STAT2 (signal transducer and activator of transcription 2) - Rat Genome Database

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Gene: STAT2 (signal transducer and activator of transcription 2) Pan paniscus
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Symbol: STAT2
Name: signal transducer and activator of transcription 2
RGD ID: 11898924
Description: ENCODES a protein that exhibits DNA binding (inferred); DNA-binding transcription factor activity (inferred); DNA-binding transcription factor activity, RNA polymerase II-specific (inferred); INVOLVED IN regulation of protein phosphorylation (ortholog); PARTICIPATES IN interleukin-27 signaling pathway; Jak-Stat signaling pathway; ASSOCIATED WITH Arenaviridae infectious disease (ortholog); Bunyaviridae Infections (ortholog); cataract 15 multiple types (ortholog); FOUND IN nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,972,152 - 37,994,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,968,913 - 37,990,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,555,523 - 32,574,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,808,586 - 32,827,732 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,808,586 - 32,827,732 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA)
cytosol  (IEA)
ISGF3 complex  (IEA)
nucleus  (IEA,ISO)
plasma membrane  (IEA)

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
STAT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,972,152 - 37,994,084 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,968,913 - 37,990,850 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,555,523 - 32,574,137 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,808,586 - 32,827,732 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,808,586 - 32,827,732 (+)Ensemblpanpan1.1panPan2
STAT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,341,597 - 56,360,107 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,341,597 - 56,360,203 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,735,381 - 56,753,891 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,021,648 - 55,040,176 (-)NCBINCBI36Build 36hg18NCBI36
Build 341255,021,650 - 55,040,176NCBI
Celera1256,388,733 - 56,407,397 (-)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,774,045 - 53,793,077 (-)NCBIHuRef
CHM1_11256,702,765 - 56,721,407 (-)NCBICHM1_1
T2T-CHM13v2.01256,309,243 - 56,327,794 (-)NCBIT2T-CHM13v2.0
Stat2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,106,367 - 128,128,722 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,106,428 - 128,128,718 (+)EnsemblGRCm39 Ensembl
GRCm3810128,270,498 - 128,292,853 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,270,559 - 128,292,849 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710127,707,632 - 127,729,905 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,673,525 - 127,695,798 (+)NCBIMGSCv36mm8
Celera10130,656,386 - 130,681,169 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.5NCBI
Stat2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,287,025 - 1,302,858 (+)NCBIGRCr8
mRatBN7.27702,565 - 718,349 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7702,495 - 718,967 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,458,867 - 3,474,660 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,334,848 - 5,350,643 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,637,673 - 5,653,273 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,691,064 - 2,707,530 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,691,369 - 2,707,741 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,669,952 - 2,685,673 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,564,385 - 1,580,652 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,564,384 - 1,580,651 (+)NCBI
Celera7578,845 - 593,799 (+)NCBICelera
Cytogenetic Map7q11NCBI
Stat2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,952,738 - 3,970,668 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,953,019 - 3,973,151 (-)NCBIChiLan1.0ChiLan1.0
STAT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110641,543 - 660,882 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10642,718 - 658,546 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10704,962 - 724,101 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010650,365 - 669,707 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10649,947 - 669,646 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110627,617 - 646,943 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010870,771 - 890,099 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010994,493 - 1,013,823 (-)NCBIUU_Cfam_GSD_1.0
Stat2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,106,734 - 58,122,062 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646748,727 - 761,287 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646747,178 - 763,449 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
STAT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,733,035 - 21,751,354 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,733,030 - 21,748,960 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2523,280,591 - 23,294,360 (-)NCBISscrofa10.2Sscrofa10.2susScr3
STAT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,297,890 - 52,316,089 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,297,543 - 52,316,105 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,669,493 - 193,688,727 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Stat2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,648,020 - 11,660,216 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,645,851 - 11,662,812 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSPPAT00000061262   ⟹   ENSPPAP00000038359
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1232,808,586 - 32,827,732 (+)Ensembl
Ensembl Acc Id: ENSPPAT00000061273   ⟹   ENSPPAP00000038370
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1232,811,768 - 32,826,009 (+)Ensembl
RefSeq Acc Id: XM_003824916   ⟹   XP_003824964
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,166 - 37,990,847 (+)NCBI
NHGRI_mPanPan11237,968,931 - 37,987,613 (+)NCBI
Mhudiblu_PPA_v01232,555,523 - 32,574,137 (+)NCBI
PanPan1.11232,808,586 - 32,827,732 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008978589   ⟹   XP_008976837
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,166 - 37,990,847 (+)NCBI
NHGRI_mPanPan11237,968,929 - 37,987,613 (+)NCBI
Mhudiblu_PPA_v01232,555,523 - 32,573,192 (+)NCBI
PanPan1.11232,808,586 - 32,826,130 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008978590   ⟹   XP_008976838
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,184 - 37,990,847 (+)NCBI
NHGRI_mPanPan11237,968,928 - 37,987,613 (+)NCBI
Mhudiblu_PPA_v01232,555,530 - 32,573,192 (+)NCBI
PanPan1.11232,808,633 - 32,826,130 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008978591   ⟹   XP_008976839
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,183 - 37,990,847 (+)NCBI
NHGRI_mPanPan11237,968,928 - 37,987,613 (+)NCBI
Mhudiblu_PPA_v01232,555,523 - 32,573,192 (+)NCBI
PanPan1.11232,808,586 - 32,826,130 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008978593   ⟹   XP_008976841
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,185 - 37,990,847 (+)NCBI
NHGRI_mPanPan11237,968,929 - 37,987,613 (+)NCBI
Mhudiblu_PPA_v01232,555,523 - 32,572,341 (+)NCBI
PanPan1.11232,808,586 - 32,827,732 (+)NCBI
Sequence:
RefSeq Acc Id: XM_055095541   ⟹   XP_054951516
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,152 - 37,990,847 (+)NCBI
NHGRI_mPanPan11237,968,918 - 37,987,613 (+)NCBI
RefSeq Acc Id: XM_055095542   ⟹   XP_054951517
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,166 - 37,994,084 (+)NCBI
NHGRI_mPanPan11237,968,913 - 37,990,850 (+)NCBI
RefSeq Acc Id: XM_055095543   ⟹   XP_054951518
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,152 - 37,994,084 (+)NCBI
NHGRI_mPanPan11237,968,915 - 37,990,850 (+)NCBI
RefSeq Acc Id: XM_063593421   ⟹   XP_063449491
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,183 - 37,990,847 (+)NCBI
RefSeq Acc Id: XM_063593422   ⟹   XP_063449492
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,185 - 37,990,847 (+)NCBI
RefSeq Acc Id: XM_063593423   ⟹   XP_063449493
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,172 - 37,994,084 (+)NCBI
RefSeq Acc Id: XR_008620399
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,166 - 37,990,847 (+)NCBI
NHGRI_mPanPan11237,968,928 - 37,987,613 (+)NCBI
RefSeq Acc Id: XR_008620400
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21037,972,152 - 37,990,847 (+)NCBI
NHGRI_mPanPan11237,968,918 - 37,987,613 (+)NCBI
RefSeq Acc Id: XP_003824964   ⟸   XM_003824916
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C943 (UniProtKB/TrEMBL),   A0A2R9C8U7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008976841   ⟸   XM_008978593
- Peptide Label: isoform X4
- UniProtKB: A0A2R9C8U7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008976837   ⟸   XM_008978589
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8U7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008976839   ⟸   XM_008978591
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C8U7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008976838   ⟸   XM_008978590
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8U7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000038359   ⟸   ENSPPAT00000061262
Ensembl Acc Id: ENSPPAP00000038370   ⟸   ENSPPAT00000061273
RefSeq Acc Id: XP_054951517   ⟸   XM_055095542
- Peptide Label: isoform X5
RefSeq Acc Id: XP_054951518   ⟸   XM_055095543
- Peptide Label: isoform X6
RefSeq Acc Id: XP_054951516   ⟸   XM_055095541
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C943 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063449493   ⟸   XM_063593423
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063449491   ⟸   XM_063593421
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063449492   ⟸   XM_063593422
- Peptide Label: isoform X4
Protein Domains
SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000041859 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000061262.1 UniProtKB/TrEMBL
  ENSPPAT00000061273.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.532.10 UniProtKB/TrEMBL
  2.60.40.630 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
  EF-hand UniProtKB/TrEMBL
  STAT transcription factor, all-alpha domain UniProtKB/TrEMBL
InterPro p53-like_TF_DNA-bd UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  STAT UniProtKB/TrEMBL
  STAT2_C UniProtKB/TrEMBL
  STAT2_SH2 UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
  STAT_N_sf UniProtKB/TrEMBL
  STAT_TF_alpha UniProtKB/TrEMBL
  STAT_TF_coiled-coil UniProtKB/TrEMBL
  STAT_TF_DNA-bd UniProtKB/TrEMBL
  STAT_TF_DNA-bd_N UniProtKB/TrEMBL
  STAT_TF_prot_interaction UniProtKB/TrEMBL
KEGG Report pps:100972085 UniProtKB/TrEMBL
NCBI Gene STAT2 ENTREZGENE
PANTHER PTHR11801 UniProtKB/TrEMBL
  SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 2 UniProtKB/TrEMBL
Pfam SH2 UniProtKB/TrEMBL
  STAT2_C UniProtKB/TrEMBL
  STAT_alpha UniProtKB/TrEMBL
  STAT_bind UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
  STAT_linker UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  STAT_int UniProtKB/TrEMBL
Superfamily-SCOP SSF47655 UniProtKB/TrEMBL
  SSF48092 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A2R9C8U7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C943 ENTREZGENE, UniProtKB/TrEMBL