IQGAP1 (IQ motif containing GTPase activating protein 1) - Rat Genome Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: IQGAP1 (IQ motif containing GTPase activating protein 1) Pan paniscus
Analyze
Symbol: IQGAP1
Name: IQ motif containing GTPase activating protein 1
RGD ID: 11868986
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); calmodulin binding (ortholog); MAP-kinase scaffold activity (ortholog); INVOLVED IN cell migration (ortholog); cellular response to calcium ion (ortholog); cellular response to epidermal growth factor stimulus (ortholog); PARTICIPATES IN E-cadherin signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH Brain Neoplasms (ortholog); Experimental Liver Cirrhosis (ortholog); hepatocellular carcinoma (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); cell leading edge (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: ras GTPase-activating-like protein IQGAP1; ras GTPase-activating-like protein IQGAP1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11588,276,762 - 88,390,721 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01569,076,025 - 69,190,082 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
IQGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11588,276,762 - 88,390,721 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01569,076,025 - 69,190,082 (+)NCBIMhudiblu_PPA_v0panPan3
IQGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1590,388,242 - 90,502,239 (+)EnsemblGRCh38hg38GRCh38
GRCh381590,388,242 - 90,502,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371590,931,474 - 91,045,471 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,732,477 - 88,846,479 (+)NCBINCBI36hg18NCBI36
Build 341588,732,476 - 88,846,479NCBI
Celera1567,336,216 - 67,450,214 (+)NCBI
Cytogenetic Map15q26.1NCBI
HuRef1567,043,721 - 67,156,752 (+)NCBIHuRef
CHM1_11590,773,219 - 90,887,196 (+)NCBICHM1_1
Iqgap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,361,331 - 80,453,288 (-)NCBIGRCm39mm39
GRCm39 Ensembl780,361,331 - 80,475,722 (-)Ensembl
GRCm38780,711,583 - 80,815,549 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,711,583 - 80,825,974 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,856,469 - 87,948,217 (-)NCBIGRCm37mm9NCBIm37
MGSCv36780,586,294 - 80,676,807 (-)NCBImm8
Celera778,116,162 - 78,211,858 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.68NCBI
Iqgap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21134,679,581 - 134,769,776 (-)NCBI
Rnor_6.0 Ensembl1142,525,046 - 142,615,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01142,525,041 - 142,615,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01143,476,882 - 143,567,395 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,552,358 - 136,642,545 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11136,631,848 - 136,722,691 (-)NCBI
Celera1126,734,261 - 126,824,269 (-)NCBICelera
Cytogenetic Map1q31NCBI
Iqgap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,560,292 - 14,650,036 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,558,628 - 14,652,031 (+)NCBIChiLan1.0ChiLan1.0
IQGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl353,683,791 - 53,792,186 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1353,683,869 - 53,791,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Iqgap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648316,489,127 - 16,594,712 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQGAP1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl752,958,106 - 53,129,960 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1753,020,479 - 53,129,964 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2758,162,005 - 58,229,482 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IQGAP1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1299,363,273 - 9,485,644 (-)NCBI
ChlSab1.1 Ensembl299,362,926 - 9,485,526 (-)Ensembl
Iqgap1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476817,703,113 - 17,797,922 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000056973   ⟹   ENSPPAP00000034092
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056983   ⟹   ENSPPAP00000034102
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056984   ⟹   ENSPPAP00000034103
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,276,851 - 88,371,415 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056992   ⟹   ENSPPAP00000034111
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,314,401 - 88,388,594 (+)Ensembl
RefSeq Acc Id: XM_008959859   ⟹   XP_008958107
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11588,276,762 - 88,390,721 (+)NCBI
Mhudiblu_PPA_v01569,076,025 - 69,190,082 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034939424   ⟹   XP_034795315
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01569,119,032 - 69,190,082 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008958107 (Get FASTA)   NCBI Sequence Viewer  
  XP_034795315 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008958107   ⟸   XM_008959859
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_034795315   ⟸   XM_034939424
- Peptide Label: isoform X2
RefSeq Acc Id: ENSPPAP00000034103   ⟸   ENSPPAT00000056984
RefSeq Acc Id: ENSPPAP00000034102   ⟸   ENSPPAT00000056983
RefSeq Acc Id: ENSPPAP00000034111   ⟸   ENSPPAT00000056992
RefSeq Acc Id: ENSPPAP00000034092   ⟸   ENSPPAT00000056973
Protein Domains
Calponin-homology (CH)   Ras-GAP   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039618 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000034092 UniProtKB/TrEMBL
  ENSPPAP00000034102 UniProtKB/TrEMBL
  ENSPPAP00000034103 UniProtKB/TrEMBL
  ENSPPAP00000034111 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056973 UniProtKB/TrEMBL
  ENSPPAT00000056983 UniProtKB/TrEMBL
  ENSPPAT00000056984 UniProtKB/TrEMBL
  ENSPPAT00000056992 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
InterPro CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
NCBI Gene IQGAP1 ENTREZGENE
Pfam PF00307 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
PROSITE PS50021 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART RasGAP UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF47576 UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9BWN0_PANPA UniProtKB/TrEMBL
  A0A2R9BWN8_PANPA UniProtKB/TrEMBL
  A0A2R9BWP1_PANPA UniProtKB/TrEMBL
  A0A2R9BXC0_PANPA UniProtKB/TrEMBL