HYAL2 (hyaluronidase 2) - Rat Genome Database

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Gene: HYAL2 (hyaluronidase 2) Pan paniscus
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Symbol: HYAL2
Name: hyaluronidase 2
RGD ID: 12009018
Description: ENCODES a protein that exhibits enzyme binding (ortholog); hyaluronic acid binding (ortholog); hyaluronoglucuronidase activity (ortholog); INVOLVED IN cartilage development (ortholog); cellular response to fibroblast growth factor stimulus (ortholog); cellular response to interleukin-1 (ortholog); ASSOCIATED WITH Kidney Reperfusion Injury (ortholog); pulmonary hypertension (ortholog); FOUND IN anchored component of external side of plasma membrane (ortholog); anchored component of plasma membrane (ortholog); apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: hyaluronidase-2; hyaluronoglucosaminidase 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,479,020 - 51,484,638 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,479,020 - 51,482,551 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,243,926 - 50,248,972 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cartilage development  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to UV-B  (ISO)
defense response to virus  (ISO)
fusion of virus membrane with host plasma membrane  (ISO)
glycosaminoglycan catabolic process  (ISO)
hematopoietic progenitor cell differentiation  (ISO)
hyaluronan catabolic process  (ISO)
kidney development  (ISO)
monocyte activation  (ISO)
multicellular organism aging  (ISO)
multicellular organismal iron ion homeostasis  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of fibroblast migration  (ISO)
negative regulation of MAP kinase activity  (ISO)
negative regulation of protein kinase B signaling  (ISO)
negative regulation of protein tyrosine kinase activity  (ISO)
positive regulation of extrinsic apoptotic signaling pathway  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of urine volume  (ISO)
renal water absorption  (ISO)
response to antibiotic  (ISO)
response to reactive oxygen species  (ISO)
response to virus  (ISO)
skeletal system morphogenesis  (ISO)
transformation of host cell by virus  (ISO)
viral entry into host cell  (ISO)

References

Genomics

Comparative Map Data
HYAL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,479,020 - 51,484,638 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,479,020 - 51,482,551 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,243,926 - 50,248,972 (-)NCBIMhudiblu_PPA_v0panPan3
HYAL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,317,790 - 50,322,782 (-)EnsemblGRCh38hg38GRCh38
GRCh38350,317,802 - 50,322,768 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,355,239 - 50,360,176 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,330,244 - 50,335,146 (-)NCBINCBI36hg18NCBI36
Build 34350,330,243 - 50,333,903NCBI
Celera350,328,056 - 50,333,116 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,410,935 - 50,415,994 (-)NCBIHuRef
CHM1_1350,307,488 - 50,312,547 (-)NCBICHM1_1
Hyal2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,445,085 - 107,449,977 (+)NCBIGRCm39mm39
GRCm39 Ensembl9107,445,144 - 107,449,978 (+)Ensembl
GRCm389107,567,873 - 107,572,778 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,567,945 - 107,572,779 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,471,494 - 107,475,109 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,427,264 - 107,430,879 (+)NCBImm8
Celera9107,177,912 - 107,181,527 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.12NCBI
Hyal2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.28108,241,895 - 108,246,853 (+)NCBI
Rnor_6.0 Ensembl8116,324,040 - 116,328,978 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.08116,324,062 - 116,328,978 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.08115,680,309 - 115,685,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,817,001 - 112,820,693 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18112,836,484 - 112,840,147 (+)NCBI
Celera8107,549,728 - 107,586,609 (+)NCBICelera
Cytogenetic Map8q32NCBI
Hyal2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,120,781 - 2,123,726 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,120,781 - 2,125,083 (-)NCBIChiLan1.0ChiLan1.0
HYAL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12039,029,426 - 39,034,451 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2039,031,735 - 39,034,130 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2038,950,366 - 38,955,492 (+)NCBI
ROS_Cfam_1.02039,385,361 - 39,390,488 (+)NCBI
UMICH_Zoey_3.12038,753,188 - 38,758,313 (+)NCBI
UNSW_CanFamBas_1.02039,156,748 - 39,161,868 (+)NCBI
UU_Cfam_GSD_1.02039,436,765 - 39,441,893 (+)NCBI
Hyal2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560265,084,685 - 65,090,478 (-)NCBI
SpeTri2.0NW_0049365291,845,445 - 1,851,106 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HYAL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,805,223 - 32,815,335 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,805,220 - 32,813,684 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21335,983,753 - 35,988,635 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap13q21NCBI
HYAL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12211,704,422 - 11,710,013 (-)NCBI
ChlSab1.1 Ensembl2211,703,790 - 11,709,454 (-)Ensembl
Vero_WHO_p1.0NW_023666041155,277,024 - 155,282,088 (+)NCBI
Hyal2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247304,170,045 - 4,175,264 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000035208   ⟹   ENSPPAP00000012542
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl351,479,020 - 51,482,551 (-)Ensembl
RefSeq Acc Id: XM_003818822   ⟹   XP_003818870
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1351,479,020 - 51,484,638 (-)NCBI
Mhudiblu_PPA_v0350,243,926 - 50,248,927 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008972212   ⟹   XP_008970460
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1351,479,020 - 51,482,549 (-)NCBI
Mhudiblu_PPA_v0350,243,926 - 50,247,481 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008972213   ⟹   XP_008970461
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1351,479,020 - 51,484,515 (-)NCBI
Mhudiblu_PPA_v0350,243,926 - 50,248,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034956513   ⟹   XP_034812404
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,243,926 - 50,248,972 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003818870 (Get FASTA)   NCBI Sequence Viewer  
  XP_008970460 (Get FASTA)   NCBI Sequence Viewer  
  XP_008970461 (Get FASTA)   NCBI Sequence Viewer  
  XP_034812404 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003818870   ⟸   XM_003818822
- Sequence:
RefSeq Acc Id: XP_008970461   ⟸   XM_008972213
- Sequence:
RefSeq Acc Id: XP_008970460   ⟸   XM_008972212
- Sequence:
RefSeq Acc Id: XP_034812404   ⟸   XM_034956513
RefSeq Acc Id: ENSPPAP00000012542   ⟸   ENSPPAT00000035208


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029458 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000012542 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035208 UniProtKB/TrEMBL
Gene3D-CATH 3.20.20.70 UniProtKB/TrEMBL
InterPro Aldolase_TIM UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
  Hyaluronidase UniProtKB/TrEMBL
KEGG Report pps:100975669 UniProtKB/TrEMBL
NCBI Gene HYAL2 ENTREZGENE
PANTHER PTHR11769 UniProtKB/TrEMBL
Pfam Glyco_hydro_56 UniProtKB/TrEMBL
PIRSF Hyaluronidase UniProtKB/TrEMBL
PRINTS GLHYDRLASE56 UniProtKB/TrEMBL
Superfamily-SCOP SSF51445 UniProtKB/TrEMBL
UniProt A0A2R9AAT0_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-08-07 HYAL2  hyaluronidase 2    hyaluronoglucosaminidase 2  Symbol and/or name change 5135510 APPROVED