DMC1 (DNA meiotic recombinase 1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: DMC1 (DNA meiotic recombinase 1) Pan paniscus
Analyze
Symbol: DMC1
Name: DNA meiotic recombinase 1
RGD ID: 11895005
Description: ENCODES a protein that exhibits ATP binding (inferred); ATP hydrolysis activity (inferred); ATP-dependent activity, acting on DNA (inferred); INVOLVED IN gamete generation (ortholog); homologous chromosome pairing at meiosis (ortholog); male meiosis I (ortholog); ASSOCIATED WITH adenylosuccinase lyase deficiency (ortholog); azoospermia (ortholog); Emery-Dreifuss muscular dystrophy (ortholog); FOUND IN site of double-strand break (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DMC1 dosage suppressor of mck1 homolog, meiosis-specific homologous recombination; meiotic recombination protein DMC1/LIM15 homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,372,518 - 48,426,403 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02219,433,989 - 19,485,804 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,253,609 - 37,305,769 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,253,609 - 37,305,769 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
DMC1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22348,372,518 - 48,426,403 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02219,433,989 - 19,485,804 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12237,253,609 - 37,305,769 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2237,253,609 - 37,305,769 (-)Ensemblpanpan1.1panPan2
DMC1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382238,509,147 - 38,570,183 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2238,518,948 - 38,570,204 (-)EnsemblGRCh38hg38GRCh38
GRCh372238,914,953 - 38,966,188 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362237,244,900 - 37,296,135 (-)NCBINCBI36Build 36hg18NCBI36
Build 342237,239,453 - 37,290,689NCBI
Celera2222,720,538 - 22,771,771 (-)NCBICelera
Cytogenetic Map22q13.1NCBI
HuRef2221,880,996 - 21,931,997 (-)NCBIHuRef
CHM1_12238,873,735 - 38,925,022 (-)NCBICHM1_1
T2T-CHM13v2.02238,973,412 - 39,034,483 (-)NCBIT2T-CHM13v2.0
Dmc1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391579,445,698 - 79,489,362 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1579,445,698 - 79,489,310 (-)EnsemblGRCm39 Ensembl
GRCm381579,561,497 - 79,605,159 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1579,561,497 - 79,605,109 (-)EnsemblGRCm38mm10GRCm38
MGSCv371579,391,930 - 79,435,514 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361579,388,755 - 79,432,339 (-)NCBIMGSCv36mm8
Celera1581,685,957 - 81,730,849 (-)NCBICelera
Cytogenetic Map15E1NCBI
cM Map1537.79NCBI
Dmc1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87113,005,278 - 113,047,854 (-)NCBIGRCr8
mRatBN7.27111,124,888 - 111,167,465 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7111,124,888 - 111,167,952 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx7112,872,520 - 112,915,092 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07115,096,054 - 115,138,630 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07115,065,426 - 115,108,004 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.07120,796,217 - 120,840,524 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7120,796,217 - 120,839,577 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.07120,789,043 - 120,833,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.47117,476,702 - 117,520,670 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.17117,514,418 - 117,553,900 (+)NCBI
Celera7107,456,300 - 107,498,828 (-)NCBICelera
Cytogenetic Map7q34NCBI
Dmc1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541324,684,073 - 24,724,344 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541324,685,311 - 24,724,269 (-)NCBIChiLan1.0ChiLan1.0
DMC1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11026,228,662 - 26,265,377 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1026,230,428 - 26,264,820 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1026,184,319 - 26,220,549 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01027,019,568 - 27,056,278 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1027,019,605 - 27,056,226 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11026,741,166 - 26,777,610 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01027,052,510 - 27,089,151 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01027,229,297 - 27,265,765 (+)NCBIUU_Cfam_GSD_1.0
Dmc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244049459,742,723 - 9,778,354 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364922,753,289 - 2,788,102 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364922,754,694 - 2,788,249 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DMC1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl59,431,177 - 9,470,113 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.159,431,236 - 9,470,333 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.256,712,304 - 6,750,854 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DMC1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11921,179,495 - 21,230,078 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1921,180,194 - 21,228,120 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666045104,535,164 - 104,586,450 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dmc1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247529,548,015 - 9,585,958 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247529,547,327 - 9,585,549 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000056603   ⟹   ENSPPAP00000033726
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2237,253,609 - 37,305,769 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000056605   ⟹   ENSPPAP00000033728
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2237,253,609 - 37,305,769 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000056609   ⟹   ENSPPAP00000033732
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl2237,254,672 - 37,303,738 (-)Ensembl
RefSeq Acc Id: XM_003821593   ⟹   XP_003821641
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22348,372,518 - 48,426,403 (-)NCBI
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBI
Mhudiblu_PPA_v02219,433,989 - 19,485,753 (-)NCBI
PanPan1.12237,253,609 - 37,305,769 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008975093   ⟹   XP_008973341
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22348,372,518 - 48,426,399 (-)NCBI
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBI
Mhudiblu_PPA_v02219,433,989 - 19,485,743 (-)NCBI
PanPan1.12237,253,609 - 37,305,769 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034948627   ⟹   XP_034804518
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22348,372,518 - 48,426,403 (-)NCBI
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBI
Mhudiblu_PPA_v02219,434,592 - 19,485,753 (-)NCBI
RefSeq Acc Id: XM_055105714   ⟹   XP_054961689
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22348,372,518 - 48,426,403 (-)NCBI
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBI
RefSeq Acc Id: XM_055105715   ⟹   XP_054961690
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22348,372,518 - 48,426,316 (-)NCBI
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBI
RefSeq Acc Id: XM_055105716   ⟹   XP_054961691
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22348,372,518 - 48,426,403 (-)NCBI
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBI
RefSeq Acc Id: XM_055105717   ⟹   XP_054961692
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22348,372,518 - 48,426,399 (-)NCBI
NHGRI_mPanPan12251,063,957 - 51,117,848 (-)NCBI
RefSeq Acc Id: XP_008973341   ⟸   XM_008975093
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BVM3 (UniProtKB/TrEMBL),   A0A2R9BVM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003821641   ⟸   XM_003821593
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BW93 (UniProtKB/TrEMBL),   A0A2R9BVM5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034804518   ⟸   XM_034948627
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BW93 (UniProtKB/TrEMBL),   A0A2R9BVM5 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000033726   ⟸   ENSPPAT00000056603
RefSeq Acc Id: ENSPPAP00000033728   ⟸   ENSPPAT00000056605
RefSeq Acc Id: ENSPPAP00000033732   ⟸   ENSPPAT00000056609
RefSeq Acc Id: XP_054961690   ⟸   XM_055105715
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BW93 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054961692   ⟸   XM_055105717
- Peptide Label: isoform X3
- UniProtKB: A0A2R9BVM3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054961691   ⟸   XM_055105716
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054961689   ⟸   XM_055105714
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BW93 (UniProtKB/TrEMBL)
Protein Domains
RecA family profile


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039727 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056603.1 UniProtKB/TrEMBL
  ENSPPAT00000056605.1 UniProtKB/TrEMBL
  ENSPPAT00000056609.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.300 UniProtKB/TrEMBL
  5' to 3' exonuclease, C-terminal subdomain UniProtKB/TrEMBL
InterPro AAA+_ATPase UniProtKB/TrEMBL
  Dmc1 UniProtKB/TrEMBL
  DNA_recomb/repair_Rad51_C UniProtKB/TrEMBL
  DNA_recomb/repair_RecA-like UniProtKB/TrEMBL
  DNA_repair_Rad51/TF_NusA_a-hlx UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RecA_ATP-bd UniProtKB/TrEMBL
  RecA_monomer-monomer_interface UniProtKB/TrEMBL
KEGG Report pps:100977598 UniProtKB/TrEMBL
NCBI Gene DMC1 ENTREZGENE
PANTHER MEIOTIC RECOMBINATION PROTEIN DMC1/LIM15 HOMOLOG UniProtKB/TrEMBL
  RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER UniProtKB/TrEMBL
Pfam HHH_5 UniProtKB/TrEMBL
  Rad51 UniProtKB/TrEMBL
PIRSF Rad51 UniProtKB/TrEMBL
PROSITE RECA_2 UniProtKB/TrEMBL
  RECA_3 UniProtKB/TrEMBL
SMART AAA UniProtKB/TrEMBL
Superfamily-SCOP SSF47794 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9BVM3 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BVM5 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BW93 ENTREZGENE, UniProtKB/TrEMBL