FSTL4 (follistatin like 4) - Rat Genome Database

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Gene: FSTL4 (follistatin like 4) Pan paniscus
Analyze
Symbol: FSTL4
Name: follistatin like 4
RGD ID: 11935376
Description: ENCODES a protein that exhibits brain-derived neurotrophic factor binding (inferred); calcium ion binding (inferred); metal ion binding (inferred); INVOLVED IN negative regulation of axon extension (ortholog); negative regulation of brain-derived neurotrophic factor receptor signaling pathway (ortholog); negative regulation of collateral sprouting (ortholog); ASSOCIATED WITH familial adenomatous polyposis 1 (ortholog); Hereditary Neoplastic Syndromes (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); secretory granule (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: follistatin-related protein 4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,501,372 - 128,911,889 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,640,933 - 127,051,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,606,171 - 129,016,734 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,764,310 - 135,171,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,766,944 - 135,163,711 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FSTL4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24128,501,372 - 128,911,889 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15126,640,933 - 127,051,425 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05128,606,171 - 129,016,734 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15134,764,310 - 135,171,980 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5134,766,944 - 135,163,711 (-)Ensemblpanpan1.1panPan2
FSTL4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385133,196,455 - 133,842,067 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5133,196,455 - 133,612,541 (-)EnsemblGRCh38hg38GRCh38
GRCh375132,532,147 - 132,948,232 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365132,560,051 - 132,976,122 (-)NCBINCBI36Build 36hg18NCBI36
Celera5128,660,188 - 129,071,771 (-)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5127,723,604 - 128,135,825 (-)NCBIHuRef
CHM1_15131,965,487 - 132,380,818 (-)NCBICHM1_1
T2T-CHM13v2.05133,716,210 - 134,365,647 (-)NCBIT2T-CHM13v2.0
Fstl4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391152,655,320 - 53,083,277 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1152,655,461 - 53,079,365 (+)EnsemblGRCm39 Ensembl
GRCm381152,764,489 - 53,192,450 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1152,764,634 - 53,188,538 (+)EnsemblGRCm38mm10GRCm38
MGSCv371152,578,208 - 53,000,849 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361152,608,129 - 53,030,770 (+)NCBIMGSCv36mm8
Celera1157,342,639 - 57,767,017 (+)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.86NCBI
Fstl4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81037,412,288 - 37,845,405 (+)NCBIGRCr8
mRatBN7.21036,911,422 - 37,344,545 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,911,420 - 37,338,588 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1041,604,194 - 42,031,429 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01041,094,180 - 41,521,446 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01036,597,935 - 37,025,179 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01038,104,344 - 38,532,216 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1038,104,558 - 38,532,196 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,877,767 - 38,314,006 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41038,190,597 - 38,635,242 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11038,196,029 - 38,642,071 (+)NCBI
Celera1036,261,450 - 36,687,189 (+)NCBICelera
Cytogenetic Map10q22NCBI
Fstl4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554084,522,031 - 4,898,690 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554084,521,922 - 4,898,697 (-)NCBIChiLan1.0ChiLan1.0
FSTL4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11121,453,982 - 21,850,969 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1121,458,678 - 21,856,547 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1120,263,099 - 20,590,135 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01122,253,158 - 22,646,541 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1122,250,466 - 22,644,782 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11120,959,653 - 21,352,662 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01120,817,666 - 21,210,744 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01121,460,502 - 21,853,816 (-)NCBIUU_Cfam_GSD_1.0
Fstl4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213114,780,303 - 114,998,812 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366471,606,731 - 1,995,738 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366471,783,065 - 1,997,203 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FSTL4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2135,488,563 - 136,096,787 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12135,486,885 - 136,096,939 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22141,008,905 - 141,041,306 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FSTL4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12336,005,475 - 36,423,806 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2336,011,179 - 36,217,708 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603441,515,669 - 41,933,290 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fstl4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473338,577,921 - 38,947,430 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473338,339,826 - 38,952,595 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003829286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000013396   ⟹   ENSPPAP00000002840
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5134,766,944 - 135,163,711 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000013401   ⟹   ENSPPAP00000002843
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl5134,766,944 - 134,968,242 (-)Ensembl
RefSeq Acc Id: XM_003829286   ⟹   XP_003829334
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v24128,501,372 - 128,911,889 (-)NCBI
NHGRI_mPanPan15126,640,933 - 127,051,425 (-)NCBI
Mhudiblu_PPA_v05128,606,171 - 129,016,734 (-)NCBI
PanPan1.15134,764,310 - 135,171,980 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003829334 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000002840.1
  ENSPPAP00000002843.1
RefSeq Acc Id: XP_003829334   ⟸   XM_003829286
- UniProtKB: A0A2R8ZCQ3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000002840   ⟸   ENSPPAT00000013396
Ensembl Acc Id: ENSPPAP00000002843   ⟸   ENSPPAT00000013401
Protein Domains
EF-hand   Ig-like   Kazal-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000012227 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000013396.1 UniProtKB/TrEMBL
  ENSPPAT00000013401.1 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.10 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  3.30.60.30 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
InterPro EF-hand-dom_pair UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_sub UniProtKB/TrEMBL
  Ig_sub2 UniProtKB/TrEMBL
  Kazal_dom UniProtKB/TrEMBL
  Kazal_dom_sf UniProtKB/TrEMBL
  Prot_Inhib_GrowthFact_Antg UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100984070 UniProtKB/TrEMBL
NCBI Gene FSTL4 ENTREZGENE
PANTHER FOLLISTATIN-RELATED UniProtKB/TrEMBL
  FOLLISTATIN-RELATED PROTEIN 4 UniProtKB/TrEMBL
Pfam Ig_3 UniProtKB/TrEMBL
  Kazal_2 UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/TrEMBL
  IG_LIKE UniProtKB/TrEMBL
  KAZAL_2 UniProtKB/TrEMBL
SMART IGc2 UniProtKB/TrEMBL
  KAZAL UniProtKB/TrEMBL
  SM00409 UniProtKB/TrEMBL
Superfamily-SCOP 3-carboxy-cis,cis-mucoante lactonizing enzyme UniProtKB/TrEMBL
  SSF100895 UniProtKB/TrEMBL
  SSF47473 UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A2R8ZCQ3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R8ZGM6_PANPA UniProtKB/TrEMBL