EZR (ezrin) - Rat Genome Database

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Gene: EZR (ezrin) Pan paniscus
Analyze
Symbol: EZR
Name: ezrin
RGD ID: 11870234
Description: ENCODES a protein that exhibits actin binding (ortholog); actin filament binding (ortholog); ATPase binding (ortholog); INVOLVED IN actin cytoskeleton reorganization (ortholog); actin filament bundle assembly (ortholog); astral microtubule organization (ortholog); PARTICIPATES IN FasL mediated signaling pathway; parathyroid hormone signaling pathway; protein kinase A (PKA) signaling pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); Experimental Liver Cirrhosis (ortholog); FOUND IN actin cytoskeleton (ortholog); actin filament (ortholog); apical part of cell (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16161,670,483 - 161,723,102 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6161,670,483 - 161,723,102 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06156,656,146 - 156,709,986 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton reorganization  (ISO)
actin filament bundle assembly  (ISO)
astral microtubule organization  (ISO)
cellular response to cAMP  (ISO)
cortical microtubule organization  (ISO)
epithelial cell differentiation  (ISO)
establishment of centrosome localization  (ISO)
establishment of endothelial barrier  (ISO)
establishment of epithelial cell apical/basal polarity  (ISO)
establishment or maintenance of apical/basal cell polarity  (ISO)
filopodium assembly  (ISO)
gland morphogenesis  (ISO)
intestinal D-glucose absorption  (ISO)
leukocyte cell-cell adhesion  (ISO)
membrane to membrane docking  (ISO)
microvillus assembly  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of interleukin-2 production  (ISO)
negative regulation of p38MAPK cascade  (ISO)
negative regulation of T cell receptor signaling pathway  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
phosphatidylinositol-mediated signaling  (ISO)
positive regulation of cellular protein catabolic process  (ISO)
positive regulation of early endosome to late endosome transport  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of multicellular organism growth  (ISO)
positive regulation of protein localization to early endosome  (ISO)
positive regulation of protein localization to plasma membrane  (ISO)
positive regulation of protein secretion  (ISO)
protein kinase A signaling  (ISO)
protein localization to cell cortex  (ISO)
protein localization to plasma membrane  (ISO)
protein-containing complex localization  (ISO)
receptor internalization  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of cell shape  (ISO)
regulation of cell size  (ISO)
regulation of microvillus length  (ISO)
regulation of NIK/NF-kappaB signaling  (ISO)
regulation of organelle assembly  (ISO)
sphingosine-1-phosphate receptor signaling pathway  (ISO)
terminal web assembly  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
EZR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.16161,670,483 - 161,723,102 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6161,670,483 - 161,723,102 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v06156,656,146 - 156,709,986 (-)NCBIMhudiblu_PPA_v0panPan3
EZR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl6158,765,741 - 158,819,368 (-)EnsemblGRCh38hg38GRCh38
GRCh386158,765,744 - 158,819,368 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh376159,186,780 - 159,240,400 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 366159,106,764 - 159,159,247 (-)NCBINCBI36hg18NCBI36
Build 346159,157,186 - 159,209,668NCBI
Celera6159,834,789 - 159,888,323 (-)NCBI
Cytogenetic Map6q25.3NCBI
HuRef6156,657,307 - 156,711,123 (-)NCBIHuRef
CHM1_16159,449,491 - 159,503,058 (-)NCBICHM1_1
Ezr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39177,005,530 - 7,050,179 (-)NCBIGRCm39mm39
GRCm39 Ensembl177,005,440 - 7,050,183 (-)Ensembl
GRCm38176,738,131 - 6,782,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl176,738,041 - 6,782,784 (-)EnsemblGRCm38mm10GRCm38
MGSCv37176,942,480 - 6,987,129 (-)NCBIGRCm37mm9NCBIm37
MGSCv36176,587,789 - 6,632,438 (-)NCBImm8
Celera1514,687,905 - 14,732,667 (+)NCBICelera
Cytogenetic Map17A1NCBI
Ezr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2146,967,961 - 47,011,505 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl146,967,658 - 47,011,505 (-)Ensembl
Rnor_6.0147,287,872 - 47,331,412 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl147,287,874 - 47,331,412 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0148,590,971 - 48,634,511 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4141,178,195 - 41,221,735 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1141,181,139 - 41,224,680 (-)NCBI
Celera142,655,531 - 42,699,079 (-)NCBICelera
Cytogenetic Map1q11NCBI
Ezr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554393,703,013 - 3,740,345 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554393,701,722 - 3,740,345 (+)NCBIChiLan1.0ChiLan1.0
EZR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1148,160,206 - 48,210,036 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl148,160,206 - 48,210,036 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha149,005,197 - 49,055,099 (-)NCBI
ROS_Cfam_1.0148,346,325 - 48,397,738 (-)NCBI
UMICH_Zoey_3.1148,223,100 - 48,272,944 (-)NCBI
UNSW_CanFamBas_1.0148,093,979 - 48,143,792 (-)NCBI
UU_Cfam_GSD_1.0148,653,395 - 48,703,265 (-)NCBI
Ezr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946143,161,383 - 143,205,800 (-)NCBI
SpeTri2.0NW_00493648910,413,374 - 10,457,771 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EZR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl18,403,453 - 8,452,750 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.118,403,362 - 8,452,750 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2110,423,530 - 10,432,162 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EZR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11386,342,954 - 86,399,827 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1386,344,051 - 86,370,622 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604058,721,321 - 58,778,578 (-)NCBIVero_WHO_p1.0
Ezr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624929827,275 - 873,743 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000050692   ⟹   ENSPPAP00000027849
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6161,670,483 - 161,723,102 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000050703   ⟹   ENSPPAP00000027860
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6161,671,646 - 161,720,870 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000050705   ⟹   ENSPPAP00000027862
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6161,671,646 - 161,697,087 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000050709   ⟹   ENSPPAP00000027866
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl6161,671,646 - 161,695,117 (-)Ensembl
RefSeq Acc Id: XM_008959500   ⟹   XP_008957748
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.16161,670,483 - 161,694,017 (-)NCBI
Mhudiblu_PPA_v06156,656,146 - 156,679,741 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034963169   ⟹   XP_034819060
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v06156,656,518 - 156,709,986 (-)NCBI
Protein Sequences
Protein RefSeqs XP_008957748 (Get FASTA)   NCBI Sequence Viewer  
  XP_034819060 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008957748   ⟸   XM_008959500
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034819060   ⟸   XM_034963169
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000027849   ⟸   ENSPPAT00000050692
RefSeq Acc Id: ENSPPAP00000027862   ⟸   ENSPPAT00000050705
RefSeq Acc Id: ENSPPAP00000027860   ⟸   ENSPPAT00000050703
RefSeq Acc Id: ENSPPAP00000027866   ⟸   ENSPPAT00000050709


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036860 Ensembl, ENTREZGENE
NCBI Gene EZR ENTREZGENE