI
PanPan1.15104,603,701 - 104,617,925 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055112515   ⟹   XP_054968490
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2498,832,811 - 98,846,498 (-)NCBI
NHGRI_mPanPan1596,986,459 - 97,000,228 (-)NCBI
RefSeq Acc Id: XM_055112516   ⟹   XP_054968491
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2498,832,811 - 98,846,494 (-)NCBI
NHGRI_mPanPan1596,986,459 - 97,000,233 (-)NCBI
RefSeq Acc Id: XM_057302319   ⟹   XP_057158302
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2498,832,811 - 98,846,787 (-)NCBI
NHGRI_mPanPan1596,986,459 - 97,000,835 (-)NCBI
RefSeq Acc Id: XP_008951926   ⟸   XM_008953678
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BGH8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003828356   ⟸   XM_003828308
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BGH8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000027380   ⟸   ENSPPAT00000050220
Ensembl Acc Id: ENSPPAP00000027381   ⟸   ENSPPAT00000050221
RefSeq Acc Id: XP_054968491   ⟸   XM_055112516
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054968490   ⟸   XM_055112515
- Peptide Label: isoform X1
RefSeq Acc Id: XP_057158302   ⟸   XM_057302319
- Peptide Label: isoform X4
Protein Domains
Nudix hydrolase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050220.1 UniProtKB/TrEMBL
  ENSPPAT00000050221.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.20 UniProtKB/TrEMBL
  3.90.79.20 UniProtKB/TrEMBL
  Nucleoside Triphosphate Pyrophosphohydrolase UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  NAD-cap_RNA_hydrolase_NudC UniProtKB/TrEMBL
  NADH_PPase-like_N UniProtKB/TrEMBL
  NudC-like_C UniProtKB/TrEMBL
  NUDIX_hydrolase-like_dom_sf UniProtKB/TrEMBL
  NUDIX_hydrolase_CS UniProtKB/TrEMBL
  NUDIX_hydrolase_dom UniProtKB/TrEMBL
  Znr_NADH_PPase UniProtKB/TrEMBL
KEGG Report pps:100968774 UniProtKB/TrEMBL
NCBI Gene NUDT12 ENTREZGENE
PANTHER NAD-CAPPED RNA HYDROLASE NUDT12 UniProtKB/TrEMBL
  NUDIX HYDROLASE, NUDC SUBFAMILY UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  NUDIX UniProtKB/TrEMBL
  NUDIX-like UniProtKB/TrEMBL
  zf-NADH-PPase UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/TrEMBL
  NUDIX UniProtKB/TrEMBL
  NUDIX_BOX UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
Superfamily-SCOP SSF48403 UniProtKB/TrEMBL
  SSF55811 UniProtKB/TrEMBL
UniProt A0A2R9BGH8 ENTREZGENE, UniProtKB/TrEMBL