STAP2 (signal transducing adaptor family member 2)

Gene: STAP2 (signal transducing adaptor family member 2) Pan paniscus

Analyze

Symbol:

STAP2

Name:

signal transducing adaptor family member 2

RGD ID:

12006641

Description:

ENCODES a protein that exhibits signaling adaptor activity (inferred); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); FOUND IN plasma membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

signal-transducing adaptor protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	8,722,364 - 8,737,278 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	7,951,770 - 7,967,028 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	3,347,373 - 3,362,722 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	4,294,376 - 4,308,764 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,294,376 - 4,308,768 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amenorrhea (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

plasma membrane (IEA)

Molecular Function

protein binding (ISO)

signaling adaptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

STAP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	8,722,364 - 8,737,278 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	7,951,770 - 7,967,028 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	3,347,373 - 3,362,722 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	4,294,376 - 4,308,764 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	4,294,376 - 4,308,768 (-)	Ensembl	panpan1.1		panPan2

STAP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	4,324,043 - 4,338,827 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	4,324,043 - 4,342,786 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	4,324,040 - 4,338,824 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	4,275,040 - 4,289,847 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	19	623,592 - 627,059 (+)	NCBI		Celera
Celera	19	4,268,585 - 4,277,087 (-)	NCBI		Celera
Cytogenetic Map	19	p13.3	NCBI
HuRef	19	4,086,751 - 4,101,309 (-)	NCBI		HuRef
CHM1_1	19	4,323,657 - 4,338,550 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	19	4,307,445 - 4,326,896 (-)	NCBI		T2T-CHM13v2.0

Stap2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	56,304,074 - 56,315,558 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	56,304,077 - 56,312,584 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	55,997,074 - 56,008,402 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	55,997,077 - 56,005,584 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	56,136,500 - 56,144,991 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	55,590,370 - 55,598,863 (-)	NCBI		MGSCv36	mm8
Celera	17	59,415,603 - 59,424,167 (-)	NCBI		Celera
Cytogenetic Map	17	D	NCBI
cM Map	17	29.1	NCBI

Stap2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	9	915,546 - 924,604 (-)	NCBI		GRCr8
mRatBN7.2	9	828,369 - 838,648 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	9	828,372 - 837,219 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	9	1,275,386 - 1,284,348 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	9	6,622,649 - 6,630,894 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	9	5,580,418 - 5,589,383 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	9	11,064,605 - 11,070,138 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	9	11,064,605 - 11,070,122 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	9	10,049,873 - 10,055,406 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	9	7,669,783 - 7,678,118 (+)	NCBI		Celera
Cytogenetic Map	9	q11	NCBI

Stap2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955495	4,541,131 - 4,553,458 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955495	4,540,867 - 4,548,769 (+)	NCBI	ChiLan1.0	ChiLan1.0

STAP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	55,325,492 - 55,336,547 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	55,325,486 - 55,336,446 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	55,053,457 - 55,064,768 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	55,984,370 - 55,995,688 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	55,984,544 - 55,995,575 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	55,044,903 - 55,056,166 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	55,525,816 - 55,537,112 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	55,724,506 - 55,735,757 (+)	NCBI		UU_Cfam_GSD_1.0

Stap2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	215,357,805 - 215,365,233 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936588	2,469,511 - 2,476,940 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936588	2,469,550 - 2,476,921 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

STAP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	74,462,388 - 74,473,791 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	74,462,318 - 74,471,535 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	74,955,354 - 74,964,485 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

STAP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	4,059,794 - 4,065,594 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666081	4,135,898 - 4,150,629 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Stap2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624828	5,340,130 - 5,347,551 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624828	5,339,041 - 5,347,631 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003819277	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972629	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008972630	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055104064	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055104065	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063599786	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063599787	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000014966 ⟹ ENSPPAP00000003245

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	4,294,376 - 4,308,768 (-)	Ensembl

RefSeq Acc Id:

XM_003819277 ⟹ XP_003819325

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	8,722,364 - 8,737,278 (-)	NCBI
NHGRI_mPanPan1	19	7,951,770 - 7,967,028 (-)	NCBI
Mhudiblu_PPA_v0	19	3,347,373 - 3,362,722 (-)	NCBI
PanPan1.1	19	4,294,376 - 4,308,759 (-)	NCBI

Sequence:

show sequence

CCCTAGGATCACTGGACCTGCTGGGATCAGCCTCTGCCCAGCCCTGGCAGGGGAGGGAGTTGAC
GGGCTGACAGAGGAAACTCCCCTGAAACCTGTTTCTCAGCTTCCCGGCCCAGCTGGGGCACCCA
CTGGAAGGAGAGGCCAGGCGGAAGACCCTGGCTCCGTCATGGCCTCTGCCCTGAGGCCACCCCG
TGTCCCCAAGCCTAAGGGTGTCCTGCCTTCACACTACTATGAGAGCTTTCTAGAGAAGAAGGGG
CCCTGTGACCGGGATTACAAGAAGTTCTGGGCAGGCCTCCAGGGTCTCACCATTTATTTCTACA
ATAGCAATCGGGACTTCCAGCACGTGGAGAAGCTCAACTTGGGAGCATTTGAGAAACTCACAGA
TGAGATTCCCTGGGGAAGCTCACGTGACCCTGGCACCCACTTCAGCCTGATTCTCCGGAATCAG
GAGATCAAGTTCAAGGTAGAGACCTTGGAGTGTCGGGAAATGTGGAAAGGCTTCATCTTAACGG
TGGTGGAGCTCCGTGTCCCGACCGACTTGACCCTGCTTCCTGGGCACCTATACATGATGTCTGA
AGTCTTGGCCAAAGAGGAGGCGCGCCGTGCACTGGAGACACCCTCGTGCTTCCTGAAGGTGAGC
CGGCTGGAGGCACAACTGCTCCTGGAGCGCTACCCCGAGTGCGGGAACCTGCTGCTGCGGCCCA
GCGGGGACGGCGCTGACGGCGTGTCGGTCACCACGCGGCAGATGCACAACGGGACGCACGTGGT
CCGGCATTACAAGGTGAAGCGGGAGGGCCCCAAGTACGTGATCGATGTGGAACAGCCGTTCTCT
TGCACCTCCCTGGACGCCGTGGTCAACTATTTCGTGTCGCATACCAAAAAGGCGCTGGTGCCAT
TCCTGTTAGACGAGGACTACGAGAAGGTGCTAGGCTACGTGGAAGCCGATAAGGAGAATGGCGA
GAATGTGTGGGTGGCGCCCTCCGCTCCGGGCCCAGGTCCTGCACCCTGCACAGGTGGCCCCAAG
CCGCTGTCACCTGCGTCTGTGCCTGTGTCTAGCCAGGACAAGCTGCCCCCACTGCCCCCACTAC
CGAACCAGGAAGAGAACTACGTGACCCCCATTGGAGATGGCCCAGCTGTTGACTATGAGAACCA
AGATGTGGCTTCCTCTAGTTGGCCAGTCATCCTGAAGCCAAAGAAGTTGCCAAAGCCTCCTGCC
AAGCTTCCAAAGCCACCCGTTGGACCCAAGCCAGAGCCCAAAGTCTTTAATGGTGGCTTGGCCA
GGAAGCTGCCAGTCAGTTCAGCCCAGCCTCTCTTCCCCACAGCCGGGCTGGCAGACATGACGGC
AGAGCTACAGAAGAAGCTGGAGAAGAGGCGGGCACTGGAGCACTGATTCGGACACACCAGGGAC
CAGCGGGCCAGTCCCGGGGCATGGCCCAGCGGCCAGATTCTTTTTCCCAGGATTAAAACTCTGA
CCCCAGGA

hide sequence

RefSeq Acc Id:

XM_055104064 ⟹ XP_054960039

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	8,722,364 - 8,737,206 (-)	NCBI
NHGRI_mPanPan1	19	7,951,770 - 7,967,028 (-)	NCBI

RefSeq Acc Id:

XM_055104065 ⟹ XP_054960040

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	8,722,364 - 8,737,206 (-)	NCBI
NHGRI_mPanPan1	19	7,951,770 - 7,967,028 (-)	NCBI

RefSeq Acc Id:

XM_063599786 ⟹ XP_063455856

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	8,722,364 - 8,737,247 (-)	NCBI

RefSeq Acc Id:

XM_063599787 ⟹ XP_063455857

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	8,722,364 - 8,737,206 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003819325	(Get FASTA)	NCBI Sequence Viewer
	XP_054960039	(Get FASTA)	NCBI Sequence Viewer
	XP_054960040	(Get FASTA)	NCBI Sequence Viewer
	XP_063455856	(Get FASTA)	NCBI Sequence Viewer
	XP_063455857	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000003245
	ENSPPAP00000003245.1

RefSeq Acc Id:	XP_003819325 ⟸ XM_003819277
- Peptide Label:	isoform X1
- UniProtKB:	A0A2R8ZKI1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MASALRPPRVPKPKGVLPSHYYESFLEKKGPCDRDYKKFWAGLQGLTIYFYNSNRDFQHVEKLN LGAFEKLTDEIPWGSSRDPGTHFSLILRNQEIKFKVETLECREMWKGFILTVVELRVPTDLTLL PGHLYMMSEVLAKEEARRALETPSCFLKVSRLEAQLLLERYPECGNLLLRPSGDGADGVSVTTR QMHNGTHVVRHYKVKREGPKYVIDVEQPFSCTSLDAVVNYFVSHTKKALVPFLLDEDYEKVLGY VEADKENGENVWVAPSAPGPGPAPCTGGPKPLSPASVPVSSQDKLPPLPPLPNQEENYVTPIGD GPAVDYENQDVASSSWPVILKPKKLPKPPAKLPKPPVGPKPEPKVFNGGLARKLPVSSAQPLFP TAGLADMTAELQKKLEKRRALEH hide sequence

RefSeq Acc Id:

ENSPPAP00000003245 ⟸ ENSPPAT00000014966

RefSeq Acc Id:	XP_054960040 ⟸ XM_055104065
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_054960039 ⟸ XM_055104064
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R8ZKI1 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063455856 ⟸ XM_063599786
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_063455857 ⟸ XM_063599787
- Peptide Label:	isoform X5

Protein Domains

SH2

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000013672	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000014966.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.29.30	UniProtKB/TrEMBL
	3.30.505.10	UniProtKB/TrEMBL
InterPro	PH-like_dom_sf	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	STAP1/STAP2	UniProtKB/TrEMBL
	STAP2_SH2	UniProtKB/TrEMBL
KEGG Report	pps:100968262	UniProtKB/TrEMBL
NCBI Gene	STAP2	ENTREZGENE
PANTHER	PTHR16186	UniProtKB/TrEMBL
	SIGNAL-TRANSDUCING ADAPTOR PROTEIN 2	UniProtKB/TrEMBL
PROSITE	SH2	UniProtKB/TrEMBL
Superfamily-SCOP	PH domain-like	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	A0A2R8ZKI1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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