CLTRN (collectrin, amino acid transport regulator)

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Gene: CLTRN (collectrin, amino acid transport regulator) Pan paniscus

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Symbol:

CLTRN

Name:

collectrin, amino acid transport regulator

RGD ID:

11875209

Description:

ENCODES a protein that exhibits protein homodimerization activity (ortholog); INVOLVED IN positive regulation of amino acid transport (ortholog); positive regulation of calcium ion-dependent exocytosis (ortholog); positive regulation of insulin secretion involved in cellular response to glucose stimulus (ortholog); ASSOCIATED WITH autistic disorder (ortholog); hepatocellular carcinoma (ortholog); Neurodevelopmental Disorders (ortholog); FOUND IN brush border membrane (ortholog); cytoplasm (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

collectrin; TMEM27; transmembrane protein 27

RGD Orthologs

Human

Mouse

Rat

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	X	15,537,112 - 15,574,842 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	X	8,255,666 - 8,293,354 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

hepatocellular carcinoma (ISO)

Neurodevelopmental Disorders (ISO)

Renal Aminoacidurias (ISO)

syndromic X-linked intellectual disability Lubs type (ISO)

ureteral obstruction (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

positive regulation of amino acid transport (ISO)

positive regulation of calcium ion-dependent exocytosis (ISO)

positive regulation of insulin secretion involved in cellular response to glucose stimulus (ISO)

positive regulation of L-proline import across plasma membrane (ISO)

positive regulation of SNARE complex assembly (ISO)

regulation of transmembrane transporter activity (ISO)

Cellular Component

brush border membrane (ISO)

cytoplasm (ISO)

plasma membrane (ISO)

Molecular Function

protein binding (ISO)

protein homodimerization activity (ISO)

References

Genomics

Comparative Map Data

CLTRN
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	X	15,537,112 - 15,574,842 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	X	8,255,666 - 8,293,354 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

CLTRN
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	X	15,627,318 - 15,675,012 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	X	15,627,318 - 15,675,624 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	X	15,645,439 - 15,683,154 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	X	15,555,372 - 15,593,075 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	X	15,405,107 - 15,442,811	NCBI
Celera	X	19,760,931 - 19,798,641 (-)	NCBI
Cytogenetic Map	X	p22.2	NCBI
HuRef	X	13,399,991 - 13,438,249 (-)	NCBI		HuRef
CHM1_1	X	15,676,401 - 15,714,121 (-)	NCBI		CHM1_1

Cltrn
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	X	162,873,183 - 162,901,855 (+)	NCBI	GRCm39		mm39
GRCm38	X	164,090,187 - 164,118,859 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	X	164,088,830 - 164,118,860 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	X	160,528,119 - 160,556,791 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	X	159,434,292 - 159,462,964 (+)	NCBI			mm8
Celera	X	147,304,655 - 147,333,264 (+)	NCBI		Celera
Cytogenetic Map	X	F5	NCBI

Cltrn
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	X	32,118,082 - 32,153,687 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	X	32,118,054 - 32,153,794 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	X	32,490,603 - 32,522,780 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	X	51,118,665 - 51,149,768 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	X	51,172,133 - 51,203,237 (-)	NCBI
Celera	X	30,705,756 - 30,738,867 (-)	NCBI		Celera
Cytogenetic Map	X	q14	NCBI

Cltrn
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955519	2,522,154 - 2,569,722 (+)	NCBI	ChiLan1.0	ChiLan1.0

CLTRN
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	X	11,798,839 - 11,900,594 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	X	11,863,479 - 11,908,361 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Cltrn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936470	5,040,831 - 5,124,611 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CLTRN
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	X	12,183,793 - 12,215,474 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	X	13,279,802 - 13,292,665 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CLTRN
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	X	14,103,046 - 14,154,936 (-)	NCBI

Cltrn
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624829	412,797 - 447,076 (-)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003805720	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	SSBP01000221	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

XM_003805720 ⟹ XP_003805768

RefSeq Status:

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1	X	15,537,112 - 15,574,842 (-)	NCBI
Mhudiblu_PPA_v0	X	8,255,666 - 8,293,354 (-)	NCBI

Sequence:

show sequence

CTTTTGAGGTAGAGTCAGAGTGGGGAAAACAACTAATCTGTTTTCCAAACAGGTTTTCATAAAT
AACTGACAAGAGATGGGCTGTTTTTATGGAAGTATTAACCCAAATGATGGGTGTTAATCATTAA
ACCTTTTAGGTGGTGGCTCGCTTGTTTCTCTGATATTCTAATCCGGGTCACAGAATGGCTAAGG
CAGATTTAAGTGCAGCGTGGATTTTTTTTTTCTCACTTTGCCTTGTGTTTTCCACCCTGAAAGA
ATGTTGTGGCTGCTCTTTTTTCTGGTGTCTGCTATTCATGCTGAACTCTGTCAACCAGGTGCAG
AAAATGCTTTTAAAGTGAGACTTAGTATCAGAACAGCTCTGGGAGATAAAGCATATGCCTGGGA
TACCAATGAAGAATACCTCTTCAAAGCGATGGTAGCTTTCTCCATGAGAAAAGTTCCCAACAGA
GAAGCAACAGAAATTTCCCATGTCCTACTTTGCAATGTAACCCAGAGGGTATCATTCTGGTTTG
TGGTTACAGACCCTTCAAAAAATCACACCCTTCCTGCTGTTGAGGTGCAATCAGCCATAAGAAT
GAACAAGAACCGGATCAACAATGCCTTCTTTCTAAATGACCAAACTCTGGAATTTTTAAAAATC
CCTTCCACACTTGCACCACCCATGGACCCATCTGTGCCCATCTGGATTATTATATTTGGTGTGA
TATTTTGCATCGTCATAGTTGCAATTGCACTACTGATTTTATCAGGGATCTGGCAACGTAGAAG
AAAGAACAAAGAACCATCTGAAGTGGATGACGCTGAAGATAAGTGTGAAAACATGATCACAATT
GAAAATGGCATCCCCTCTGATCCCCTGGACATGAAGGGAGGGCATATTAATGATGCCTTCATGA
CAGAGGATGAGAGGCTCACCCCTCTCTGAAGGGCTGTTGTTCTGCTTCCTCAAGAAATTAAACA
TTTGTTTCTGTGTGACTGCTGAGCATCCTGAAATACCAAGAGCAGATCATATATTTTGTTTCAC
CATTCTTCTTTTGTAATAAATTTTGAATGTGCTTGAAAGTGAAAAGCAATCAATTATACCCACC
AACACCACTGAAATCATAAGCTATTCACGACTCAAAATATTCTAAAATATTTTTCTGACAATAT
AGTGTATAAATGTGGTCATGTGGTATTTGTAGTTATTGATTTAAGCATTTTTAGAAATAAGATC
AGGCGTATGTATATATTTTCACACTTCAAAGACCTAAGGAAAAATAAATTTTCCAGTGGAGAAT
ACATATAATATGGTGTAGAAATCATTTAAAATGGATCCTTTTTGACGATCACTTATATCACTCT
GTATATGACTAAGTAAACAAAAGTGAGAAGTAATTATTGTAAATGGATGGATAAAAATGGAATT
ACTGATATACAGGGTGGAATTTTATCCTGTTATCACACCAACAGTTGATTATATATTTTCTGAA
TATCAACCCCTAATAGGACAATTCTATTTGTTGACCATTTCTACAATTTGTAAAAGTCCAATCT
GTGCTAACTTAATAAAGTAATAATCATCTCTTTTTGATTGTG

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Protein Sequences


Protein RefSeqs	XP_003805768	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_003805768 ⟸ XM_003805720

- Sequence:

show sequence

MLWLLFFLVSAIHAELCQPGAENAFKVRLSIRTALGDKAYAWDTNEEYLFKAMVAFSMRKVPNR
EATEISHVLLCNVTQRVSFWFVVTDPSKNHTLPAVEVQSAIRMNKNRINNAFFLNDQTLEFLKI
PSTLAPPMDPSVPIWIIIFGVIFCIVIVAIALLILSGIWQRRRKNKEPSEVDDAEDKCENMITI
ENGIPSDPLDMKGGHINDAFMTEDERLTPL

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Protein Domains

Collectrin

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000029681	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSPPAP00000013010	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000035678	ENTREZGENE, UniProtKB/TrEMBL
InterPro	Collectrin	UniProtKB/TrEMBL
	Collectrin_dom	UniProtKB/TrEMBL
KEGG Report	pps:100971158	UniProtKB/TrEMBL
NCBI Gene	TMEM27	ENTREZGENE
PANTHER	PTHR46884	UniProtKB/TrEMBL
Pfam	Collectrin	UniProtKB/TrEMBL
UniProt	A0A2R9A7Z1_PANPA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2017-12-19	CLTRN	collectrin, amino acid transport regulator	TMEM27	transmembrane protein 27	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD