MSL2 (MSL complex subunit 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: MSL2 (MSL complex subunit 2) Pan paniscus
Analyze
Symbol: MSL2
Name: MSL complex subunit 2
RGD ID: 11942787
Description: ENCODES a protein that exhibits histone H2B ubiquitin ligase activity (ortholog); promoter-enhancer loop anchoring activity (ortholog); INVOLVED IN DNA damage response (ortholog); epigenetic regulation of gene expression (ortholog); protein monoubiquitination (ortholog); ASSOCIATED WITH autistic disorder (ortholog); genetic disease (ortholog); Primary Lymphedema with Myelodysplasia (ortholog); FOUND IN chromatin (ortholog); MSL complex (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: E3 ubiquitin-protein ligase MSL2; male-specific lethal 2 homolog; male-specific lethal 2 homolog (Drosophila)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22134,080,638 - 134,130,979 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13134,084,840 - 134,137,823 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03133,203,579 - 133,252,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13140,667,652 - 140,714,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3140,667,652 - 140,714,294 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
MSL complex  (IEA,ISO)
nucleus  (IEA,ISO)

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
MSL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22134,080,638 - 134,130,979 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan13134,084,840 - 134,137,823 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v03133,203,579 - 133,252,294 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13140,667,652 - 140,714,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3140,667,652 - 140,714,294 (-)Ensemblpanpan1.1panPan2
MSL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383136,148,917 - 136,196,335 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3136,148,917 - 136,197,241 (-)EnsemblGRCh38hg38GRCh38
GRCh373135,867,759 - 135,915,177 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363137,350,450 - 137,397,378 (-)NCBINCBI36Build 36hg18NCBI36
Build 343137,350,457 - 137,397,386NCBI
Celera3134,293,973 - 134,340,053 (-)NCBICelera
Cytogenetic Map3q22.3NCBI
HuRef3133,245,191 - 133,291,938 (-)NCBIHuRef
CHM1_13135,831,027 - 135,878,223 (-)NCBICHM1_1
T2T-CHM13v2.03138,894,723 - 138,942,140 (-)NCBIT2T-CHM13v2.0
Msl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399100,956,107 - 100,981,999 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9100,956,154 - 100,981,999 (+)EnsemblGRCm39 Ensembl
GRCm389101,074,054 - 101,104,800 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9101,074,101 - 101,104,800 (+)EnsemblGRCm38mm10GRCm38
MGSCv379101,002,900 - 101,007,130 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv379100,978,451 - 100,979,143 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369100,956,680 - 100,964,191 (+)NCBIMGSCv36mm8
Celera9100,614,669 - 100,640,555 (+)NCBICelera
Cytogenetic Map9E4NCBI
cM Map953.17NCBI
Msl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88110,555,579 - 110,642,096 (+)NCBIGRCr8
mRatBN7.28101,676,605 - 101,702,818 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8101,676,765 - 101,763,833 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8107,339,727 - 107,364,664 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08105,539,044 - 105,563,982 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08103,381,562 - 103,406,501 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08109,456,097 - 109,480,143 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8109,455,786 - 109,478,584 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08108,872,826 - 108,898,055 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48106,034,690 - 106,059,395 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.18106,053,694 - 106,077,241 (+)NCBI
Celera8101,068,882 - 101,092,934 (+)NCBICelera
Cytogenetic Map8q31NCBI
Msl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555012,601,424 - 2,645,341 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555012,601,424 - 2,645,341 (+)NCBIChiLan1.0ChiLan1.0
MSL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12332,629,120 - 32,663,885 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2332,631,804 - 32,664,277 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2332,614,866 - 32,649,754 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02333,158,560 - 33,193,474 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2333,160,078 - 33,191,904 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12332,841,610 - 32,876,769 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02332,909,086 - 32,943,982 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02333,152,766 - 33,187,730 (-)NCBIUU_Cfam_GSD_1.0
Msl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560272,274,029 - 72,309,624 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365299,033,895 - 9,068,567 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365299,035,198 - 9,068,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1377,146,318 - 77,180,745 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11377,147,823 - 77,181,410 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21384,517,847 - 84,550,666 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MSL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11554,246,090 - 54,290,809 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1554,246,127 - 54,288,555 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604127,303,470 - 27,351,025 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Msl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473012,569,562 - 12,618,933 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000030507   ⟹   ENSPPAP00000007889
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl3140,667,652 - 140,714,294 (-)Ensembl
RefSeq Acc Id: XM_003822496   ⟹   XP_003822544
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22134,080,638 - 134,126,080 (-)NCBI
NHGRI_mPanPan13134,084,840 - 134,130,795 (-)NCBI
Mhudiblu_PPA_v03133,203,579 - 133,250,415 (-)NCBI
PanPan1.13140,667,652 - 140,714,002 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008976071   ⟹   XP_008974319
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22134,080,638 - 134,127,609 (-)NCBI
NHGRI_mPanPan13134,084,840 - 134,132,883 (-)NCBI
Mhudiblu_PPA_v03133,203,579 - 133,252,294 (-)NCBI
PanPan1.13140,667,652 - 140,714,924 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055110509   ⟹   XP_054966484
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22134,080,638 - 134,130,979 (-)NCBI
NHGRI_mPanPan13134,084,840 - 134,137,823 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003822544 (Get FASTA)   NCBI Sequence Viewer  
  XP_008974319 (Get FASTA)   NCBI Sequence Viewer  
  XP_054966484 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000007889
  ENSPPAP00000007889.1
Reference Protein Sequences
RefSeq Acc Id: XP_008974319   ⟸   XM_008976071
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003822544   ⟸   XM_003822496
- Peptide Label: isoform X1
- UniProtKB: A0A2R8ZSD7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000007889   ⟸   ENSPPAT00000030507
RefSeq Acc Id: XP_054966484   ⟸   XM_055110509
- Peptide Label: isoform X2
Protein Domains
RING-type


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000027164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000030507.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.40.10 UniProtKB/TrEMBL
InterPro MSL2 UniProtKB/TrEMBL
  Msl2-CXC UniProtKB/TrEMBL
  Msl2_Znf-RING UniProtKB/TrEMBL
  Tesmin/TSO1-like_CXC UniProtKB/TrEMBL
  Znf_RING UniProtKB/TrEMBL
  Znf_RING/FYVE/PHD UniProtKB/TrEMBL
KEGG Report pps:100980453 UniProtKB/TrEMBL
NCBI Gene MSL2 ENTREZGENE
PANTHER E3 UBIQUITIN-PROTEIN LIGASE MSL2 UniProtKB/TrEMBL
  PTHR16048 UniProtKB/TrEMBL
Pfam MSL2-CXC UniProtKB/TrEMBL
  zf-RING_10 UniProtKB/TrEMBL
PROSITE ZF_RING_2 UniProtKB/TrEMBL
SMART CXC UniProtKB/TrEMBL
Superfamily-SCOP RING/U-box UniProtKB/TrEMBL
UniProt A0A2R8ZSD7 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-30 MSL2  MSL complex subunit 2    male-specific lethal 2 homolog (Drosophila)  Symbol and/or name change 5135510 APPROVED