EPHA4 (EPH receptor A4) - Rat Genome Database

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Pathways
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Gene: EPHA4 (EPH receptor A4) Pan paniscus
Analyze
Symbol: EPHA4
Name: EPH receptor A4
RGD ID: 11968478
Description: ENCODES a protein that exhibits ephrin receptor binding (ortholog); INVOLVED IN adult walking behavior (ortholog); axon guidance (ortholog); glial cell migration (ortholog); PARTICIPATES IN ephrin - ephrin receptor bidirectional signaling axis; ASSOCIATED WITH Alzheimer's disease (ortholog); Brain Hypoxia-Ischemia (ortholog); Brain Injuries (ortholog); FOUND IN axon terminus (ortholog); axonal growth cone (ortholog); cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ephrin type-A receptor 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213124,035,467 - 124,192,876 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B124,050,435 - 124,207,734 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B108,664,475 - 108,818,802 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B227,246,593 - 227,402,791 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B227,248,958 - 227,402,790 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adherens junction organization  (IEA)
adult walking behavior  (IEA,ISO)
axon guidance  (IEA,ISO)
cell surface receptor protein tyrosine kinase signaling pathway  (IEA)
cellular response to amyloid-beta  (IEA)
cochlea development  (IEA)
corticospinal tract morphogenesis  (IEA)
ephrin receptor signaling pathway  (IEA)
fasciculation of motor neuron axon  (IEA)
fasciculation of sensory neuron axon  (IEA)
glial cell migration  (ISO)
innervation  (ISO)
motor neuron axon guidance  (IEA)
negative regulation of axon regeneration  (IEA,ISO)
negative regulation of cell adhesion  (IEA)
negative regulation of cell migration  (IEA)
negative regulation of cellular response to hypoxia  (IEA,ISO)
negative regulation of epithelial to mesenchymal transition  (IEA)
negative regulation of ERK1 and ERK2 cascade  (IEA)
negative regulation of long-term synaptic potentiation  (IEA)
negative regulation of neuron apoptotic process  (ISO)
negative regulation of neuron projection development  (IEA)
negative regulation of proteolysis involved in protein catabolic process  (IEA)
nephric duct morphogenesis  (IEA,ISO)
neuron projection fasciculation  (IEA)
neuron projection guidance  (IEA)
positive regulation of amyloid-beta formation  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of cell population proliferation  (IEA)
positive regulation of dendrite morphogenesis  (ISO)
protein stabilization  (IEA)
regulation of astrocyte differentiation  (IEA)
regulation of axonogenesis  (IEA)
regulation of dendritic spine morphogenesis  (IEA)
regulation of modification of synaptic structure  (IEA)
regulation of synapse pruning  (ISO)
synapse pruning  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
EPHA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v213124,035,467 - 124,192,876 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B124,050,435 - 124,207,734 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B108,664,475 - 108,818,802 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B227,246,593 - 227,402,791 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B227,248,958 - 227,402,790 (-)Ensemblpanpan1.1panPan2
EPHA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382221,418,027 - 221,574,202 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2221,418,027 - 221,574,202 (-)EnsemblGRCh38hg38GRCh38
GRCh372222,282,747 - 222,438,922 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362221,990,991 - 222,145,254 (-)NCBINCBI36Build 36hg18NCBI36
Build 342222,108,253 - 222,262,515NCBI
Celera2216,050,899 - 216,205,191 (-)NCBICelera
Cytogenetic Map2q36.1NCBI
HuRef2214,137,116 - 214,291,409 (-)NCBIHuRef
CHM1_12222,288,287 - 222,442,879 (-)NCBICHM1_1
T2T-CHM13v2.02221,903,096 - 222,059,275 (-)NCBIT2T-CHM13v2.0
Epha4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,343,819 - 77,491,763 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl177,343,822 - 77,491,725 (-)EnsemblGRCm39 Ensembl
GRCm38177,367,182 - 77,515,107 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl177,367,185 - 77,515,088 (-)EnsemblGRCm38mm10GRCm38
MGSCv37177,363,760 - 77,511,663 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36177,250,333 - 77,398,236 (-)NCBIMGSCv36mm8
Celera177,858,813 - 78,000,449 (-)NCBICelera
Cytogenetic Map1C4NCBI
cM Map139.55NCBI
Epha4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8986,263,982 - 86,406,744 (-)NCBIGRCr8
mRatBN7.2978,815,460 - 78,958,139 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl978,815,460 - 78,958,139 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx987,245,229 - 87,387,938 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0992,374,666 - 92,517,486 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0990,760,851 - 90,903,498 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0983,111,222 - 83,253,486 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl983,111,222 - 83,253,458 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0982,880,599 - 83,022,444 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4976,676,778 - 76,820,752 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera976,344,796 - 76,487,530 (-)NCBICelera
Cytogenetic Map9q33NCBI
Epha4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545312,099,757 - 12,240,199 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495545312,099,800 - 12,240,199 (+)NCBIChiLan1.0ChiLan1.0
EPHA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13727,670,143 - 27,809,642 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3727,677,566 - 27,809,646 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3728,506,808 - 28,649,559 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03727,690,393 - 27,834,663 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3727,697,197 - 27,834,652 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13727,600,660 - 27,743,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03727,535,209 - 27,678,026 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03727,555,060 - 27,698,047 (-)NCBIUU_Cfam_GSD_1.0
Epha4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303177,190,052 - 177,327,435 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365693,540,053 - 3,670,348 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365693,539,269 - 3,670,322 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPHA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl15123,352,816 - 123,503,126 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.115123,350,867 - 123,501,872 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.215136,746,506 - 136,804,962 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Sscrofa10.215136,931,366 - 136,936,233 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EPHA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.110107,344,442 - 107,501,375 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl10107,352,530 - 107,499,788 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604091,884,095 - 92,041,139 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Epha4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248233,555,288 - 3,698,990 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248233,555,273 - 3,697,794 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000066074   ⟹   ENSPPAP00000043139
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B227,248,958 - 227,271,646 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000066076   ⟹   ENSPPAP00000043141
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B227,254,733 - 227,402,790 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000066077   ⟹   ENSPPAP00000043142
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B227,254,840 - 227,311,589 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000066078   ⟹   ENSPPAP00000043143
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2B227,390,905 - 227,400,650 (-)Ensembl
RefSeq Acc Id: XM_034955256   ⟹   XP_034811147
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213124,035,467 - 124,189,854 (-)NCBI
NHGRI_mPanPan12B124,050,435 - 124,207,734 (-)NCBI
Mhudiblu_PPA_v02B108,664,475 - 108,818,802 (-)NCBI
RefSeq Acc Id: XM_034955258   ⟹   XP_034811149
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213124,035,467 - 124,189,854 (-)NCBI
NHGRI_mPanPan12B124,050,435 - 124,204,822 (-)NCBI
Mhudiblu_PPA_v02B108,664,475 - 108,816,872 (-)NCBI
RefSeq Acc Id: XM_063595288   ⟹   XP_063451358
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v213124,178,988 - 124,192,876 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034811147 (Get FASTA)   NCBI Sequence Viewer  
  XP_034811149 (Get FASTA)   NCBI Sequence Viewer  
  XP_063451358 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000043139.1
  ENSPPAP00000043141.1
  ENSPPAP00000043142.1
  ENSPPAP00000043143.1
Reference Protein Sequences
RefSeq Acc Id: XP_034811147   ⟸   XM_034955256
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CME8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034811149   ⟸   XM_034955258
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000043143   ⟸   ENSPPAT00000066078
RefSeq Acc Id: ENSPPAP00000043142   ⟸   ENSPPAT00000066077
RefSeq Acc Id: ENSPPAP00000043141   ⟸   ENSPPAT00000066076
RefSeq Acc Id: ENSPPAP00000043139   ⟸   ENSPPAT00000066074
RefSeq Acc Id: XP_063451358   ⟸   XM_063595288
- Peptide Label: isoform X3
Protein Domains
Eph LBD   Fibronectin type-III   Protein kinase   SAM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000044107 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000066074.1 UniProtKB/TrEMBL
  ENSPPAT00000066076.1 UniProtKB/TrEMBL
  ENSPPAT00000066077.1 UniProtKB/TrEMBL
  ENSPPAT00000066078.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  ephrin a2 ectodomain UniProtKB/TrEMBL
  Galactose-binding domain-like UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
  Tumor Necrosis Factor Receptor, subunit A, domain 2 UniProtKB/TrEMBL
InterPro Eph_TM UniProtKB/TrEMBL
  EphA4_rcpt_lig-bd UniProtKB/TrEMBL
  EphA4_SAM UniProtKB/TrEMBL
  Ephrin_rcpt_lig-bd_dom UniProtKB/TrEMBL
  FN3_dom UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  Galactose-bd-like_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr-kin_ephrin_A/B_rcpt-like UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_ephrin_rcpt UniProtKB/TrEMBL
  Tyr_kinase_rcpt_V_CS UniProtKB/TrEMBL
NCBI Gene EPHA4 ENTREZGENE
PANTHER EPH RECEPTOR A5 UniProtKB/TrEMBL
  EPHRIN TYPE-A RECEPTOR 4 UniProtKB/TrEMBL
Pfam EphA2_TM UniProtKB/TrEMBL
  Ephrin_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  fn3 UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SAM_2 UniProtKB/TrEMBL
PIRSF TyrPK_ephrin_receptor UniProtKB/TrEMBL
PRINTS FNTYPEIII UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE EPH_LBD UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_1 UniProtKB/TrEMBL
  RECEPTOR_TYR_KIN_V_2 UniProtKB/TrEMBL
  SAM_DOMAIN UniProtKB/TrEMBL
SMART EPH_lbd UniProtKB/TrEMBL
  Ephrin_rec_like UniProtKB/TrEMBL
  FN3 UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
  SAM UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF47769 UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49785 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9CMD8_PANPA UniProtKB/TrEMBL
  A0A2R9CME8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CP75_PANPA UniProtKB/TrEMBL
  A0A2R9CTK8_PANPA UniProtKB/TrEMBL