ADAM21 (ADAM metallopeptidase domain 21) - Rat Genome Database

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Gene: ADAM21 (ADAM metallopeptidase domain 21) Pan paniscus
Analyze
Symbol: ADAM21
Name: ADAM metallopeptidase domain 21
RGD ID: 11963860
Description: ENCODES a protein that exhibits metal ion binding (inferred); metalloendopeptidase activity (inferred); metallopeptidase activity (inferred); INVOLVED IN male gonad development (inferred); proteolysis (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN axon (ortholog); neuron projection (ortholog); neuronal cell body (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: disintegrin and metalloproteinase domain-containing protein 21; LOC100969567
RGD Orthologs
Human
Mouse
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21571,539,713 - 71,581,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,756,226 - 70,797,982 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01451,009,420 - 51,051,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,913,385 - 69,921,117 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1469,918,713 - 69,920,880 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ADAM21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21571,539,713 - 71,581,469 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11470,756,226 - 70,797,982 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01451,009,420 - 51,051,012 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11469,913,385 - 69,921,117 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1469,918,713 - 69,920,880 (+)Ensemblpanpan1.1panPan2
ADAM21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381470,452,174 - 70,459,905 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1470,417,107 - 70,460,427 (+)EnsemblGRCh38hg38GRCh38
GRCh371470,918,891 - 70,926,622 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361469,993,970 - 69,996,375 (+)NCBINCBI36Build 36hg18NCBI36
Build 341469,993,969 - 69,996,375NCBI
Celera1450,988,177 - 50,990,582 (+)NCBICelera
Cytogenetic Map14q24.2NCBI
HuRef1451,087,543 - 51,095,293 (+)NCBIHuRef
CHM1_11470,856,830 - 70,864,579 (+)NCBICHM1_1
T2T-CHM13v2.01464,658,196 - 64,665,929 (+)NCBIT2T-CHM13v2.0
Adam21
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391281,605,349 - 81,615,248 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1281,605,358 - 81,615,248 (-)EnsemblGRCm39 Ensembl
GRCm381281,558,575 - 81,568,474 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1281,558,584 - 81,568,474 (-)EnsemblGRCm38mm10GRCm38
MGSCv371282,659,571 - 82,669,461 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361282,477,432 - 82,487,322 (-)NCBIMGSCv36mm8
Celera1283,025,745 - 83,035,635 (-)NCBICelera
Cytogenetic Map12D1NCBI
cM Map1237.79NCBI
Adam21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81643,351,935 - 43,361,020 (+)NCBIGRCr8
mRatBN7.21636,625,324 - 36,627,657 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1636,618,860 - 36,628,008 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01639,138,561 - 39,148,460 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01638,925,310 - 38,934,356 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1634,773,480 - 34,783,278 (+)NCBICelera
Cytogenetic Map16p11NCBI
ADAM21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1844,238,624 - 44,269,244 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl844,238,864 - 44,241,023 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha843,903,984 - 43,934,597 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0844,463,005 - 44,493,634 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl844,463,245 - 44,465,404 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1844,115,179 - 44,145,773 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0844,161,974 - 44,192,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0844,522,701 - 44,553,570 (-)NCBIUU_Cfam_GSD_1.0
LOC100515389
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1794,084,019 - 94,087,956 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27100,372,847 - 100,392,821 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000035498   ⟹   ENSPPAP00000012831
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1469,918,713 - 69,920,880 (+)Ensembl
RefSeq Acc Id: XM_034937733   ⟹   XP_034793624
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21571,539,713 - 71,581,469 (+)NCBI
NHGRI_mPanPan11470,756,226 - 70,797,982 (+)NCBI
Mhudiblu_PPA_v01451,009,420 - 51,051,012 (+)NCBI
RefSeq Acc Id: XM_055097743   ⟹   XP_054953718
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21571,573,689 - 71,581,469 (+)NCBI
NHGRI_mPanPan11470,789,774 - 70,797,982 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034793624 (Get FASTA)   NCBI Sequence Viewer  
  XP_054953718 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000012831.1
Reference Protein Sequences
RefSeq Acc Id: XP_034793624   ⟸   XM_034937733
- UniProtKB: A0A2R9AB15 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000012831   ⟸   ENSPPAT00000035498
RefSeq Acc Id: XP_054953718   ⟸   XM_055097743
- UniProtKB: A0A2R9AB15 (UniProtKB/TrEMBL)
Protein Domains
Disintegrin   Peptidase M12B


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029592 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000035498.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.390.10 UniProtKB/TrEMBL
  4.10.70.10 UniProtKB/TrEMBL
InterPro ADAM_Cys-rich UniProtKB/TrEMBL
  Disintegrin_dom UniProtKB/TrEMBL
  Disintegrin_dom_sf UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Peptidase_M12B UniProtKB/TrEMBL
  Peptidase_M12B_N UniProtKB/TrEMBL
  Reprolysin_adamalysin UniProtKB/TrEMBL
NCBI Gene ADAM21 ENTREZGENE
PANTHER ADAM A DISINTEGRIN AND METALLOPROTEASE DOMAIN UniProtKB/TrEMBL
  DISINTEGRIN AND METALLOPROTEINASE DOMAIN-CONTAINING PROTEIN 21 UniProtKB/TrEMBL
Pfam ADAM_CR UniProtKB/TrEMBL
  Disintegrin UniProtKB/TrEMBL
  Pep_M12B_propep UniProtKB/TrEMBL
  Reprolysin UniProtKB/TrEMBL
PROSITE ADAM_MEPRO UniProtKB/TrEMBL
  DISINTEGRIN_2 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
SMART ACR UniProtKB/TrEMBL
  DISIN UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF57552 UniProtKB/TrEMBL
UniProt A0A2R9AB15 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-04-25 ADAM21  ADAM metallopeptidase domain 21  LOC100969567  disintegrin and metalloproteinase domain-containing protein 21  Symbol and/or name change 5135510 APPROVED
2020-07-01 LOC100969567  disintegrin and metalloproteinase domain-containing protein 21  ADAM21  ADAM metallopeptidase domain 21  Symbol and/or name change 5135510 APPROVED