EMD (emerin) - Rat Genome Database

Name: EMD
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: EMD (emerin) Pan paniscus

Analyze

Symbol:

EMD

Name:

emerin

RGD ID:

11995328

Description:

ENCODES a protein that exhibits actin binding (inferred); beta-tubulin binding (inferred); cadherin binding (inferred); INVOLVED IN nuclear membrane reassembly (ortholog); skeletal muscle cell differentiation (ortholog); ASSOCIATED WITH adrenoleukodystrophy (ortholog); autistic disorder (ortholog); Barth syndrome (ortholog); FOUND IN nuclear envelope (ortholog); nucleus (ortholog); TMEM240-body (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	EMD (emerin)	NCBI	Ortholog
Mus musculus (house mouse):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	EMD (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	EMD (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	EMD (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Emd (emerin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	154,324,795 - 154,332,696 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	154,328,400 - 154,330,769 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,792,178 - 143,794,530 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adrenoleukodystrophy (ISO)

autistic disorder (ISO)

Barth syndrome (ISO)

cardiomyopathy (ISO)

cerebral creatine deficiency syndrome 1 (ISO)

Charcot-Marie-Tooth disease type 2 (ISO)

dilated cardiomyopathy (ISO)

dilated cardiomyopathy 1A (ISO)

dilated cardiomyopathy 1B (ISO)

dyskeratosis congenita (ISO)

Emery-Dreifuss muscular dystrophy (ISO)

familial hypertrophic cardiomyopathy (ISO)

favism (ISO)

hypertrophic cardiomyopathy (ISO)

immunodeficiency 33 (ISO)

myopathy (ISO)

neuromuscular disease (ISO)

paraplegia (ISO)

periventricular nodular heterotopia (ISO)

severe congenital encephalopathy due to MECP2 mutation (ISO)

Splenomegaly (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

X-linked Emery-Dreifuss muscular dystrophy 1 (ISO)

X-linked Emery-Dreifuss muscular dystrophy 6 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to growth factor stimulus (IEA)

negative regulation of canonical Wnt signaling pathway (IEA)

negative regulation of fibroblast proliferation (IEA)

nuclear membrane organization (IEA)

nuclear membrane reassembly (ISO)

positive regulation of protein export from nucleus (IEA)

regulation of canonical Wnt signaling pathway (IEA)

skeletal muscle cell differentiation (ISO)

Cellular Component

cortical endoplasmic reticulum (IEA)

cytoplasm (IEA)

endoplasmic reticulum (IEA)

membrane (IEA)

nuclear envelope (IEA,ISO)

nuclear inner membrane (IEA)

nuclear membrane (IEA)

nuclear outer membrane (IEA)

nucleoplasm (IEA)

nucleus (ISO)

spindle (IEA)

spindle pole centrosome (IEA)

TMEM240-body (ISO)

Molecular Function

actin binding (IEA)

beta-tubulin binding (IEA)

cadherin binding (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

EMD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	X	154,324,795 - 154,332,696 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	X	154,328,400 - 154,330,769 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	X	143,792,178 - 143,794,530 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

EMD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	X	154,379,295 - 154,381,523 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	X	154,379,273 - 154,381,574 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	X	153,607,655 - 153,609,883 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	153,260,981 - 153,263,075 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	X	153,128,633 - 153,130,728	NCBI
Celera	X	153,768,677 - 153,770,963 (+)	NCBI		Celera
Cytogenetic Map	X	q28	NCBI
HuRef	X	142,185,074 - 142,187,360 (+)	NCBI		HuRef
CHM1_1	X	153,519,221 - 153,521,507 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	X	152,610,118 - 152,618,066 (+)	NCBI		T2T-CHM13v2.0

Emd
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	73,298,297 - 73,305,188 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	X	73,298,293 - 73,305,154 (+)	Ensembl		GRCm39 Ensembl
GRCm38	X	74,254,674 - 74,261,563 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	74,254,687 - 74,261,548 (+)	Ensembl	GRCm38		mm10	GRCm38
GRCm38.p6 Ensembl	X	74,261,032 - 74,261,374 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	71,500,178 - 71,503,086 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	X	70,507,559 - 70,510,467 (+)	NCBI		MGSCv36	mm8
Celera	X	65,508,981 - 65,511,889 (+)	NCBI		Celera
Cytogenetic Map	X	A7.3	NCBI
cM Map	X	37.92	NCBI

Emd
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	X	157,190,438 - 157,193,479 (+)	NCBI		GRCr8
mRatBN7.2	X	152,038,990 - 152,042,190 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	X	152,038,998 - 152,045,807 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	X	154,180,279 - 154,183,290 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	X	157,743,512 - 157,746,523 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	X	155,415,308 - 155,418,319 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	X	156,452,847 - 156,455,858 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	156,452,818 - 156,456,035 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	152,192,993 - 152,196,004 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	160,351,228 - 160,354,239 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	X	160,427,431 - 160,430,442 (-)	NCBI
Celera	1	135,854,577 - 135,857,588 (-)	NCBI		Celera
Cytogenetic Map	X	q37	NCBI

Emd
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955580	864,532 - 866,904 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955580	864,532 - 866,904 (-)	NCBI	ChiLan1.0	ChiLan1.0

EMD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	X	122,050,309 - 122,052,629 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	X	122,050,455 - 122,052,524 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	X	107,379,062 - 107,381,339 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	X	125,192,020 - 125,194,303 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	X	125,192,024 - 125,204,015 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	X	120,961,089 - 120,963,363 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	X	123,475,997 - 123,478,261 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	X	123,237,823 - 123,240,104 (-)	NCBI		UU_Cfam_GSD_1.0

Emd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	X	119,389,931 - 119,392,424 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936809	1,127,710 - 1,130,195 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936809	1,127,701 - 1,130,195 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

EMD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	X	124,883,049 - 124,885,432 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	X	124,883,047 - 124,885,429 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

EMD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	128,689,588 - 128,692,105 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	X	128,689,588 - 128,692,625 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666065	66,578,574 - 66,581,198 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Emd
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624946	801,639 - 808,162 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624946	805,573 - 808,001 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003804719	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_003804719 ⟹ XP_003804767

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	X	154,324,795 - 154,332,696 (-)	NCBI
NHGRI_mPanPan1	X	154,328,400 - 154,330,769 (-)	NCBI
Mhudiblu_PPA_v0	X	143,792,178 - 143,794,530 (-)	NCBI

Sequence:

show sequence

CGGGCCCCGCCCCTCCATCACTAGCCAATCCCCGTGCTTGTGACATATGGGCTTGCGGCCCCGC
CCGCTCCCATCGCGAGACCGGTTCCCACCGCCCTGACTCCCGGGCGGGCCCCGCCCTCTCCGCC
GCTAGCCAATCCTCGCGTTGATGACATTTGGGCTCGCGGCCCCAGCCTCCCAGCTCTCAGGGCA
CGGCCGGTCTGTGCCGGCTGCTCCCGCGGTTAGGTCCCGCCCCGCGCAGCGCGCGCAGCCTGCG
GAGCCAGCGGCCGTGACGCGACAACGATTCGGCTGTGACGCGACAACGATTCGGCTGTGACGCG
AGCGCGGCCGCTCCCGATGCGCTCGTGCCGCCCCCGCCGTGCTCCTCGGCAGCCGTTGCTCGGC
CGGTTTTGGTAGGCCCGGGCCGCCGCCAGGCCTCCGCCTGAGCCCGCACCCGCCATGGACAACT
ACGCAGATCTTTCGGATACCGAGCTGACCACCTTGCTGCGCCGGTACAACATCCCGCACGGGCC
TGTAGTAGGATCAACTCGTAGGCTTTACGAGAAGAAGATTTTCGAGTACGAGACCCAGAGGCGG
CGGCTCTCGCCCCCCAGCTCGTCCGCCGCCTCCTCTTATAGCTTCTCTGACTTGAATTCTACTA
GAGGGGATGCAGATATGTATGATCTTCCCAAGAAAGAGGACGCTTTACTCTACCAGAGCAAGGG
CTACAATGACGACTACTATGAAGAGAGCTACTTCACCACCAGGACTTATGGGGAGCCCGAGTCT
GCGGGCCCGTCCAGGGCTGTCCGCCAGTCAGTGACTTCATTCCCAGATGCTGACGCTTTCCATC
ACCAGGTGCGTGATGACGATCTTTTGTCTTCTTCTGAAGAGGAGTGCAAGGATAGGGAACGCCC
CATGTACGGCCGGGACAGTGCCTACCAGAGCATCACGCACTACCGCCCTGTTTCAGCCTCTAGG
AGCTCCCTGGACCTGTCCTATTATCCTACTTCCTCCTCCACCTCTTTTCTGTCCTCCTCATCAT
CTTCCTCTTCATGGCTCACCCGCCGTGCCATCCGGCCTGAAAACCATGCTCCTGGGGCTGGGCT
GGGCCAGGATCGCCAGGTCCCGCTCTGGGGCCAGCTGCTGCTTTTCCTGGTCTTTGTGATCGTC
CTCTTCTTCATTTACCACTTCATGCAGGCTGAAGAAGGCAACCCCTTCTAGAGGGAGCCATGAG
GGTCTGGGCTTCAGAGCTAGGTCTTTGGGGAAGTCCTGGCTGACTGCCTTAGCAGTGGGGGTGG
GGGTGGGGGTGGGGGCAGGGGCAGGGGCTTTTATGTGTTTTTGCTTGGGGGGCGCTGGGCCTAG
CCCAGAGTAGTGCTTGCTCCCCCTGCCTTGTCCCACCAGGGAGGCAGCAGACTCAGGCCCTCCA
TGGTCCTCTTTGTCATTTTGTTGACATGCATTCCTCCTTTTGTCATCTTGTTGGGGGGAGGGGA
TTAACCAAAGGCCACCCTGACTTTGTTTTTGTGGACACACAATAAAAGCCCCGTTTATTTGTAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003804767	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000008530
	ENSPPAP00000008530.1
	ENSPPAP00000008534.1

RefSeq Acc Id:

XP_003804767 ⟸ XM_003804719

- UniProtKB:

A0A2R8ZU88 (UniProtKB/TrEMBL), A0A2R8ZU91 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDNYADLSDTELTTLLRRYNIPHGPVVGSTRRLYEKKIFEYETQRRRLSPPSSSAASSYSFSDL
NSTRGDADMYDLPKKEDALLYQSKGYNDDYYEESYFTTRTYGEPESAGPSRAVRQSVTSFPDAD
AFHHQVRDDDLLSSSEEECKDRERPMYGRDSAYQSITHYRPVSASRSSLDLSYYPTSSSTSFLS
SSSSSSSWLTRRAIRPENHAPGAGLGQDRQVPLWGQLLLFLVFVIVLFFIYHFMQAEEGNPF

hide sequence

Protein Domains

LEM

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000027507	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000031166.1	UniProtKB/TrEMBL
	ENSPPAT00000031170.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.720.40	UniProtKB/TrEMBL
InterPro	Emerin	UniProtKB/TrEMBL
	LEM/LEM-like_dom_sf	UniProtKB/TrEMBL
	LEM_dom	UniProtKB/TrEMBL
	LEM_emerin	UniProtKB/TrEMBL
KEGG Report	pps:100980664	UniProtKB/TrEMBL
NCBI Gene	EMD	ENTREZGENE
PANTHER	EMERIN	UniProtKB/TrEMBL
	PTHR15171	UniProtKB/TrEMBL
Pfam	LEM	UniProtKB/TrEMBL
PROSITE	LEM	UniProtKB/TrEMBL
SMART	LEM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF63451	UniProtKB/TrEMBL
UniProt	A0A2R8ZU88	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R8ZU91	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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