FGF8 (fibroblast growth factor 8) - Rat Genome Database

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Pathways
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Gene: FGF8 (fibroblast growth factor 8) Pan paniscus
Analyze
Symbol: FGF8
Name: fibroblast growth factor 8
RGD ID: 12002404
Description: ENCODES a protein that exhibits chemoattractant activity (ortholog); type 1 fibroblast growth factor receptor binding (ortholog); type 2 fibroblast growth factor receptor binding (ortholog); INVOLVED IN aorta morphogenesis (ortholog); apoptotic process (ortholog); blood vessel remodeling (ortholog); PARTICIPATES IN fibroblast growth factor signaling pathway; ASSOCIATED WITH 22q11 Deletion Syndrome (ortholog); breast cancer (ortholog); Cardiovascular Abnormalities (ortholog); FOUND IN external side of plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28113,656,283 - 113,662,837 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110113,661,598 - 113,668,156 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,372,251 - 98,378,811 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110101,844,792 - 101,849,873 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,844,792 - 101,853,916 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aorta morphogenesis  (IEA,ISO)
apoptotic process  (IEA,ISO)
blood vessel remodeling  (IEA,ISO)
bone development  (IEA)
branching involved in blood vessel morphogenesis  (IEA,ISO)
branching involved in salivary gland morphogenesis  (IEA,ISO)
branching involved in ureteric bud morphogenesis  (IEA,ISO)
cell fate commitment  (IEA,ISO)
cell migration involved in mesendoderm migration  (IEA,ISO)
cell population proliferation  (IEA,ISO)
cell proliferation in forebrain  (IEA,ISO)
central nervous system neuron development  (ISO)
corticotropin hormone secreting cell differentiation  (IEA,ISO)
determination of left/right symmetry  (IEA,ISO)
dopaminergic neuron differentiation  (IEA)
dorsal/ventral axon guidance  (ISO)
dorsal/ventral pattern formation  (IEA)
embryo development ending in birth or egg hatching  (IEA,ISO)
embryonic heart tube development  (IEA,ISO)
embryonic hindlimb morphogenesis  (IEA,ISO)
embryonic neurocranium morphogenesis  (IEA,ISO)
epithelial to mesenchymal transition involved in endocardial cushion formation  (IEA,ISO)
fibroblast growth factor receptor signaling pathway  (IEA,ISO)
forebrain dorsal/ventral pattern formation  (IEA,ISO)
forebrain morphogenesis  (IEA,ISO)
forebrain neuron development  (ISO)
generation of neurons  (IEA,ISO)
gonad development  (IEA)
heart development  (IEA,ISO)
heart looping  (IEA,ISO)
heart morphogenesis  (IEA,ISO)
inner ear morphogenesis  (IEA,ISO)
kidney development  (IEA,ISO)
larynx morphogenesis  (IEA,ISO)
limb morphogenesis  (IEA,ISO)
lung development  (IEA,ISO)
lung morphogenesis  (IEA,ISO)
male genitalia development  (IEA,ISO)
MAPK cascade  (IEA,ISO)
mesodermal cell migration  (IEA,ISO)
mesonephros development  (IEA)
metanephros development  (IEA)
midbrain-hindbrain boundary development  (IEA,ISO)
mitotic nuclear division  (IEA,ISO)
motor neuron axon guidance  (ISO)
negative regulation of apoptotic process  (IEA,ISO)
negative regulation of cardiac muscle tissue development  (IEA)
negative regulation of neuron apoptotic process  (IEA,ISO)
neural plate morphogenesis  (IEA,ISO)
neuroepithelial cell differentiation  (IEA)
neuron apoptotic process  (IEA,ISO)
neuron differentiation  (IEA)
odontogenesis  (IEA)
organ growth  (IEA,ISO)
organ induction  (IEA,ISO)
otic vesicle formation  (IEA,ISO)
outflow tract morphogenesis  (IEA,ISO)
outflow tract septum morphogenesis  (IEA)
pallium development  (IEA,ISO)
pharyngeal system development  (IEA,ISO)
positive regulation of cell population proliferation  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA,ISO)
positive regulation of G protein-coupled receptor signaling pathway  (IEA,ISO)
positive regulation of gene expression  (IEA,ISO)
positive regulation of mitotic nuclear division  (IEA,ISO)
positive regulation of organ growth  (IEA,ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (IEA,ISO)
positive regulation of protein phosphorylation  (IEA)
positive regulation of stem cell proliferation  (IEA,ISO)
regulation of cell migration  (IEA)
regulation of odontogenesis of dentin-containing tooth  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction involved in regulation of gene expression  (IEA,ISO)
stem cell proliferation  (IEA,ISO)
subpallium development  (IEA,ISO)
telencephalon development  (IEA,ISO)
thyroid gland development  (IEA,ISO)
thyroid-stimulating hormone-secreting cell differentiation  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FGF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28113,656,283 - 113,662,837 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110113,661,598 - 113,668,156 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,372,251 - 98,378,811 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110101,844,792 - 101,849,873 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,844,792 - 101,853,916 (-)Ensemblpanpan1.1panPan2
FGF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810101,770,109 - 101,780,369 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10101,770,109 - 101,780,371 (-)EnsemblGRCh38hg38GRCh38
GRCh3710103,529,866 - 103,540,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,519,877 - 103,525,817 (-)NCBINCBI36Build 36hg18NCBI36
Build 3410103,519,876 - 103,525,817NCBI
Celera1097,268,628 - 97,274,500 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,160,317 - 97,170,664 (-)NCBIHuRef
CHM1_110103,813,541 - 103,823,715 (-)NCBICHM1_1
T2T-CHM13v2.010102,653,607 - 102,663,864 (-)NCBIT2T-CHM13v2.0
Fgf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391945,724,930 - 45,731,380 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1945,725,237 - 45,731,354 (-)EnsemblGRCm39 Ensembl
GRCm381945,736,491 - 45,742,941 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1945,736,798 - 45,742,915 (-)EnsemblGRCm38mm10GRCm38
MGSCv371945,811,288 - 45,817,374 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361945,790,129 - 45,796,184 (-)NCBIMGSCv36mm8
Celera1946,499,127 - 46,505,223 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
Fgf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,533,504 - 254,539,605 (-)NCBIGRCr8
mRatBN7.21244,584,477 - 244,590,578 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,584,652 - 244,590,359 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1252,726,050 - 252,731,769 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,424,173 - 259,429,872 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,076,241 - 252,081,969 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,492,949 - 265,498,965 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,493,124 - 265,498,831 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01272,923,589 - 272,929,296 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41250,951,023 - 250,956,730 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11251,211,591 - 251,217,299 (-)NCBI
Celera1240,393,901 - 240,399,608 (-)NCBICelera
Cytogenetic Map1q54NCBI
Fgf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,517,412 - 8,521,770 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554858,517,412 - 8,521,732 (+)NCBIChiLan1.0ChiLan1.0
FGF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,362,407 - 14,367,109 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,362,109 - 14,367,468 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2814,530,980 - 14,536,626 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02814,830,423 - 14,836,072 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2814,829,998 - 14,836,143 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,376,915 - 14,382,561 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,416,494 - 14,421,136 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,548,787 - 14,554,435 (-)NCBIUU_Cfam_GSD_1.0
Fgf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,401,605 - 32,407,401 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366004,004,824 - 4,010,689 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366004,004,847 - 4,010,626 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FGF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,808,162 - 112,814,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114112,808,215 - 112,814,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214122,661,225 - 122,666,751 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FGF8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1994,797,157 - 94,803,725 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl994,798,088 - 94,803,629 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604855,874,226 - 55,880,198 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fgf8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,253,044 - 1,257,741 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248311,251,991 - 1,259,247 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000057158   ⟹   ENSPPAP00000034277
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl10101,844,792 - 101,849,877 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000057166   ⟹   ENSPPAP00000034285
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl10101,844,988 - 101,853,916 (-)Ensembl
RefSeq Acc Id: XM_034931341   ⟹   XP_034787232
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28113,656,283 - 113,662,837 (-)NCBI
NHGRI_mPanPan110113,661,598 - 113,668,156 (-)NCBI
Mhudiblu_PPA_v01098,372,251 - 98,378,811 (-)NCBI
RefSeq Acc Id: XM_034931342   ⟹   XP_034787233
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28113,656,284 - 113,662,837 (-)NCBI
NHGRI_mPanPan110113,661,599 - 113,668,156 (-)NCBI
Mhudiblu_PPA_v01098,372,251 - 98,378,811 (-)NCBI
RefSeq Acc Id: XM_034931343   ⟹   XP_034787234
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28113,656,285 - 113,662,837 (-)NCBI
NHGRI_mPanPan110113,661,600 - 113,668,156 (-)NCBI
Mhudiblu_PPA_v01098,372,252 - 98,378,809 (-)NCBI
RefSeq Acc Id: XM_034931344   ⟹   XP_034787235
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v28113,656,285 - 113,662,837 (-)NCBI
NHGRI_mPanPan110113,661,600 - 113,668,156 (-)NCBI
Mhudiblu_PPA_v01098,372,253 - 98,378,808 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034787232 (Get FASTA)   NCBI Sequence Viewer  
  XP_034787233 (Get FASTA)   NCBI Sequence Viewer  
  XP_034787234 (Get FASTA)   NCBI Sequence Viewer  
  XP_034787235 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000034277.1
  ENSPPAP00000034285.1
RefSeq Acc Id: XP_034787233   ⟸   XM_034931342
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BX65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787232   ⟸   XM_034931341
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BX65 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787234   ⟸   XM_034931343
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C0K2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034787235   ⟸   XM_034931344
- Peptide Label: isoform X4
- UniProtKB: A0A2R9C0K2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000034277   ⟸   ENSPPAT00000057158
Ensembl Acc Id: ENSPPAP00000034285   ⟸   ENSPPAT00000057166


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039985 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000057158.1 UniProtKB/TrEMBL
  ENSPPAT00000057166.1 UniProtKB/TrEMBL
Gene3D-CATH 2.80.10.50 UniProtKB/TrEMBL
InterPro Fibroblast_GF_fam UniProtKB/TrEMBL
  IL1/FGF UniProtKB/TrEMBL
NCBI Gene FGF8 ENTREZGENE
PANTHER PTHR11486 UniProtKB/TrEMBL
  PTHR11486:SF3 UniProtKB/TrEMBL
Pfam FGF UniProtKB/TrEMBL
PRINTS IL1HBGF UniProtKB/TrEMBL
PROSITE HBGF_FGF UniProtKB/TrEMBL
SMART FGF UniProtKB/TrEMBL
Superfamily-SCOP SSF50353 UniProtKB/TrEMBL
UniProt A0A2R9BX65 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C0K2 ENTREZGENE, UniProtKB/TrEMBL