SPINT2 (serine peptidase inhibitor, Kunitz type 2)

Gene: SPINT2 (serine peptidase inhibitor, Kunitz type 2) Pan paniscus

Analyze

Symbol:

SPINT2

Name:

serine peptidase inhibitor, Kunitz type 2

RGD ID:

11874755

Description:

ENCODES a protein that exhibits serine-type endopeptidase inhibitor activity (inferred); INVOLVED IN basement membrane organization (ortholog); cellular response to BMP stimulus (ortholog); epithelial cell morphogenesis involved in placental branching (ortholog); ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); biliary atresia (ortholog); carcinoma (ortholog); FOUND IN cytoplasm (inferred); membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

kunitz-type protease inhibitor 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	44,550,481 - 44,581,135 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	46,421,471 - 46,451,498 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	35,354,043 - 35,384,063 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	43,928,847 - 43,958,886 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	43,928,847 - 43,958,886 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Animal Mammary Neoplasms (ISO)

biliary atresia (ISO)

carcinoma (ISO)

cholestasis (ISO)

congenital secretory sodium diarrhea 3 (ISO)

congenital secretory sodium diarrhea 8 (ISO)

Experimental Mammary Neoplasms (ISO)

genetic disease (ISO)

neural tube defect (ISO)

placenta disease (ISO)

Prenatal Injuries (ISO)

primary biliary cholangitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

basement membrane organization (IEA,ISO)

cellular response to BMP stimulus (ISO)

epithelial cell morphogenesis involved in placental branching (IEA,ISO)

establishment or maintenance of cell polarity (IEA,ISO)

negative regulation of cell motility (IEA,ISO)

negative regulation of cell-cell adhesion (IEA,ISO)

negative regulation of neural precursor cell proliferation (ISO)

neural tube closure (IEA,ISO)

Cellular Component

cytoplasm (IEA)

membrane (IEA)

Molecular Function

serine-type endopeptidase inhibitor activity (IEA)

References

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

SPINT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	20	44,550,481 - 44,581,135 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	19	46,421,471 - 46,451,498 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	19	35,354,043 - 35,384,063 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	19	43,928,847 - 43,958,886 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	19	43,928,847 - 43,958,886 (+)	Ensembl	panpan1.1		panPan2

SPINT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	19	38,264,573 - 38,292,615 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	19	38,244,035 - 38,292,615 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	19	38,755,213 - 38,783,255 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	19	43,447,042 - 43,474,948 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	19	43,447,041 - 43,474,948	NCBI
Celera	19	35,557,341 - 35,585,496 (+)	NCBI		Celera
Cytogenetic Map	19	q13.2	NCBI
HuRef	19	35,203,084 - 35,231,226 (+)	NCBI		HuRef
CHM1_1	19	38,755,457 - 38,783,611 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	19	41,066,744 - 41,094,785 (+)	NCBI		T2T-CHM13v2.0

Spint2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	28,955,755 - 28,981,484 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	28,955,748 - 28,981,337 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	29,256,330 - 29,282,059 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	29,256,323 - 29,281,912 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	30,041,349 - 30,066,996 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	28,962,340 - 28,990,672 (-)	NCBI		MGSCv36	mm8
Celera	7	23,827,594 - 23,853,242 (-)	NCBI		Celera
Cytogenetic Map	7	B1	NCBI
cM Map	7	16.94	NCBI

Spint2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	93,685,637 - 93,708,091 (-)	NCBI		GRCr8
mRatBN7.2	1	84,558,159 - 84,580,616 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	84,558,166 - 84,580,616 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	89,969,614 - 89,992,076 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	98,429,257 - 98,452,000 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	91,725,462 - 91,747,920 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	87,199,373 - 87,221,826 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	87,199,313 - 87,221,892 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	88,379,991 - 88,402,444 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	84,393,845 - 84,416,299 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	84,471,959 - 84,494,410 (-)	NCBI
Celera	1	78,945,340 - 78,967,783 (-)	NCBI		Celera
Cytogenetic Map	1	q21	NCBI

Spint2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955468	1,143,118 - 1,169,632 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955468	1,142,718 - 1,181,210 (-)	NCBI	ChiLan1.0	ChiLan1.0

SPINT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	1	114,699,050 - 114,727,802 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	1	114,699,241 - 114,727,763 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	1	114,102,476 - 114,131,030 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	115,300,913 - 115,329,535 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	115,300,927 - 115,329,591 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	114,873,736 - 114,902,272 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	114,491,884 - 114,520,398 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	115,530,220 - 115,559,152 (-)	NCBI		UU_Cfam_GSD_1.0

Spint2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	12,876,574 - 12,904,236 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936801	1,041,708 - 1,069,776 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936801	1,041,946 - 1,069,617 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SPINT2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	47,181,768 - 47,210,559 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	47,181,772 - 47,210,564 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	42,682,276 - 42,710,782 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SPINT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	6	32,902,336 - 32,935,681 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	6	32,902,946 - 32,939,136 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666073	10,846,319 - 10,880,946 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Spint2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624794	11,738,487 - 11,769,117 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624794	11,738,137 - 11,765,579 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003812282	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000056709 ⟹ ENSPPAP00000033830

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	43,928,847 - 43,958,886 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000056717 ⟹ ENSPPAP00000033838

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	43,929,313 - 43,958,424 (+)	Ensembl

RefSeq Acc Id:

ENSPPAT00000056720 ⟹ ENSPPAP00000033841

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	19	43,929,313 - 43,958,424 (+)	Ensembl

RefSeq Acc Id:

XM_003812282 ⟹ XP_003812330

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	20	44,550,481 - 44,581,135 (+)	NCBI
NHGRI_mPanPan1	19	46,421,471 - 46,451,498 (+)	NCBI
Mhudiblu_PPA_v0	19	35,354,043 - 35,384,063 (+)	NCBI
PanPan1.1	19	43,928,847 - 43,958,886 (+)	NCBI

Sequence:

show sequence

GGGCGGGCCCAGGTGCGCCCAGGGCGGGGGAGCGGCCGCGCAGGTGCCTGCCCTTTGCGCCTGC
GCCAAGCTCGCCCTGCCTAGCCAGGTGCGCCCCGCCCCCTGCCTGCCCGGCCACCTTCGGGAGC
GGCTTCCAATAGGCGTTCGCCATTGGCTCTGGCGACCTCCGCGCGTTGGGAGGTGTAGCGGGGC
TCTGAACGCGCTGAGGGCCGTTGAGTGTCGCAGGCGGCGAGGGCGCGAGTGAGGAGCAGACCCA
GGCATCGCGCGCCGAGAAGGCCGGGCGTCCCCACACTGAAGGTCCGGAAAGGCGACTTCCGGGG
GCTTTGGCACCTGGCGGACCCTCCCGGAGCGTCGGCACCTGAACGCGAGGCGCTCCAGTGCGCG
TGCGCGGCGAGGGGCTTCCCGCACCTGATCGCGAGACCCCAACGGCTGGTGGCGTCGCCTGCGC
GTCTCGGCTGAGCTGGCCATGGCGCAGCTGTGCGGGCTGAGGCGGAGCCGGGCGTTTCTCGCCC
TGCTGGGATCGCTGCTCCTCTCTGGGGTCCTGGCGGCCGACCGAGAACGCAGCATCCACGACTT
CTGCCTGGTGTCGAAGGTGGTGGGCAGATGCCGGGCCTCCATGCCTAGGTGGTGGTACAATGTC
ACTGACGGATCCTGCCAGCTGTTTGTGTATGGGGGCTGTGATGGAAACAGCAATAATTACCTGA
CCAAGGAGGAGTGCCTCAAGAAATGTGCCACTGTCACAGAGAATGCCACGGGTGACCTGGCCAC
CAGCAGGAATGCAGCGGATTCCTCTGTCCCAAGTGCTCCCAGAAGGCAGGATTCTGAAGACCAC
TCCAGCGATATGTTCAACTATGAAGAATACTGCGCCGCCAAGGCAGTCACTGGGCCTTGCCGTG
CATCCTTCCCACGCTGGTACTTTGACGTGGAGAGGAACTCCTGCAATAACTTCATCTATGGAGG
CTGCCGGGGCAATAAGAACAGCTACCGCTCTGAGGAGGCCTGCATGCTCCGCTGCTTCCGCCAG
CAGGAGAATCCTCCCCTGCCCCTTGGCTCAAAGGTGGTGGTTCTGGCGGGGCTGTTCGTGATGG
TGTTGATCCTCTTCCTGGGAGCCTCCATGGTCTACCTGATCCGGGTGGCACGGAGGAACCAGGA
GCGTGCCCTGCGCACCGTCTGGAGCTCCGGAGATGACAAGGAGCAGCTGGTGAAGAACACATAT
GTCCTGTGACCGCCCTGTCGCCAAGAGGACTGGGGAAGGGAGGGGAGACTATGTGTGAGCTTTT
TTTAAATAGAGGGATTGACTCGGATTTGAGTGATCATTAGGGCTGAGGTCTGTTTCTCTGGGAG
GTAGGACGGCTGCTTCCTGGTCTGGCAGGGATGGGTTTGCTTTGGAAATCCTCTAGGAGGCTCC
TCCTCGCATGGCCTGCAGTCTGGCAGCAGCCCCGAGTTGTTTCCTCGCTGATCGATTTCTTTCC
TCCAGGTAGAGTTTTCTTTGCTTATGTTGAATTCCATTGCCTCTTTTCTCATCACAGAAGTGAT
GTTGGAATCGTTTCTTTTGTTTGTCTGATTTTTGGTTTTTTTAAGTATAAACAAAAGTTTTTTA
TTAGCATTCTGAAAGAAGGAAAGTAAAATGTACAAGTTTAATAAAAAGGGGCCTTCCCCTTTAG
AATAAATTTCAGCATGTGCTTTC

hide sequence

Protein Sequences


Protein RefSeqs	XP_003812330	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000033830
	ENSPPAP00000033830.1
	ENSPPAP00000033838.1
	ENSPPAP00000033841.1

RefSeq Acc Id:

XP_003812330 ⟸ XM_003812282

- UniProtKB:

A0A2R9BZB3 (UniProtKB/TrEMBL), A0A2R9BVY3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAQLCGLRRSRAFLALLGSLLLSGVLAADRERSIHDFCLVSKVVGRCRASMPRWWYNVTDGSCQ
LFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFN
YEEYCAAKAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPL
PLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERALRTVWSSGDDKEQLVKNTYVL

hide sequence

RefSeq Acc Id:

ENSPPAP00000033838 ⟸ ENSPPAT00000056717

RefSeq Acc Id:

ENSPPAP00000033830 ⟸ ENSPPAT00000056709

RefSeq Acc Id:

ENSPPAP00000033841 ⟸ ENSPPAT00000056720

Protein Domains

BPTI/Kunitz inhibitor

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000039778	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000056709.1	UniProtKB/TrEMBL
	ENSPPAT00000056717.1	UniProtKB/TrEMBL
	ENSPPAT00000056720.1	UniProtKB/TrEMBL
Gene3D-CATH	4.10.410.10	UniProtKB/TrEMBL
InterPro	Kunitz_BPTI	UniProtKB/TrEMBL
	Kunitz_BPTI_sf	UniProtKB/TrEMBL
	Prtase_inh_Kunz-CS	UniProtKB/TrEMBL
KEGG Report	pps:100987420	UniProtKB/TrEMBL
NCBI Gene	SPINT2	ENTREZGENE
PANTHER	KUNITZ-TYPE PROTEASE INHIBITOR 2	UniProtKB/TrEMBL
	KUNITZ-TYPE PROTEASE INHIBITOR 2	UniProtKB/TrEMBL
Pfam	Kunitz_BPTI	UniProtKB/TrEMBL
PRINTS	BASICPTASE	UniProtKB/TrEMBL
PROSITE	BPTI_KUNITZ_1	UniProtKB/TrEMBL
	BPTI_KUNITZ_2	UniProtKB/TrEMBL
SMART	SM00131	UniProtKB/TrEMBL
Superfamily-SCOP	SSF57362	UniProtKB/TrEMBL
UniProt	A0A2R9BVY3	ENTREZGENE, UniProtKB/TrEMBL
	A0A2R9BWK7_PANPA	UniProtKB/TrEMBL
	A0A2R9BZB3	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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