ERCC5 (ERCC excision repair 5, endonuclease) - Rat Genome Database

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Gene: ERCC5 (ERCC excision repair 5, endonuclease) Pan paniscus
Analyze
Symbol: ERCC5 (Ensembl: BIVM-ERCC5)
Name: ERCC excision repair 5, endonuclease (Ensembl:BIVM-ERCC5 readthrough)
RGD ID: 12000588
Description: ENCODES a protein that exhibits bubble DNA binding (ortholog); damaged DNA binding (ortholog); double-stranded DNA binding (ortholog); INVOLVED IN base-excision repair, AP site formation (ortholog); determination of adult lifespan (ortholog); DNA repair (ortholog); PARTICIPATES IN altered nucleotide excision repair pathway; nucleotide excision repair pathway; RNA polymerase II transcription initiation pathway; ASSOCIATED WITH Anal Atresia, Hypospadias, and Penoscrotal Inversion (ortholog); cerebrooculofacioskeletal syndrome 3 (ortholog); Cockayne syndrome (ortholog); FOUND IN DNA replication factor A complex (ortholog); nucleotide-excision repair complex (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA excision repair protein ERCC-5; DNA repair protein complementing XP-G cells; excision repair cross-complementing rodent repair deficiency, complementation group 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,361,975 - 104,393,675 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113103,033,007 - 103,063,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01384,005,950 - 84,036,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113103,142,508 - 103,173,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13103,096,344 - 103,174,182 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ERCC5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v214104,361,975 - 104,393,675 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan113103,033,007 - 103,063,245 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01384,005,950 - 84,036,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.113103,142,508 - 103,173,022 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl13103,096,344 - 103,174,182 (+)Ensemblpanpan1.1panPan2
ERCC5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3813102,846,032 - 102,875,995 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl13102,845,831 - 102,875,995 (+)EnsemblGRCh38hg38GRCh38
GRCh3713103,498,382 - 103,528,345 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3613102,296,175 - 102,326,346 (+)NCBINCBI36Build 36hg18NCBI36
Build 3413102,296,174 - 102,326,346NCBI
Celera1384,342,654 - 84,372,832 (+)NCBICelera
Cytogenetic Map13q33.1NCBI
HuRef1384,090,418 - 84,120,587 (+)NCBIHuRef
CHM1_113103,467,640 - 103,497,809 (+)NCBICHM1_1
T2T-CHM13v2.013102,064,228 - 102,094,203 (+)NCBIT2T-CHM13v2.0
Ercc5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39144,184,084 - 44,220,399 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl144,186,904 - 44,220,420 (+)EnsemblGRCm39 Ensembl
GRCm38144,146,948 - 44,181,260 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl144,147,744 - 44,181,260 (+)EnsemblGRCm38mm10GRCm38
MGSCv37144,204,589 - 44,238,105 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36144,092,393 - 44,125,806 (+)NCBIMGSCv36mm8
Celera144,491,664 - 44,523,751 (+)NCBICelera
Cytogenetic Map1C1.1NCBI
cM Map123.55NCBI
Ercc5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8953,801,471 - 53,846,611 (+)NCBIGRCr8
mRatBN7.2946,309,477 - 46,354,478 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl946,309,389 - 46,354,472 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.0950,928,847 - 50,970,962 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl950,925,619 - 50,970,955 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0950,591,955 - 50,637,694 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4943,248,023 - 43,293,196 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera944,012,579 - 44,057,619 (+)NCBICelera
Cytogenetic Map9q22NCBI
Ercc5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554048,294,346 - 8,321,112 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554048,294,506 - 8,321,505 (-)NCBIChiLan1.0ChiLan1.0
ERCC5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12252,339,011 - 52,372,618 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2252,118,439 - 52,152,268 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02252,786,543 - 52,820,389 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2252,786,765 - 52,820,387 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12252,438,966 - 52,472,791 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02252,455,293 - 52,489,134 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02252,496,357 - 52,530,203 (+)NCBIUU_Cfam_GSD_1.0
Ercc5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945187,718,036 - 187,758,810 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364728,209,540 - 8,234,334 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364728,209,482 - 8,234,696 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERCC5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1171,141,842 - 71,168,322 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11171,141,823 - 71,168,326 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ERCC5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1381,406,103 - 81,441,422 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl381,405,872 - 81,436,040 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604637,942,886 - 37,972,889 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ercc5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247938,632,471 - 8,657,346 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247938,632,581 - 8,657,514 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000058740   ⟹   ENSPPAP00000035851
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl13103,096,344 - 103,138,551 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000058782   ⟹   ENSPPAP00000035893
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl13103,104,298 - 103,172,930 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000058788   ⟹   ENSPPAP00000035899
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl13103,142,502 - 103,174,182 (+)Ensembl
RefSeq Acc Id: XM_014347484   ⟹   XP_014202970
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v214104,361,975 - 104,393,675 (+)NCBI
NHGRI_mPanPan113103,033,007 - 103,063,245 (+)NCBI
Mhudiblu_PPA_v01384,005,951 - 84,036,710 (+)NCBI
PanPan1.113103,142,508 - 103,173,022 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_014202970 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000035893.1
  ENSPPAP00000035899
  ENSPPAP00000035899.1
Reference Protein Sequences
RefSeq Acc Id: XP_014202970   ⟸   XM_014347484
- UniProtKB: A0A2R9C1V3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000035899   ⟸   ENSPPAT00000058788
RefSeq Acc Id: ENSPPAP00000035851   ⟸   ENSPPAT00000058740
RefSeq Acc Id: ENSPPAP00000035893   ⟸   ENSPPAT00000058782
Protein Domains
XPG N-terminal   XPG-I


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040707 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058782.1 UniProtKB/TrEMBL
  ENSPPAT00000058788.1 UniProtKB/TrEMBL
Gene3D-CATH 5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
  5'-nuclease UniProtKB/TrEMBL
InterPro 5-3_exonuclease_C_sf UniProtKB/TrEMBL
  HhH2 UniProtKB/TrEMBL
  PIN-like_dom_sf UniProtKB/TrEMBL
  XPG-I_dom UniProtKB/TrEMBL
  XPG/Rad2 UniProtKB/TrEMBL
  XPG/Rad2_eukaryotes UniProtKB/TrEMBL
  XPG_CS UniProtKB/TrEMBL
  XPG_DNA_repair_N UniProtKB/TrEMBL
KEGG Report pps:100980042 UniProtKB/TrEMBL
NCBI Gene ERCC5 ENTREZGENE
PANTHER BASIC IMMUNOGLOBULIN-LIKE VARIABLE MOTIF-CONTAINING PROTEIN UniProtKB/TrEMBL
  DNA EXCISION REPAIR PROTEIN ERCC-5 UniProtKB/TrEMBL
  DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED UniProtKB/TrEMBL
Pfam XPG_I UniProtKB/TrEMBL
  XPG_N UniProtKB/TrEMBL
PRINTS XPGRADSUPER UniProtKB/TrEMBL
  XRODRMPGMNTG UniProtKB/TrEMBL
PROSITE XPG_1 UniProtKB/TrEMBL
  XPG_2 UniProtKB/TrEMBL
SMART HhH2 UniProtKB/TrEMBL
  XPGI UniProtKB/TrEMBL
  XPGN UniProtKB/TrEMBL
Superfamily-SCOP SSF47807 UniProtKB/TrEMBL
  SSF88723 UniProtKB/TrEMBL
UniProt A0A2R9C1T5_PANPA UniProtKB/TrEMBL
  A0A2R9C1V3 ENTREZGENE, UniProtKB/TrEMBL