PROX1 (prospero homeobox 1) - Rat Genome Database

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Gene: PROX1 (prospero homeobox 1) Pan paniscus
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Symbol: PROX1
Name: prospero homeobox 1
RGD ID: 11970467
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA binding domain binding (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN acinar cell differentiation (ortholog); blood vessel endothelial cell differentiation (ortholog); branching involved in pancreas morphogenesis (ortholog); ASSOCIATED WITH dilated cardiomyopathy (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); nucleoplasm (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prospero homeobox protein 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2135,361,029 - 35,413,818 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1135,325,338 - 35,378,134 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,556,124 - 189,609,297 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11194,412,980 - 194,466,170 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1194,412,980 - 194,460,763 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
acinar cell differentiation  (IEA,ISO)
aorta smooth muscle tissue morphogenesis  (IEA)
atrial cardiac muscle tissue morphogenesis  (IEA)
blood vessel endothelial cell differentiation  (IEA,ISO)
brain development  (IEA)
branching involved in pancreas morphogenesis  (IEA,ISO)
cell development  (IEA)
cell population proliferation  (IEA,ISO)
cerebellar granule cell differentiation  (IEA)
circadian rhythm  (IEA)
dentate gyrus development  (IEA)
embryonic retina morphogenesis in camera-type eye  (IEA)
endocardium formation  (IEA)
epithelial cell migration  (IEA,ISO)
hepatocyte cell migration  (IEA,ISO)
hepatocyte differentiation  (IEA)
hepatocyte proliferation  (IEA,ISO)
inner ear development  (IEA,ISO)
kidney development  (IEA)
lens development in camera-type eye  (IEA)
lens fiber cell morphogenesis  (IEA)
lens morphogenesis in camera-type eye  (IEA)
lens placode formation involved in camera-type eye formation  (IEA)
liver development  (IEA,ISO)
lung development  (IEA)
lymph vessel development  (IEA,ISO)
lymphangiogenesis  (IEA)
lymphatic endothelial cell differentiation  (IEA,ISO)
lymphatic endothelial cell fate commitment  (IEA)
negative regulation of bile acid biosynthetic process  (IEA)
negative regulation of cell population proliferation  (IEA)
negative regulation of DNA-templated transcription  (IEA)
negative regulation of neuroblast proliferation  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of viral genome replication  (IEA)
nervous system development  (IEA)
neuroblast proliferation  (IEA,ISO)
neuron fate determination  (IEA,ISO)
neuronal stem cell population maintenance  (IEA)
pancreas development  (IEA)
positive regulation of cell cycle  (IEA)
positive regulation of cell cycle checkpoint  (IEA,ISO)
positive regulation of cell population proliferation  (IEA)
positive regulation of endothelial cell migration  (IEA)
positive regulation of endothelial cell proliferation  (IEA)
positive regulation of forebrain neuron differentiation  (IEA)
positive regulation of heart growth  (IEA)
positive regulation of neural precursor cell proliferation  (IEA)
positive regulation of sarcomere organization  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
regulation of circadian rhythm  (IEA)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA)
response to nutrient levels  (ISO)
skeletal muscle thin filament assembly  (IEA)
transcription by RNA polymerase II  (IEA,ISO)
venous blood vessel morphogenesis  (IEA)
ventricular cardiac muscle tissue morphogenesis  (IEA)
ventricular cardiac myofibril assembly  (IEA)
ventricular septum morphogenesis  (IEA)

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
nucleoplasm  (IEA)
nucleus  (IEA)

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PROX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2135,361,029 - 35,413,818 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1135,325,338 - 35,378,134 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,556,124 - 189,609,297 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11194,412,980 - 194,466,170 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1194,412,980 - 194,460,763 (+)Ensemblpanpan1.1panPan2
PROX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381213,983,151 - 214,041,510 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1213,983,181 - 214,041,510 (+)EnsemblGRCh38hg38GRCh38
GRCh371214,161,316 - 214,214,853 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361212,228,483 - 212,276,389 (+)NCBINCBI36Build 36hg18NCBI36
Build 341210,550,254 - 210,598,155NCBI
Celera1187,384,890 - 187,432,754 (+)NCBICelera
Cytogenetic Map1q32.3NCBI
HuRef1184,835,849 - 184,890,058 (+)NCBIHuRef
CHM1_11215,433,762 - 215,487,303 (+)NCBICHM1_1
T2T-CHM13v2.01213,222,727 - 213,281,050 (+)NCBIT2T-CHM13v2.0
Prox1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391189,850,232 - 189,903,024 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1189,850,232 - 189,902,911 (-)EnsemblGRCm39 Ensembl
GRCm381190,118,035 - 190,170,827 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1190,118,035 - 190,170,714 (-)EnsemblGRCm38mm10GRCm38
MGSCv371191,945,654 - 191,994,559 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361191,822,563 - 191,871,468 (-)NCBIMGSCv36mm8
Celera1197,032,975 - 197,082,606 (-)NCBICelera
Cytogenetic Map1H6NCBI
cM Map195.85NCBI
Prox1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr813104,196,615 - 104,251,007 (-)NCBIGRCr8
mRatBN7.213101,669,184 - 101,719,804 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl13101,669,184 - 101,711,183 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx13104,184,132 - 104,234,742 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.013105,573,270 - 105,623,873 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.013102,780,918 - 102,831,509 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013108,382,536 - 108,444,107 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13108,382,399 - 108,443,294 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013113,004,568 - 113,064,606 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.413106,421,541 - 106,471,350 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.113106,611,772 - 106,660,015 (-)NCBI
Celera13101,149,597 - 101,200,064 (-)NCBICelera
Cytogenetic Map13q26NCBI
Prox1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554063,719,972 - 3,770,555 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554063,715,140 - 3,770,019 (-)NCBIChiLan1.0ChiLan1.0
PROX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1711,996,282 - 12,047,693 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl711,996,703 - 12,044,036 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha711,570,534 - 11,623,681 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0711,705,650 - 11,758,863 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl711,705,620 - 11,755,413 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1711,629,931 - 11,683,010 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0711,734,165 - 11,787,370 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0711,858,013 - 11,911,782 (+)NCBIUU_Cfam_GSD_1.0
Prox1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934462,175,888 - 62,230,044 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366284,185,706 - 4,238,451 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366284,185,712 - 4,240,680 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PROX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9129,532,184 - 129,580,982 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19129,527,704 - 129,583,693 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29142,424,393 - 142,480,770 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PROX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12515,533,546 - 15,592,834 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2515,538,964 - 15,587,059 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605516,013,948 - 16,067,368 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prox1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462477119,196,366 - 19,233,338 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462477119,188,543 - 19,238,621 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000047241   ⟹   ENSPPAP00000024416
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1194,412,980 - 194,460,763 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047245   ⟹   ENSPPAP00000024420
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1194,421,581 - 194,422,365 (+)Ensembl
RefSeq Acc Id: XM_055108188   ⟹   XP_054964163
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2135,361,029 - 35,413,818 (-)NCBI
NHGRI_mPanPan1135,325,338 - 35,378,134 (-)NCBI
RefSeq Acc Id: XM_055108191   ⟹   XP_054964166
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2135,361,029 - 35,413,386 (-)NCBI
NHGRI_mPanPan1135,325,338 - 35,377,676 (-)NCBI
RefSeq Acc Id: XM_055108193   ⟹   XP_054964168
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2135,361,029 - 35,413,630 (-)NCBI
NHGRI_mPanPan1135,325,338 - 35,377,938 (-)NCBI
RefSeq Acc Id: XM_055108199   ⟹   XP_054964174
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2135,361,029 - 35,413,818 (-)NCBI
NHGRI_mPanPan1135,325,338 - 35,378,134 (-)NCBI
RefSeq Acc Id: XM_055108205   ⟹   XP_054964180
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2135,361,029 - 35,413,818 (-)NCBI
NHGRI_mPanPan1135,325,338 - 35,378,134 (-)NCBI
RefSeq Acc Id: ENSPPAP00000024416   ⟸   ENSPPAT00000047241
RefSeq Acc Id: ENSPPAP00000024420   ⟸   ENSPPAT00000047245
RefSeq Acc Id: XP_054964180   ⟸   XM_055108205
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054964174   ⟸   XM_055108199
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B5U5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054964163   ⟸   XM_055108188
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054964168   ⟸   XM_055108193
- Peptide Label: isoform X1
RefSeq Acc Id: XP_054964166   ⟸   XM_055108191
- Peptide Label: isoform X1
Protein Domains
Prospero


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035353 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047241.1 UniProtKB/TrEMBL
  ENSPPAT00000047245.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.10.500 UniProtKB/TrEMBL
InterPro Homeo_prospero_dom UniProtKB/TrEMBL
  Homeo_prospero_dom_sf UniProtKB/TrEMBL
  Homeobox-like_sf UniProtKB/TrEMBL
  Prospero_homeodomain UniProtKB/TrEMBL
KEGG Report pps:100994482 UniProtKB/TrEMBL
NCBI Gene PROX1 ENTREZGENE
PANTHER PTHR12198 UniProtKB/TrEMBL
  PTHR12198:SF6 UniProtKB/TrEMBL
Pfam HPD UniProtKB/TrEMBL
PROSITE HOMEO_PROSPERO UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
UniProt A0A2R9B5U5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9B844_PANPA UniProtKB/TrEMBL