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Gene: SERPINA6 (serpin family A member 6) Pan paniscus

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Symbol:

SERPINA6

Name:

serpin family A member 6

RGD ID:

11908031

Description:

ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); steroid binding (inferred); INVOLVED IN glucocorticoid metabolic process (ortholog); ASSOCIATED WITH achondrogenesis type IA (ortholog); Chemical and Drug Induced Liver Injury (ortholog); corticosteroid-binding globulin deficiency (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

corticosteroid-binding globulin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	95,461,767 - 95,480,904 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	94,678,417 - 94,688,646 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	74,936,724 - 74,955,799 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	94,269,299 - 94,288,391 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	94,269,299 - 94,288,391 (-)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

achondrogenesis type IA (ISO)

Chemical and Drug Induced Liver Injury (ISO)

corticosteroid-binding globulin deficiency (ISO)

DICER1 syndrome (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

liver cirrhosis (ISO)

pleuropulmonary blastoma (ISO)

steatotic liver disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glucocorticoid metabolic process (IEA,ISO)

Cellular Component

extracellular region (IEA)

extracellular space (IEA)

Molecular Function

serine-type endopeptidase inhibitor activity (IEA)

steroid binding (IEA)

References

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

SERPINA6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	95,461,767 - 95,480,904 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	94,678,417 - 94,688,646 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	74,936,724 - 74,955,799 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	94,269,299 - 94,288,391 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	94,269,299 - 94,288,391 (-)	Ensembl	panpan1.1		panPan2

SERPINA6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	94,304,248 - 94,323,336 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	94,304,248 - 94,323,389 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	94,770,585 - 94,789,673 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	93,840,338 - 93,859,441 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	93,840,338 - 93,859,426	NCBI
Celera	14	74,824,369 - 74,843,477 (-)	NCBI		Celera
Cytogenetic Map	14	q32.13	NCBI
HuRef	14	74,950,383 - 74,969,481 (-)	NCBI		HuRef
CHM1_1	14	94,708,390 - 94,727,495 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	14	88,531,534 - 88,550,620 (-)	NCBI		T2T-CHM13v2.0

Serpina6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	12	103,612,889 - 103,623,477 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	12	103,612,889 - 103,623,471 (-)	Ensembl		GRCm39 Ensembl
GRCm38	12	103,646,630 - 103,657,218 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	12	103,646,630 - 103,657,212 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	12	104,884,842 - 104,895,281 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	12	104,047,682 - 104,058,121 (-)	NCBI		MGSCv36	mm8
Celera	12	104,862,913 - 104,873,376 (-)	NCBI		Celera
Cytogenetic Map	12	E	NCBI
cM Map	12	52.98	NCBI

Serpina6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	6	128,544,828 - 128,555,064 (-)	NCBI		GRCr8
mRatBN7.2	6	122,780,040 - 122,790,274 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	6	122,780,043 - 122,790,349 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	6	122,920,505 - 122,930,725 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	6	123,215,781 - 123,226,001 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	6	122,552,673 - 122,562,896 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	6	127,523,948 - 127,534,178 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	6	127,523,906 - 127,534,247 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	6	136,742,720 - 136,752,950 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	6	127,911,618 - 127,921,851 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	6	120,260,306 - 120,270,532 (-)	NCBI		Celera
Cytogenetic Map	6	q32	NCBI

Serpina6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955438	16,356,540 - 16,380,872 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955438	16,356,600 - 16,380,861 (-)	NCBI	ChiLan1.0	ChiLan1.0

SERPINA6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	8	63,323,896 - 63,341,829 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	8	63,323,933 - 63,453,708 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	8	62,900,449 - 62,925,083 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	8	63,589,497 - 63,614,157 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	8	63,589,530 - 63,614,404 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	8	63,266,111 - 63,290,719 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	8	63,318,270 - 63,342,932 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	8	63,648,530 - 63,673,205 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101973017
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	11,314,687 - 11,325,700 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936733	2,141,392 - 2,148,151 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936733	2,141,484 - 2,148,129 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SERPINA6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	115,535,697 - 115,554,570 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	115,535,552 - 115,554,536 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	122,544,744 - 122,563,955 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SERPINA6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	24	72,079,084 - 72,098,549 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	24	72,077,274 - 72,098,154 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666053	59,312,190 - 59,331,143 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Serpina6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624734	10,637,515 - 10,651,033 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624734	10,638,031 - 10,650,297 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008958247	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000063234 ⟹ ENSPPAP00000040318

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	14	94,269,299 - 94,288,391 (-)	Ensembl

RefSeq Acc Id:

XM_008958247 ⟹ XP_008956495

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	15	95,461,767 - 95,480,904 (-)	NCBI
NHGRI_mPanPan1	14	94,678,417 - 94,688,646 (-)	NCBI
Mhudiblu_PPA_v0	14	74,936,724 - 74,955,799 (-)	NCBI
PanPan1.1	14	94,269,299 - 94,288,391 (-)	NCBI

Sequence:

show sequence

ATTAACCACCCAGGAAGCTGGCAAACAAAATTTAACAGGCAGCATCCACCGCAGGCTTACTGTA
CACATGCTAGGGTCCAGGACAGCAGGACCAAGCCAGCAGAAACAGCCTGAGCCCACCGCAGACT
GGCCTGGCTATACTGGACAATGCCACTCCTCCTGTACACCTGTCTTCTCTGGCTGTCCACCAGC
GGCCTCTGGACCATCCAGGCCATGGATCCTAACGCTGCTTATGTGAACATGAGTAACCATCACC
GGGGCCTGGCTTCAGCCAACGTTGACTTTGCCTTCAGCCTGTATAAGCACCTAGTGGCCTTGAG
TCCCAAAAAGAACATTTTCATCTCCCCTGTGAGCATCTCCATGGCCTTAGCTATGCTGTCCCTG
GGCACCTGTGGCCACACACGGGCCCAGCTTCTCCAGGGCCTGGGTTTCAACCTCACTGAGAGGT
CTGAGACTGAGATCCACCAGGGTTTCCAGCACCTGCACCAACTCTTTGCAAAGTCAGACACCAG
CTTAGAAATGACCATGGGCAATGCCTTATTTCTTGATGGCAGCCTGGAGTTGCTGCAGTCATTC
TCAGCAGACATCAAGCACTACTATGAGTCAGAGGTCTTGGCTACGAATTTCCAGGACTGGGCAA
CAGCCAGCAGACAGATCAACAGCTATGTCAAGAGTAAGACACAGGGGAAAATTGCCGACTTGTT
GTCAGGGCTGGATAGCCCAGCCATCCTCGTCCTGGTCAACTATATCTTCTTCAAAGGCACATGG
ACACAGCCCTTTGACCTGGCAAGCACCAGGGAGGAGAACTTCTATGTGGACGAGACAACTGTGG
TGAAGGTGCCCATGATGTTGCAGTCGAGTACCATCAGTTACCTTCATGACTCAGAGCTCCCCTG
CCAGCTGGTGCAGATGAACTACGTGGGCAATGGGACTGTCTTCTTCATCCTTCCAGACAAGGGG
AAGATGAACACAGTCATCGCAGCGCTGAGCCGGGACACGATTAACAGGTGGTCTGCAGGCCTGA
CCAGCAGCCAGGTGGACCTGTACATTCCAAAGGTCACCATCTCTGGAGTCTATGACCTCGGAGA
TGTGCTGGAGGAAATGGGCATTGCAGACTTGTTCACCAACCAGGCAAATTTCTCACGCATCACC
CAGGACGCCCAGCTGAAGTCATCAAAGGTGGTCCATAAAGCTGTGCTGCAACTCAATGAGGAGG
GTGTGGACACAGCTGGCTCCACTGGGGTCACCCTAAACCTGACGTCCAAGCCTATCATCTTGCG
TTTCAACCAGCCCTTCATCATCATGATCTTCGACCACTTCACCTGGAGCAGCCTTTTCCTGGCC
AGGGTTATGAACCCAGTGTAAGAGACCACCCACCCAGAGCCTCAGCACTGTCTGACTTTGGGAA
CCAGGGATCCCACAGAAATGTTCTGGAGAGCGGGAGGTTTCCCCCAGTCTCCTCCAAGTTCTTC
TCCCTCCAACCAGAGTTGTGTCTACCTTTAGGCATCTTTTAATAAATGTCATTGCGACTCTGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_008956495	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000040318.1

RefSeq Acc Id:

XP_008956495 ⟸ XM_008958247

- UniProtKB:

A0A2R9CH07 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPLLLYTCLLWLSTSGLWTIQAMDPNAAYVNMSNHHRGLASANVDFAFSLYKHLVALSPKKNIF
ISPVSISMALAMLSLGTCGHTRAQLLQGLGFNLTERSETEIHQGFQHLHQLFAKSDTSLEMTMG
NALFLDGSLELLQSFSADIKHYYESEVLATNFQDWATASRQINSYVKSKTQGKIADLLSGLDSP
AILVLVNYIFFKGTWTQPFDLASTREENFYVDETTVVKVPMMLQSSTISYLHDSELPCQLVQMN
YVGNGTVFFILPDKGKMNTVIAALSRDTINRWSAGLTSSQVDLYIPKVTISGVYDLGDVLEEMG
IADLFTNQANFSRITQDAQLKSSKVVHKAVLQLNEEGVDTAGSTGVTLNLTSKPIILRFNQPFI
IMIFDHFTWSSLFLARVMNPV

hide sequence

Ensembl Acc Id:

ENSPPAP00000040318 ⟸ ENSPPAT00000063234

Protein Domains

SERPIN

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000042823	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000063234.1	UniProtKB/TrEMBL
Gene3D-CATH	2.30.39.10	UniProtKB/TrEMBL
	3.30.497.10	UniProtKB/TrEMBL
InterPro	Serpin_CS	UniProtKB/TrEMBL
	Serpin_dom	UniProtKB/TrEMBL
	Serpin_fam	UniProtKB/TrEMBL
	Serpin_sf	UniProtKB/TrEMBL
	Serpin_sf_1	UniProtKB/TrEMBL
	Serpin_sf_2	UniProtKB/TrEMBL
KEGG Report	pps:100985000	UniProtKB/TrEMBL
NCBI Gene	SERPINA6	ENTREZGENE
PANTHER	CORTICOSTEROID-BINDING GLOBULIN	UniProtKB/TrEMBL
	PTHR11461	UniProtKB/TrEMBL
Pfam	Serpin	UniProtKB/TrEMBL
PRINTS	LEUSERPINII	UniProtKB/TrEMBL
PROSITE	SERPIN	UniProtKB/TrEMBL
SMART	SERPIN	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56574	UniProtKB/TrEMBL
UniProt	A0A2R9CH07	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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