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Gene: FEZF2 (FEZ family zinc finger 2) Pan paniscus

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Symbol:

FEZF2

Name:

FEZ family zinc finger 2

RGD ID:

11999448

Description:

ENCODES a protein that exhibits chromatin binding (inferred); DNA-binding transcription activator activity, RNA polymerase II-specific (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN telencephalon development (ortholog); ASSOCIATED WITH Neurodevelopmental Disorders (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

fez family zinc finger protein 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	62,204,917 - 62,317,594 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	62,318,265 - 62,323,032 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	62,292,878 - 62,296,987 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	63,679,898 - 63,683,700 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	63,680,307 - 63,683,052 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neurodevelopmental Disorders (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

axonal fasciculation (IEA)

cell dedifferentiation (IEA)

central nervous system neuron differentiation (IEA)

cerebral cortex GABAergic interneuron migration (IEA)

cerebral cortex neuron differentiation (IEA)

commitment of neuronal cell to specific neuron type in forebrain (IEA)

dendrite development (IEA)

dentate gyrus development (IEA)

forebrain anterior/posterior pattern specification (IEA)

forebrain development (IEA)

GABAergic neuron differentiation (IEA)

locomotory behavior (IEA)

negative regulation of cell population proliferation (IEA)

negative regulation of neuron differentiation (IEA)

negative regulation of transcription by RNA polymerase II (IEA)

neuron differentiation (IEA)

neuron fate determination (IEA)

positive regulation of DNA-templated transcription (IEA)

positive regulation of neuron differentiation (IEA)

positive regulation of transcription by RNA polymerase II (IEA)

regulation of axon guidance (IEA)

regulation of neurogenesis (IEA)

regulation of transcription by RNA polymerase II (IEA)

telencephalon development (IEA,ISO)

Molecular Function

chromatin binding (IEA)

DNA-binding transcription activator activity, RNA polymerase II-specific (IEA)

DNA-binding transcription factor activity, RNA polymerase II-specific (IEA)

DNA-binding transcription repressor activity, RNA polymerase II-specific (IEA)

RNA polymerase II cis-regulatory region sequence-specific DNA binding (IEA)

sequence-specific DNA binding (IEA)

transcription cis-regulatory region binding (IEA)

zinc ion binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

FEZF2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	62,204,917 - 62,317,594 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	62,318,265 - 62,323,032 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	62,292,878 - 62,296,987 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	63,679,898 - 63,683,700 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	63,680,307 - 63,683,052 (-)	Ensembl	panpan1.1		panPan2

FEZF2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	62,369,681 - 62,373,550 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	62,369,681 - 62,374,324 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	62,355,356 - 62,359,225 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	62,330,387 - 62,334,230 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	62,330,398 - 62,334,061	NCBI
Celera	3	62,372,439 - 62,376,282 (-)	NCBI		Celera
Cytogenetic Map	3	p14.2	NCBI
HuRef	3	62,453,442 - 62,457,287 (-)	NCBI		HuRef
CHM1_1	3	62,306,475 - 62,310,318 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	62,413,195 - 62,417,065 (-)	NCBI		T2T-CHM13v2.0

Fezf2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	10,121,561 - 10,130,771 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	10,121,574 - 10,127,669 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	12,338,992 - 12,346,803 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	12,342,094 - 12,348,189 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	13,174,406 - 13,178,379 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	11,135,369 - 11,139,095 (-)	NCBI		MGSCv36	mm8
Celera	14	7,971,161 - 7,975,134 (-)	NCBI		Celera
Cytogenetic Map	14	A1	NCBI
cM Map	14	6.36	NCBI

Fezf2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	15,199,045 - 15,207,982 (+)	NCBI		GRCr8
mRatBN7.2	15	12,768,614 - 12,777,554 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	12,773,762 - 12,777,554 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	14,902,423 - 14,906,214 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	15,860,874 - 15,864,667 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	14,115,673 - 14,119,460 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	12,825,333 - 12,831,496 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	12,827,707 - 12,831,496 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	16,852,526 - 16,858,715 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	14,350,796 - 14,354,585 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	14,350,780 - 14,354,571 (+)	NCBI
Celera	15	12,771,624 - 12,775,413 (+)	NCBI		Celera
Cytogenetic Map	15	p15	NCBI

Fezf2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955517	3,439,999 - 3,443,846 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955517	3,439,999 - 3,443,477 (+)	NCBI	ChiLan1.0	ChiLan1.0

FEZF2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	20	28,704,287 - 28,708,620 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	20	28,703,623 - 28,708,282 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	20	28,630,343 - 28,636,829 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	28,936,971 - 28,943,463 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	28,940,148 - 28,943,133 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	20	28,422,707 - 28,429,181 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	20	28,780,654 - 28,787,141 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	28,880,642 - 28,887,134 (+)	NCBI		UU_Cfam_GSD_1.0

Fezf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	165,652,364 - 165,661,504 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936637	4,047,119 - 4,052,741 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936637	4,045,224 - 4,051,058 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FEZF2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	43,953,910 - 43,957,473 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	43,953,914 - 43,958,419 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	47,998,138 - 48,002,064 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FEZF2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	23,442,699 - 23,453,026 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	23,443,114 - 23,445,908 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	143,417,725 - 143,422,588 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fezf2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624888	3,462,233 - 3,468,293 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624888	3,462,132 - 3,467,701 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003811606	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034956795	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063602789	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000055905 ⟹ ENSPPAP00000033035

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	3	63,680,307 - 63,683,052 (-)	Ensembl

RefSeq Acc Id:

XM_003811606 ⟹ XP_003811654

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	62,204,917 - 62,317,594 (-)	NCBI
NHGRI_mPanPan1	3	62,318,265 - 62,323,032 (-)	NCBI
Mhudiblu_PPA_v0	3	62,292,878 - 62,296,987 (-)	NCBI
PanPan1.1	3	63,679,898 - 63,683,700 (-)	NCBI

Sequence:

show sequence

TCCTTTTAAAGTTTGAGGGGTGGTGGTGGCGGCGGCCGGCAGGCGCGGGGGAACACAGGGGCCG
CTACGGGAGCCGGGCCGCCGCCCATGTCATTCCACTTCAAGTGACTTCATGTGATGTCAGCTGA
ATGTAAAAGACAGTGATCTCACGCGGAGGGGAAGATGTTTGCCATCAAAATGTGACAGAAGAGA
CACGCTGCATGGCTCGGAACGCATCTCCTTGGTGGTGGGGGAAAGAGACTTAGAGGAGAGAGGC
TGCGCCCTGGCCCAGCCTGGCTCGGCTCAGCTCCGCGCGCCATGGCAAGCTCGGCTTCCCTGGA
GACCATGGTGCCCCCGGCCTGCCCGCGCGCCGGAGCGTCGCCGGCCACTTCCAAGACACTGGCC
TTTTCCATCGAGCGCATCATGGCCAAGACGTCGGAGCCCCGTGCGCCCTTTGAGCCCCGGCCTG
GAGCGCTAGAGGCGGACGGCAGCCAGGGCAAGAAACTGCTCAACCTCTGCTCGCCGCTGCCCTG
TATGATCCCCCTCCAGCCCNTAGGCTACGAGGTGCCGTCAAAGACACTGCTCAGTTACTCGGAG
CTCTGGAAAAGCAGCCTCCGGGCGGGCGGCGGCGGAGGCGGCGGCGGTNNNNNNNNNNNNNNNN
NNNNCAACTGTGGCGTGTGCTGCAAGGCCGAGCTGGGCCTGGCGCCGTCCGCGCTGCCCGCGGG
CAGGGTCATCAAGCCGCAGGTCATCAACCAGGCTGTGGGGCTGCCGGCCAGCGGCTCGCTCTAC
TACTTCAACTACCTGGACTCGACCGCGTACCCGCCGTCTGAGCTCCTCAGCGGCCACCTCTTCC
CGTCTGGCCTCCTCAATGCGCAGGCCCCCGCCGCCCTGGCTGCTCACCCCAAGCTCTTTCTGCT
GGAGAACGCCAAGCTGGCCGGCCTGGCGGCGGACAAGTTCCCCCATCCGGCTCCCTATCCCCAT
AAGGAGCGCTTGCCGGCGCCGCTGGAGCAGGTACTGAAGGAAAACTCGGCCCTGACTGCAGAGC
GCGGAGGCGTCAAGGGCCACAGCAAGCTGCCAGGAGGCTCCGCAGATGGCAAGCCCAAAAACTT
CACCTGCGAGGTGTGCGGCAAGGTGTTTAACGCTCACTATAATCTCACCCGCCACATGCCGGTC
CACACCGGAGCCAGACCGTTCGTGTGCAAAGTCTGCGGCAAAGGCTTTCGCCAGGCCAGCACGC
TCTGCAGGCACAAAATTATCCACACCCAGGAAAAGCCACATAAATGCAACCAGTGCGGCAAAGC
GTTCAACCGCAGCTCCACGCTCAACACGCATATCCGCATCCACGCGGGCTACAAGCCCTTCGTC
TGCGAATTTTGCGGCAAAGGCTTTCACCAAAAAGGGAACTACAAGAACCACAAGCTGACCCACA
GCGGCGAGAAGCAGTACAAATGTACCATCTGCAACAAGGCCTTCCACCAGGTCTACAACCTAAC
CTTCCATATGCACACCCACAACGACAAGAAGCCTTTCACGTGCGCCACTTGCGGCAAAGGGTTT
TGCAGAAACTTTGACTTAAAGAAACATGTGCGCAAACTCCACGACAGCGTGGGCCCTGCTGCCC
CCTCCGCAAAGGACCTGACTAGGACAGTGCAGAGCTGAGAGCTACTGCCTTGCCCTTCCTTCCC
TCCCTGTACCACCTGAAAACAGATCACACATATAAACTTATTTCTAAAATTAAAAGAAAAAAAA
ACTATAGCAGAGAGGCTAAAATCTATTTATCGAAACCAGCATATTTTTGGAAAGCTAAATGTTT
CCTCGATGACTGGCAGCAAACTCGTGGCCCCCACCTTTGTATATTCAGGAAACTTATTTAAATC
CAGTGCGCCGAAACGTATTTAATTCCAGGCCTCCGCTTCTCCTGGGGCAGCCAGTTTTAACCCC
AGCCTGTCACCGTGAGCGCCCCAGAAGAGCGCGGCGCCCCTAGCCATCTTTATACAGCCATGTA
AATCCTCCTGTACAAGCGAACACGGAATATATACATATATAACTCAATAAACAGAATCATTAG

hide sequence

RefSeq Acc Id:

XM_063602789 ⟹ XP_063458859

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	2	62,204,917 - 62,317,594 (-)	NCBI

Protein Sequences


Protein RefSeqs	XP_003811654	(Get FASTA)	NCBI Sequence Viewer
	XP_063458859	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000033035.1

RefSeq Acc Id:

XP_003811654 ⟸ XM_003811606

- Sequence:

show sequence

MASSASLETMVPPACPRAGASPATSKTLAFSIERIMAKTSEPRAPFEPRPGALEADGSQGKKLL
NLCSPLPCMIPLQPXGYEVPSKTLLSYSELWKSSLRAGGGGGGGGXXXXXXXNCGVCCKAELGL
APSALPAGRVIKPQVINQAVGLPASGSLYYFNYLDSTAYPPSELLSGHLFPSGLLNAQAPAALA
AHPKLFLLENAKLAGLAADKFPHPAPYPHKERLPAPLEQVLKENSALTAERGGVKGHSKLPGGS
ADGKPKNFTCEVCGKVFNAHYNLTRHMPVHTGARPFVCKVCGKGFRQASTLCRHKIIHTQEKPH
KCNQCGKAFNRSSTLNTHIRIHAGYKPFVCEFCGKGFHQKGNYKNHKLTHSGEKQYKCTICNKA
FHQVYNLTFHMHTHNDKKPFTCATCGKGFCRNFDLKKHVRKLHDSVGPAAPSAKDLTRTVQS

hide sequence

Ensembl Acc Id:

ENSPPAP00000033035 ⟸ ENSPPAT00000055905

RefSeq Acc Id:

XP_063458859 ⟸ XM_063602789

Protein Domains

C2H2-type

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039379	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000055905.1	UniProtKB/TrEMBL
Gene3D-CATH	Classic Zinc Finger	UniProtKB/TrEMBL
InterPro	Znf_C2H2_sf	UniProtKB/TrEMBL
	Znf_C2H2_type	UniProtKB/TrEMBL
NCBI Gene	FEZF2	ENTREZGENE
PANTHER	FEZ FAMILY ZINC FINGER PROTEIN 1	UniProtKB/TrEMBL
	KRUEPPEL-LIKE TRANSCRIPTION FACTOR	UniProtKB/TrEMBL
Pfam	zf-C2H2	UniProtKB/TrEMBL
	zf-C2H2_6	UniProtKB/TrEMBL
PROSITE	ZINC_FINGER_C2H2_1	UniProtKB/TrEMBL
	ZINC_FINGER_C2H2_2	UniProtKB/TrEMBL
SMART	ZnF_C2H2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57667	UniProtKB/TrEMBL
UniProt	A0A2R9BX39_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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