IQGAP1 (IQ motif containing GTPase activating protein 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: IQGAP1 (IQ motif containing GTPase activating protein 1) Pan paniscus
Analyze
Symbol: IQGAP1
Name: IQ motif containing GTPase activating protein 1
RGD ID: 11868986
Description: ENCODES a protein that exhibits mitogen-activated protein kinase binding (ortholog); protein-containing complex binding (ortholog); INVOLVED IN cellular response to fibroblast growth factor stimulus (ortholog); cellular response to platelet-derived growth factor stimulus (ortholog); fibroblast growth factor receptor signaling pathway (ortholog); PARTICIPATES IN E-cadherin signaling pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH Bloom syndrome (ortholog); Brain Neoplasms (ortholog); colorectal cancer (ortholog); FOUND IN actin cytoskeleton (ortholog); axon (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: ras GTPase-activating-like protein IQGAP1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,935,362 - 80,049,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,634,820 - 83,748,904 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,076,025 - 69,190,082 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,276,762 - 88,390,721 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IQGAP1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21679,935,362 - 80,049,434 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11583,634,820 - 83,748,904 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01569,076,025 - 69,190,082 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11588,276,762 - 88,390,721 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensemblpanpan1.1panPan2
IQGAP1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381590,388,242 - 90,502,239 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1590,388,242 - 90,502,239 (+)EnsemblGRCh38hg38GRCh38
GRCh371590,931,474 - 91,045,471 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361588,732,477 - 88,846,479 (+)NCBINCBI36Build 36hg18NCBI36
Build 341588,732,476 - 88,846,479NCBI
Celera1567,336,216 - 67,450,214 (+)NCBICelera
Cytogenetic Map15q26.1NCBI
HuRef1567,043,721 - 67,156,752 (+)NCBIHuRef
CHM1_11590,773,219 - 90,887,196 (+)NCBICHM1_1
T2T-CHM13v2.01588,144,255 - 88,258,256 (+)NCBIT2T-CHM13v2.0
Iqgap1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39780,361,331 - 80,453,288 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl780,361,331 - 80,475,722 (-)EnsemblGRCm39 Ensembl
GRCm38780,711,583 - 80,815,549 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl780,711,583 - 80,825,974 (-)EnsemblGRCm38mm10GRCm38
MGSCv37787,856,469 - 87,948,217 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36780,586,294 - 80,676,807 (-)NCBIMGSCv36mm8
Celera778,116,162 - 78,211,858 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map745.68NCBI
Iqgap1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81144,088,788 - 144,178,989 (-)NCBIGRCr8
mRatBN7.21134,679,581 - 134,769,776 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1134,679,586 - 134,769,755 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1142,588,968 - 142,679,115 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01149,758,382 - 149,848,532 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01142,676,568 - 142,767,383 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01142,525,041 - 142,615,673 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1142,525,046 - 142,615,673 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01143,476,882 - 143,567,395 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41136,552,358 - 136,642,545 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11136,631,848 - 136,722,691 (-)NCBI
Celera1126,734,261 - 126,824,269 (-)NCBICelera
Cytogenetic Map1q31NCBI
Iqgap1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541614,560,292 - 14,650,036 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541614,558,628 - 14,652,031 (+)NCBIChiLan1.0ChiLan1.0
IQGAP1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1353,683,869 - 53,791,136 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl353,683,791 - 53,792,186 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha356,321,230 - 56,429,279 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0354,099,750 - 54,207,801 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl354,098,495 - 54,207,760 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1353,618,792 - 53,726,768 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0353,830,202 - 53,938,180 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0354,170,507 - 54,278,357 (-)NCBIUU_Cfam_GSD_1.0
Iqgap1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640129,739,918 - 129,845,387 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648316,489,133 - 16,594,783 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648316,489,127 - 16,594,712 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQGAP1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1299,363,273 - 9,485,644 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl299,362,926 - 9,485,526 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605937,209,223 - 37,324,055 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iqgap1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476817,702,728 - 17,799,022 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476817,703,113 - 17,797,922 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000056973   ⟹   ENSPPAP00000034092
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056983   ⟹   ENSPPAP00000034102
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,276,851 - 88,388,594 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056984   ⟹   ENSPPAP00000034103
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,276,851 - 88,371,415 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000056992   ⟹   ENSPPAP00000034111
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1588,314,401 - 88,388,594 (+)Ensembl
RefSeq Acc Id: XM_008959859   ⟹   XP_008958107
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21679,935,362 - 80,049,434 (+)NCBI
NHGRI_mPanPan11583,634,820 - 83,748,904 (+)NCBI
Mhudiblu_PPA_v01569,076,025 - 69,190,082 (+)NCBI
PanPan1.11588,276,762 - 88,390,721 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034939424   ⟹   XP_034795315
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21679,978,383 - 80,049,434 (+)NCBI
NHGRI_mPanPan11583,677,842 - 83,748,904 (+)NCBI
Mhudiblu_PPA_v01569,119,032 - 69,190,082 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008958107 (Get FASTA)   NCBI Sequence Viewer  
  XP_034795315 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000034092.1
  ENSPPAP00000034102.1
  ENSPPAP00000034103.1
  ENSPPAP00000034111.1
Reference Protein Sequences
RefSeq Acc Id: XP_008958107   ⟸   XM_008959859
- Peptide Label: isoform X1
- UniProtKB: A0A2R9BWN0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034795315   ⟸   XM_034939424
- Peptide Label: isoform X2
- UniProtKB: A0A2R9BXC0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000034103   ⟸   ENSPPAT00000056984
RefSeq Acc Id: ENSPPAP00000034102   ⟸   ENSPPAT00000056983
RefSeq Acc Id: ENSPPAP00000034111   ⟸   ENSPPAT00000056992
RefSeq Acc Id: ENSPPAP00000034092   ⟸   ENSPPAT00000056973
Protein Domains
Calponin-homology (CH)   Ras-GAP   WW


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039618 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056973.1 UniProtKB/TrEMBL
  ENSPPAT00000056983.1 UniProtKB/TrEMBL
  ENSPPAT00000056984.1 UniProtKB/TrEMBL
  ENSPPAT00000056992.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/TrEMBL
  1.20.5.190 UniProtKB/TrEMBL
  2.20.70.10 UniProtKB/TrEMBL
  Myosin, subunit A UniProtKB/TrEMBL
InterPro CH-domain UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
  RasGAP_CS UniProtKB/TrEMBL
  RasGAP_dom UniProtKB/TrEMBL
  Rho_GTPase_activation_prot UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
NCBI Gene IQGAP1 ENTREZGENE
PANTHER RAS GTPASE-ACTIVATING PROTEIN WITH IQ MOTIF UniProtKB/TrEMBL
  RAS GTPASE-ACTIVATING-LIKE PROTEIN IQGAP1 UniProtKB/TrEMBL
Pfam PF00307 UniProtKB/TrEMBL
  PF00612 UniProtKB/TrEMBL
  RasGAP UniProtKB/TrEMBL
  RasGAP_C UniProtKB/TrEMBL
PROSITE PS50021 UniProtKB/TrEMBL
  PS50096 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_1 UniProtKB/TrEMBL
  RAS_GTPASE_ACTIV_2 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART RasGAP UniProtKB/TrEMBL
  SM00015 UniProtKB/TrEMBL
  SM00033 UniProtKB/TrEMBL
  SM00456 UniProtKB/TrEMBL
Superfamily-SCOP RGC domain-like UniProtKB/TrEMBL
  SSF47576 UniProtKB/TrEMBL
  SSF48350 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A2R9BWN0 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9BWN8_PANPA UniProtKB/TrEMBL
  A0A2R9BWP1_PANPA UniProtKB/TrEMBL
  A0A2R9BXC0 ENTREZGENE, UniProtKB/TrEMBL