PGAM1 (phosphoglycerate mutase 1)

Gene: PGAM1 (phosphoglycerate mutase 1) Pan paniscus

Analyze

Symbol:

PGAM1

Name:

phosphoglycerate mutase 1

RGD ID:

11887182

Description:

ENCODES a protein that exhibits phosphoglycerate mutase activity (ortholog); protein kinase binding (ortholog); INVOLVED IN canonical glycolysis (ortholog); gluconeogenesis (ortholog); PARTICIPATES IN Fanconi syndrome pathway; fructose-1,6-bisphosphatase deficiency pathway; gluconeogenesis pathway; ASSOCIATED WITH adenocarcinoma (ortholog); Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog)

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	109,340,381 - 109,347,709 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	109,345,921 - 109,353,028 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	94,048,829 - 94,056,082 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	97,542,558 - 97,549,867 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	97,542,558 - 97,549,867 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

Animal Mammary Neoplasms (ISO)

carcinoma (ISO)

Experimental Mammary Neoplasms (ISO)

genetic disease (ISO)

lung non-small cell carcinoma (ISO)

Mouth Neoplasms (ISO)

squamous cell carcinoma (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

canonical glycolysis (ISO)

gluconeogenesis (ISO)

glycolytic process (IEA)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

Molecular Function

2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity (IEA)

bisphosphoglycerate mutase activity (IEA)

intramolecular phosphotransferase activity (IEA)

isomerase activity (IEA)

phosphoglycerate mutase activity (IEA,ISO)

protein binding (ISO)

protein kinase binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

Fanconi syndrome pathway (ISO)

fructose-1,6-bisphosphatase deficiency pathway (ISO)

gluconeogenesis pathway (ISO)

glycogen storage disease type Ia pathway (ISO)

glycogen storage disease type Ib pathway (ISO)

glycogen storage disease type VII pathway (ISO)

glycolysis pathway (ISO)

phosphoenolpyruvate carboxykinase deficiency pathway (ISO)

triosephosphate isomerase deficiency pathway (ISO)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

PGAM1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	109,340,381 - 109,347,709 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	109,345,921 - 109,353,028 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	94,048,829 - 94,056,082 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	97,542,558 - 97,549,867 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	97,542,558 - 97,549,867 (+)	Ensembl	panpan1.1		panPan2

PGAM1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	97,426,191 - 97,433,444 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	97,426,191 - 97,433,444 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	99,185,948 - 99,193,201 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	99,176,017 - 99,183,188 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	99,176,016 - 99,183,187	NCBI
Celera	10	92,924,180 - 92,931,355 (+)	NCBI		Celera
Cytogenetic Map	10	q24.1	NCBI
HuRef	10	92,811,681 - 92,818,852 (+)	NCBI		HuRef
CHM1_1	10	99,467,767 - 99,474,938 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	98,306,372 - 98,313,625 (+)	NCBI		T2T-CHM13v2.0

Pgam1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	41,900,310 - 41,907,104 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	41,900,362 - 41,907,099 (+)	Ensembl		GRCm39 Ensembl
GRCm38	19	41,911,871 - 41,918,665 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	41,911,923 - 41,918,660 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	19	41,986,361 - 41,993,155 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	19	41,965,271 - 41,971,976 (+)	NCBI		MGSCv36	mm8
Celera	19	42,711,451 - 42,718,243 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	35.44	NCBI

Pgam1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	250,673,152 - 250,680,762 (+)	NCBI		GRCr8
mRatBN7.2	1	240,723,832 - 240,731,443 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	240,723,920 - 240,738,452 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	248,868,982 - 248,876,729 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	255,566,135 - 255,573,881 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	248,219,147 - 248,226,892 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	261,158,204 - 261,165,814 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	261,158,261 - 261,165,808 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	268,610,733 - 268,618,280 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	236,559,231 - 236,566,463 (+)	NCBI		Celera
Cytogenetic Map	1	q54	NCBI

Pgam1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955507	3,562,513 - 3,571,400 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955507	3,562,513 - 3,571,400 (+)	NCBI	ChiLan1.0	ChiLan1.0

PGAM1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	10,720,235 - 10,727,709 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	10,720,094 - 10,930,286 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	10,902,930 - 10,910,408 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	11,042,559 - 11,050,038 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	11,042,496 - 11,050,038 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	10,703,632 - 10,711,101 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	10,764,397 - 10,771,643 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	10,904,327 - 10,911,807 (+)	NCBI		UU_Cfam_GSD_1.0

Pgam1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	36,201,336 - 36,209,529 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936636	2,236,508 - 2,248,768 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936636	2,240,452 - 2,248,689 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PGAM1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	108,822,812 - 108,833,058 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	108,822,782 - 108,832,818 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	118,326,760 - 118,336,762 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PGAM1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	90,581,593 - 90,585,054 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	51,492,428 - 51,500,247 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Pgam1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	9,088,539 - 9,096,348 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624737	9,088,545 - 9,096,350 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003825429	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000008	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000033340 ⟹ ENSPPAP00000010688

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	10	97,542,558 - 97,549,867 (+)	Ensembl

RefSeq Acc Id:

XM_003825429 ⟹ XP_003825477

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	8	109,340,381 - 109,347,709 (+)	NCBI
NHGRI_mPanPan1	10	109,345,921 - 109,353,028 (+)	NCBI
Mhudiblu_PPA_v0	10	94,048,829 - 94,056,082 (+)	NCBI
PanPan1.1	10	97,542,558 - 97,549,867 (+)	NCBI

Sequence:

show sequence

GCCCCCTCCCGTCGGGGCCGCAGCGCCAGGATGCGGCGCATGCGCACACCTGGAGGGCGGAGAG
CGGTCCAGAGCGAGTGGAAAGATTTGGGCGAGAACTTGCGCGGGAGCCGGACTGTGCGGTGCGA
GCGCGCAGGCGCGGCCGACGGGGCGGGCTGCTACTCCGGAATCTGCTAATCCCAGTCGGTGCCG
CATCCCCAGCCCGCCGCCATGGCCGCCTACAAACTGGTGCTGATCCGGCACGGCGAGAGCGCAT
GGAACCTGGAGAACCGCTTCAGCGGCTGGTACGACGCCGACCTCAGCCCGGCGGGCCACGAGGA
GGCGAAGCGCGGCGGGCAGGCGCTACGAGATGCTGGCTATGAGTTTGACATCTGCTTCACCTCA
GTGCAGAAGAGAGCGATCCGGACCCTCTGGACAGTGCTAGATGCCATTGATCAGATGTGGCTGC
CAGTGGTGAGGACTTGGCGCCTCAACGAGCGGCACTATGGGGGTCTAACCGGTCTCAATAAAGC
AGAAACTGCTGCAAAGCATGGTGAGGCCCAGGTGAAGATCTGGAGGCGCTCCTATGATGTCCCA
CCACCTCCGATGGAGCCCGACCATCCTTTCTACAGCAACATCAGTAAGGATCGCAGGTATGCAG
ACCTCACAGAAGATCAGCTACCCTCCTGTGAGAGTCTGAAGGATACTATTGCCAGAGCTCTGCC
CTTCTGGAATGAAGAAATAGTTCCCCAGATCAAGGAGGGGAAACGTGTACTGATTGCAGCCCAT
GGCAACAGCCTCCGGGGCATTGTCAAGCATCTGGAGGGTCTCTCTGAAGAGGCTATCATGGAGC
TGAACCTGCCGACTGGTATTCCCATTGTCTATGAATTGGACAAGAACTTGAAGCCTATCAAGCC
CATGCAGTTTCTGGGGGATGAAGAGACGGTGCGCAAAGCCATGGAAGCTGTGGCTGCCCAGGGC
AAGGCCAAGAAGTGAAGGCCGGCGGGGAGGATACTGTCCCCAGGAGCACCCTCCCTGCCTGTCT
TGTCCCTCTGCCCCTCCCACCTGCACATGTCACACTGACCACATCTGTAGACATCTTGAGTTGT
AGCTGCATATGGGGACCAGTGGCTCCCATTTTCATTTAGCCATTTTGTCGCCTGCACCCACTCC
CTTCATACAATCTAGTCAGAATAGCAGTTCTGGAGCACAGGTTCTCAGTCTAAGCTATGGAAAA
GCTCCCCTTATCCAACAGAGTTTAAAAGTAGTGACTTGGGTTTTGCGAGTGCTTTGTTTACTAA
GGACTTTGGGGAGGAACCATGCTAAGTCATGACCAGTGAGGAGAAGCAACAGAGCCTGTCTGTC
CCCATGAGCAGAGTCTGTCCTCTGCTCTTCTGCAGTCAGGCCACTGCCCACTGCCTGGGGGCTC
TAGTCATTCCAGTGGAAGACGAATGTAACCTGCGTGGTGATGTGACAACTGTTTCCTCCCTGAC
CCCAGAGGATCTGGCTCTAGGTTGGGATCAATCCTGAATTTCGTTATGTGTTAATTTACTTTTA
TTAAAAAAGTATAGTATATATAAATAATACAAAACAATAACCCTTCTGGGGTTTCTTGTGGCGG
TTGAAATAGTCCCACATGTGGTCATCAGAAAATAAGCCATTCCTCATACCAATGTAGGATCAGC
TCCTTGACCTCTGAGGGGCAGGAGTGCTTCCTGGTGTGTGTATTAGAATCCCTTCCTGCCTTGT
TTCATGGCAGTGAAATGCCTCTTGGTCCTGTCCAAGTGTGTCTTTCACTGATTTCTGAATCATG
TTCTAGTTGCTTGACCCTGCCACATGGGTCCAGTGTTCATCTGAGCATAACTGTACTAAATCCT
TTTTCCATGTCAGTATAATAAAGGAGTGATGTGCAATAGC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003825477	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000001192.1
	ENSPPAP00000010688
	ENSPPAP00000010688.1

RefSeq Acc Id:

XP_003825477 ⟸ XM_003825429

- UniProtKB:

A0A2R9A1H4 (UniProtKB/TrEMBL), A0A2R8Z8F8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAAYKLVLIRHGESAWNLENRFSGWYDADLSPAGHEEAKRGGQALRDAGYEFDICFTSVQKRAI
RTLWTVLDAIDQMWLPVVRTWRLNERHYGGLTGLNKAETAAKHGEAQVKIWRRSYDVPPPPMEP
DHPFYSNISKDRRYADLTEDQLPSCESLKDTIARALPFWNEEIVPQIKEGKRVLIAAHGNSLRG
IVKHLEGLSEEAIMELNLPTGIPIVYELDKNLKPIKPMQFLGDEETVRKAMEAVAAQGKAKK

hide sequence

RefSeq Acc Id:

ENSPPAP00000010688 ⟸ ENSPPAT00000033340

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000004829	UniProtKB/TrEMBL
	ENSPPAG00000028548	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000005678.1	UniProtKB/TrEMBL
	ENSPPAT00000033340.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.1240	UniProtKB/TrEMBL
InterPro	His_Pase_superF_clade-1	UniProtKB/TrEMBL
	His_PPase_superfam	UniProtKB/TrEMBL
	PG/BPGM_mutase_AS	UniProtKB/TrEMBL
	Phosphogly_mut1	UniProtKB/TrEMBL
KEGG Report	pps:100982690	UniProtKB/TrEMBL
NCBI Gene	PGAM1	ENTREZGENE
PANTHER	PHOSPHOGLYCERATE MUTASE 1	UniProtKB/TrEMBL
	PTHR11931	UniProtKB/TrEMBL
Pfam	His_Phos_1	UniProtKB/TrEMBL
PIRSF	6PFK_2-Ptase	UniProtKB/TrEMBL
PROSITE	PG_MUTASE	UniProtKB/TrEMBL
SMART	PGAM	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53254	UniProtKB/TrEMBL
UniProt	A0A2R8Z8F8	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9A1H4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB