IDUA (alpha-L-iduronidase) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: IDUA (alpha-L-iduronidase) Pan paniscus
Analyze
Symbol: IDUA
Name: alpha-L-iduronidase
RGD ID: 11911894
Description: ENCODES a protein that exhibits L-iduronidase activity (ortholog); signaling receptor binding (ortholog); INVOLVED IN adult locomotory behavior (ortholog); adult walking behavior (ortholog); bone development (ortholog); ASSOCIATED WITH calcium oxalate nephrolithiasis (ortholog); Calcium Oxalate Nephrolithiasis 1 (ortholog); cherubism (ortholog); FOUND IN extracellular space (ortholog); lysosomal lumen (ortholog); lysosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: iduronidase alpha-L-; iduronidase, alpha-L-
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v231,315,303 - 1,334,024 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan141,282,815 - 1,304,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,102,288 - 1,120,973 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,020,519 - 1,037,990 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,020,582 - 1,037,877 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IDUA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v231,315,303 - 1,334,024 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan141,282,815 - 1,304,372 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v041,102,288 - 1,120,973 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.141,020,519 - 1,037,990 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl41,020,582 - 1,037,877 (+)Ensemblpanpan1.1panPan2
IDUA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384986,997 - 1,008,351 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4986,997 - 1,004,564 (+)EnsemblGRCh38hg38GRCh38
GRCh374980,785 - 998,352 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364970,785 - 988,317 (+)NCBINCBI36Build 36hg18NCBI36
Build 344970,614 - 988,146NCBI
Celera4917,731 - 935,177 (+)NCBICelera
Cytogenetic Map4p16.3NCBI
HuRef4952,003 - 969,463 (+)NCBIHuRef
CHM1_14980,568 - 998,100 (+)NCBICHM1_1
T2T-CHM13v2.04985,128 - 1,002,611 (+)NCBIT2T-CHM13v2.0
Idua
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395108,808,197 - 108,833,312 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5108,808,197 - 108,832,423 (+)EnsemblGRCm39 Ensembl
GRCm385108,660,331 - 108,685,446 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5108,660,331 - 108,684,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv375109,098,125 - 109,113,577 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365108,909,667 - 108,924,856 (+)NCBIMGSCv36mm8
Celera5105,791,051 - 105,807,497 (+)NCBICelera
Cytogenetic Map5FNCBI
cM Map553.24NCBI
Idua
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8141,175,994 - 1,203,913 (-)NCBIGRCr8
mRatBN7.2141,031,588 - 1,059,494 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl141,032,171 - 1,046,522 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx14932,006 - 946,365 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0142,233,783 - 2,248,142 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.014930,476 - 944,835 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0142,041,828 - 2,056,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl142,042,411 - 2,056,762 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0142,037,369 - 2,052,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera141,071,517 - 1,085,862 (-)NCBICelera
Cytogenetic Map14p22NCBI
Idua
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955514475,731 - 488,007 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955514474,830 - 488,007 (+)NCBIChiLan1.0ChiLan1.0
IDUA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1391,517,225 - 91,534,593 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl391,522,035 - 91,534,593 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha393,988,643 - 94,001,108 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0392,515,340 - 92,532,617 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl392,519,804 - 92,532,813 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1391,693,928 - 91,706,431 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0391,746,826 - 91,759,387 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0392,130,626 - 92,143,201 (-)NCBIUU_Cfam_GSD_1.0
Idua
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528568,493,659 - 68,512,811 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647722,200,474 - 22,215,077 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647722,200,471 - 22,215,473 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IDUA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8334,617 - 351,969 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18334,604 - 351,970 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IDUA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12747,778,220 - 47,794,435 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2747,778,335 - 47,794,352 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366680862,223 - 78,429 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Idua
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475526,154,186 - 26,169,365 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475526,151,302 - 26,169,324 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000041102   ⟹   ENSPPAP00000018372
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl41,020,582 - 1,037,877 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000041107   ⟹   ENSPPAP00000018377
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl41,020,582 - 1,037,877 (+)Ensembl
RefSeq Acc Id: XM_034958124   ⟹   XP_034814015
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v231,315,303 - 1,334,024 (+)NCBI
NHGRI_mPanPan141,282,817 - 1,304,372 (+)NCBI
Mhudiblu_PPA_v041,102,298 - 1,120,973 (+)NCBI
RefSeq Acc Id: XM_063603635   ⟹   XP_063459705
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v231,315,322 - 1,334,024 (+)NCBI
RefSeq Acc Id: XM_063603636   ⟹   XP_063459706
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v231,315,323 - 1,334,024 (+)NCBI
RefSeq Acc Id: XM_063603637   ⟹   XP_063459707
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v231,315,324 - 1,334,024 (+)NCBI
RefSeq Acc Id: XM_063603638   ⟹   XP_063459708
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v231,315,307 - 1,334,024 (+)NCBI
RefSeq Acc Id: XM_063603639   ⟹   XP_063459709
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v231,316,127 - 1,334,024 (+)NCBI
RefSeq Acc Id: XM_063603640   ⟹   XP_063459710
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v231,316,127 - 1,334,024 (+)NCBI
RefSeq Acc Id: XR_010111890
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v231,315,318 - 1,333,823 (+)NCBI
RefSeq Acc Id: XP_034814015   ⟸   XM_034958124
- Peptide Label: isoform X5
- UniProtKB: A0A2R9ALZ1 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSPPAP00000018372   ⟸   ENSPPAT00000041102
Ensembl Acc Id: ENSPPAP00000018377   ⟸   ENSPPAT00000041107
RefSeq Acc Id: XP_063459708   ⟸   XM_063603638
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063459705   ⟸   XM_063603635
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063459706   ⟸   XM_063603636
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063459707   ⟸   XM_063603637
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063459710   ⟸   XM_063603640
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063459709   ⟸   XM_063603639
- Peptide Label: isoform X6
Protein Domains
Alpha-L-iduronidase C-terminal   Glycosyl hydrolases family 39 N-terminal catalytic


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032304 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000041102.1 UniProtKB/TrEMBL
  ENSPPAT00000041107.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  Glycosidases UniProtKB/TrEMBL
InterPro GH39_as UniProtKB/TrEMBL
  GH39_C UniProtKB/TrEMBL
  GH39_cat UniProtKB/TrEMBL
  Glyco_hydro_39 UniProtKB/TrEMBL
  Glycoside_hydrolase_SF UniProtKB/TrEMBL
  Glycosyl_Hydrolase_39 UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
NCBI Gene IDUA ENTREZGENE
PANTHER ALPHA-L-IDURONIDASE UniProtKB/TrEMBL
  ALPHA-L-IDURONIDASE UniProtKB/TrEMBL
Pfam Glyco_hydro_39 UniProtKB/TrEMBL
  Glyco_hydro_39_C UniProtKB/TrEMBL
PRINTS GLHYDRLASE39 UniProtKB/TrEMBL
PROSITE GLYCOSYL_HYDROL_F39 UniProtKB/TrEMBL
Superfamily-SCOP Glycosyl hydrolase domain UniProtKB/TrEMBL
  SSF51445 UniProtKB/TrEMBL
UniProt A0A2R9ALZ1 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9ALZ4_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-20 IDUA  alpha-L-iduronidase  IDUA  iduronidase alpha-L-  Symbol and/or name change 5135510 APPROVED
2019-01-29 IDUA  iduronidase alpha-L-    iduronidase, alpha-L-  Symbol and/or name change 5135510 APPROVED