OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3) - Rat Genome Database

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Gene: OPA3 (outer mitochondrial membrane lipid metabolism regulator OPA3) Pan paniscus
Analyze
Symbol: OPA3
Name: outer mitochondrial membrane lipid metabolism regulator OPA3
RGD ID: 11869082
Description: INVOLVED IN bone development (ortholog); fat cell differentiation (ortholog); mitochondrion organization (ortholog); ASSOCIATED WITH 3-methylglutaconic aciduria type 3 (ortholog); achromatopsia (ortholog); Foveal Hypoplasia (ortholog); FOUND IN mitochondrion (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: OPA3 outer mitochondrial membrane lipid metabolism regulator; OPA3, outer mitochondrial membrane lipid metabolism regulator; optic atrophy 3 (autosomal recessive, with chorea and spastic paraplegia); optic atrophy 3 protein homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,689,574 - 51,750,652 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,560,990 - 53,622,129 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,477,467 - 42,546,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,073,322 - 51,130,555 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,073,322 - 51,130,555 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
OPA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22051,689,574 - 51,750,652 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11953,560,990 - 53,622,129 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01942,477,467 - 42,546,814 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11951,073,322 - 51,130,555 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1951,073,322 - 51,130,555 (-)Ensemblpanpan1.1panPan2
OPA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381945,527,427 - 45,584,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1945,527,767 - 45,602,212 (-)EnsemblGRCh38hg38GRCh38
GRCh371946,030,685 - 46,088,060 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361950,722,865 - 50,779,962 (-)NCBINCBI36Build 36hg18NCBI36
Build 341950,747,641 - 50,779,917NCBI
Celera1942,837,136 - 42,894,236 (-)NCBICelera
Cytogenetic Map19q13.32NCBI
HuRef1942,460,247 - 42,517,324 (-)NCBIHuRef
CHM1_11946,034,268 - 46,091,400 (-)NCBICHM1_1
T2T-CHM13v2.01948,354,701 - 48,412,074 (-)NCBIT2T-CHM13v2.0
Opa3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39718,962,314 - 18,980,742 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl718,962,259 - 18,990,468 (+)EnsemblGRCm39 Ensembl
GRCm38719,228,389 - 19,246,817 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl719,228,334 - 19,256,543 (+)EnsemblGRCm38mm10GRCm38
MGSCv37719,813,738 - 19,832,166 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36718,386,905 - 18,405,158 (+)NCBIMGSCv36mm8
Celera716,641,243 - 16,659,819 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map79.48NCBI
Opa3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8188,007,707 - 88,037,639 (+)NCBIGRCr8
mRatBN7.2178,879,612 - 78,910,453 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,880,862 - 78,913,056 (+)EnsemblmRatBN7.2 Ensembl
mRatBN7.2 Ensembl178,880,114 - 78,901,469 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx184,270,502 - 84,289,703 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0192,828,026 - 92,847,264 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0186,025,584 - 86,044,786 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0180,141,630 - 80,160,145 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl180,141,630 - 80,160,145 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0181,408,113 - 81,426,628 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4178,592,874 - 78,611,029 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1178,670,662 - 78,687,666 (+)NCBI
Celera173,343,904 - 73,362,059 (+)NCBICelera
Cytogenetic Map1q21NCBI
Opa3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495557460,652 - 82,343 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495557460,652 - 82,343 (-)NCBIChiLan1.0ChiLan1.0
Opa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934917,598,813 - 17,647,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367061,964,237 - 1,995,175 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367061,961,571 - 1,996,637 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OPA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl651,917,379 - 51,964,488 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1651,917,956 - 51,967,624 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
OPA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1638,974,455 - 39,032,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl639,001,467 - 39,032,347 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607318,595,898 - 18,655,810 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Opa3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248327,580,823 - 7,605,443 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248327,580,402 - 7,619,122 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000058763   ⟹   ENSPPAP00000035874
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1951,073,322 - 51,130,555 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000058770   ⟹   ENSPPAP00000035881
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1951,098,657 - 51,130,552 (-)Ensembl
RefSeq Acc Id: XM_003817517   ⟹   XP_003817565
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22051,689,574 - 51,750,652 (-)NCBI
NHGRI_mPanPan11953,560,990 - 53,622,129 (-)NCBI
Mhudiblu_PPA_v01942,477,467 - 42,530,078 (-)NCBI
PanPan1.11951,073,322 - 51,130,555 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008970730   ⟹   XP_008968978
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22051,710,636 - 51,749,045 (-)NCBI
NHGRI_mPanPan11953,582,041 - 53,620,524 (-)NCBI
Mhudiblu_PPA_v01942,498,037 - 42,530,049 (-)NCBI
PanPan1.11951,098,652 - 51,130,551 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063600410   ⟹   XP_063456480
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v22051,710,636 - 51,716,689 (-)NCBI
Protein Sequences
Protein RefSeqs XP_003817565 (Get FASTA)   NCBI Sequence Viewer  
  XP_008968978 (Get FASTA)   NCBI Sequence Viewer  
  XP_063456480 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000035874
  ENSPPAP00000035874.1
  ENSPPAP00000035881.1
Reference Protein Sequences
RefSeq Acc Id: XP_003817565   ⟸   XM_003817517
- Peptide Label: isoform X2
- UniProtKB: A0A2R9C1S7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008968978   ⟸   XM_008970730
- Peptide Label: isoform X3
- UniProtKB: A0A2R9C4S4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSPPAP00000035874   ⟸   ENSPPAT00000058763
RefSeq Acc Id: ENSPPAP00000035881   ⟸   ENSPPAT00000058770
RefSeq Acc Id: XP_063456480   ⟸   XM_063600410
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000040725 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000058763.1 UniProtKB/TrEMBL
  ENSPPAT00000058770.1 UniProtKB/TrEMBL
InterPro OPA3-like UniProtKB/TrEMBL
KEGG Report pps:100987559 UniProtKB/TrEMBL
NCBI Gene OPA3 ENTREZGENE
PANTHER OPTIC ATROPHY 3 PROTEIN UniProtKB/TrEMBL
  PTHR12499 UniProtKB/TrEMBL
Pfam OPA3 UniProtKB/TrEMBL
UniProt A0A2R9C1S7 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9C4S4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 OPA3  outer mitochondrial membrane lipid metabolism regulator OPA3    OPA3 outer mitochondrial membrane lipid metabolism regulator  Symbol and/or name change 5135510 APPROVED
2019-01-29 OPA3  OPA3 outer mitochondrial membrane lipid metabolism regulator    OPA3, outer mitochondrial membrane lipid metabolism regulator  Symbol and/or name change 5135510 APPROVED