NKD2 (NKD inhibitor of WNT signaling pathway 2)

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: NKD2 (NKD inhibitor of WNT signaling pathway 2) Pan paniscus

Analyze

Symbol:

NKD2

Name:

NKD inhibitor of WNT signaling pathway 2

RGD ID:

11941017

Description:

ENCODES a protein that exhibits ATPase binding (ortholog); growth factor binding (ortholog); myosin heavy chain binding (ortholog); INVOLVED IN Golgi vesicle fusion to target membrane (ortholog); negative regulation of canonical Wnt signaling pathway (ortholog); positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ortholog); PARTICIPATES IN Wnt signaling, canonical pathway; ASSOCIATED WITH idiopathic pulmonary fibrosis (ortholog); FOUND IN basolateral plasma membrane (ortholog); cell periphery (ortholog); cytoplasmic vesicle (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

naked cuticle homolog 2; NKD2, WNT signaling pathway inhibitor

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	1,075,172 - 1,081,628 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	1,075,172 - 1,081,664 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	1,285,217 - 1,311,285 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

idiopathic pulmonary fibrosis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Golgi vesicle fusion to target membrane (ISO)

negative regulation of canonical Wnt signaling pathway (ISO)

positive regulation of proteasomal ubiquitin-dependent protein catabolic process (ISO)

positive regulation of protein localization to plasma membrane (ISO)

positive regulation of protein processing (ISO)

protein localization to plasma membrane (ISO)

Cellular Component

basolateral plasma membrane (ISO)

cell periphery (ISO)

cytoplasmic vesicle (ISO)

exocytic vesicle (ISO)

lateral plasma membrane (ISO)

plasma membrane (ISO)

Molecular Function

ATPase binding (ISO)

growth factor binding (ISO)

myosin heavy chain binding (ISO)

protein binding (ISO)

ubiquitin protein ligase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Wnt signaling, canonical pathway (ISO)

References

Genomics

Comparative Map Data

NKD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	5	1,075,172 - 1,081,628 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	5	1,075,172 - 1,081,664 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	5	1,285,217 - 1,311,285 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

NKD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	5	1,008,802 - 1,038,943 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	5	1,008,802 - 1,038,943 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	5	1,008,917 - 1,039,058 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	5	1,062,168 - 1,091,925 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	5	1,062,167 - 1,091,925	NCBI
Celera	5	1,048,097 - 1,076,601 (+)	NCBI
Cytogenetic Map	5	p15.33	NCBI
HuRef	5	993,646 - 1,021,595 (+)	NCBI		HuRef
CHM1_1	5	1,008,923 - 1,038,814 (+)	NCBI		CHM1_1

Nkd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	13	73,966,653 - 73,995,750 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	13	73,966,653 - 73,995,750 (-)	Ensembl
GRCm38	13	73,818,534 - 73,847,631 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	13	73,818,534 - 73,847,631 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	13	73,956,776 - 73,985,079 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	13	74,286,135 - 74,313,614 (-)	NCBI			mm8
Celera	13	76,148,658 - 76,177,277 (-)	NCBI		Celera
Cytogenetic Map	13	C1	NCBI

Nkd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	29,442,898 - 29,470,839 (+)	NCBI
Rnor_6.0 Ensembl	1	32,058,044 - 32,084,877 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	1	32,054,390 - 32,085,416 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	1	33,482,721 - 33,509,561 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	30,252,093 - 30,278,933 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	1	30,252,483 - 30,285,229 (+)	NCBI
Celera	1	28,092,060 - 28,118,895 (+)	NCBI		Celera
Cytogenetic Map	1	p11	NCBI

Nkd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955504	507,388 - 526,407 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955504	507,253 - 527,275 (+)	NCBI	ChiLan1.0	ChiLan1.0

NKD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	34	11,447,888 - 11,459,509 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	34	11,447,895 - 11,468,067 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Nkd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936815	669,389 - 701,402 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NKD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	16	79,400,323 - 79,419,779 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

NKD2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	4	857,938 - 884,840 (+)	NCBI
ChlSab1.1 Ensembl	4	858,809 - 884,758 (+)	Ensembl

Nkd2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624751	495,561 - 507,756 (+)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_034959693	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034959694	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000045668 ⟹ ENSPPAP00000022854

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	1,075,172 - 1,081,664 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000045670 ⟹ ENSPPAP00000022856

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	5	1,075,205 - 1,080,610 (+)	Ensembl

RefSeq Acc Id:

XM_034959693 ⟹ XP_034815584

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	5	1,285,217 - 1,311,285 (+)	NCBI

RefSeq Acc Id:

XM_034959694 ⟹ XP_034815585

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
Mhudiblu_PPA_v0	5	1,285,328 - 1,311,077 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_034815584	(Get FASTA)	NCBI Sequence Viewer
	XP_034815585	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	XP_034815584 ⟸ XM_034959693
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_034815585 ⟸ XM_034959694
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSPPAP00000022854 ⟸ ENSPPAT00000045668

RefSeq Acc Id:

ENSPPAP00000022856 ⟸ ENSPPAT00000045670

Protein Domains

EF-hand

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000034599	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000022854	UniProtKB/TrEMBL
	ENSPPAP00000022856	UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000045668	UniProtKB/TrEMBL
	ENSPPAT00000045670	UniProtKB/TrEMBL
InterPro	EF-hand-dom_pair	UniProtKB/TrEMBL
	EF_hand_dom	UniProtKB/TrEMBL
	nkd-like	UniProtKB/TrEMBL
KEGG Report	pps:100992786	UniProtKB/TrEMBL
NCBI Gene	NKD2	ENTREZGENE
PANTHER	PTHR22611	UniProtKB/TrEMBL
PROSITE	EF_HAND_2	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47473	UniProtKB/TrEMBL
UniProt	A0A2R9AZU6_PANPA	UniProtKB/TrEMBL
	A0A2R9B6B6_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-01-29	NKD2	NKD inhibitor of WNT signaling pathway 2		NKD2, WNT signaling pathway inhibitor	Symbol and/or name change	5135510	APPROVED
2018-11-29	NKD2	NKD2, WNT signaling pathway inhibitor		naked cuticle homolog 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Annotations - PID (archival)