PAX8 (paired box 8) - Rat Genome Database

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Gene: PAX8 (paired box 8) Pan paniscus
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Symbol: PAX8
Name: paired box 8
RGD ID: 11957893
Description: ENCODES a protein that exhibits DNA binding (ortholog); DNA-binding transcription activator activity, RNA polymerase II-specific (ortholog); DNA-binding transcription factor activity (ortholog); INVOLVED IN branching involved in ureteric bud morphogenesis (ortholog); cell differentiation (ortholog); cellular response to gonadotropin stimulus (ortholog); ASSOCIATED WITH Colorectal Neoplasms (ortholog); congenital hypothyroidism (ortholog); congenital nongoitrous hypothyroidism 2 (ortholog); FOUND IN nucleoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: paired box protein Pax-8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A114,162,110 - 114,222,865 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,162,110 - 114,222,865 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A88,845,877 - 88,905,266 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
branching involved in ureteric bud morphogenesis  (ISO)
cell differentiation  (ISO)
cellular response to gonadotropin stimulus  (ISO)
central nervous system development  (ISO)
inner ear morphogenesis  (ISO)
kidney development  (ISO)
kidney epithelium development  (ISO)
mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
mesonephric tubule development  (ISO)
mesonephros development  (ISO)
metanephric comma-shaped body morphogenesis  (ISO)
metanephric distal convoluted tubule development  (ISO)
metanephric epithelium development  (ISO)
metanephric nephron tubule formation  (ISO)
metanephric S-shaped body morphogenesis  (ISO)
metanephros development  (ISO)
negative regulation of apoptotic process involved in metanephric collecting duct development  (ISO)
negative regulation of apoptotic process involved in metanephric nephron tubule development  (ISO)
negative regulation of cardiac muscle cell apoptotic process  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis  (ISO)
negative regulation of mesenchymal cell apoptotic process involved in metanephros development  (ISO)
otic vesicle development  (ISO)
positive regulation of branching involved in ureteric bud morphogenesis  (ISO)
positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis  (ISO)
positive regulation of metanephric DCT cell differentiation  (ISO)
positive regulation of thyroid hormone generation  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO)
pronephric field specification  (ISO)
pronephros development  (ISO)
regulation of apoptotic process  (ISO)
regulation of metanephric nephron tubule epithelial cell differentiation  (ISO)
regulation of thyroid-stimulating hormone secretion  (ISO)
regulation of transcription, DNA-templated  (ISO)
S-shaped body morphogenesis  (ISO)
sulfur compound metabolic process  (ISO)
thyroid gland development  (ISO)
transcription, DNA-templated  (ISO)
urogenital system development  (ISO)
ventricular septum development  (ISO)

Cellular Component
nucleoplasm  (ISO)
nucleus  (ISO)

References

Genomics

Comparative Map Data
PAX8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A114,162,110 - 114,222,865 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A114,162,110 - 114,222,865 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A88,845,877 - 88,905,266 (+)NCBIMhudiblu_PPA_v0panPan3
PAX8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2113,215,997 - 113,278,921 (-)EnsemblGRCh38hg38GRCh38
GRCh382113,215,997 - 113,278,921 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372113,973,574 - 114,036,498 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362113,690,045 - 113,752,968 (-)NCBINCBI36hg18NCBI36
Build 342113,691,170 - 113,752,728NCBI
Celera2107,358,161 - 107,421,066 (-)NCBI
Cytogenetic Map2q14.1NCBI
HuRef2106,427,614 - 106,522,962 (-)NCBIHuRef
CHM1_12113,977,965 - 114,040,915 (-)NCBICHM1_1
Pax8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39224,310,563 - 24,365,611 (-)NCBIGRCm39mm39
GRCm39 Ensembl224,310,572 - 24,365,611 (-)Ensembl
GRCm38224,420,551 - 24,475,599 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl224,420,560 - 24,475,599 (-)EnsemblGRCm38mm10GRCm38
MGSCv37224,276,080 - 24,331,086 (-)NCBIGRCm37mm9NCBIm37
MGSCv36224,242,569 - 24,297,575 (-)NCBImm8
Celera224,140,049 - 24,195,191 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map216.43NCBI
Pax8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.237,185,721 - 7,242,363 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl37,185,723 - 7,242,363 (-)Ensembl
Rnor_6.031,527,316 - 1,586,019 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl31,527,279 - 1,584,946 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.031,520,144 - 1,576,052 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.432,671,478 - 2,726,801 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.132,672,153 - 2,726,345 (-)NCBI
Celera32,022,899 - 2,078,650 (-)NCBICelera
Cytogenetic Map3p13NCBI
Pax8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554701,016,289 - 1,073,796 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554701,016,226 - 1,072,643 (+)NCBIChiLan1.0ChiLan1.0
PAX8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11737,307,130 - 37,331,729 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1737,306,033 - 37,363,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1737,077,650 - 37,133,660 (-)NCBI
ROS_Cfam_1.01738,084,443 - 38,141,710 (-)NCBI
UMICH_Zoey_3.11737,220,866 - 37,276,852 (-)NCBI
UNSW_CanFamBas_1.01737,277,373 - 37,333,166 (-)NCBI
UU_Cfam_GSD_1.01737,490,112 - 37,546,218 (-)NCBI
Pax8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629282,629,178 - 82,682,663 (-)NCBI
SpeTri2.0NW_0049367831,523,658 - 1,553,464 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAX8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11416,236,074 - 16,299,650 (-)NCBI
ChlSab1.1 Ensembl1416,233,378 - 16,297,365 (-)Ensembl
Vero_WHO_p1.0NW_0236660803,382,976 - 3,450,250 (+)NCBI
Pax8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474913,291,880 - 13,358,066 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000039028   ⟹   ENSPPAP00000016333
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A114,162,110 - 114,222,865 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000039159   ⟹   ENSPPAP00000016463
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A114,162,110 - 114,222,384 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000039190   ⟹   ENSPPAP00000016494
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A114,164,648 - 114,192,442 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000039192   ⟹   ENSPPAP00000016496
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A114,164,648 - 114,192,442 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000039217   ⟹   ENSPPAP00000016522
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A114,166,206 - 114,222,309 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000039222   ⟹   ENSPPAP00000016525
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A114,166,206 - 114,222,309 (-)Ensembl
RefSeq Acc Id: XM_003804490   ⟹   XP_003804538
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.12A114,162,110 - 114,222,837 (-)NCBI
Mhudiblu_PPA_v02A88,845,877 - 88,905,266 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008960400   ⟹   XP_008958648
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.12A114,162,110 - 114,222,865 (-)NCBI
Mhudiblu_PPA_v02A88,845,884 - 88,905,266 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003804538 (Get FASTA)   NCBI Sequence Viewer  
  XP_008958648 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008958648   ⟸   XM_008960400
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_003804538   ⟸   XM_003804490
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSPPAP00000016333   ⟸   ENSPPAT00000039028
RefSeq Acc Id: ENSPPAP00000016463   ⟸   ENSPPAT00000039159
RefSeq Acc Id: ENSPPAP00000016496   ⟸   ENSPPAT00000039192
RefSeq Acc Id: ENSPPAP00000016494   ⟸   ENSPPAT00000039190
RefSeq Acc Id: ENSPPAP00000016525   ⟸   ENSPPAT00000039222
RefSeq Acc Id: ENSPPAP00000016522   ⟸   ENSPPAT00000039217


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000031225 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000016463 ENTREZGENE
NCBI Gene PAX8 ENTREZGENE