LRRC8E (leucine rich repeat containing 8 VRAC subunit E) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: LRRC8E (leucine rich repeat containing 8 VRAC subunit E) Pan paniscus
Analyze
Symbol: LRRC8E
Name: leucine rich repeat containing 8 VRAC subunit E
RGD ID: 11870221
Description: ENCODES a protein that exhibits volume-sensitive anion channel activity (ortholog); INVOLVED IN aspartate transmembrane transport (inferred); cell volume homeostasis (inferred); cellular response to osmotic stress (inferred); ASSOCIATED WITH familial hemophagocytic lymphohistiocytosis 5 (ortholog); genetic disease (ortholog); long QT syndrome (ortholog); FOUND IN cytoplasm (inferred); endoplasmic reticulum membrane (inferred); lysosomal membrane (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: leucine rich repeat containing 8 family member E; volume-regulated anion channel subunit LRRC8E
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,567,759 - 12,584,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,684,938 - 11,701,046 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,189,490 - 7,203,310 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,041,185 - 8,055,684 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,041,185 - 8,055,684 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
LRRC8E
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22012,567,759 - 12,584,833 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11911,684,938 - 11,701,046 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0197,189,490 - 7,203,310 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1198,041,185 - 8,055,684 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl198,041,185 - 8,055,684 (+)Ensemblpanpan1.1panPan2
LRRC8E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38197,888,510 - 7,902,016 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl197,888,505 - 7,902,021 (+)EnsemblGRCh38hg38GRCh38
GRCh37197,953,395 - 7,966,901 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36197,859,390 - 7,872,907 (+)NCBINCBI36Build 36hg18NCBI36
Celera197,824,591 - 7,838,110 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef197,623,841 - 7,637,152 (+)NCBIHuRef
CHM1_1197,952,868 - 7,966,380 (+)NCBICHM1_1
T2T-CHM13v2.0197,889,464 - 7,902,971 (+)NCBIT2T-CHM13v2.0
Lrrc8e
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3984,274,269 - 4,287,470 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl84,276,827 - 4,287,470 (+)EnsemblGRCm39 Ensembl
GRCm3884,224,268 - 4,237,470 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl84,226,827 - 4,237,470 (+)EnsemblGRCm38mm10GRCm38
MGSCv3784,226,827 - 4,237,470 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3684,226,827 - 4,236,898 (+)NCBIMGSCv36mm8
Celera84,416,312 - 4,438,059 (+)NCBICelera
Cytogenetic Map8A1.1NCBI
cM Map81.99NCBI
Lrrc8e
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8127,376,103 - 7,387,250 (+)NCBIGRCr8
mRatBN7.2122,578,240 - 2,589,407 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl122,578,315 - 2,589,412 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx123,226,163 - 3,237,359 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0123,849,752 - 3,860,950 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0122,612,632 - 2,624,059 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0122,557,267 - 2,568,416 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl122,557,275 - 2,568,382 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0124,710,039 - 4,721,300 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4121,554,464 - 1,566,012 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1121,554,997 - 1,566,044 (-)NCBI
Celera124,393,851 - 4,404,933 (+)NCBICelera
Cytogenetic Map12p12NCBI
Lrrc8e
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555631,362,266 - 1,370,226 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555631,362,266 - 1,370,221 (-)NCBIChiLan1.0ChiLan1.0
LRRC8E
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12052,585,636 - 52,593,207 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2052,588,973 - 52,593,214 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2052,388,171 - 52,395,753 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02053,113,833 - 53,121,423 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2053,113,855 - 53,120,403 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12052,317,074 - 52,324,699 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02052,761,721 - 52,769,297 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02052,993,083 - 53,000,668 (+)NCBIUU_Cfam_GSD_1.0
Lrrc8e
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118212,954,121 - 212,961,388 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365884,873,412 - 4,880,533 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365884,873,412 - 4,880,574 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC8E
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl271,309,402 - 71,314,701 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1271,309,404 - 71,318,225 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2271,710,888 - 71,718,616 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRRC8E
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.167,337,918 - 7,351,914 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl67,346,243 - 7,351,855 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666081462,397 - 474,514 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc8e
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624828860,744 - 868,595 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624828859,419 - 868,595 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000050110   ⟹   ENSPPAP00000027270
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl198,041,185 - 8,055,684 (+)Ensembl
RefSeq Acc Id: XM_003809986   ⟹   XP_003810034
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22012,567,759 - 12,584,833 (+)NCBI
NHGRI_mPanPan11911,684,938 - 11,701,046 (+)NCBI
Mhudiblu_PPA_v0197,189,490 - 7,203,303 (+)NCBI
PanPan1.1198,041,185 - 8,055,684 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003810034 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000027270
  ENSPPAP00000027270.1
Reference Protein Sequences
RefSeq Acc Id: XP_003810034   ⟸   XM_003809986
- UniProtKB: A0A2R9BKS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000027270   ⟸   ENSPPAT00000050110
Protein Domains
LRRC8 pannexin-like TM region


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000036697 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000050110.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/TrEMBL
InterPro Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRC8_Pannexin-like UniProtKB/TrEMBL
KEGG Report pps:100974726 UniProtKB/TrEMBL
NCBI Gene LRRC8E ENTREZGENE
PANTHER PTHR48051 UniProtKB/TrEMBL
  VOLUME-REGULATED ANION CHANNEL SUBUNIT LRRC8E UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  Pannexin_like UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
UniProt A0A2R9BKS4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-08-08 LRRC8E  leucine rich repeat containing 8 VRAC subunit E    leucine rich repeat containing 8 family member E  Symbol and/or name change 5135510 APPROVED