Advanced Search (OLGA)

Gene: FLVCR1 (FLVCR choline and heme transporter 1) Pan paniscus

Analyze

Symbol:

FLVCR1

Name:

FLVCR choline and heme transporter 1

RGD ID:

11926766

Description:

ENCODES a protein that exhibits choline transmembrane transporter activity (inferred); ethanolamine transmembrane transporter activity (inferred); heme binding (inferred); INVOLVED IN blood vessel development (inferred); choline transport (inferred); embryonic digit morphogenesis (inferred); ASSOCIATED WITH asphyxiating thoracic dystrophy (ortholog); Diamond-Blackfan anemia (ortholog); fundus dystrophy (ortholog); FOUND IN membrane (inferred); mitochondrial membrane (inferred); mitochondrion (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

feline leukemia virus subgroup C cellular receptor 1; feline leukemia virus subgroup C receptor-related protein 1; FLVCR heme transporter 1; heme transporter FLVCR1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	36,504,306 - 36,545,327 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	36,468,659 - 36,509,726 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	188,425,697 - 188,466,721 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	193,284,158 - 193,321,962 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	193,284,158 - 193,320,554 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asphyxiating thoracic dystrophy (ISO)

Diamond-Blackfan anemia (ISO)

fundus dystrophy (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

hereditary sensory neuropathy (ISO)

neurodevelopmental disorder with microcephaly, absent speech, and hypotonia (ISO)

parathyroid carcinoma (ISO)

retinitis pigmentosa (ISO)

Retinopathy-sensory neuropathy syndrome (ISO)

sensory peripheral neuropathy (ISO)

Stargardt disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood vessel development (IEA)

choline transport (IEA)

embryonic digit morphogenesis (IEA)

embryonic skeletal system morphogenesis (IEA)

erythrocyte differentiation (IEA)

erythrocyte maturation (IEA)

ethanolamine transport (IEA)

head morphogenesis (IEA)

heme biosynthetic process (IEA)

heme export (IEA)

heme transport (IEA)

in utero embryonic development (IEA)

limb morphogenesis (IEA)

mitochondrial transport (IEA)

multicellular organism growth (IEA)

phospholipid biosynthetic process (IEA)

regulation of organ growth (IEA)

spleen development (IEA)

transmembrane transport (IEA)

Cellular Component

membrane (IEA)

mitochondrial membrane (IEA)

mitochondrion (IEA)

plasma membrane (IEA)

Molecular Function

choline transmembrane transporter activity (IEA)

ethanolamine transmembrane transporter activity (IEA)

heme binding (IEA)

heme transmembrane transporter activity (IEA)

protein binding (ISO)

transmembrane transporter activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

FLVCR1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	36,504,306 - 36,545,327 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	36,468,659 - 36,509,726 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	188,425,697 - 188,466,721 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	193,284,158 - 193,321,962 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	193,284,158 - 193,320,554 (+)	Ensembl	panpan1.1		panPan2

FLVCR1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	212,858,275 - 212,899,363 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	212,858,275 - 212,899,363 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	213,031,617 - 213,072,705 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	211,098,220 - 211,135,379 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	186,257,592 - 186,295,983 (+)	NCBI		Celera
Cytogenetic Map	1	q32.3	NCBI
HuRef	1	183,708,670 - 183,749,562 (+)	NCBI		HuRef
CHM1_1	1	214,303,965 - 214,345,035 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	212,103,255 - 212,144,367 (+)	NCBI		T2T-CHM13v2.0

Flvcr1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	190,738,029 - 190,758,387 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	190,738,044 - 190,758,355 (-)	Ensembl		GRCm39 Ensembl
GRCm38	1	191,005,832 - 191,026,190 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	191,005,847 - 191,026,158 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	192,829,711 - 192,850,069 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	192,706,447 - 192,726,805 (-)	NCBI		MGSCv36	mm8
Celera	1	197,930,699 - 197,951,041 (-)	NCBI		Celera
Cytogenetic Map	1	H6	NCBI
cM Map	1	96.28	NCBI

Flvcr1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	105,117,402 - 105,139,780 (-)	NCBI		GRCr8
GRCr8 Ensembl	13	105,117,402 - 105,139,759 (-)	Ensembl		GRCr8 Ensembl
mRatBN7.2	13	102,586,263 - 102,608,647 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	102,586,257 - 102,608,661 (-)	Ensembl		mRatBN7.2 Ensembl
Rnor_6.0	13	109,578,294 - 109,624,235 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	109,578,074 - 109,629,482 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	114,211,863 - 114,224,490 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	13	114,180,812 - 114,183,817 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	13	102,055,793 - 102,074,779 (-)	NCBI		Celera
Cytogenetic Map	13	q27	NCBI

Flvcr1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955406	4,674,140 - 4,702,763 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955406	4,673,797 - 4,702,858 (-)	NCBI	ChiLan1.0	ChiLan1.0

FLVCR1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	7	11,001,155 - 11,038,910 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	7	11,001,101 - 11,035,980 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	7	10,576,761 - 10,614,312 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	7	10,707,668 - 10,745,429 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	7	10,707,433 - 10,745,177 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	7	10,630,123 - 10,667,529 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	7	10,731,550 - 10,769,463 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	7	10,856,188 - 10,893,897 (+)	NCBI		UU_Cfam_GSD_1.0

Flvcr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	63,453,117 - 63,486,909 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936557	692,489 - 726,965 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936557	693,445 - 727,166 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FLVCR1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	130,541,660 - 130,570,702 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	130,543,911 - 130,570,486 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	143,470,869 - 143,497,447 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

FLVCR1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	16,656,219 - 16,688,397 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	16,652,246 - 16,688,376 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	17,151,582 - 17,183,388 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Flvcr1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624771	18,239,437 - 18,270,408 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008966792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000052083 ⟹ ENSPPAP00000029234

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	193,284,158 - 193,320,554 (+)	Ensembl

Ensembl Acc Id:

ENSPPAT00000052088 ⟹ ENSPPAP00000029239

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	193,284,401 - 193,320,421 (+)	Ensembl

RefSeq Acc Id:

XM_008966792 ⟹ XP_008965040

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	36,504,306 - 36,545,327 (-)	NCBI
NHGRI_mPanPan1	1	36,468,659 - 36,509,725 (-)	NCBI
Mhudiblu_PPA_v0	1	188,425,697 - 188,466,721 (+)	NCBI
PanPan1.1	1	193,284,158 - 193,320,554 (+)	NCBI

Sequence:

show sequence

AGGGGCGGGACCAGACAAGGGGTGACTGCCGCGTGGCGCGGGGGAGGAGACCTTCATCTGTTCA
CGCGGTAGCGCGGATTGCGGTTCGCGGCGCGCACCACCGGGGAAGGAGCGGTGGGCCGAGGGGT
TGGAGGTGGGGTCCCAGGAGGACCTCGGGCTGTGGGCCGGGAGAGCGGAGTCGGGGAGTGGGGC
GGGGGAGCGAGGTGGCGCCGGGGAGCGAGGTGGCGCCGGGGAGCCTGGGATATGGCGCGGCCAG
ACGATGAGGAGGGGGCGGCGGTGGCGCCCGGACACCCGCTCGCGAAAGGATACCTCCCGTTGCC
GAGGGGCGCGCCCGTTGGGAAGGAGAGCGTGGAGCTGCAGAACGGGCCCAAAGCGGGCACCTTC
CCGGTGAATGGGGCCCCCCGGGACAGCCTCGCTGCCGCCTCGGGAGTTCTGGGCGGGCCTCAGA
CTCCACTGGCCCCAGAAGAGGAGACCCAGGCCCGGCTGCTGCCTGCGGGCGCGGGAGCTGAGAC
CCCGGGGGCCGAGAGCAGCCCGCTGCCCCGGACGGCGCTCTCCCCGCGGCGCTTCGTGGTGCTC
CTGATCTTCAGCCTGTACTCGCTGGTCAACGCCTTTCAGTGGATCCAGTACAGCATCATTAGCA
ACGTCTTCGAGGGCTTCTACGGTGTCACCTTGCTGCACATCGACTGGCTGTCCATGGTGTACAT
GCTGGCCTACGTGCCCCTCATCTTCCCGGCCACCTGGCTGCTGGACACCAGAGGCCTGCGGCTC
ACCGCCCTGCTGGGCTCCGGCCTCAACTGCCTGGGTGCCTGGATCAAGTGCGGCAGTGTGCAGC
AGCATCTCTTCTGGGTCACCATGTTGGGCCAGTGCCTGTGCTCGGTGGCCCAGGTTTTCATCCT
GGGCTTGCCCTCCCGCATCGCCTCAGTGTGGTTTGGGCCCAAAGAGGTGTCCACAGCTTGTGCC
ACCGCCGTGCTGGGCAATCAGCTTGGAACTGCAGTTGGCTTTTTGCTACCACCAGTTTTAGTAC
CCAACACACAGAATGACACAAATCTCCTGGCTTGTAATATCAGCACCATGTTTTACGGAACATC
AGCTGTTGCCACACTTTTATTTATTTTAACAGCAATTGCCTTCAAAGAAAAACCTCGGTATCCA
CCAAGTCAGGCTCAAGCAGCTCTTCAAGACAGTCCCCCTGAAGAGTACTCCTATAAGAAATCAA
TAAGAAACCTGTTTAAAAACATTCCTTTTGTCCTTCTGTTGATCACTTATGGTATCATGACTGG
TGCCTTTTATTCAGTCTCAACGTTATTAAATCAAATGATATTGACATATTATGAGGGAGAAGAA
GTCAATGCTGGAAGGATTGGGCTAACGCTAGTAGTAGCTGGAATGGTGGGCTCTATTCTTTGTG
GCTTATGGCTGGATTATACTAAAACATACAAACAGACTACTCTGATAGTTTATATTTTGTCTTT
TATTGGAATGGTTATCTTTACTTTCACATTGGACCTTAGATATATTATCATCGTGTTTGTTACT
GGAGGGGTGCTTGGCTTCTTCATGACTGGTTACCTCCCTTTGGGTTTTGAATTTGCTGTTGAAA
TCACTTACCCTGAATCTGAAGGTACTTCATCTGGTCTTCTTAATGCTTCTGCACAGATATTTGG
AATTTTGTTCACATTGGCTCAAGGAAAGCTCACATCAGACTATGGTCCTAAGGCAGGGAACATT
TTTCTCTGTGTCTGGATGTTTATAGGCATCATATTAACAGCATTAATCAAGTCTGATCTGCGAA
GACACAACATAAATATAGGAATTACAAATGTTGATGTTAAAGCTATACCAGCTGACAGTCCCAC
AGACCAAGAACCAAAAATGGTTATGTTGTCCAAGCAGTCAGAATCAGCAATTTGAAGAGAAAGG
AAAAGTTACTGTCCTGTAGTAATTGGGGACAATGTGATCATCCTTGGAGAGAGATGTGAGCACC
AAGGCTGGGTTTGTATGTGGTGGGGGAATAAACACACTTACTTGAAAATTACCATATGAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008965040	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000029234.1
	ENSPPAP00000029239.1
	ENSPPAP00050003883

RefSeq Acc Id:

XP_008965040 ⟸ XM_008966792

- UniProtKB:

A0A2R9BHV5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MARPDDEEGAAVAPGHPLAKGYLPLPRGAPVGKESVELQNGPKAGTFPVNGAPRDSLAAASGVL
GGPQTPLAPEEETQARLLPAGAGAETPGAESSPLPRTALSPRRFVVLLIFSLYSLVNAFQWIQY
SIISNVFEGFYGVTLLHIDWLSMVYMLAYVPLIFPATWLLDTRGLRLTALLGSGLNCLGAWIKC
GSVQQHLFWVTMLGQCLCSVAQVFILGLPSRIASVWFGPKEVSTACATAVLGNQLGTAVGFLLP
PVLVPNTQNDTNLLACNISTMFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYS
YKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVG
SILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLGFFMTGYLPLGFE
FAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIK
SDLRRHNINIGITNVDVKAIPADSPTDQEPKMVMLSKQSESAI

hide sequence

Ensembl Acc Id:

ENSPPAP00000029239 ⟸ ENSPPAT00000052088

Ensembl Acc Id:

ENSPPAP00000029234 ⟸ ENSPPAT00000052083

Protein Domains

Major facilitator superfamily (MFS) profile

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000037631	Ensembl, UniProtKB/TrEMBL
	ENSPPAG00050003200	ENTREZGENE
Ensembl Transcript	ENSPPAT00000052083.1	UniProtKB/TrEMBL
	ENSPPAT00000052088.1	UniProtKB/TrEMBL
	ENSPPAT00050006728	ENTREZGENE
Gene3D-CATH	1.20.1250.20	UniProtKB/TrEMBL
InterPro	MFS	UniProtKB/TrEMBL
	MFS_dom	UniProtKB/TrEMBL
	MFS_trans_sf	UniProtKB/TrEMBL
	SLC49-like	UniProtKB/TrEMBL
KEGG Report	pps:100967760	UniProtKB/TrEMBL
NCBI Gene	FLVCR1	ENTREZGENE
PANTHER	FELINE LEUKEMIA VIRUS SUBGROUP C RECEPTOR-RELATED PROTEIN 1	UniProtKB/TrEMBL
	MAJOR FACILITATOR SUPERFAMILY PROTEIN-RELATED	UniProtKB/TrEMBL
Pfam	MFS_1	UniProtKB/TrEMBL
PROSITE	MFS	UniProtKB/TrEMBL
Superfamily-SCOP	SSF103473	UniProtKB/TrEMBL
UniProt	A0A2R9BHV5	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BHW0_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2023-07-11	FLVCR1	FLVCR choline and heme transporter 1	FLVCR1	FLVCR heme transporter 1	Symbol and/or name change	5135510	APPROVED
2019-10-08	FLVCR1	FLVCR heme transporter 1	FLVCR1	feline leukemia virus subgroup C cellular receptor 1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

Imported Disease Annotations - OMIM