DPYD (dihydropyrimidine dehydrogenase) - Rat Genome Database
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Gene: DPYD (dihydropyrimidine dehydrogenase) Pan paniscus
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Symbol: DPYD
Name: dihydropyrimidine dehydrogenase
RGD ID: 11940354
Description: ENCODES a protein that exhibits dihydropyrimidine dehydrogenase (NADP+) activity (ortholog); dihydrouracil dehydrogenase (NAD+) activity (ortholog); FAD binding (ortholog); INVOLVED IN aging (ortholog); circadian rhythm (ortholog); CMP catabolic process (ortholog); PARTICIPATES IN beta-alanine metabolic pathway; beta-ureidopropionase deficiency pathway; carnosinemia pathway; ASSOCIATED WITH acute lymphoblastic leukemia (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: dihydropyrimidine dehydrogenase [NADP(+)]
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1198,457,934 - 99,300,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,736,145 - 100,576,663 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

Genomics

Comparative Map Data
DPYD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1198,457,934 - 99,300,094 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,736,145 - 100,576,663 (-)NCBIMhudiblu_PPA_v0panPan3
DPYD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl197,077,743 - 97,995,000 (-)EnsemblGRCh38hg38GRCh38
GRCh38197,077,743 - 97,921,059 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37197,543,299 - 98,386,615 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,315,887 - 98,159,203 (-)NCBINCBI36hg18NCBI36
Build 34197,255,322 - 98,098,600NCBI
Celera195,797,301 - 96,640,303 (-)NCBI
Cytogenetic Map1p21.3NCBI
HuRef195,664,181 - 96,508,076 (-)NCBIHuRef
CHM1_1197,659,318 - 98,502,216 (-)NCBICHM1_1
Dpyd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393118,355,758 - 119,226,573 (+)NCBIGRCm39mm39
GRCm383118,562,109 - 119,432,924 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3118,562,129 - 119,432,924 (+)EnsemblGRCm38mm10GRCm38
MGSCv373118,265,096 - 119,135,836 (+)NCBIGRCm37mm9NCBIm37
MGSCv363118,554,182 - 119,424,922 (+)NCBImm8
Celera3124,970,410 - 125,843,833 (+)NCBICelera
Cytogenetic Map3G1NCBI
Dpyd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22206,609,043 - 207,474,982 (+)NCBI
Rnor_6.0 Ensembl2221,823,687 - 222,694,627 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02221,823,692 - 222,694,627 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02239,874,415 - 240,000,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.02240,072,322 - 240,744,042 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42214,931,901 - 215,818,809 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12214,894,962 - 215,781,871 (+)NCBI
Celera2199,080,477 - 199,932,183 (+)NCBICelera
Cytogenetic Map2q41NCBI
Dpyd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554352,007,185 - 2,766,138 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554352,007,185 - 2,800,907 (-)NCBIChiLan1.0ChiLan1.0
DPYD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl651,814,573 - 52,580,923 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1651,789,786 - 52,564,802 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dpyd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365371,660,461 - 2,439,305 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DPYD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4119,931,458 - 120,712,462 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.14119,931,471 - 120,712,461 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24131,845,556 - 132,550,018 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DPYD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12035,376,738 - 36,215,388 (+)NCBI
ChlSab1.1 Ensembl2035,377,266 - 36,215,679 (+)Ensembl


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000061234   ⟹   ENSPPAP00000038331
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061244   ⟹   ENSPPAP00000038341
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl198,457,934 - 99,300,100 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061257   ⟹   ENSPPAP00000038354
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl198,459,266 - 99,267,178 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061259   ⟹   ENSPPAP00000038356
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl198,573,095 - 99,300,100 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000061272   ⟹   ENSPPAP00000038369
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl198,687,487 - 99,058,647 (-)Ensembl
RefSeq Acc Id: XM_003808457   ⟹   XP_003808505
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1198,457,934 - 99,300,094 (-)NCBI
Mhudiblu_PPA_v0199,736,145 - 100,576,618 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008960543   ⟹   XP_008958791
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1198,457,934 - 99,300,094 (-)NCBI
Mhudiblu_PPA_v0199,736,145 - 100,576,620 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008960544   ⟹   XP_008958792
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1199,098,746 - 99,300,094 (-)NCBI
Mhudiblu_PPA_v01100,375,191 - 100,576,662 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034931763   ⟹   XP_034787654
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0199,736,145 - 100,355,726 (-)NCBI
RefSeq Acc Id: XM_034931766   ⟹   XP_034787657
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0199,859,241 - 100,576,618 (-)NCBI
RefSeq Acc Id: XR_004664922
RefSeq Status:
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01100,355,669 - 100,576,663 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_008958791   ⟸   XM_008960543
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003808505   ⟸   XM_003808457
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008958792   ⟸   XM_008960544
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_034787654   ⟸   XM_034931763
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034787657   ⟸   XM_034931766
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000038354   ⟸   ENSPPAT00000061257
RefSeq Acc Id: ENSPPAP00000038356   ⟸   ENSPPAT00000061259
RefSeq Acc Id: ENSPPAP00000038369   ⟸   ENSPPAT00000061272
RefSeq Acc Id: ENSPPAP00000038341   ⟸   ENSPPAT00000061244
RefSeq Acc Id: ENSPPAP00000038331   ⟸   ENSPPAT00000061234

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041846 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000038331 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000038341 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000038354 UniProtKB/TrEMBL
  ENSPPAP00000038356 UniProtKB/TrEMBL
  ENSPPAP00000038369 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061234 UniProtKB/TrEMBL
  ENSPPAT00000061244 UniProtKB/TrEMBL
  ENSPPAT00000061257 UniProtKB/TrEMBL
  ENSPPAT00000061259 UniProtKB/TrEMBL
  ENSPPAT00000061272 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1060.10 UniProtKB/TrEMBL
  3.20.20.70 UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/TrEMBL
InterPro 4Fe4S_Fe-S-bd UniProtKB/TrEMBL
  4Fe4S_Fe_S_CS UniProtKB/TrEMBL
  Aldolase_TIM UniProtKB/TrEMBL
  Dihydroorotate_DH UniProtKB/TrEMBL
  DPD_II UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/TrEMBL
  FAD/NAD-binding_dom UniProtKB/TrEMBL
  Helical_ferredxn UniProtKB/TrEMBL
KEGG Report pps:100967375 UniProtKB/TrEMBL
NCBI Gene DPYD ENTREZGENE
Pfam DHO_dh UniProtKB/TrEMBL
  Fer4_20 UniProtKB/TrEMBL
  Pyr_redox_2 UniProtKB/TrEMBL
PROSITE 4FE4S_FER_1 UniProtKB/TrEMBL
  4FE4S_FER_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF46548 UniProtKB/TrEMBL
  SSF51905 UniProtKB/TrEMBL
TIGRFAMs pyrD_sub1_fam UniProtKB/TrEMBL
UniProt A0A2R9C8R4_PANPA UniProtKB/TrEMBL
  A0A2R9C8S4_PANPA UniProtKB/TrEMBL
  A0A2R9C8U2_PANPA UniProtKB/TrEMBL
  A0A2R9C938_PANPA UniProtKB/TrEMBL
  A0A2R9C953_PANPA UniProtKB/TrEMBL