TNPO1 (transportin 1) - Rat Genome Database

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Gene: TNPO1 (transportin 1) Pan paniscus
Analyze
Symbol: TNPO1
Name: transportin 1
RGD ID: 11991703
Description: ENCODES a protein that exhibits nuclear import signal receptor activity (inferred); nuclear localization sequence binding (inferred); small GTPase binding (inferred); INVOLVED IN protein import into nucleus (inferred); ASSOCIATED WITH genetic disease (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN cytoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: transportin-1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2442,405,424 - 42,511,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1540,559,052 - 40,656,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0542,404,013 - 42,501,748 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1543,001,210 - 43,098,077 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl543,001,210 - 43,098,077 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IEA)
nucleus  (IEA)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TNPO1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2442,405,424 - 42,511,998 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1540,559,052 - 40,656,791 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0542,404,013 - 42,501,748 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1543,001,210 - 43,098,077 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl543,001,210 - 43,098,077 (-)Ensemblpanpan1.1panPan2
TNPO1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38572,816,661 - 72,914,388 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl572,816,312 - 72,916,733 (+)EnsemblGRCh38hg38GRCh38
GRCh37572,112,488 - 72,210,215 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36572,148,174 - 72,245,971 (+)NCBINCBI36Build 36hg18NCBI36
Celera568,007,813 - 68,105,601 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef567,317,777 - 67,415,712 (+)NCBIHuRef
CHM1_1571,545,168 - 71,642,989 (+)NCBICHM1_1
T2T-CHM13v2.0573,297,810 - 73,395,474 (+)NCBIT2T-CHM13v2.0
Tnpo1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391398,975,527 - 99,062,851 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1398,975,527 - 99,062,892 (-)EnsemblGRCm39 Ensembl
GRCm381398,839,019 - 98,926,384 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1398,839,019 - 98,926,384 (-)EnsemblGRCm38mm10GRCm38
MGSCv371399,612,036 - 99,696,339 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361399,942,895 - 100,026,500 (-)NCBIMGSCv36mm8
Celera13102,502,817 - 102,586,946 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.24NCBI
Tnpo1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8231,941,731 - 32,034,366 (-)NCBIGRCr8
mRatBN7.2230,207,529 - 30,300,162 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl230,211,510 - 30,300,375 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx237,268,846 - 37,361,422 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0235,363,201 - 35,455,776 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0230,175,882 - 30,268,487 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0229,056,219 - 29,126,882 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl229,056,219 - 29,121,104 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0248,238,550 - 48,308,427 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4229,482,093 - 29,539,145 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1229,401,327 - 29,490,924 (-)NCBI
Celera226,240,332 - 26,302,645 (-)NCBICelera
Cytogenetic Map2q12NCBI
Tnpo1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542527,666,091 - 27,748,920 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542527,666,091 - 27,748,920 (-)NCBIChiLan1.0ChiLan1.0
TNPO1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1255,795,737 - 55,859,366 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl255,799,907 - 55,851,213 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha252,730,047 - 52,826,981 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0256,278,862 - 56,375,623 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl256,278,940 - 56,370,542 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1253,338,799 - 53,435,381 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0254,107,115 - 54,203,851 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0255,032,870 - 55,094,744 (+)NCBIUU_Cfam_GSD_1.0
Tnpo1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213187,147,529 - 187,238,494 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365493,620,479 - 3,711,382 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TNPO1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1649,048,686 - 49,151,922 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11649,048,686 - 49,151,926 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21653,229,707 - 53,296,875 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TNPO1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1467,158,072 - 67,255,843 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl467,158,101 - 67,248,256 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604915,924,492 - 16,018,409 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tnpo1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249051,909,405 - 1,992,484 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000062759   ⟹   ENSPPAP00000039847
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl543,001,210 - 43,098,077 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062814   ⟹   ENSPPAP00000039902
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl543,001,210 - 43,066,736 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062828   ⟹   ENSPPAP00000039915
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl543,009,842 - 43,066,459 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062830   ⟹   ENSPPAP00000039917
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl543,009,842 - 43,066,459 (-)Ensembl
RefSeq Acc Id: XM_003810483   ⟹   XP_003810531
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2442,405,424 - 42,511,998 (-)NCBI
NHGRI_mPanPan1540,559,052 - 40,656,791 (-)NCBI
Mhudiblu_PPA_v0542,404,013 - 42,501,748 (-)NCBI
PanPan1.1543,001,210 - 43,098,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003810484   ⟹   XP_003810532
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2442,405,424 - 42,471,650 (-)NCBI
NHGRI_mPanPan1540,559,052 - 40,625,277 (-)NCBI
Mhudiblu_PPA_v0542,404,013 - 42,470,226 (-)NCBI
PanPan1.1543,001,210 - 43,066,718 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008962837   ⟹   XP_008961085
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2442,405,424 - 42,471,634 (-)NCBI
NHGRI_mPanPan1540,559,052 - 40,625,281 (-)NCBI
Mhudiblu_PPA_v0542,404,013 - 42,470,253 (-)NCBI
PanPan1.1543,001,210 - 43,066,736 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034959965   ⟹   XP_034815856
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2442,418,710 - 42,511,998 (-)NCBI
NHGRI_mPanPan1540,572,338 - 40,656,756 (-)NCBI
Mhudiblu_PPA_v0542,417,305 - 42,501,748 (-)NCBI
RefSeq Acc Id: XR_004671518
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2442,415,997 - 42,511,998 (-)NCBI
NHGRI_mPanPan1540,569,625 - 40,656,756 (-)NCBI
Mhudiblu_PPA_v0542,414,590 - 42,501,748 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003810531   ⟸   XM_003810483
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CNL4 (UniProtKB/TrEMBL),   A0A2R9CDA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008961085   ⟸   XM_008962837
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CDA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003810532   ⟸   XM_003810484
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CDA4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034815856   ⟸   XM_034959965
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CDA4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000039847   ⟸   ENSPPAT00000062759
RefSeq Acc Id: ENSPPAP00000039915   ⟸   ENSPPAT00000062828
RefSeq Acc Id: ENSPPAP00000039917   ⟸   ENSPPAT00000062830
RefSeq Acc Id: ENSPPAP00000039902   ⟸   ENSPPAT00000062814
Protein Domains
Importin N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042518 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062759.1 UniProtKB/TrEMBL
  ENSPPAT00000062814.1 UniProtKB/TrEMBL
  ENSPPAT00000062828.1 UniProtKB/TrEMBL
  ENSPPAT00000062830.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.10.10 UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/TrEMBL
  HEAT UniProtKB/TrEMBL
  Importin-beta_N UniProtKB/TrEMBL
  Importin_beta UniProtKB/TrEMBL
KEGG Report pps:100970374 UniProtKB/TrEMBL
NCBI Gene TNPO1 ENTREZGENE
PANTHER PTHR10527 UniProtKB/TrEMBL
  TRANSPORTIN-1 UniProtKB/TrEMBL
Pfam HEAT UniProtKB/TrEMBL
  HEAT_EZ UniProtKB/TrEMBL
  IBN_N UniProtKB/TrEMBL
PROSITE IMPORTIN_B_NT UniProtKB/TrEMBL
SMART IBN_N UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/TrEMBL
UniProt A0A2R9CDA4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CNL4 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CNQ0_PANPA UniProtKB/TrEMBL
  A0A2R9CNR1_PANPA UniProtKB/TrEMBL