LOC100991754 (histone PARylation factor 1)

Gene: LOC100991754 (histone PARylation factor 1) Pan paniscus

Analyze

Symbol:

LOC100991754 (Ensembl: HPF1)

Name:

histone PARylation factor 1

RGD ID:

11952364

Description:

ENCODES a protein that exhibits chromatin binding (inferred); histone binding (inferred); poly-ADP-D-ribose binding (inferred); INVOLVED IN DNA damage response (inferred); DNA repair (inferred); DNA repair-dependent chromatin remodeling (inferred); ASSOCIATED WITH genetic disease (ortholog); FOUND IN site of DNA damage (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

C4H4orf27; chromosome 4 open reading frame, human C4orf27; UPF0609 protein C4orf27 homolog

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	167,506,176 - 167,534,704 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	167,862,061 - 167,890,643 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	161,949,343 - 161,977,887 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	174,021,060 - 174,049,213 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	174,021,060 - 174,049,213 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

DNA damage response (IEA)

DNA repair (IEA)

DNA repair-dependent chromatin remodeling (IEA)

double-strand break repair (IEA)

Cellular Component

chromatin (IEA)

nucleus (IEA)

site of DNA damage (IEA,ISO)

Molecular Function

chromatin binding (IEA)

histone binding (IEA)

poly-ADP-D-ribose binding (IEA)

protein ADP-ribosyltransferase-substrate adaptor activity (IEA)

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

LOC100991754
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	167,506,176 - 167,534,704 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	167,862,061 - 167,890,643 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	161,949,343 - 161,977,887 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	174,021,060 - 174,049,213 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	174,021,060 - 174,049,213 (-)	Ensembl	panpan1.1		panPan2

HPF1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	169,729,470 - 169,757,944 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	169,729,470 - 169,757,944 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	170,650,621 - 170,679,095 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	170,887,194 - 170,915,668 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	167,983,601 - 168,012,093 (-)	NCBI		Celera
Cytogenetic Map	4	q33	NCBI
HuRef	4	166,405,437 - 166,433,881 (-)	NCBI		HuRef
CHM1_1	4	170,627,188 - 170,655,678 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	173,089,586 - 173,118,075 (-)	NCBI		T2T-CHM13v2.0

Hpf1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	61,342,533 - 61,360,615 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	61,343,452 - 61,361,705 (+)	Ensembl		GRCm39 Ensembl
GRCm38	8	60,890,392 - 60,907,580 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	60,890,418 - 60,908,671 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	63,369,248 - 63,386,369 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	8	63,648,378 - 63,799,724 (+)	NCBI		MGSCv36	mm8
Celera	8	63,457,542 - 63,474,667 (+)	NCBI		Celera
Cytogenetic Map	8	B3.1	NCBI
cM Map	8	30.9	NCBI

Hpf1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	34,211,971 - 34,230,551 (-)	NCBI		GRCr8
mRatBN7.2	16	29,203,749 - 29,219,651 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	29,183,256 - 29,219,716 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	32,798,620 - 32,814,503 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	36,232,348 - 36,248,229 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	32,433,869 - 32,449,730 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	32,524,128 - 32,540,233 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	32,519,924 - 32,540,217 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	32,358,968 - 32,375,073 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	32,523,650 - 32,539,537 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	32,523,724 - 32,539,655 (-)	NCBI
Celera	16	29,198,257 - 29,214,140 (-)	NCBI		Celera
Cytogenetic Map	16	p12	NCBI

LOC102030373
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	36,594,269 - 36,622,724 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	36,594,319 - 36,621,020 (+)	NCBI	ChiLan1.0	ChiLan1.0

HPF1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	25	20,622,781 - 20,645,459 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	25	20,622,774 - 20,644,822 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	25	21,257,443 - 21,279,874 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	25	20,798,645 - 20,821,091 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	25	20,798,649 - 20,820,457 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	25	20,682,932 - 20,705,345 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	25	20,618,769 - 20,641,207 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	25	20,718,372 - 20,740,811 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101970824
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404943	21,349,641 - 21,371,280 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936516	1,763,935 - 1,785,538 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HPF1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	20,014,274 - 20,039,332 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	20,014,254 - 20,037,791 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	21,313,121 - 21,329,267 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103236518
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	115,934,687 - 115,966,404 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	115,934,692 - 115,966,369 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	95,880,912 - 95,912,880 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101705414
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624769	1,239,455 - 1,261,901 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624769	1,239,399 - 1,261,770 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003821812	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000000047 ⟹ ENSPPAP00000000022

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	4	174,021,060 - 174,049,213 (-)	Ensembl

RefSeq Acc Id:

XM_003821812 ⟹ XP_003821860

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	3	167,506,176 - 167,534,704 (-)	NCBI
NHGRI_mPanPan1	4	167,862,061 - 167,890,643 (-)	NCBI
Mhudiblu_PPA_v0	4	161,949,343 - 161,977,887 (-)	NCBI
PanPan1.1	4	174,021,060 - 174,049,213 (-)	NCBI

Sequence:

show sequence

AGCAGTTGGCGGCGCTCGGAAGCGGCAGCGGATCGGGGAATTCTGCTGGCGCTGCAGCTGCAGA
ATGGTCGGCGGTGGCGGGAAGCGCAGGCCCGGCGGGGAGGGGCCGCAGTGTGAAAAAACAACTG
ATGTGAAGAAAAGTAAATTCTGTGAAGCTGATGTCTCCAGTGACCTTCGAAAAGAAGTAGAAAA
TCATTATAAGCTTTCTTTACCTGAAGATTTCTATCACTTCTGGAAGTTCTGTGAAGAACTTGAT
CCTGAAAAGCCATCTGATTCACTTTCTGCAAGCCTTGGACTTCAATTAGTTGGTCCTTATGATA
TCCTTGCTGGAAAACATAAAATGAAGAAAAAATCAACAGGCCTGAATTTTAACCTTCACTGGAG
GTTTTACTATGATCCTCCTGAGTTCCAGACCATTATTATTGGAGATAATAAAACTCAGTACCAC
ATGGGGTATTTCAGGGATTCTCCTGATGAATTTCCTGTATATGTTGGTATAAATGAAGCAAAGA
AAAATTGTATAATTGTTCCAAATGGAGATAATGTATTTGCTGCAGTCAAATTATTTTTGACGAA
AAAACTTAAAGAAATAACGGATAAAAAGAAAATCAATCTCTTGAAAAACATAGATGAAAAACTC
ACAGAAGCAGCCAGAGAATTGGGGTATTCGCTTGAACAGAGAACCATGAAGATGAAACAGAGAG
ATAAGAAAGTTGTGACAAAGACCTTTCATGGTGCTGGCTTGGTTGTTCCAGTAGATAAAAATGA
TGTTGGGTACCGAGAGCTCCCTGAAACAGATGCTGACCTCAAGAGAATTTGCAAGACAATAGTT
GAGGCTGCAAGTGATGAGGAGAGACTAAAAGCTTTTGCTCCCATTCAGGAAATGATGACTTTTG
TGCAGTTTGCTAATGATGAATGTGATTATGGCATGGGGCTTGAATTGGGCATGGATCTCTTTTG
CTATGGCTCACATTATTTTCATAAAGTTGCTGGCCAGCTTTTACCTCTTGCATATAATCTGTTG
AAGAGGAATCTGTTTGCAGAAATTATTGAGGAGCATCTGGCAAACAGAAGTAAAGAGAACATAG
ACCAACTTGCTGCATGAGTAAGGTGGCTTTGATTGGTGTACAGTATTTCAAAGGACTAGTATTA
AACTTGTGATTTTTGTTTTGTTTTTAAGGAATACAAAAAATAAACATTTACTAAAAACGTT

hide sequence

Protein Sequences


Protein RefSeqs	XP_003821860	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000000022
	ENSPPAP00000000022.1

RefSeq Acc Id:

XP_003821860 ⟸ XM_003821812

- UniProtKB:

A0A2R8Z5N0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVGGGGKRRPGGEGPQCEKTTDVKKSKFCEADVSSDLRKEVENHYKLSLPEDFYHFWKFCEELD
PEKPSDSLSASLGLQLVGPYDILAGKHKMKKKSTGLNFNLHWRFYYDPPEFQTIIIGDNKTQYH
MGYFRDSPDEFPVYVGINEAKKNCIIVPNGDNVFAAVKLFLTKKLKEITDKKKINLLKNIDEKL
TEAARELGYSLEQRTMKMKQRDKKVVTKTFHGAGLVVPVDKNDVGYRELPETDADLKRICKTIV
EAASDEERLKAFAPIQEMMTFVQFANDECDYGMGLELGMDLFCYGSHYFHKVAGQLLPLAYNLL
KRNLFAEIIEEHLANRSKENIDQLAA

hide sequence

RefSeq Acc Id:

ENSPPAP00000000022 ⟸ ENSPPAT00000000047

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000000046	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000000047.1	UniProtKB/TrEMBL
InterPro	HPF1	UniProtKB/TrEMBL
KEGG Report	pps:100991754	UniProtKB/TrEMBL
NCBI Gene	C4H4orf27	ENTREZGENE
PANTHER	HISTONE PARYLATION FACTOR 1	UniProtKB/TrEMBL
	PTHR13386	UniProtKB/TrEMBL
Pfam	DUF2228	UniProtKB/TrEMBL
UniProt	A0A2R8Z5N0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-05-08	LOC100991754	histone PARylation factor 1	C4H4orf27	chromosome 4 open reading frame, human C4orf27	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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