NKD2 (NKD inhibitor of WNT signaling pathway 2) - Rat Genome Database
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Gene: NKD2 (NKD inhibitor of WNT signaling pathway 2) Pan paniscus
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Symbol: NKD2
Name: NKD inhibitor of WNT signaling pathway 2
RGD ID: 11941017
Description: ENCODES a protein that exhibits ATPase binding (ortholog); growth factor binding (ortholog); myosin heavy chain binding (ortholog); INVOLVED IN Golgi vesicle fusion to target membrane (ortholog); negative regulation of canonical Wnt signaling pathway (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH idiopathic pulmonary fibrosis (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell periphery (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: naked cuticle homolog 2; NKD2, WNT signaling pathway inhibitor
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.151,075,172 - 1,081,628 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl51,075,172 - 1,081,664 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v051,285,217 - 1,311,285 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
NKD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.151,075,172 - 1,081,628 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl51,075,172 - 1,081,664 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v051,285,217 - 1,311,285 (+)NCBIMhudiblu_PPA_v0panPan3
NKD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl51,008,802 - 1,038,943 (+)EnsemblGRCh38hg38GRCh38
GRCh3851,008,802 - 1,038,943 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3751,008,917 - 1,039,058 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3651,062,168 - 1,091,925 (+)NCBINCBI36hg18NCBI36
Build 3451,062,167 - 1,091,925NCBI
Celera51,048,097 - 1,076,601 (+)NCBI
Cytogenetic Map5p15.33NCBI
HuRef5993,646 - 1,021,595 (+)NCBIHuRef
CHM1_151,008,923 - 1,038,814 (+)NCBICHM1_1
Nkd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391373,966,653 - 73,995,750 (-)NCBIGRCm39mm39
GRCm39 Ensembl1373,966,653 - 73,995,750 (-)Ensembl
GRCm381373,818,534 - 73,847,631 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1373,818,534 - 73,847,631 (-)EnsemblGRCm38mm10GRCm38
MGSCv371373,956,776 - 73,985,079 (-)NCBIGRCm37mm9NCBIm37
MGSCv361374,286,135 - 74,313,614 (-)NCBImm8
Celera1376,148,658 - 76,177,277 (-)NCBICelera
Cytogenetic Map13C1NCBI
Nkd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2129,442,898 - 29,470,839 (+)NCBI
Rnor_6.0 Ensembl132,058,044 - 32,084,877 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0132,054,390 - 32,085,416 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0133,482,721 - 33,509,561 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4130,252,093 - 30,278,933 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1130,252,483 - 30,285,229 (+)NCBI
Celera128,092,060 - 28,118,895 (+)NCBICelera
Cytogenetic Map1p11NCBI
Nkd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955504507,388 - 526,407 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955504507,253 - 527,275 (+)NCBIChiLan1.0ChiLan1.0
NKD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3411,447,888 - 11,459,509 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13411,447,895 - 11,468,067 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nkd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936815669,389 - 701,402 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NKD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11679,400,323 - 79,419,779 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NKD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.14857,938 - 884,840 (+)NCBI
ChlSab1.1 Ensembl4858,809 - 884,758 (+)Ensembl
Nkd2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624751495,561 - 507,756 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000045668   ⟹   ENSPPAP00000022854
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl51,075,172 - 1,081,664 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000045670   ⟹   ENSPPAP00000022856
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl51,075,205 - 1,080,610 (+)Ensembl
RefSeq Acc Id: XM_034959693   ⟹   XP_034815584
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v051,285,217 - 1,311,285 (+)NCBI
RefSeq Acc Id: XM_034959694   ⟹   XP_034815585
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v051,285,328 - 1,311,077 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034815584 (Get FASTA)   NCBI Sequence Viewer  
  XP_034815585 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034815584   ⟸   XM_034959693
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034815585   ⟸   XM_034959694
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000022854   ⟸   ENSPPAT00000045668
RefSeq Acc Id: ENSPPAP00000022856   ⟸   ENSPPAT00000045670
Protein Domains
EF-hand


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000034599 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000022854 UniProtKB/TrEMBL
  ENSPPAP00000022856 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000045668 UniProtKB/TrEMBL
  ENSPPAT00000045670 UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  nkd-like UniProtKB/TrEMBL
KEGG Report pps:100992786 UniProtKB/TrEMBL
NCBI Gene NKD2 ENTREZGENE
PANTHER PTHR22611 UniProtKB/TrEMBL
PROSITE EF_HAND_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/TrEMBL
UniProt A0A2R9AZU6_PANPA UniProtKB/TrEMBL
  A0A2R9B6B6_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-01-29 NKD2  NKD inhibitor of WNT signaling pathway 2    NKD2, WNT signaling pathway inhibitor  Symbol and/or name change 5135510 APPROVED
2018-11-29 NKD2  NKD2, WNT signaling pathway inhibitor    naked cuticle homolog 2  Symbol and/or name change 5135510 APPROVED