SPN (sialophorin) - Rat Genome Database

Name: SPN
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: SPN (sialophorin) Pan paniscus

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Symbol:

SPN

Name:

sialophorin

RGD ID:

11915696

Description:

ENCODES a protein that exhibits protein domain specific binding (ortholog); INVOLVED IN apoptotic signaling pathway (ortholog); cell surface receptor signaling pathway (ortholog); chronic inflammatory response (ortholog); ASSOCIATED WITH alcohol use disorder (ortholog); autism spectrum disorder (ortholog); autistic disorder (ortholog); FOUND IN basement membrane (ortholog); cell surface (ortholog); cleavage furrow (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

leukosialin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SPN (sialophorin)	NCBI	Ortholog
Mus musculus (house mouse):	Spn (sialophorin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Spn (sialophorin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Spn (sialophorin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SPN (sialophorin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Spn (sialophorin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SPN (sialophorin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SPN (sialophorin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Spn (sialophorin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	30,412,474 - 30,416,344 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	35,809,899 - 35,813,772 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	30,034,739 - 30,037,033 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	30,035,243 - 30,036,445 (+)	Ensembl	panpan1.1		panPan2

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

alcohol use disorder (ISO)

autism spectrum disorder (ISO)

autistic disorder (ISO)

calcinosis (ISO)

chromosome 16p11.2 deletion syndrome, 593-kb (ISO)

chromosome 16p11.2 duplication syndrome (ISO)

dilated cardiomyopathy (ISO)

Experimental Arthritis (ISO)

heart valve disease (ISO)

Neurodevelopmental Disorders (ISO)

schizophrenia (ISO)

spondylocostal dysostosis 5 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic signaling pathway (ISO)

cell surface receptor signaling pathway (IEA,ISO)

chronic inflammatory response (ISO)

defense response to bacterium (IEA,ISO)

leukocyte tethering or rolling (ISO)

monocyte activation (ISO)

negative regulation of cell adhesion (ISO)

negative regulation of T cell activation (ISO)

negative regulation of T cell proliferation (ISO)

negative regulation of type IV hypersensitivity (ISO)

negative thymic T cell selection (ISO)

positive regulation of protein phosphorylation (ISO)

positive regulation of T cell migration (ISO)

positive regulation of T cell proliferation (ISO)

positive regulation of tumor necrosis factor production (IEA,ISO)

protein phosphorylation (ISO)

regulation of defense response to virus (ISO)

regulation of gene expression (ISO)

regulation of immune response (IEA,ISO)

regulation of T cell activation (IEA)

regulation of T cell migration (IEA)

response to protozoan (ISO)

T cell costimulation (ISO)

T cell proliferation (ISO)

T cell receptor signaling pathway (ISO)

T-helper 1 cell lineage commitment (IEA)

thymocyte aggregation (ISO)

Cellular Component

basement membrane (ISO)

cell surface (IEA,ISO)

cleavage furrow (ISO)

external side of plasma membrane (IEA)

extracellular space (IEA)

membrane (IEA)

microvillus (ISO)

plasma membrane (ISO)

uropod (ISO)

Molecular Function

heat shock protein binding (IEA)

Hsp70 protein binding (IEA)

protein binding (ISO)

protein domain specific binding (ISO)

transmembrane signaling receptor activity (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

SPN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	30,412,474 - 30,416,344 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	35,809,899 - 35,813,772 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	30,034,739 - 30,037,033 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	30,035,243 - 30,036,445 (+)	Ensembl	panpan1.1		panPan2

SPN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	29,662,963 - 29,670,876 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	29,662,979 - 29,670,876 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	29,674,284 - 29,682,197 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	29,581,801 - 29,589,329 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	8	64,262,738 - 64,263,150	NCBI
Celera	16	73,114,178 - 73,121,702 (-)	NCBI		Celera
Cytogenetic Map	16	p11.2	NCBI
HuRef	16	27,335,753 - 27,343,116 (+)	NCBI		HuRef
CHM1_1	16	30,686,100 - 30,693,653 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	29,945,006 - 29,952,917 (+)	NCBI		T2T-CHM13v2.0

Spn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	126,731,404 - 126,743,785 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	126,731,404 - 126,736,995 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	127,123,637 - 127,145,552 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	127,132,232 - 127,137,823 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	134,276,978 - 134,281,331 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	126,924,612 - 126,928,965 (-)	NCBI		MGSCv36	mm8
Celera	7	126,982,004 - 126,986,358 (-)	NCBI		Celera
Cytogenetic Map	7	F3	NCBI
cM Map	7	69.35	NCBI

Spn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	191,177,449 - 191,190,115 (-)	NCBI		GRCr8
mRatBN7.2	1	181,746,937 - 181,759,564 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	181,746,429 - 181,759,628 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	190,098,274 - 190,102,501 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	197,284,362 - 197,288,589 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	189,953,011 - 189,957,242 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	198,572,999 - 198,585,664 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	198,572,999 - 198,577,226 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	205,563,659 - 205,576,290 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	186,388,120 - 186,391,887 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	186,538,248 - 186,541,733 (-)	NCBI
Celera	1	179,399,985 - 179,404,212 (-)	NCBI		Celera
Cytogenetic Map	1	q37	NCBI

Spn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955493	7,256,505 - 7,258,607 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	17,770,303 - 17,774,946 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	19,347,439 - 19,352,997 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	17,904,551 - 17,908,967 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	17,704,496 - 17,710,054 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	17,619,970 - 17,625,528 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	17,935,701 - 17,941,231 (+)	NCBI		UU_Cfam_GSD_1.0

Spn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	124,676,088 - 124,678,845 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936501	12,773,967 - 12,776,642 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	3	17,978,801 - 17,982,864 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	3	17,978,731 - 17,982,222 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	18,608,470 - 18,612,200 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPN
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	26,987,810 - 26,990,214 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666068	2,533,410 - 2,535,788 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spn
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624782	13,471,083 - 13,483,712 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003809380	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000000764 ⟹ ENSPPAP00000000191

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	30,035,243 - 30,036,445 (+)	Ensembl

RefSeq Acc Id:

XM_003809380 ⟹ XP_003809428

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	30,412,474 - 30,416,344 (+)	NCBI
NHGRI_mPanPan1	16	35,809,899 - 35,813,772 (-)	NCBI
PanPan1.1	16	30,034,739 - 30,037,033 (+)	NCBI

Sequence:

show sequence

CCCTTGGGGCCCTGTCCTTCCCAGTCTTGCCCCAGCCTCGGGAGGTGGTGGAGTGACCTGGCCC
CAGTGCTGCGTCCTTATCAGCCCAGCCGGTCCCAGCTCTTGCTCCTGCCTGTTTGCCTGGAAAT
GGCCACGCTTCTCCTTCTCCTTGGGGTGCTGGTGGTAAGCCCAGACGCTCTGGGGAGCACGACA
GCAGTGCAGACACCCACCTCCGGAGAGCCTTTGGTCTCTACTAGCGAGCCCCTGAGCTCAAAGA
TGTACCCCACTTCAATAACAAGTGACCCTAAGGCCGACAGCACTGGGGACCAGACCTCAGCCCT
ACCTCCCTCAACTTCCATCAATGAGGGATCCCCTCTTTGGACTTCCATTGGTGCCAGCACTGGT
TCCCCTTTACCTGAGCCAACAACCTACCAGGAAGTTTCCATCAAGATGTCATCAGTGCCCCAGG
AAACCCCTCATGCAACCAGTCATCCTGCTGTTCCCATAACAGCAAACTCTCTAGGATCCCACAC
CGTGACAGGTGGAACCATAACAACGAACTCTCCAGAAACCTCCAGTAGGACCAGTGGAGCCCCT
GTTACCACGGCAGCTAGCTCTCTGGAGACCTCCAGAGGCACCTCTGGACCCCCTCTTACCATGG
CAACTGTCTCTCTGGAGACTTCCAAAGGCACCTCTGGACCCCCTTTTACCATGGCAACTAACTC
TCTGGAGACCTCCACTGGGACCACTGGACCCCCTGTTACCATGACAACTGGCTCTCTGGAGCCC
TCCAGCGGGGCCAGTGGACCCCAGGTCTCTAGCGTAAAACTATCCACAGTGATGACTCCAACGA
CCTCCACCAACGCAAGCACTGTGCCCTTCCGGAACCCAGATGAGAACTCACGAGGCATGCTGCC
AGTGGCCGTGCTTGTGGCCCTGCTGGCGGTCATAGTCCTCGTGGCTCTGCTCCTGCTGTGGCGC
CGGCGGCAGAAGCGGCGGACTGGGGCCCTAGTGCTGAGCAGAGGCGGCAAGCGTAACGGGGTGG
TGGACGCCTGGGCTGGGCCAGCCCAGGTCCCTGAGGAGGGGGCCGTGACAGTGACCGTGGGAGG
GTCCGGGGGTGACAAGGGCTCTGGGTTCCCCGATGGGGAGGGGTCTAGCCGGCGGCCCACGCTC
ACCACTTTCTTTGGCAGACGGAAGTCTCGCCAGGGCTCCCTGGCGATGGAGGAGCTGAAGTCTG
GGTCAGGCCCCAGCCTCAAAGGGGAGGAGGAGCCACTGGTGGCCAGTGAGGATGGGGCTGTGGA
CGCCCCAGCTCCTGATGAGCCCGAAGGGGGAGACGGGGCTGCCCCTTAAGTGTCGGTGAATAGT
GAGGCTGGAGGCCGGAATCTCAGCCAGCCTCCAGCACCTTCCCTCTCACCATCCCACTGCCCCT
CGCTCCCATGTTTCCACCCGGCACCCTGATCCTCACCCGAATTCTCCTTTTTTTTTTTTTCTTT
TGAGACAGAGTTTTGCTTTGTCGCCCAGGCTGGAGTGCAATGCACGATCTCAGTTCATTGCAAC
CTCTGCCTCCTAAGTTCAGGCGATTCTCCTGCCTCAGCTTCCCGAGTAACTGAGATTACAGGCA
CCCACCACCATGCCCAGCTGCTTTTTTGTATTTTTGGTAGAGATGGGGTTTCACCATGTTGGCT
AGGCTGGTCTCAAACTCCTGACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAAGTGCTGAGAT
TACAGACATGAGCCTCCGCGCCTTGCCTCCTCACCCACCTCTTCACTCTGAATCCTCATCAGGC
TTCTCAGCCCTGGATTTCCTGCTGGCATCCTCACCCAGCACCCACAACTAGCACCTGGGCAGGG
CAGGGCTGGCACCTCTCAACGTCTGTGGACTGAATGAATAAACCCTCCTCATCCACCCCTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_003809428	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000000191.1

RefSeq Acc Id:

XP_003809428 ⟸ XM_003809380

- Sequence:

show sequence

MATLLLLLGVLVVSPDALGSTTAVQTPTSGEPLVSTSEPLSSKMYPTSITSDPKADSTGDQTSA
LPPSTSINEGSPLWTSIGASTGSPLPEPTTYQEVSIKMSSVPQETPHATSHPAVPITANSLGSH
TVTGGTITTNSPETSSRTSGAPVTTAASSLETSRGTSGPPLTMATVSLETSKGTSGPPFTMATN
SLETSTGTTGPPVTMTTGSLEPSSGASGPQVSSVKLSTVMTPTTSTNASTVPFRNPDENSRGML
PVAVLVALLAVIVLVALLLLWRRRQKRRTGALVLSRGGKRNGVVDAWAGPAQVPEEGAVTVTVG
GSGGDKGSGFPDGEGSSRRPTLTTFFGRRKSRQGSLAMEELKSGSGPSLKGEEEPLVASEDGAV
DAPAPDEPEGGDGAAP

hide sequence

Ensembl Acc Id:

ENSPPAP00000000191 ⟸ ENSPPAT00000000764

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000000724	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000000764.1	UniProtKB/TrEMBL
InterPro	Leukosialin	UniProtKB/TrEMBL
KEGG Report	pps:100978861	UniProtKB/TrEMBL
NCBI Gene	SPN	ENTREZGENE
PANTHER	LEUKOSIALIN	UniProtKB/TrEMBL
	PTHR35265	UniProtKB/TrEMBL
UniProt	A0A2R8ZC48_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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