VWC2 (von Willebrand factor C domain containing 2)

Gene: VWC2 (von Willebrand factor C domain containing 2) Pan paniscus

Analyze

Symbol:

VWC2

Name:

von Willebrand factor C domain containing 2

RGD ID:

11899995

Description:

INVOLVED IN neurotransmitter receptor localization to postsynaptic specialization membrane (ortholog); positive regulation of cell-substrate adhesion (ortholog); ASSOCIATED WITH genetic disease (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN extrinsic component of postsynaptic membrane (ortholog); glutamatergic synapse (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

brorin

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	54,649,664 - 54,800,128 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	102,974,392 - 103,124,851 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	50,412,363 - 50,562,837 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	50,661,384 - 50,810,596 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	50,661,384 - 50,800,814 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of BMP signaling pathway (IEA)

neurotransmitter receptor localization to postsynaptic specialization membrane (ISO)

positive regulation of cell-substrate adhesion (IEA,ISO)

positive regulation of neuron differentiation (IEA)

Cellular Component

AMPA glutamate receptor complex (IEA)

basement membrane (IEA)

extracellular matrix (IEA)

extracellular region (IEA)

extracellular space (IEA)

extrinsic component of postsynaptic membrane (ISO)

glutamatergic synapse (ISO)

interstitial matrix (IEA)

Molecular Function

protein binding (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

VWC2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	54,649,664 - 54,800,128 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	102,974,392 - 103,124,851 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	50,412,363 - 50,562,837 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	50,661,384 - 50,810,596 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	50,661,384 - 50,800,814 (+)	Ensembl	panpan1.1		panPan2

VWC2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	49,773,638 - 49,922,205 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	49,773,638 - 49,921,950 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	49,813,234 - 49,961,546 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	49,783,803 - 49,922,684 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	7	49,907,441 - 50,046,308 (+)	NCBI		Celera
Cytogenetic Map	7	p12.2	NCBI
HuRef	7	49,694,094 - 49,833,168 (+)	NCBI		HuRef
CHM1_1	7	49,815,530 - 49,954,428 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	7	49,934,695 - 50,083,976 (+)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	49,850,406 - 49,989,256 (+)	NCBI

Vwc2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	11,063,836 - 11,219,295 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	11,064,223 - 11,218,931 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	11,113,868 - 11,269,295 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	11,114,223 - 11,268,931 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	11,014,019 - 11,163,529 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	11,014,747 - 11,167,726 (+)	NCBI		MGSCv36	mm8
Celera	11	11,572,129 - 11,719,075 (+)	NCBI		Celera
Cytogenetic Map	11	A1	NCBI
cM Map	11	6.27	NCBI

Vwc2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	89,897,543 - 90,038,732 (+)	NCBI		GRCr8
mRatBN7.2	14	85,683,670 - 85,825,068 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	85,684,414 - 85,818,524 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	14	90,094,126 - 90,234,756 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	91,338,869 - 91,479,511 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	87,806,017 - 87,946,689 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	91,201,141 - 91,348,219 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	91,201,730 - 91,348,219 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	14	90,987,662 - 91,137,489 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	14	84,692,637 - 84,825,429 (+)	NCBI		Celera
Cytogenetic Map	14	q21	NCBI

Vwc2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955456	3,951,428 - 4,075,624 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955456	3,949,885 - 4,075,622 (-)	NCBI	ChiLan1.0	ChiLan1.0

VWC2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	1,248,612 - 1,350,965 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	1,257,357 - 1,350,856 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	1,248,381 - 1,346,106 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	1,314,358 - 1,412,133 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	1,312,740 - 1,408,185 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	1,289,016 - 1,386,728 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	1,285,780 - 1,383,481 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	1,421,893 - 1,519,636 (+)	NCBI		UU_Cfam_GSD_1.0

Vwc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	104,506,578 - 104,681,083 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936686	1,861,537 - 2,015,255 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936686	1,844,435 - 2,016,953 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

VWC2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	135,982,227 - 136,083,616 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	135,982,814 - 136,083,069 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	149,507,786 - 149,609,257 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

VWC2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	8,876,382 - 9,027,007 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	8,885,377 - 9,025,229 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666062	13,227,901 - 13,385,430 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Vwc2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624740	4,109,100 - 4,234,009 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624740	4,100,196 - 4,234,098 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_008962894	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034964078	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034964079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063606230	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_004672468	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_004672469	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_008955792	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000065082 ⟹ ENSPPAP00000042153

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	7	50,661,384 - 50,800,814 (+)	Ensembl

RefSeq Acc Id:

XM_008962894 ⟹ XP_008961142

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	54,650,123 - 54,800,128 (+)	NCBI
NHGRI_mPanPan1	7	102,974,841 - 103,124,851 (+)	NCBI
Mhudiblu_PPA_v0	7	50,412,821 - 50,561,982 (+)	NCBI
PanPan1.1	7	50,661,384 - 50,801,171 (+)	NCBI

Sequence:

show sequence

GCCGCTGCTACCCCTGCGCCCGCCGCGAGCCCGGCGTCCGGCCCGCGCCCTGCGCTCATGGACG
GCGGCTCCCGGCTGGCGGCGGTGCGCCCCCGGGCTGTGAATGCGACTCGCCCCTCGGCCGCGCT
CCCCGCCCGCCCGCCCGCCGGGACGTGGTAGGGGATGCCCAGCTCCACTGCGATGGCAGTTGGC
GCGCTCTCCAGTTCCCTCCTGGTCACCTGCTGCCTGATGGTGGCTCTGTGCAGTCCGAGCATCC
CGCTGGAGAAGCTGGCCCAGGCACCAGAGCAGCCGGGCCAGGAGAAGCGTGAGCACGCCTCTCG
GGACGGCCCGGGGCGGGTGAACGAGCTCGGGCGCCCGGCGAGGGACGAGGGCGGCAGCGGCCGG
GACTGGAAGAGCAAGAGCGGCCGTGGGCTCGCCGGCCGTGAGCCGTGGAGCAAGCTGAAGCAGG
CCTGGGTCTCCCAGGGCGGGGGCGCCAAGGCCGGGGATCTGCAGGTCCGGCCCCGCGGGGACAC
CCCGCAGGGGGAAGCCCTGGCCGCAGCCGCCCAGGACGCGATTGGCCCGGAACTCGCGCCCACG
CCCGAGCCACCCGAGGAGTACGTGTACCCGGACTACCGTGGCAAGGGCTGCGTGGACGAGAGCG
GCTTCGTGTACGCGATCGGGGAGAAGTTCGCGCCGGGCCCCTCGGCCTGCCCGTGCCTGTGCAC
CGAGGAGGGGCCGCTGTGCGCGCAGCCCGAGTGCCCGAGGCTGCACCCGCGCTGCATCCACGTC
GACACGAGCCAGTGCTGTCCGCAGTGCAAGGAAAGGAAGAACTACTGCGAGTTCCGGGGCAAGA
CCTATCAGACTTTGGAGGAGTTCGTGGTGTCTCCATGCGAGAGATGTCGCTGTGAAGCCAACGG
TGAGGTGCTATGCACAGTGTCAGCGTGTCCCCAGACGGAGTGTGTGGACCCTGTGTACGAGCCT
GATCAGTGCTGTCCCATCTGCAAAAATGGTCCAAACTGCTTTGCAGAAACCGCGGTGATCCCTG
CTGGCAGAGAAGTGAAGACTGACGAGTGCACCATATGCCACTGTACTTATGAGGAAGGCACATG
GAGAATCGAGCGGCAGGCCATGTGCACGAGACATGAATGCAGGCAAATGTAGACGCTTCCCAGA
ACACAAACTCTGACTTTTTCTAGAACATTTTACTGATGTGAACATTCTAGATGACTCTAGGAAG
TATCAGTCAAAGAAGACTTTTGATGAGGAATAATGGAAAATTGTTGGTACTTTTCCTTTTCTTG
ATAACAGTTACTACAACAGAAGGAAATGGATATATTTCAAAACATCAACAAGAACTTTGGGCAT
AAAATCCTTCTCTAAATAAATGTGCTATTTTCACAGTAAGTACACAAAAGTACACTATTATATA
TCAAATGTATTTCTATAATCCCTCCATTAGAGAGCTTATATAAGTGTTTTCTATAGATGCAGAT
TAAAAATGCTGTGTTGTCAACCGTC

hide sequence

RefSeq Acc Id:

XM_034964078 ⟹ XP_034819969

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	54,650,104 - 54,800,128 (+)	NCBI
NHGRI_mPanPan1	7	102,974,819 - 103,124,851 (+)	NCBI
Mhudiblu_PPA_v0	7	50,412,807 - 50,557,632 (+)	NCBI

RefSeq Acc Id:

XM_034964079 ⟹ XP_034819970

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	54,649,664 - 54,800,128 (+)	NCBI
NHGRI_mPanPan1	7	102,974,392 - 103,124,851 (+)	NCBI
Mhudiblu_PPA_v0	7	50,412,363 - 50,557,632 (+)	NCBI

RefSeq Acc Id:

XM_063606230 ⟹ XP_063462300

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	54,649,664 - 54,800,128 (+)	NCBI

RefSeq Acc Id:

XR_004672468

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	54,650,104 - 54,800,128 (+)	NCBI
NHGRI_mPanPan1	7	102,974,819 - 103,124,851 (+)	NCBI
Mhudiblu_PPA_v0	7	50,412,807 - 50,562,837 (+)	NCBI

RefSeq Acc Id:

XR_008955792

Type:

NON-CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	6	54,649,684 - 54,800,128 (+)	NCBI
NHGRI_mPanPan1	7	102,976,649 - 103,124,851 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_008961142	(Get FASTA)	NCBI Sequence Viewer
	XP_034819969	(Get FASTA)	NCBI Sequence Viewer
	XP_034819970	(Get FASTA)	NCBI Sequence Viewer
	XP_063462300	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000042153.1

RefSeq Acc Id:

XP_008961142 ⟸ XM_008962894

- Peptide Label:

isoform X2

- Sequence:

show sequence

MPSSTAMAVGALSSSLLVTCCLMVALCSPSIPLEKLAQAPEQPGQEKREHASRDGPGRVNELGR
PARDEGGSGRDWKSKSGRGLAGREPWSKLKQAWVSQGGGAKAGDLQVRPRGDTPQGEALAAAAQ
DAIGPELAPTPEPPEEYVYPDYRGKGCVDESGFVYAIGEKFAPGPSACPCLCTEEGPLCAQPEC
PRLHPRCIHVDTSQCCPQCKERKNYCEFRGKTYQTLEEFVVSPCERCRCEANGEVLCTVSACPQ
TECVDPVYEPDQCCPICKNGPNCFAETAVIPAGREVKTDECTICHCTYEEGTWRIERQAMCTRH
ECRQM

hide sequence

RefSeq Acc Id:	XP_034819970 ⟸ XM_034964079
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_034819969 ⟸ XM_034964078
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSPPAP00000042153 ⟸ ENSPPAT00000065082

RefSeq Acc Id:	XP_063462300 ⟸ XM_063606230
- Peptide Label:	isoform X1

Protein Domains

VWFC

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000043662	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000065082.1	UniProtKB/TrEMBL
Gene3D-CATH	6.20.200.20	UniProtKB/TrEMBL
InterPro	VWC2/VWC2L	UniProtKB/TrEMBL
	VWF_dom	UniProtKB/TrEMBL
KEGG Report	pps:100976970	UniProtKB/TrEMBL
NCBI Gene	VWC2	ENTREZGENE
PANTHER	BRORIN	UniProtKB/TrEMBL
	PTHR46252	UniProtKB/TrEMBL
Pfam	VWC	UniProtKB/TrEMBL
PROSITE	VWFC_1	UniProtKB/TrEMBL
	VWFC_2	UniProtKB/TrEMBL
SMART	VWC	UniProtKB/TrEMBL
Superfamily-SCOP	FnI-like domain	UniProtKB/TrEMBL
UniProt	A0A2R9CMA3_PANPA	UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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