AFF3 (ALF transcription elongation factor 3) - Rat Genome Database

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Gene: AFF3 (ALF transcription elongation factor 3) Pan paniscus
Analyze
Symbol: AFF3
Name: ALF transcription elongation factor 3
RGD ID: 11919769
Description: ENCODES a protein that exhibits DNA-binding transcription factor activity (inferred); double-stranded DNA binding (inferred); INVOLVED IN embryonic hindlimb morphogenesis (inferred); regulation of DNA-templated transcription (inferred); regulation of gene expression (inferred); ASSOCIATED WITH genetic disease (ortholog); KINSSHIP syndrome (ortholog); rheumatoid arthritis (ortholog); FOUND IN cytosol (inferred); membrane-bounded organelle (inferred); nuclear body (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: AF4/FMR2 family member 3
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21228,083,022 - 28,680,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A28,120,669 - 28,683,384 (+)NCBINHGRI_mPanPan1
PanPan1.12A100,531,658 - 101,088,928 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A100,535,363 - 100,993,626 (-)Ensemblpanpan1.1panPan2


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
AFF3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21228,083,022 - 28,680,759 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A28,120,669 - 28,683,384 (+)NCBINHGRI_mPanPan1
PanPan1.12A100,531,658 - 101,088,928 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A100,535,363 - 100,993,626 (-)Ensemblpanpan1.1panPan2
AFF3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38299,545,419 - 100,142,590 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl299,545,419 - 100,192,428 (-)EnsemblGRCh38hg38GRCh38
GRCh372100,161,881 - 100,759,052 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36299,530,147 - 100,125,469 (-)NCBINCBI36Build 36hg18NCBI36
Build 34299,626,333 - 100,179,486NCBI
Celera294,368,402 - 94,963,584 (-)NCBICelera
Cytogenetic Map2q11.2NCBI
HuRef293,928,916 - 94,523,831 (-)NCBIHuRef
CHM1_12100,168,034 - 100,763,379 (-)NCBICHM1_1
T2T-CHM13v2.02100,004,081 - 100,601,540 (-)NCBIT2T-CHM13v2.0
Aff3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39138,212,936 - 38,704,036 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl138,216,407 - 38,704,036 (-)EnsemblGRCm39 Ensembl
GRCm38138,175,393 - 38,630,178 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl138,177,326 - 38,664,955 (-)EnsemblGRCm38mm10GRCm38
MGSCv37138,234,172 - 38,721,800 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36138,123,789 - 38,572,845 (-)NCBIMGSCv36mm8
MGSCv36138,685,934 - 39,133,869 (-)NCBIMGSCv36mm8
Celera137,969,239 - 38,454,986 (-)NCBICelera
Cytogenetic Map1BNCBI
cM Map116.58NCBI
Aff3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8947,894,903 - 48,352,380 (-)NCBIGRCr8
mRatBN7.2940,399,099 - 40,856,716 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl940,404,375 - 40,857,247 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx948,899,305 - 49,265,012 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0954,022,065 - 54,387,766 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0952,305,093 - 52,671,188 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0944,837,979 - 45,291,964 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl944,839,960 - 45,292,047 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0944,533,605 - 44,986,525 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4937,121,330 - 37,516,836 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1937,122,871 - 37,648,080 (-)NCBI
Celera938,156,616 - 38,521,867 (-)NCBICelera
Cytogenetic Map9q21-q22NCBI
Aff3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554705,804,117 - 6,183,222 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554705,800,152 - 6,183,761 (-)NCBIChiLan1.0ChiLan1.0
AFF3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11042,587,173 - 43,111,739 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1042,586,394 - 43,247,328 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1042,510,236 - 43,038,653 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01043,455,381 - 43,984,215 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1043,415,081 - 43,983,969 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11043,175,847 - 43,697,657 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01043,449,400 - 43,980,218 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01043,639,835 - 44,162,265 (+)NCBIUU_Cfam_GSD_1.0
Aff3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629285,304,979 - 85,798,241 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936661771,265 - 1,262,166 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936661771,265 - 1,264,456 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AFF3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl354,135,532 - 54,727,885 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1354,135,476 - 54,730,201 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2356,762,725 - 57,316,245 (+)NCBISscrofa10.2Sscrofa10.2susScr3
AFF3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1143,268,751 - 3,880,415 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl143,270,636 - 3,573,300 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041170,866,487 - 171,459,229 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Aff3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247494,498,621 - 4,773,900 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247494,494,740 - 5,015,118 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000040636   ⟹   ENSPPAP00000017915
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A100,535,363 - 100,993,626 (-)Ensembl
RefSeq Acc Id: XM_055107596   ⟹   XP_054963571
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21228,117,907 - 28,680,759 (+)NCBI
NHGRI_mPanPan12A28,120,669 - 28,683,384 (+)NCBI
RefSeq Acc Id: XM_055107600   ⟹   XP_054963575
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21228,117,906 - 28,680,759 (+)NCBI
NHGRI_mPanPan12A28,120,669 - 28,683,384 (+)NCBI
RefSeq Acc Id: XM_063594762   ⟹   XP_063450832
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21228,120,592 - 28,676,334 (+)NCBI
RefSeq Acc Id: XM_063594763   ⟹   XP_063450833
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21228,117,905 - 28,674,014 (+)NCBI
RefSeq Acc Id: XM_063594764   ⟹   XP_063450834
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21228,120,592 - 28,676,334 (+)NCBI
RefSeq Acc Id: XM_063594765   ⟹   XP_063450835
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21228,117,905 - 28,680,759 (+)NCBI
RefSeq Acc Id: XM_063594766   ⟹   XP_063450836
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21228,083,022 - 28,680,759 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSPPAP00000017915   ⟸   ENSPPAT00000040636
RefSeq Acc Id: XP_054963571   ⟸   XM_055107596
- Peptide Label: isoform X2
- UniProtKB: A0A2R9AQ92 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054963575   ⟸   XM_055107600
- Peptide Label: isoform X6
- UniProtKB: A0A2R9AQ92 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063450836   ⟸   XM_063594766
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063450835   ⟸   XM_063594765
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063450833   ⟸   XM_063594763
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063450832   ⟸   XM_063594762
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063450834   ⟸   XM_063594764
- Peptide Label: isoform X4
Protein Domains
AF4/FMR2 C-terminal homology


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032057 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040636.1 UniProtKB/TrEMBL
Gene3D-CATH 6.10.250.2670 UniProtKB/TrEMBL
InterPro AF4/FMR2 UniProtKB/TrEMBL
  AF4/FMR2_CHD UniProtKB/TrEMBL
  AF4_int UniProtKB/TrEMBL
NCBI Gene AFF3 ENTREZGENE
PANTHER AF4/FMR2 FAMILY MEMBER 3 UniProtKB/TrEMBL
  PTHR10528 UniProtKB/TrEMBL
Pfam AF-4 UniProtKB/TrEMBL
  AF-4_C UniProtKB/TrEMBL
  AF4_int UniProtKB/TrEMBL
UniProt A0A2R9AQ92 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-21 AFF3  ALF transcription elongation factor 3  AFF3  AF4/FMR2 family member 3  Symbol and/or name change 5135510 APPROVED