RGS2 (regulator of G protein signaling 2)

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Gene: RGS2 (regulator of G protein signaling 2) Pan paniscus

Analyze

Symbol:

RGS2

Name:

regulator of G protein signaling 2

RGD ID:

11932695

Description:

ENCODES a protein that exhibits beta-tubulin binding (ortholog); G-protein alpha-subunit binding (ortholog); GTPase activator activity (ortholog); INVOLVED IN brain development (ortholog); brown fat cell differentiation (ortholog); maternal process involved in female pregnancy (ortholog); PARTICIPATES IN acetylcholine signaling pathway via muscarinic acetylcholine receptor; angiotensin II signaling pathway via AT1 receptor; calcium signaling pathway via the calcium-sensing receptor; ASSOCIATED WITH acute myeloid leukemia (ortholog); bladder disease (ortholog); Breast Neoplasms (ortholog); FOUND IN cytoplasm (ortholog); cytoplasmic side of plasma membrane (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

regulator of G-protein signaling 2; regulator of G-protein signaling 2, 24kDa

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	172,566,701 - 172,569,955 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	172,566,701 - 172,569,955 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	168,273,112 - 168,276,348 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

acute myeloid leukemia (ISO)

bladder disease (ISO)

Breast Neoplasms (ISO)

Experimental Liver Cirrhosis (ISO)

female stress incontinence (ISO)

glomerulosclerosis (ISO)

Hyperparathyroidism 1 (ISO)

hypertension (ISO)

liver cirrhosis (ISO)

opioid abuse (ISO)

secondary Parkinson disease (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

brain development (ISO)

brown fat cell differentiation (ISO)

maternal process involved in female pregnancy (ISO)

negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process (ISO)

negative regulation of cAMP-mediated signaling (ISO)

negative regulation of cardiac muscle hypertrophy (ISO)

negative regulation of cell growth involved in cardiac muscle cell development (ISO)

negative regulation of G protein-coupled receptor signaling pathway (ISO)

negative regulation of glycine import across plasma membrane (ISO)

negative regulation of MAP kinase activity (ISO)

negative regulation of phospholipase activity (ISO)

negative regulation of translation (ISO)

ovulation (ISO)

positive regulation of cardiac muscle contraction (ISO)

positive regulation of neuron projection development (ISO)

regulation of G protein-coupled receptor signaling pathway (ISO)

relaxation of cardiac muscle (ISO)

relaxation of vascular associated smooth muscle (ISO)

response to amphetamine (ISO)

response to ethanol (ISO)

spermatogenesis (ISO)

Cellular Component

cytoplasm (ISO)

cytoplasmic side of plasma membrane (ISO)

cytosol (ISO)

neuron projection (ISO)

nucleus (ISO)

plasma membrane (ISO)

Molecular Function

beta-tubulin binding (ISO)

G-protein alpha-subunit binding (ISO)

GTPase activator activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylcholine signaling pathway via muscarinic acetylcholine receptor (ISO)

angiotensin II signaling pathway via AT1 receptor (ISO)

calcium signaling pathway via the calcium-sensing receptor (ISO)

dopamine signaling pathway via D1 family of receptors (ISO)

dopamine signaling pathway via D2 family of receptors (ISO)

G protein mediated signaling pathway via Galphai family (ISO)

G protein mediated signaling pathway via Galphaq family (ISO)

G protein mediated signaling pathway via Galphas family (ISO)

References

Genomics

Comparative Map Data

RGS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	1	172,566,701 - 172,569,955 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	172,566,701 - 172,569,955 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	1	168,273,112 - 168,276,348 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

RGS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	1	192,809,039 - 192,812,275 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	1	192,809,039 - 192,812,275 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	1	192,778,169 - 192,781,407 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	191,044,794 - 191,048,026 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	1	189,509,827 - 189,513,060	NCBI
Celera	1	165,887,766 - 165,891,002 (+)	NCBI
Cytogenetic Map	1	q31.2	NCBI
HuRef	1	164,013,977 - 164,017,213 (+)	NCBI		HuRef
CHM1_1	1	194,199,847 - 194,203,081 (+)	NCBI		CHM1_1

Rgs2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	143,875,076 - 143,879,887 (-)	NCBI	GRCm39		mm39
GRCm38	1	143,999,338 - 144,004,149 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	143,999,338 - 144,004,161 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	145,846,468 - 145,851,279 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	1	145,762,215 - 145,766,367 (-)	NCBI			mm8
Celera	1	146,559,706 - 146,564,519 (-)	NCBI		Celera
Cytogenetic Map	1	F	NCBI
cM Map	1	62.56	NCBI

Rgs2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	13	60,846,458 - 60,849,061 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	60,846,308 - 60,849,094 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	65,831,386 - 65,833,989 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	57,891,849 - 57,894,452 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	13	57,905,025 - 57,908,545 (-)	NCBI
Celera	13	55,875,644 - 55,878,228 (-)	NCBI		Celera
Cytogenetic Map	13	q21	NCBI

Rgs2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	30,261,757 - 30,266,005 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	30,261,757 - 30,265,389 (+)	NCBI	ChiLan1.0	ChiLan1.0

RGS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	38	6,200,657 - 6,203,494 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	38	6,200,237 - 6,203,491 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Rgs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936638	1,065,866 - 1,068,649 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RGS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	936,789 - 940,098 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	936,836 - 940,083 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	2,543,481 - 2,546,729 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	10	p	NCBI

RGS2
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	36,620,047 - 36,623,367 (-)	NCBI
ChlSab1.1 Ensembl	25	36,619,140 - 36,623,308 (-)	Ensembl

Rgs2
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624814	754,743 - 758,148 (-)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003820595	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000180	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSPPAT00000048251 ⟹ ENSPPAP00000025424

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	172,566,701 - 172,569,955 (+)	Ensembl

RefSeq Acc Id:

XM_003820595 ⟹ XP_003820643

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	1	172,566,701 - 172,569,955 (+)	NCBI
Mhudiblu_PPA_v0	1	168,273,112 - 168,276,348 (+)	NCBI

Sequence:

show sequence

ACGCCCAGCCGCAAACAGCCGGGGCTCCAGCGGGAGAACGATAATGCAAAGTGCTATGTTCTTG
GCTGTTCAACACGACTGCAGACCCATGGACAAGAGCGCAGGCAGCGGCCACAAGAGCGAGGAGA
AGCGGGAAAAGATGAAACGGACCCTTTTAAAAGATTGGAAGACCCGTTTGAGCTACTTCTTGCA
AAATTCCTCTACTCCTGGGAAGCCCAAAACCGGCAAAAAAAGCAAACAGCAAGCTTTCATCAAG
CCTTCTCCTGAGGAAGCACAGCTGTGGTCAGAAGCATTTGACGAGCTGCTAGCCAGCAAATATG
GTCTTGCTGCATTCAGGGCTTTTTTAAAGTCGGAATTCTGTGAAGAAAATATTGAATTCTGGCT
GGCCTGTGAAGACTTCAAAAAAACCAAATCACCCCAAAAGCTGTCCTCAAAAGCAAGGAAAATA
TATACTGACTTCATAGAAAAGGAAGCTCCAAAAGAGATAAACATAGATTTTCAAACCAAAACTC
TGATTGCCCAGAATATACAAGAAGCTACAAGTGGCTGCTTTACAACTGCCCAGAAAAGGGTATA
CAGCTTGATGGAGAACAACTCTTATCCCCGTTTCTTGGAGTCAGAATTCTACCAGGACTTGTGT
AAAAAGCCACAAATCACCACAGAGCCTCATGCTACATGAAATGTAAAAGGGAGCCCAGAAATGG
AGGACATTTCATTCTTTTTCCTGAGGGGAAGGACTGTGACCTGCCATAAAGACTGACCTTGAAT
TCAGCCTGGGTGTTCAGGAAACATCACTCAGAACTATTGATTCAAAGTTGGGTAGTGAATCAGG
AAGCCAGTAACTGACTAGGAGAAGCTGGTATCAGAACAGCTTCCCTCACTGTGTACAGAACGCA
AGAAGGGAATAGGTGGTCTGAACGTGGTGTCTCACTCTGAAAAGCAGGAATGTAAGATGATGAA
AGAGACAATGTAATACTGTTGGTCCAAAAGCATTTAAAATCAATAGATCTGGGATTATGTGGCC
TTAGGTAGCTGGTTGTACATCTTTCCCTAAATCGATCCATGTTACCACATAGTAGTTTTAGTTT
AGGATTCAGTAACAGTGAAGTGTTTACTATGTGCAAGGGTATTGAAGTTCTTATGACCACAGAT
CATCAGTACTGTTGTCTCATGTAATGCTAAAACTGAAATGGTCCGTGTTTGCTTTGTTAAAAAT
GATGTGTGAAATAGAATGAGTGCTATGGTGTTGAAAACTGCAGTGTCCGTTATGAGTGCCAAAA
ATCTGTCTTGAAGGCAGCTACACTTTGAAGTGGTCTTTGAATACTTTTAATAAATTTATTTTGA
TAAATAATATTGAACA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003820643	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003820643 ⟸ XM_003820595

- Sequence:

show sequence

MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKS
KQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKL
SSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLES
EFYQDLCKKPQITTEPHAT

hide sequence

RefSeq Acc Id:

ENSPPAP00000025424 ⟸ ENSPPAT00000048251

Protein Domains

RGS

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000035845	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000025424	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000048251	UniProtKB/TrEMBL
Gene3D-CATH	1.10.196.10	UniProtKB/TrEMBL
InterPro	RGS	UniProtKB/TrEMBL
	RGS2	UniProtKB/TrEMBL
	RGS_sf	UniProtKB/TrEMBL
	RGS_subdom1/3	UniProtKB/TrEMBL
KEGG Report	pps:100995309	UniProtKB/TrEMBL
NCBI Gene	RGS2	ENTREZGENE
PANTHER	PTHR10845:SF43	UniProtKB/TrEMBL
Pfam	RGS	UniProtKB/TrEMBL
PRINTS	RGSPROTEIN	UniProtKB/TrEMBL
PROSITE	RGS	UniProtKB/TrEMBL
SMART	RGS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48097	UniProtKB/TrEMBL
UniProt	A0A2R9BEH1_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-11-07	RGS2	regulator of G protein signaling 2		regulator of G-protein signaling 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations