PTPN5 (protein tyrosine phosphatase non-receptor type 5) - Rat Genome Database

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Gene: PTPN5 (protein tyrosine phosphatase non-receptor type 5) Pan paniscus
Analyze
Symbol: PTPN5
Name: protein tyrosine phosphatase non-receptor type 5
RGD ID: 11915509
Description: ENCODES a protein that exhibits identical protein binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN exploration behavior (ortholog); negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Brain Hypoxia-Ischemia (ortholog); genetic disease (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein phosphatase non-receptor type 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,037,528 - 21,101,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,997,916 - 21,061,597 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,758,285 - 18,822,845 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,672,360 - 18,737,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,673,366 - 18,711,885 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PTPN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,037,528 - 21,101,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,997,916 - 21,061,597 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,758,285 - 18,822,845 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,672,360 - 18,737,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,673,366 - 18,711,885 (-)Ensemblpanpan1.1panPan2
PTPN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,727,928 - 18,792,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,727,928 - 18,792,721 (-)EnsemblGRCh38hg38GRCh38
GRCh371118,749,475 - 18,814,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,706,051 - 18,769,965 (-)NCBINCBI36Build 36hg18NCBI36
Build 341118,706,052 - 18,769,874NCBI
Celera1118,885,312 - 18,948,746 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,434,330 - 18,498,764 (-)NCBIHuRef
CHM1_11118,748,812 - 18,813,611 (-)NCBICHM1_1
T2T-CHM13v2.01118,825,966 - 18,890,761 (-)NCBIT2T-CHM13v2.0
Ptpn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,727,543 - 46,783,774 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,727,543 - 46,783,432 (-)EnsemblGRCm39 Ensembl
GRCm38747,077,795 - 47,134,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl747,077,795 - 47,133,684 (-)EnsemblGRCm38mm10GRCm38
MGSCv37754,333,168 - 54,389,054 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,945,824 - 47,001,706 (-)NCBIMGSCv36mm8
Celera742,560,280 - 42,616,180 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.7NCBI
Ptpn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,756,896 - 106,817,369 (-)NCBIGRCr8
mRatBN7.2197,620,638 - 97,681,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,620,642 - 97,679,882 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1103,010,604 - 103,069,779 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,482,589 - 111,541,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,768,970 - 104,828,192 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,197,918 - 103,258,309 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1103,197,915 - 103,256,823 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01104,263,139 - 104,321,833 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,629,192 - 97,643,225 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,707,302 - 97,721,336 (-)NCBI
Celera191,865,125 - 91,880,882 (-)NCBICelera
Cytogenetic Map1q22NCBI
Ptpn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,377,322 - 33,437,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541433,381,783 - 33,436,974 (-)NCBIChiLan1.0ChiLan1.0
PTPN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12141,097,563 - 41,154,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2141,097,569 - 41,136,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,576,516 - 40,632,837 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02142,220,694 - 42,277,125 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,137,874 - 42,277,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,223,899 - 41,280,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,401,047 - 41,457,402 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,778,556 - 41,834,892 (-)NCBIUU_Cfam_GSD_1.0
Ptpn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,491,082 - 44,552,326 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936528525,769 - 586,327 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936528523,884 - 586,306 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,459,049 - 40,521,461 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,458,865 - 40,521,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,468,196 - 43,530,692 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,134,109 - 46,197,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,153,340 - 46,199,002 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038143,475,470 - 143,539,473 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476610,147,840 - 10,204,238 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476610,147,859 - 10,204,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000034674   ⟹   ENSPPAP00000012012
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,673,366 - 18,711,885 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034678   ⟹   ENSPPAP00000012016
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,673,366 - 18,689,700 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000034682   ⟹   ENSPPAP00000012020
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1118,673,366 - 18,686,851 (-)Ensembl
RefSeq Acc Id: XM_003830472   ⟹   XP_003830520
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2921,037,528 - 21,101,193 (-)NCBI
NHGRI_mPanPan11120,997,916 - 21,061,582 (-)NCBI
Mhudiblu_PPA_v01118,758,285 - 18,821,918 (-)NCBI
PanPan1.11118,672,360 - 18,736,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014346766   ⟹   XP_014202252
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2921,037,528 - 21,101,193 (-)NCBI
NHGRI_mPanPan11120,997,916 - 21,061,582 (-)NCBI
Mhudiblu_PPA_v01118,758,285 - 18,821,918 (-)NCBI
PanPan1.11118,672,360 - 18,736,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014346767   ⟹   XP_014202253
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2921,037,528 - 21,101,192 (-)NCBI
NHGRI_mPanPan11120,997,916 - 21,061,581 (-)NCBI
Mhudiblu_PPA_v01118,758,285 - 18,821,918 (-)NCBI
PanPan1.11118,672,360 - 18,736,284 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034932280   ⟹   XP_034788171
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2921,038,265 - 21,101,209 (-)NCBI
NHGRI_mPanPan11120,998,644 - 21,061,597 (-)NCBI
Mhudiblu_PPA_v01118,759,249 - 18,821,889 (-)NCBI
RefSeq Acc Id: XM_055094231   ⟹   XP_054950206
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2921,037,528 - 21,056,665 (-)NCBI
NHGRI_mPanPan11120,997,916 - 21,017,053 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_014202253   ⟸   XM_014346767
- Peptide Label: isoform X2
- UniProtKB: A0A2R9A9C9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_014202252   ⟸   XM_014346766
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A3Y0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003830520   ⟸   XM_003830472
- Peptide Label: isoform X1
- UniProtKB: A0A2R9A3Y0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034788171   ⟸   XM_034932280
- Peptide Label: isoform X4
RefSeq Acc Id: ENSPPAP00000012016   ⟸   ENSPPAT00000034678
RefSeq Acc Id: ENSPPAP00000012012   ⟸   ENSPPAT00000034674
RefSeq Acc Id: ENSPPAP00000012020   ⟸   ENSPPAT00000034682
RefSeq Acc Id: XP_054950206   ⟸   XM_055094231
- Peptide Label: isoform X3
Protein Domains
Tyrosine specific protein phosphatases   Tyrosine-protein phosphatase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029191 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000034674.1 UniProtKB/TrEMBL
  ENSPPAT00000034678.1 UniProtKB/TrEMBL
  ENSPPAT00000034682.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTPase_domain UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_KIM-con UniProtKB/TrEMBL
  Tyr_Pase_rcpt_R/non-rcpt_5 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/TrEMBL
NCBI Gene PTPN5 ENTREZGENE
PANTHER PTHR46198 UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 5 UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PIRSF PTPRR UniProtKB/TrEMBL
PRINTS KIMPTPASE UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A2R9A3Y0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9A8Q3_PANPA UniProtKB/TrEMBL
  A0A2R9A9C9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 PTPN5  protein tyrosine phosphatase non-receptor type 5    protein tyrosine phosphatase, non-receptor type 5  Symbol and/or name change 5135510 APPROVED