CLDN2 (claudin 2) - Rat Genome Database

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Gene: CLDN2 (claudin 2) Pan paniscus
Analyze
Symbol: CLDN2
Name: claudin 2
RGD ID: 11960138
Description: ENCODES a protein that exhibits channel activity (inferred); identical protein binding (inferred); structural molecule activity (inferred); INVOLVED IN bicellular tight junction assembly (inferred); calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (inferred); cell-cell adhesion (inferred); ASSOCIATED WITH autistic disorder (ortholog); AZOOSPERMIA, OBSTRUCTIVE, WITH NEPHROLITHIASIS (ortholog); Charcot-Marie-Tooth disease type X (ortholog); FOUND IN bicellular tight junction (inferred); cell-cell junction (inferred); membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: claudin-2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X106,410,924 - 106,414,386 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X106,414,543 - 106,417,987 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X96,020,274 - 96,031,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X106,405,707 - 106,408,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX106,405,879 - 106,406,571 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CLDN2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X106,410,924 - 106,414,386 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X106,414,543 - 106,417,987 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X96,020,274 - 96,031,157 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X106,405,707 - 106,408,516 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX106,405,879 - 106,406,571 (+)Ensemblpanpan1.1panPan2
CLDN2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X106,900,164 - 106,930,861 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX106,900,164 - 106,930,861 (+)EnsemblGRCh38hg38GRCh38
GRCh37X106,143,394 - 106,174,091 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X106,050,290 - 106,060,747 (+)NCBINCBI36Build 36hg18NCBI36
Build 34X105,969,778 - 105,980,236NCBI
CeleraX106,614,779 - 106,645,477 (+)NCBICelera
Cytogenetic MapXq22.3NCBI
HuRefX95,771,755 - 95,802,061 (+)NCBIHuRef
CHM1_1X106,054,200 - 106,084,897 (+)NCBICHM1_1
T2T-CHM13v2.0X105,336,674 - 105,367,377 (+)NCBIT2T-CHM13v2.0
Cldn2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X138,701,552 - 138,712,135 (+)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX138,701,577 - 138,712,135 (+)EnsemblGRCm39 Ensembl
GRCm38X139,800,808 - 139,811,386 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX139,800,828 - 139,811,386 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X136,335,367 - 136,345,923 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36X135,147,192 - 135,157,748 (+)NCBIMGSCv36mm8
CeleraX123,063,444 - 123,074,101 (+)NCBICelera
Cytogenetic MapXF1NCBI
cM MapX61.35NCBI
Cldn2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8X108,248,383 - 108,258,847 (+)NCBIGRCr8
mRatBN7.2X103,459,870 - 103,473,794 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 EnsemblX103,459,780 - 103,474,838 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_UtxX105,592,416 - 105,602,750 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0X109,091,151 - 109,101,485 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0X106,655,156 - 106,665,516 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0X111,122,552 - 111,133,188 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX111,122,552 - 111,137,769 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0353,456,573 - 53,472,568 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X127,538,685 - 127,549,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera344,457,488 - 44,467,822 (-)NCBICelera
Cytogenetic MapXq32NCBI
Cldn2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554909,136,986 - 9,145,034 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554909,137,157 - 9,180,945 (-)NCBIChiLan1.0ChiLan1.0
CLDN2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X80,456,313 - 80,491,944 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX80,483,333 - 80,530,012 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX66,603,000 - 66,603,952 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X82,119,947 - 82,128,336 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1X79,592,206 - 79,593,158 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X81,302,056 - 81,303,008 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X81,081,052 - 81,082,004 (+)NCBIUU_Cfam_GSD_1.0
Cldn2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X79,829,508 - 79,839,529 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364997,820,410 - 7,821,102 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364997,818,436 - 7,828,444 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CLDN2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX87,321,152 - 87,355,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X87,352,695 - 87,355,724 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CLDN2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X94,752,552 - 94,762,247 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366606519,835,977 - 19,848,312 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cldn2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248039,839,911 - 9,846,367 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248039,839,916 - 9,849,891 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034950043 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000024 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000003627   ⟹   ENSPPAP00000000762
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 EnsemblX106,405,879 - 106,406,571 (+)Ensembl
RefSeq Acc Id: XM_034950043   ⟹   XP_034805934
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2X106,410,924 - 106,414,386 (+)NCBI
NHGRI_mPanPan1X106,414,543 - 106,417,987 (+)NCBI
Mhudiblu_PPA_v0X96,020,274 - 96,031,157 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034805934 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000000762.1
Reference Protein Sequences
RefSeq Acc Id: XP_034805934   ⟸   XM_034950043
- UniProtKB: A0A2R8Z7D8 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000000762   ⟸   ENSPPAT00000003627


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000003384 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000003627.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.140.150 UniProtKB/TrEMBL
InterPro Claudin UniProtKB/TrEMBL
  Claudin2 UniProtKB/TrEMBL
  Claudin_CS UniProtKB/TrEMBL
  PMP22/EMP/MP20/Claudin UniProtKB/TrEMBL
NCBI Gene CLDN2 ENTREZGENE
PANTHER CLAUDIN-2 UniProtKB/TrEMBL
  PTHR12002 UniProtKB/TrEMBL
Pfam PMP22_Claudin UniProtKB/TrEMBL
PRINTS CLAUDIN UniProtKB/TrEMBL
  CLAUDIN2 UniProtKB/TrEMBL
PROSITE CLAUDIN UniProtKB/TrEMBL
UniProt A0A2R8Z7D8 ENTREZGENE, UniProtKB/TrEMBL