CCL21 (C-C motif chemokine ligand 21) - Rat Genome Database

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Gene: CCL21 (C-C motif chemokine ligand 21) Pan paniscus
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Symbol: CCL21
Name: C-C motif chemokine ligand 21
RGD ID: 11872706
Description: ENCODES a protein that exhibits CCR7 chemokine receptor binding (ortholog); chemokine activity (ortholog); chemokine receptor binding (ortholog); INVOLVED IN activation of GTPase activity (ortholog); antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cell chemotaxis (ortholog); ASSOCIATED WITH amyotrophic lateral sclerosis type 14 (ortholog); anauxetic dysplasia (ortholog); Cytomegalovirus Infections (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: C-C motif chemokine 21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1935,353,768 - 35,354,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,353,768 - 35,354,924 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0934,545,248 - 34,546,801 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of GTPase activity  (ISO)
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell chemotaxis  (ISO)
cell maturation  (ISO)
cellular response to chemokine  (ISO)
chemokine (C-C motif) ligand 21 signaling pathway  (ISO)
dendritic cell chemotaxis  (ISO)
dendritic cell dendrite assembly  (ISO)
establishment of T cell polarity  (ISO)
G protein-coupled receptor signaling pathway  (ISO)
immunological synapse formation  (ISO)
induction of positive chemotaxis  (ISO)
killing of cells of other organism  (ISO)
lymph node development  (ISO)
mesangial cell-matrix adhesion  (ISO)
negative regulation of dendritic cell apoptotic process  (ISO)
negative regulation of dendritic cell dendrite assembly  (ISO)
negative regulation of leukocyte tethering or rolling  (ISO)
positive regulation of actin filament polymerization  (ISO)
positive regulation of cell adhesion mediated by integrin  (ISO)
positive regulation of cell motility  (ISO)
positive regulation of cell-matrix adhesion  (ISO)
positive regulation of chemotaxis  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of filopodium assembly  (ISO)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of JNK cascade  (ISO)
positive regulation of myeloid dendritic cell chemotaxis  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of phosphatidylinositol 3-kinase activity  (ISO)
positive regulation of protein kinase activity  (ISO)
positive regulation of protein kinase B signaling  (ISO)
positive regulation of pseudopodium assembly  (ISO)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of T cell chemotaxis  (ISO)
positive regulation of T cell migration  (ISO)
release of sequestered calcium ion into cytosol  (ISO)
response to prostaglandin E  (ISO)
ruffle organization  (ISO)
T cell costimulation  (ISO)

Molecular Function

References

Genomics

Comparative Map Data
CCL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1935,353,768 - 35,354,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,353,768 - 35,354,924 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0934,545,248 - 34,546,801 (-)NCBIMhudiblu_PPA_v0panPan3
CCL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl934,709,005 - 34,710,136 (-)EnsemblGRCh38hg38GRCh38
GRCh38934,709,005 - 34,710,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37934,709,002 - 34,710,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,699,002 - 34,700,147 (-)NCBINCBI36hg18NCBI36
Build 34934,699,001 - 34,700,147NCBI
Celera934,640,475 - 34,641,620 (-)NCBI
Cytogenetic Map9p13.3NCBI
HuRef934,663,256 - 34,664,418 (-)NCBIHuRef
CHM1_1934,708,790 - 34,709,952 (-)NCBICHM1_1
Ccl21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39442,772,860 - 42,773,991 (-)NCBIGRCm39mm39
GRCm39 Ensembl442,772,860 - 42,773,993 (-)Ensembl
GRCm38442,772,860 - 42,773,991 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl442,772,860 - 42,773,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv37442,786,392 - 42,787,523 (-)NCBIGRCm37mm9NCBIm37
MGSCv36442,794,620 - 42,795,751 (-)NCBImm8
Cytogenetic Map4A5NCBI
cM Map422.43NCBI
Ccl21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2556,980,557 - 56,981,661 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl556,980,558 - 56,981,686 (-)Ensembl
Rnor_6.0558,197,678 - 58,198,782 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,197,680 - 58,198,782 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,722,614 - 62,723,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,238,897 - 59,240,001 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1559,239,077 - 59,240,180 (-)NCBI
Celera555,572,689 - 55,573,793 (-)NCBICelera
Cytogenetic Map5q22NCBI
Ccl21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,427,710 - 1,429,102 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,427,660 - 1,428,771 (+)NCBIChiLan1.0ChiLan1.0
CCL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,375,107 - 51,375,790 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,003,106 - 50,003,792 (-)NCBI
ROS_Cfam_1.01152,316,124 - 52,316,815 (-)NCBI
UMICH_Zoey_3.11150,978,674 - 50,979,359 (-)NCBI
UNSW_CanFamBas_1.01150,846,574 - 50,847,257 (-)NCBI
UU_Cfam_GSD_1.01151,611,593 - 51,612,281 (-)NCBI
Ccl21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,240,383 - 166,241,531 (-)NCBI
SpeTri2.0NW_0049365242,787,963 - 2,789,116 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1031,933,733 - 32,094,583 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,093,783 - 32,094,482 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,233,288 - 36,233,987 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11245,787,118 - 45,788,506 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,787,356 - 45,908,711 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603843,020,959 - 43,022,109 (+)NCBIVero_WHO_p1.0
Ccl21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473639,121,575 - 39,122,708 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003829814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000289 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000014434   ⟹   ENSPPAP00000003129
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl935,353,768 - 35,354,924 (-)Ensembl
RefSeq Acc Id: XM_003829814   ⟹   XP_003829862
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1935,353,768 - 35,354,924 (-)NCBI
Mhudiblu_PPA_v0934,545,248 - 34,546,801 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003829862 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003829862   ⟸   XM_003829814
- Sequence:
RefSeq Acc Id: ENSPPAP00000003129   ⟸   ENSPPAT00000014434


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000013183 Ensembl, ENTREZGENE
Ensembl Protein ENSPPAP00000003129 ENTREZGENE
NCBI Gene CCL21 ENTREZGENE