FBXW5 (F-box and WD repeat domain containing 5) - Rat Genome Database

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Gene: FBXW5 (F-box and WD repeat domain containing 5) Pan paniscus
Analyze
Symbol: FBXW5
Name: F-box and WD repeat domain containing 5
RGD ID: 11898263
Description: ENCODES a protein that exhibits protein kinase binding (inferred); INVOLVED IN proteasome-mediated ubiquitin-dependent protein catabolic process (inferred); protein ubiquitination (inferred); regulation of centrosome duplication (inferred); ASSOCIATED WITH Adams-Oliver Syndrome 5 (ortholog); autosomal dominant intellectual developmental disorder 8 (ortholog); autosomal dominant nocturnal frontal lobe epilepsy 5 (ortholog); FOUND IN Cul4-RING E3 ubiquitin ligase complex (inferred); cytoplasm (inferred); SCF ubiquitin ligase complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: F-box/WD repeat-containing protein 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,456,288 - 2,460,584 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,458,634 - 2,462,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,998,949 - 108,003,247 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,969,957 - 136,973,945 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,969,957 - 136,973,945 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
FBXW5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,456,288 - 2,460,584 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,458,634 - 2,462,918 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09107,998,949 - 108,003,247 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19136,969,957 - 136,973,945 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9136,969,957 - 136,973,945 (-)Ensemblpanpan1.1panPan2
FBXW5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389136,940,435 - 136,944,738 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9136,940,435 - 136,944,738 (-)EnsemblGRCh38hg38GRCh38
GRCh379139,834,887 - 139,839,190 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369138,954,708 - 138,958,994 (-)NCBINCBI36Build 36hg18NCBI36
Celera9110,349,118 - 110,353,404 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,294,320 - 109,297,993 (-)NCBIHuRef
CHM1_19139,983,564 - 139,987,884 (-)NCBICHM1_1
T2T-CHM13v2.09149,174,796 - 149,179,098 (-)NCBIT2T-CHM13v2.0
Fbxw5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,390,762 - 25,395,482 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,390,762 - 25,395,483 (+)EnsemblGRCm39 Ensembl
GRCm38225,500,750 - 25,505,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,500,750 - 25,505,471 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,356,298 - 25,360,990 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,322,787 - 25,327,479 (+)NCBIMGSCv36mm8
Celera225,228,300 - 25,232,992 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.31NCBI
Fbxw5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,720,670 - 28,725,237 (+)NCBIGRCr8
mRatBN7.238,322,543 - 8,327,092 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,322,543 - 8,327,092 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,428,288 - 11,432,242 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0320,014,512 - 20,018,466 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0318,204,356 - 18,208,310 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,726,705 - 2,731,213 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,727,254 - 2,731,212 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,708,140 - 2,712,626 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,673,918 - 3,677,876 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,673,917 - 3,677,876 (+)NCBI
Celera33,148,236 - 3,152,194 (+)NCBICelera
Cytogenetic Map3p13NCBI
Fbxw5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555134,993,161 - 4,996,921 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555134,993,161 - 4,996,922 (-)NCBIChiLan1.0ChiLan1.0
FBXW5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,674,299 - 48,678,846 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,673,456 - 48,679,128 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,887,844 - 47,892,230 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,552,288 - 49,556,674 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl949,552,803 - 49,556,678 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1948,328,495 - 48,332,881 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,627,207 - 48,631,592 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,674,373 - 48,678,759 (+)NCBIUU_Cfam_GSD_1.0
Fbxw5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,382,005 - 202,386,426 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669988,963 - 993,843 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669988,615 - 993,053 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FBXW5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa10.21313,759,762 - 313,764,361 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FBXW5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,246,416 - 1,250,930 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,246,702 - 1,252,688 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,050,247 - 4,054,615 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fbxw5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624760940,256 - 943,644 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624760939,896 - 943,636 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000038154   ⟹   ENSPPAP00000015464
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl9136,969,957 - 136,973,945 (-)Ensembl
RefSeq Acc Id: XM_034929583   ⟹   XP_034785474
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2112,456,288 - 2,460,584 (+)NCBI
NHGRI_mPanPan192,458,634 - 2,462,918 (+)NCBI
Mhudiblu_PPA_v09107,998,949 - 108,003,247 (-)NCBI
RefSeq Acc Id: XM_034929584   ⟹   XP_034785475
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2112,456,996 - 2,460,584 (+)NCBI
NHGRI_mPanPan192,459,340 - 2,462,918 (+)NCBI
Mhudiblu_PPA_v09107,998,949 - 108,002,531 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034785474 (Get FASTA)   NCBI Sequence Viewer  
  XP_034785475 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000015464.1
Reference Protein Sequences
RefSeq Acc Id: XP_034785474   ⟸   XM_034929583
- Peptide Label: isoform X1
- UniProtKB: A0A2R9AIN8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034785475   ⟸   XM_034929584
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000015464   ⟸   ENSPPAT00000038154
Protein Domains
F-box


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000030876 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000038154.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1280.50 UniProtKB/TrEMBL
  2.130.10.10 UniProtKB/TrEMBL
InterPro F-box-like_dom_sf UniProtKB/TrEMBL
  F-box_dom UniProtKB/TrEMBL
  FBXW5 UniProtKB/TrEMBL
  WD40/YVTN_repeat-like_dom_sf UniProtKB/TrEMBL
  WD40_repeat UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/TrEMBL
NCBI Gene FBXW5 ENTREZGENE
PANTHER F-BOX/WD REPEAT-CONTAINING PROTEIN 5 UniProtKB/TrEMBL
  PTHR20995 UniProtKB/TrEMBL
Pfam F-box-like UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
PROSITE FBOX UniProtKB/TrEMBL
  WD_REPEATS_2 UniProtKB/TrEMBL
  WD_REPEATS_REGION UniProtKB/TrEMBL
SMART FBOX UniProtKB/TrEMBL
  WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/TrEMBL
  SSF81383 UniProtKB/TrEMBL
UniProt A0A2R9AIN8 ENTREZGENE, UniProtKB/TrEMBL