MCM8 (minichromosome maintenance 8 homologous recombination repair factor) - Rat Genome Database

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Gene: MCM8 (minichromosome maintenance 8 homologous recombination repair factor) Pan paniscus
Analyze
Symbol: MCM8
Name: minichromosome maintenance 8 homologous recombination repair factor
RGD ID: 11949554
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); chromatin binding (inferred); INVOLVED IN DNA replication (ortholog); ASSOCIATED WITH azoospermia (ortholog); genetic disease (ortholog); Huntington's disease-like 1 (ortholog); FOUND IN MCM8-MCM9 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA helicase MCM8; minichromosome maintenance complex component 8
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2216,872,653 - 6,918,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1206,869,479 - 6,920,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0205,945,034 - 5,993,725 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1205,727,789 - 5,775,133 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl205,729,174 - 5,775,133 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
MCM complex  (IEA)
MCM8-MCM9 complex  (IEA,ISO)
nucleus  (IEA)

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MCM8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2216,872,653 - 6,918,874 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1206,869,479 - 6,920,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0205,945,034 - 5,993,725 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1205,727,789 - 5,775,133 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl205,729,174 - 5,775,133 (+)Ensemblpanpan1.1panPan2
MCM8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38205,950,652 - 5,998,977 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl205,950,652 - 5,998,977 (+)EnsemblGRCh38hg38GRCh38
GRCh37205,931,298 - 5,979,623 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36205,879,298 - 5,923,833 (+)NCBINCBI36Build 36hg18NCBI36
Celera206,002,910 - 6,047,121 (+)NCBICelera
Cytogenetic Map20p12.3NCBI
HuRef205,887,832 - 5,932,254 (+)NCBIHuRef
CHM1_1205,931,687 - 5,975,911 (+)NCBICHM1_1
T2T-CHM13v2.0205,990,987 - 6,039,282 (+)NCBIT2T-CHM13v2.0
Mcm8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392132,658,061 - 132,686,117 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2132,658,061 - 132,686,117 (+)EnsemblGRCm39 Ensembl
GRCm382132,816,137 - 132,844,197 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2132,816,141 - 132,844,197 (+)EnsemblGRCm38mm10GRCm38
MGSCv372132,642,071 - 132,669,933 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362132,507,776 - 132,535,638 (+)NCBIMGSCv36mm8
Celera2134,043,779 - 134,071,682 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.75NCBI
Mcm8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83140,539,590 - 140,569,891 (+)NCBIGRCr8
mRatBN7.23120,086,741 - 120,117,008 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3120,086,763 - 120,117,008 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3123,981,812 - 124,012,084 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03132,585,444 - 132,615,628 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03130,237,946 - 130,268,218 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.03125,470,499 - 125,500,795 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3125,470,551 - 125,500,795 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03131,954,303 - 131,984,573 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43120,614,429 - 120,644,673 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13120,520,853 - 120,549,803 (+)NCBI
Celera3118,872,729 - 118,902,973 (+)NCBICelera
Cytogenetic Map3q36NCBI
Mcm8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541516,346,253 - 16,379,021 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541516,345,472 - 16,379,922 (+)NCBIChiLan1.0ChiLan1.0
MCM8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12415,850,602 - 15,893,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2415,814,770 - 15,893,458 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2415,672,843 - 15,715,552 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02416,253,280 - 16,296,002 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2416,217,448 - 16,295,816 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12415,860,050 - 15,902,521 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02415,968,188 - 16,010,880 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02416,299,900 - 16,342,388 (-)NCBIUU_Cfam_GSD_1.0
Mcm8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640164,641,384 - 164,677,033 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648513,072,600 - 13,108,411 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648513,072,791 - 13,108,392 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1714,790,396 - 14,837,416 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11714,790,398 - 14,837,420 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21715,896,975 - 15,943,939 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MCM8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1232,137,983 - 32,181,187 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl232,138,173 - 32,181,179 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607112,360,094 - 12,404,612 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mcm8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247416,787,578 - 6,827,188 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247416,787,555 - 6,826,033 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000044036   ⟹   ENSPPAP00000021236
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl205,729,174 - 5,775,133 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000044045   ⟹   ENSPPAP00000021244
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl205,729,174 - 5,774,554 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000044051   ⟹   ENSPPAP00000021250
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl205,729,179 - 5,774,810 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000044056   ⟹   ENSPPAP00000021255
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl205,734,274 - 5,774,810 (+)Ensembl
RefSeq Acc Id: XM_003821352   ⟹   XP_003821400
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2216,872,653 - 6,918,874 (+)NCBI
NHGRI_mPanPan1206,869,479 - 6,920,372 (+)NCBI
Mhudiblu_PPA_v0205,945,034 - 5,993,725 (+)NCBI
PanPan1.1205,727,789 - 5,775,133 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008974818   ⟹   XP_008973066
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2216,872,696 - 6,917,899 (+)NCBI
NHGRI_mPanPan1206,869,522 - 6,914,725 (+)NCBI
Mhudiblu_PPA_v0205,945,303 - 5,991,396 (+)NCBI
PanPan1.1205,727,789 - 5,773,992 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003821400 (Get FASTA)   NCBI Sequence Viewer  
  XP_008973066 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000021236.1
  ENSPPAP00000021244.1
  ENSPPAP00000021250.1
  ENSPPAP00000021255.1
Reference Protein Sequences
RefSeq Acc Id: XP_003821400   ⟸   XM_003821352
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AVA6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008973066   ⟸   XM_008974818
- Peptide Label: isoform X2
- UniProtKB: A0A2R9B1E8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000021236   ⟸   ENSPPAT00000044036
RefSeq Acc Id: ENSPPAP00000021244   ⟸   ENSPPAT00000044045
RefSeq Acc Id: ENSPPAP00000021250   ⟸   ENSPPAT00000044051
RefSeq Acc Id: ENSPPAP00000021255   ⟸   ENSPPAT00000044056
Protein Domains
MCM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033799 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000044036.1 UniProtKB/TrEMBL
  ENSPPAT00000044045.1 UniProtKB/TrEMBL
  ENSPPAT00000044051.1 UniProtKB/TrEMBL
  ENSPPAT00000044056.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.28.10 UniProtKB/TrEMBL
  2.40.50.140 UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  MCM UniProtKB/TrEMBL
  MCM_dom UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report pps:100993730 UniProtKB/TrEMBL
NCBI Gene MCM8 ENTREZGENE
PANTHER DNA HELICASE MCM8 UniProtKB/TrEMBL
  PTHR11630 UniProtKB/TrEMBL
Pfam MCM UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
PRINTS MCMFAMILY UniProtKB/TrEMBL
PROSITE MCM_2 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
  MCM UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9AVA6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9AZH0_PANPA UniProtKB/TrEMBL
  A0A2R9AZH5_PANPA UniProtKB/TrEMBL
  A0A2R9B1E8 ENTREZGENE, UniProtKB/TrEMBL