PRKD2 (protein kinase D2) - Rat Genome Database
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Gene: PRKD2 (protein kinase D2) Pan paniscus
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Symbol: PRKD2
Name: protein kinase D2
RGD ID: 11897261
Description: ENCODES a protein that exhibits protein kinase activity (ortholog); protein kinase C binding (ortholog); protein serine/threonine kinase activity (ortholog); INVOLVED IN cell death (ortholog); cellular response to vascular endothelial growth factor stimulus (ortholog); intracellular signal transduction (ortholog); ASSOCIATED WITH B-Cell Chronic Lymphocytic Leukemia (ortholog); polycystic ovary syndrome (ortholog); Walker-Warburg syndrome (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC112437897; LOW QUALITY PROTEIN: serine/threonine-protein kinase D2; serine/threonine-protein kinase D2; uncharacterized LOC112437897
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,195,096 - 52,238,758 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,195,303 - 52,237,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01943,666,591 - 43,710,858 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell death  (ISO)
cellular response to vascular endothelial growth factor stimulus  (ISO)
intracellular signal transduction  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of blood vessel endothelial cell migration  (ISO)
positive regulation of cell adhesion  (ISO)
positive regulation of CREB transcription factor activity  (ISO)
positive regulation of DNA biosynthetic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endothelial cell chemotaxis  (ISO)
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway  (ISO)
positive regulation of endothelial cell migration  (ISO)
positive regulation of endothelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast growth factor receptor signaling pathway  (ISO)
positive regulation of histone deacetylase activity  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of intracellular signal transduction  (ISO)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of T cell receptor signaling pathway  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular endothelial growth factor receptor signaling pathway  (ISO)
protein autophosphorylation  (ISO)
protein kinase D signaling  (ISO)
protein phosphorylation  (ISO)
T cell receptor signaling pathway  (ISO)
vascular endothelial growth factor receptor signaling pathway  (ISO)

Cellular Component
cytoplasm  (ISO)
cytosol  (ISO)
nucleoplasm  (ISO)
nucleus  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
PRKD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11952,195,096 - 52,238,758 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1952,195,303 - 52,237,731 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01943,666,591 - 43,710,858 (-)NCBIMhudiblu_PPA_v0panPan3
PRKD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1946,674,275 - 46,717,127 (-)EnsemblGRCh38hg38GRCh38
GRCh381946,674,316 - 46,717,114 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371947,177,573 - 47,220,371 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361951,869,413 - 51,912,224 (-)NCBINCBI36hg18NCBI36
Build 341951,869,412 - 51,911,506NCBI
Celera1943,981,103 - 44,023,914 (-)NCBI
Cytogenetic Map19q13.32NCBI
HuRef1943,602,696 - 43,645,312 (-)NCBIHuRef
CHM1_11947,179,449 - 47,222,284 (-)NCBICHM1_1
Prkd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39716,576,827 - 16,604,386 (+)NCBIGRCm39mm39
GRCm39 Ensembl716,576,827 - 16,604,389 (+)Ensembl
GRCm38716,842,902 - 16,870,461 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl716,842,902 - 16,870,464 (+)EnsemblGRCm38mm10GRCm38
MGSCv37717,428,414 - 17,455,810 (+)NCBIGRCm37mm9NCBIm37
MGSCv36716,001,587 - 16,028,983 (+)NCBImm8
Celera714,041,053 - 14,076,870 (+)NCBICelera
Cytogenetic Map7A2NCBI
Prkd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2177,513,625 - 77,542,386 (+)NCBI
Rnor_6.0 Ensembl178,767,911 - 78,796,231 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0178,767,911 - 78,796,223 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0180,015,106 - 80,043,535 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4177,168,290 - 77,197,277 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1177,246,400 - 77,275,388 (+)NCBI
Celera171,999,137 - 72,027,468 (+)NCBICelera
Cytogenetic Map1q21NCBI
Prkd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955574723,933 - 750,793 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955574723,933 - 750,794 (-)NCBIChiLan1.0ChiLan1.0
PRKD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1109,207,067 - 109,330,007 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11109,206,400 - 109,241,529 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Prkd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936664524,532 - 551,451 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PRKD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl652,559,393 - 52,599,132 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1652,559,066 - 52,599,174 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2647,880,007 - 47,919,799 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PRKD2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1640,028,214 - 40,071,523 (-)NCBI
ChlSab1.1 Ensembl640,027,552 - 40,071,455 (-)Ensembl
Prkd2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248326,885,627 - 6,915,316 (+)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000051321   ⟹   ENSPPAP00000028474
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1952,195,303 - 52,237,731 (-)Ensembl
RefSeq Acc Id: XM_034945994   ⟹   XP_034801885
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01943,666,591 - 43,709,465 (-)NCBI
RefSeq Acc Id: XM_034945995   ⟹   XP_034801886
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01943,666,591 - 43,709,689 (-)NCBI
RefSeq Acc Id: XM_034945996   ⟹   XP_034801887
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01943,666,591 - 43,709,830 (-)NCBI
RefSeq Acc Id: XM_034945997   ⟹   XP_034801888
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01943,666,591 - 43,708,578 (-)NCBI
RefSeq Acc Id: XR_004667958
RefSeq Status:
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01943,670,911 - 43,710,858 (-)NCBI
Protein Sequences
Protein RefSeqs XP_034801885 (Get FASTA)   NCBI Sequence Viewer  
  XP_034801886 (Get FASTA)   NCBI Sequence Viewer  
  XP_034801887 (Get FASTA)   NCBI Sequence Viewer  
  XP_034801888 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_034801887   ⟸   XM_034945996
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034801886   ⟸   XM_034945995
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034801885   ⟸   XM_034945994
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034801888   ⟸   XM_034945997
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000028474   ⟸   ENSPPAT00000051321
Protein Domains
PH   Phorbol-ester/DAG-type   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037267 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000028474 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000051321 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
InterPro DAG/PE-bd UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  PE/DAG-bd UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Protein_Kinase_C_mu-related UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene PRKD2 ENTREZGENE
PANTHER PTHR22968 UniProtKB/TrEMBL
Pfam C1_1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_Tyr UniProtKB/TrEMBL
PIRSF PKC_mu_nu_D2 UniProtKB/TrEMBL
PRINTS DAGPEDOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  ZF_DAG_PE_1 UniProtKB/TrEMBL
  ZF_DAG_PE_2 UniProtKB/TrEMBL
SMART SM00109 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9BFP5_PANPA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-11 PRKD2  protein kinase D2  LOC112437897  uncharacterized LOC112437897  Data Merged 737654 PROVISIONAL