PREPL (prolyl endopeptidase like) - Rat Genome Database

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Gene: PREPL (prolyl endopeptidase like) Pan paniscus
Analyze
Symbol: PREPL
Name: prolyl endopeptidase like
RGD ID: 11895619
Description: ENCODES a protein that exhibits peptidase activity (inferred); serine-type endopeptidase activity (inferred); serine-type peptidase activity (inferred); INVOLVED IN Golgi to plasma membrane protein transport (inferred); proteolysis (inferred); regulation of synaptic vesicle exocytosis (inferred); ASSOCIATED WITH congenital myasthenic syndrome (ortholog); congenital myasthenic syndrome 22 (ortholog); cystinuria (ortholog); FOUND IN cytoskeleton (inferred); cytosol (inferred); Golgi apparatus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: prolyl endopeptidase-like
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,044,665 - 82,090,876 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,048,635 - 82,094,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A44,417,735 - 44,463,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A45,353,326 - 45,398,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A45,353,326 - 45,397,903 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
PREPL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21282,044,665 - 82,090,876 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A82,048,635 - 82,094,846 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A44,417,735 - 44,463,542 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A45,353,326 - 45,398,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A45,353,326 - 45,397,903 (-)Ensemblpanpan1.1panPan2
PREPL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38244,317,607 - 44,361,862 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl244,316,281 - 44,361,862 (-)EnsemblGRCh38hg38GRCh38
GRCh37244,544,746 - 44,589,001 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36244,399,406 - 44,440,393 (-)NCBINCBI36Build 36hg18NCBI36
Celera244,383,700 - 44,427,951 (-)NCBICelera
Cytogenetic Map2p21NCBI
HuRef244,281,407 - 44,325,655 (-)NCBIHuRef
CHM1_1244,472,451 - 44,516,684 (-)NCBICHM1_1
T2T-CHM13v2.0244,322,928 - 44,367,164 (-)NCBIT2T-CHM13v2.0
Prepl
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391785,370,122 - 85,397,702 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1785,370,898 - 85,397,669 (-)EnsemblGRCm39 Ensembl
GRCm381785,062,511 - 85,090,504 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1785,063,470 - 85,090,241 (-)EnsemblGRCm38mm10GRCm38
MGSCv371785,462,817 - 85,489,614 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361784,971,812 - 84,998,534 (-)NCBIMGSCv36mm8
Celera1789,425,166 - 89,451,900 (-)NCBICelera
Cytogenetic Map17E4NCBI
cM Map1755.19NCBI
Prepl
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8615,333,107 - 15,362,825 (+)NCBIGRCr8
mRatBN7.269,580,367 - 9,609,957 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl69,580,217 - 9,607,772 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx69,869,516 - 9,898,814 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0610,178,893 - 10,208,191 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.069,700,429 - 9,729,763 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.068,316,861 - 8,346,293 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl68,318,979 - 8,346,197 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.068,249,345 - 8,278,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.468,419,874 - 8,447,739 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.168,419,873 - 8,447,739 (-)NCBI
Celera69,304,799 - 9,331,994 (+)NCBICelera
Cytogenetic Map6q12NCBI
Prepl
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544111,418,299 - 11,453,218 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544111,418,299 - 11,453,889 (-)NCBIChiLan1.0ChiLan1.0
PREPL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11046,733,769 - 46,792,465 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1046,726,676 - 46,792,405 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1046,595,349 - 46,654,047 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01047,613,473 - 47,672,368 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1047,613,473 - 47,672,322 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11047,320,610 - 47,379,420 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01047,611,662 - 47,670,468 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01047,794,300 - 47,853,142 (-)NCBIUU_Cfam_GSD_1.0
Prepl
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629236,209,248 - 36,243,112 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365087,637,882 - 7,674,877 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365087,637,844 - 7,674,232 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PREPL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl396,092,334 - 96,159,525 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1396,092,314 - 96,159,533 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23102,248,639 - 102,314,853 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PREPL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11462,879,616 - 62,925,265 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1462,875,133 - 62,924,746 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604548,954,858 - 49,006,885 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Prepl
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473825,802,793 - 25,834,762 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473825,802,156 - 25,835,663 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000057759   ⟹   ENSPPAP00000034874
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A45,353,326 - 45,397,903 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057782   ⟹   ENSPPAP00000034897
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A45,355,917 - 45,396,061 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000057785   ⟹   ENSPPAP00000034900
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2A45,355,917 - 45,396,061 (-)Ensembl
RefSeq Acc Id: XM_003822646   ⟹   XP_003822694
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21282,045,277 - 82,090,876 (+)NCBI
NHGRI_mPanPan12A82,049,230 - 82,094,846 (+)NCBI
Mhudiblu_PPA_v02A44,417,735 - 44,463,203 (-)NCBI
PanPan1.12A45,353,326 - 45,397,907 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003822648   ⟹   XP_003822696
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21282,044,954 - 82,090,876 (+)NCBI
NHGRI_mPanPan12A82,048,924 - 82,094,846 (+)NCBI
Mhudiblu_PPA_v02A44,417,735 - 44,463,242 (-)NCBI
PanPan1.12A45,353,326 - 45,397,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003822650   ⟹   XP_003822698
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21282,044,799 - 82,090,876 (+)NCBI
NHGRI_mPanPan12A82,048,769 - 82,094,846 (+)NCBI
Mhudiblu_PPA_v02A44,417,735 - 44,463,542 (-)NCBI
PanPan1.12A45,353,326 - 45,398,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008976234   ⟹   XP_008974482
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21282,044,959 - 82,090,876 (+)NCBI
NHGRI_mPanPan12A82,048,929 - 82,094,846 (+)NCBI
Mhudiblu_PPA_v02A44,417,735 - 44,463,203 (-)NCBI
PanPan1.12A45,353,326 - 45,397,883 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008976235   ⟹   XP_008974483
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21282,045,255 - 82,090,876 (+)NCBI
NHGRI_mPanPan12A82,049,225 - 82,094,846 (+)NCBI
Mhudiblu_PPA_v02A44,417,735 - 44,463,189 (-)NCBI
PanPan1.12A45,353,326 - 45,397,859 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008976236   ⟹   XP_008974484
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21282,045,239 - 82,090,876 (+)NCBI
NHGRI_mPanPan12A82,049,209 - 82,094,846 (+)NCBI
Mhudiblu_PPA_v02A44,417,735 - 44,463,236 (-)NCBI
PanPan1.12A45,353,326 - 45,397,898 (-)NCBI
Sequence:
RefSeq Acc Id: XM_055108019   ⟹   XP_054963994
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21282,044,665 - 82,090,876 (+)NCBI
NHGRI_mPanPan12A82,048,635 - 82,094,846 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: XP_003822698   ⟸   XM_003822650
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8X9 (UniProtKB/TrEMBL),   A0A2R9BYZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003822696   ⟸   XM_003822648
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8X9 (UniProtKB/TrEMBL),   A0A2R9BYZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003822694   ⟸   XM_003822646
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BYZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008974484   ⟸   XM_008976236
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BYZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008974482   ⟸   XM_008976234
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8X9 (UniProtKB/TrEMBL),   A0A2R9BYZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008974483   ⟸   XM_008976235
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8X9 (UniProtKB/TrEMBL),   A0A2R9BYZ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000034874   ⟸   ENSPPAT00000057759
RefSeq Acc Id: ENSPPAP00000034897   ⟸   ENSPPAT00000057782
RefSeq Acc Id: ENSPPAP00000034900   ⟸   ENSPPAT00000057785
RefSeq Acc Id: XP_054963994   ⟸   XM_055108019
- Peptide Label: isoform X1
- UniProtKB: A0A2R9C8X9 (UniProtKB/TrEMBL)
Protein Domains
Peptidase S9 prolyl oligopeptidase catalytic   Peptidase S9A N-terminal


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040256 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000057759.1 UniProtKB/TrEMBL
  ENSPPAT00000057782.1 UniProtKB/TrEMBL
  ENSPPAT00000057785.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
  Prolyl oligopeptidase, N-terminal domain UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Pept_S9A_N UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
  Peptidase_S9A UniProtKB/TrEMBL
NCBI Gene PREPL ENTREZGENE
PANTHER PROLYL ENDOPEPTIDASE-LIKE UniProtKB/TrEMBL
  PROTEASE FAMILY S9A OLIGOPEPTIDASE UniProtKB/TrEMBL
Pfam Peptidase_S9 UniProtKB/TrEMBL
  Peptidase_S9_N UniProtKB/TrEMBL
PRINTS PROLIGOPTASE UniProtKB/TrEMBL
Superfamily-SCOP Peptidase/esterase 'gauge' domain UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A2R9BYZ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C280_PANPA UniProtKB/TrEMBL
  A0A2R9C8X9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-01-09 PREPL  prolyl endopeptidase like    prolyl endopeptidase-like  Symbol and/or name change 5135510 APPROVED