LATS1 (large tumor suppressor kinase 1) - Rat Genome Database

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Gene: LATS1 (large tumor suppressor kinase 1) Pan paniscus
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Symbol: LATS1
Name: large tumor suppressor kinase 1
RGD ID: 11994520
Description: ENCODES a protein that exhibits ATP binding (ortholog); estrogen receptor binding (ortholog); magnesium ion binding (ortholog); INVOLVED IN cellular protein localization (ortholog); cytoplasmic sequestering of protein (ortholog); G2/M transition of mitotic cell cycle (ortholog); ASSOCIATED WITH basal cell carcinoma (ortholog); Glandular and Epithelial Neoplasms (ortholog); high grade glioma (ortholog); FOUND IN spindle pole (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LATS, large tumor suppressor, homolog 1; serine/threonine-protein kinase LATS1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16152,182,394 - 152,239,276 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6152,182,394 - 152,239,276 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06147,476,913 - 147,533,491 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
spindle pole  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
LATS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16152,182,394 - 152,239,276 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6152,182,394 - 152,239,276 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06147,476,913 - 147,533,491 (-)NCBIMhudiblu_PPA_v0panPan3
LATS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6149,658,153 - 149,718,105 (-)EnsemblGRCh38hg38GRCh38
GRCh386149,658,153 - 149,718,101 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376149,979,289 - 150,039,237 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366150,023,744 - 150,081,085 (-)NCBINCBI36hg18NCBI36
Build 346150,023,743 - 150,131,506NCBI
Celera6150,717,306 - 150,774,645 (-)NCBI
Cytogenetic Map6q25.1NCBI
HuRef6147,545,928 - 147,605,163 (-)NCBIHuRef
CHM1_16150,243,964 - 150,304,031 (-)NCBICHM1_1
Lats1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39107,556,964 - 7,592,225 (+)NCBIGRCm39mm39
GRCm39 Ensembl107,556,978 - 7,592,224 (+)Ensembl
GRCm38107,681,200 - 7,716,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl107,681,214 - 7,716,460 (+)EnsemblGRCm38mm10GRCm38
MGSCv37107,401,007 - 7,436,259 (+)NCBIGRCm37mm9NCBIm37
MGSCv36107,371,399 - 7,403,706 (+)NCBImm8
Celera107,558,767 - 7,594,190 (+)NCBICelera
Cytogenetic Map10A1NCBI
Lats1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.212,160,411 - 2,193,640 (+)NCBI
Rnor_6.0 Ensembl11,784,078 - 1,817,310 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.011,784,078 - 1,817,310 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.013,480,828 - 3,514,060 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.412,375,233 - 2,383,106 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1708,453 - 741,716 (+)NCBICelera
Cytogenetic Map1p13NCBI
Lats1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,559,657 - 11,611,660 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543911,559,655 - 11,611,287 (+)NCBIChiLan1.0ChiLan1.0
LATS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1140,430,096 - 40,475,193 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl140,260,064 - 40,457,609 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha141,279,729 - 41,298,611 (-)NCBI
ROS_Cfam_1.0140,610,288 - 40,657,158 (-)NCBI
UMICH_Zoey_3.1140,498,195 - 40,517,078 (-)NCBI
UNSW_CanFamBas_1.0140,363,168 - 40,382,087 (-)NCBI
UU_Cfam_GSD_1.0140,704,342 - 40,723,233 (-)NCBI
Lats1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946135,353,630 - 135,397,886 (-)NCBI
SpeTri2.0NW_0049364892,607,114 - 2,649,879 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LATS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,274,970 - 16,320,619 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,274,955 - 16,320,980 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2118,600,766 - 18,633,991 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LATS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11321,901,153 - 21,966,227 (+)NCBI
ChlSab1.1 Ensembl1321,919,280 - 21,967,117 (+)Ensembl
Vero_WHO_p1.0NW_023666040197,931,430 - 197,990,883 (+)NCBI
Lats1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247858,356,238 - 8,405,877 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000048755   ⟹   ENSPPAP00000025924
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6152,182,394 - 152,239,276 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000048757   ⟹   ENSPPAP00000025926
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6152,218,014 - 152,223,009 (-)Ensembl
RefSeq Acc Id: XM_003811519   ⟹   XP_003811567
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.16152,182,394 - 152,239,276 (-)NCBI
Mhudiblu_PPA_v06147,476,913 - 147,533,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014345517   ⟹   XP_014201003
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.16152,188,501 - 152,239,082 (-)NCBI
Mhudiblu_PPA_v06147,482,824 - 147,533,215 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034963063   ⟹   XP_034818954
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06147,492,001 - 147,533,215 (-)NCBI
RefSeq Acc Id: XM_034963064   ⟹   XP_034818955
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06147,478,922 - 147,533,215 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003811567 (Get FASTA)   NCBI Sequence Viewer  
  XP_014201003 (Get FASTA)   NCBI Sequence Viewer  
  XP_034818954 (Get FASTA)   NCBI Sequence Viewer  
  XP_034818955 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003811567   ⟸   XM_003811519
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_014201003   ⟸   XM_014345517
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034818955   ⟸   XM_034963064
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034818954   ⟸   XM_034963063
- Peptide Label: isoform X3
RefSeq Acc Id: ENSPPAP00000025926   ⟸   ENSPPAT00000048757
RefSeq Acc Id: ENSPPAP00000025924   ⟸   ENSPPAT00000048755
Protein Domains
AGC-kinase C-terminal   Protein kinase   UBA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036080 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000025924 UniProtKB/TrEMBL
  ENSPPAP00000025926 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000048755 UniProtKB/TrEMBL
  ENSPPAT00000048757 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  LATS1 UniProtKB/TrEMBL
  LATS1_STKc UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
KEGG Report pps:100991134 UniProtKB/TrEMBL
NCBI Gene LATS1 ENTREZGENE
PANTHER PTHR24356:SF138 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9B8J7_PANPA UniProtKB/TrEMBL
  A0A2R9BCB1_PANPA UniProtKB/TrEMBL