CCL21 (C-C motif chemokine ligand 21) - Rat Genome Database

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Gene: CCL21 (C-C motif chemokine ligand 21) Pan paniscus
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Symbol: CCL21
Name: C-C motif chemokine ligand 21
RGD ID: 11872706
Description: ENCODES a protein that exhibits CCR7 chemokine receptor binding (ortholog); INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); cell maturation (ortholog); cellular response to chemokine (ortholog); ASSOCIATED WITH acromesomelic dysplasia, Maroteaux type (ortholog); anauxetic dysplasia (ortholog); autosomal recessive distal hereditary motor neuronopathy 2 (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: C-C motif chemokine 21
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,886,250 - 89,895,097 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,892,190 - 89,901,037 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,545,248 - 34,546,801 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,353,768 - 35,354,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,353,768 - 35,354,924 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antimicrobial humoral immune response mediated by antimicrobial peptide  (ISO)
cell chemotaxis  (IEA)
cell maturation  (ISO)
cell migration  (IEA)
cellular response to chemokine  (ISO)
chemokine (C-C motif) ligand 21 signaling pathway  (ISO)
chemotaxis  (IEA)
dendritic cell chemotaxis  (IEA)
dendritic cell dendrite assembly  (ISO)
establishment of T cell polarity  (IEA)
G protein-coupled receptor signaling pathway  (IEA)
immune response  (IEA)
immunological synapse formation  (ISO)
induction of positive chemotaxis  (ISO)
lymph node development  (ISO)
mesangial cell-matrix adhesion  (IEA)
negative regulation of dendritic cell apoptotic process  (IEA)
negative regulation of dendritic cell dendrite assembly  (ISO)
negative regulation of leukocyte tethering or rolling  (IEA)
positive regulation of actin filament polymerization  (IEA)
positive regulation of canonical NF-kappaB signal transduction  (IEA)
positive regulation of cell adhesion mediated by integrin  (IEA)
positive regulation of cell motility  (IEA)
positive regulation of cell-matrix adhesion  (IEA)
positive regulation of chemotaxis  (ISO)
positive regulation of dendritic cell antigen processing and presentation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of filopodium assembly  (IEA)
positive regulation of glycoprotein biosynthetic process  (ISO)
positive regulation of JNK cascade  (IEA)
positive regulation of myeloid dendritic cell chemotaxis  (IEA)
positive regulation of neutrophil chemotaxis  (IEA)
positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (IEA)
positive regulation of pseudopodium assembly  (IEA)
positive regulation of receptor-mediated endocytosis  (ISO)
positive regulation of T cell chemotaxis  (ISO)
positive regulation of T cell migration  (IEA,ISO)
release of sequestered calcium ion into cytosol  (IEA)
response to prostaglandin E  (IEA)
ruffle organization  (IEA)
signal transduction  (IEA)
T cell costimulation  (ISO)

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CCL21
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21189,886,250 - 89,895,097 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1989,892,190 - 89,901,037 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0934,545,248 - 34,546,801 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1935,353,768 - 35,354,924 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl935,353,768 - 35,354,924 (-)Ensemblpanpan1.1panPan2
CCL21
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38934,709,005 - 34,710,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl934,709,005 - 34,710,136 (-)EnsemblGRCh38hg38GRCh38
GRCh37934,709,002 - 34,710,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36934,699,002 - 34,700,147 (-)NCBINCBI36Build 36hg18NCBI36
Build 34934,699,001 - 34,700,147NCBI
Celera934,640,475 - 34,641,620 (-)NCBICelera
Cytogenetic Map9p13.3NCBI
HuRef934,663,256 - 34,664,418 (-)NCBIHuRef
CHM1_1934,708,790 - 34,709,952 (-)NCBICHM1_1
T2T-CHM13v2.0934,728,031 - 34,729,162 (-)NCBIT2T-CHM13v2.0
Ccl21a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39442,772,860 - 42,773,991 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl442,772,860 - 42,773,993 (-)EnsemblGRCm39 Ensembl
GRCm38442,772,860 - 42,773,991 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl442,772,860 - 42,773,993 (-)EnsemblGRCm38mm10GRCm38
MGSCv37442,786,392 - 42,787,523 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36442,794,620 - 42,795,751 (-)NCBIMGSCv36mm8
Cytogenetic Map4A5NCBI
cM Map422.43NCBI
Ccl21
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8561,776,411 - 61,777,515 (-)NCBIGRCr8
mRatBN7.2556,980,557 - 56,981,661 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl556,980,558 - 56,981,686 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx558,954,871 - 58,955,975 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0560,773,700 - 60,774,804 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0560,759,810 - 60,760,914 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0558,197,678 - 58,198,782 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl558,197,680 - 58,198,782 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0562,722,614 - 62,723,718 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4559,238,897 - 59,240,001 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1559,239,077 - 59,240,180 (-)NCBI
Celera555,572,689 - 55,573,793 (-)NCBICelera
Cytogenetic Map5q22NCBI
Ccl21
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554721,427,710 - 1,429,102 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554721,427,660 - 1,428,771 (+)NCBIChiLan1.0ChiLan1.0
CCL21
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11151,375,107 - 51,375,790 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1150,003,106 - 50,003,792 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01152,316,124 - 52,316,815 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1152,315,730 - 52,336,844 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11150,978,674 - 50,979,359 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01150,846,574 - 50,847,257 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01151,611,593 - 51,612,281 (-)NCBIUU_Cfam_GSD_1.0
Ccl21
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947166,240,383 - 166,241,531 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365242,788,341 - 2,789,016 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365242,787,963 - 2,789,116 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CCL21
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1032,093,763 - 32,096,224 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11032,093,783 - 32,094,482 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21036,233,288 - 36,233,987 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CCL21
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11245,787,118 - 45,788,506 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1245,787,356 - 45,908,711 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603843,020,959 - 43,022,109 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ccl21
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473639,121,466 - 39,122,962 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473639,121,575 - 39,122,708 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003829814 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JARIFH020000011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSPPAT00000014434   ⟹   ENSPPAP00000003129
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl935,353,768 - 35,354,924 (-)Ensembl
RefSeq Acc Id: XM_003829814   ⟹   XP_003829862
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21189,886,250 - 89,895,097 (+)NCBI
NHGRI_mPanPan1989,892,190 - 89,901,037 (+)NCBI
Mhudiblu_PPA_v0934,545,248 - 34,546,801 (-)NCBI
PanPan1.1935,353,768 - 35,354,924 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003829862 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000003129
  ENSPPAP00000003129.1
RefSeq Acc Id: XP_003829862   ⟸   XM_003829814
- UniProtKB: A0A2R8ZHA3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSPPAP00000003129   ⟸   ENSPPAT00000014434

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000013183 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000014434.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.40 UniProtKB/TrEMBL
InterPro Chemokine_b/g/d UniProtKB/TrEMBL
  Chemokine_CC_DCCL UniProtKB/TrEMBL
  Chemokine_IL8-like_dom UniProtKB/TrEMBL
  Interleukin_8-like_sf UniProtKB/TrEMBL
KEGG Report pps:100978564 UniProtKB/TrEMBL
NCBI Gene CCL21 ENTREZGENE
PANTHER PTHR12015 UniProtKB/TrEMBL
  PTHR12015:SF72 UniProtKB/TrEMBL
Pfam IL8 UniProtKB/TrEMBL
SMART SCY UniProtKB/TrEMBL
Superfamily-SCOP SSF54117 UniProtKB/TrEMBL
UniProt A0A2R8ZHA3 ENTREZGENE, UniProtKB/TrEMBL