KLHL2 (kelch like family member 2) - Rat Genome Database

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Gene: KLHL2 (kelch like family member 2) Pan paniscus
Analyze
Symbol: KLHL2
Name: kelch like family member 2
RGD ID: 11931447
Description: ENCODES a protein that exhibits actin binding (ortholog); identical protein binding (ortholog); ubiquitin-like ligase-substrate adaptor activity (ortholog); INVOLVED IN protein ubiquitination (ortholog); ASSOCIATED WITH genetic disease (ortholog); FOUND IN actin cytoskeleton (ortholog); Cul3-RING ubiquitin ligase complex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: kelch-like 2, Mayven; kelch-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23162,956,665 - 163,072,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,314,357 - 163,430,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04157,402,905 - 157,518,639 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14169,572,832 - 169,602,304 (+)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
KLHL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23162,956,665 - 163,072,228 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14163,314,357 - 163,430,083 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04157,402,905 - 157,518,639 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14169,572,832 - 169,602,304 (+)NCBIpanpan1.1PanPan1.1panPan2
KLHL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384165,207,561 - 165,323,156 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4165,207,561 - 165,323,156 (+)EnsemblGRCh38hg38GRCh38
GRCh374166,128,713 - 166,244,308 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364166,348,238 - 166,463,749 (+)NCBINCBI36Build 36hg18NCBI36
Build 344166,486,395 - 166,601,903NCBI
Celera4163,459,950 - 163,579,735 (+)NCBICelera
Cytogenetic Map4q32.3NCBI
HuRef4161,880,568 - 161,996,120 (+)NCBIHuRef
CHM1_14166,105,246 - 166,220,767 (+)NCBICHM1_1
T2T-CHM13v2.04168,553,548 - 168,669,151 (+)NCBIT2T-CHM13v2.0
Klhl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39865,192,707 - 65,302,821 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl865,192,709 - 65,302,669 (-)EnsemblGRCm39 Ensembl
GRCm38864,739,673 - 64,850,169 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl864,739,675 - 64,850,017 (-)EnsemblGRCm38mm10GRCm38
MGSCv37867,335,578 - 67,373,716 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36867,631,868 - 67,672,057 (-)NCBIMGSCv36mm8
Celera867,303,934 - 67,417,078 (-)NCBICelera
Cytogenetic Map8B3.1NCBI
cM Map832.3NCBI
Klhl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81629,627,171 - 29,739,782 (+)NCBIGRCr8
mRatBN7.21624,860,744 - 24,973,348 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1624,860,667 - 24,973,341 (+)EnsemblmRatBN7.2 Ensembl
Rnor_6.01626,755,246 - 26,852,134 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1626,739,389 - 26,852,179 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01626,622,472 - 26,731,058 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41626,634,400 - 26,690,756 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11626,648,722 - 26,691,115 (+)NCBI
Celera1624,962,535 - 25,057,740 (+)NCBICelera
Cytogenetic Map16p13NCBI
Klhl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540340,012,453 - 40,094,853 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540340,013,840 - 40,094,853 (-)NCBIChiLan1.0ChiLan1.0
KLHL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11561,204,371 - 61,289,020 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1561,204,363 - 61,298,581 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1561,500,904 - 61,598,362 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01562,054,076 - 62,151,403 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1562,054,088 - 62,151,392 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11561,235,595 - 61,332,798 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01561,279,065 - 61,376,285 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01561,672,882 - 61,770,206 (+)NCBIUU_Cfam_GSD_1.0
Klhl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494317,804,579 - 17,886,216 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936555684,093 - 766,006 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936555684,300 - 765,934 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLHL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl843,749,423 - 43,870,923 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1843,749,423 - 43,871,011 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2845,677,143 - 45,798,587 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KLHL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17111,569,027 - 111,684,065 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7111,569,125 - 111,684,879 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603791,412,273 - 91,534,401 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klhl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475811,649,396 - 11,765,961 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475811,649,603 - 11,765,636 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_034959371   ⟹   XP_034815262
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23162,956,682 - 163,072,228 (+)NCBI
NHGRI_mPanPan14163,314,357 - 163,430,083 (+)NCBI
Mhudiblu_PPA_v04157,402,905 - 157,518,639 (+)NCBI
RefSeq Acc Id: XM_034959372   ⟹   XP_034815263
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23162,968,840 - 163,072,228 (+)NCBI
NHGRI_mPanPan14163,326,718 - 163,430,083 (+)NCBI
Mhudiblu_PPA_v04157,415,265 - 157,518,639 (+)NCBI
RefSeq Acc Id: XM_034959373   ⟹   XP_034815264
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23162,977,724 - 163,072,228 (+)NCBI
NHGRI_mPanPan14163,335,591 - 163,430,083 (+)NCBI
Mhudiblu_PPA_v04157,424,140 - 157,518,639 (+)NCBI
RefSeq Acc Id: XR_004671261
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v23162,956,665 - 163,072,228 (+)NCBI
NHGRI_mPanPan14163,314,538 - 163,430,083 (+)NCBI
Mhudiblu_PPA_v04157,403,077 - 157,518,639 (+)NCBI
Protein Sequences
Protein RefSeqs XP_034815262 (Get FASTA)   NCBI Sequence Viewer  
  XP_034815263 (Get FASTA)   NCBI Sequence Viewer  
  XP_034815264 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000004876.1
  ENSPPAP00000004878.1
Reference Protein Sequences
RefSeq Acc Id: XP_034815262   ⟸   XM_034959371
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034815263   ⟸   XM_034959372
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034815264   ⟸   XM_034959373
- Peptide Label: isoform X3
Protein Domains
BACK


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000020375 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000022353.1 UniProtKB/TrEMBL
  ENSPPAT00000022362.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.420 UniProtKB/TrEMBL
  2.120.10.80 UniProtKB/TrEMBL
InterPro BACK UniProtKB/TrEMBL
  Kelch-typ_b-propeller UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
NCBI Gene KLHL2 ENTREZGENE
PANTHER KELCH-LIKE PROTEIN DIABLO UniProtKB/TrEMBL
  LD33804P UniProtKB/TrEMBL
Pfam BACK UniProtKB/TrEMBL
  Kelch_1 UniProtKB/TrEMBL
PRINTS KELCHREPEAT UniProtKB/TrEMBL
SMART BACK UniProtKB/TrEMBL
  Kelch UniProtKB/TrEMBL
Superfamily-SCOP SSF117281 UniProtKB/TrEMBL
UniProt A0A2R8ZIS5_PANPA UniProtKB/TrEMBL
  A0A2R8ZPY9_PANPA UniProtKB/TrEMBL