ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) - Rat Genome Database

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Gene: ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) Pan paniscus
Analyze
Symbol: ABL2
Name: ABL proto-oncogene 2, non-receptor tyrosine kinase
RGD ID: 11867229
Description: ENCODES a protein that exhibits ATP binding (inferred); magnesium ion binding (inferred); manganese ion binding (inferred); INVOLVED IN actin cytoskeleton organization (ortholog); actin filament bundle assembly (ortholog); actin filament organization (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); gastrointestinal stromal tumor (ortholog); genetic disease (ortholog); FOUND IN actin cytoskeleton (ortholog); dendritic spine (ortholog); glutamatergic synapse (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: Abelson tyrosine-protein kinase 2; tyrosine-protein kinase ABL2; v-abl Abelson murine leukemia viral oncogene homolog 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2170,530,839 - 70,660,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1170,195,232 - 70,322,490 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01154,586,423 - 154,711,621 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,275,334 - 158,313,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,280,994 - 158,313,915 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISO)
actin filament bundle assembly  (ISO)
actin filament organization  (ISO)
adult walking behavior  (ISO)
aggressive behavior  (ISO)
alpha-beta T cell differentiation  (ISO)
auditory behavior  (ISO)
Bergmann glial cell differentiation  (ISO)
canonical NF-kappaB signal transduction  (ISO)
cell communication  (IEA)
cell-cell adhesion  (ISO)
cellular response to retinoic acid  (IEA)
cerebellum morphogenesis  (ISO)
circulatory system development  (ISO)
dendrite morphogenesis  (ISO)
dendritic spine maintenance  (ISO)
DN4 thymocyte differentiation  (ISO)
epidermal growth factor receptor signaling pathway  (ISO)
establishment of localization in cell  (ISO)
exploration behavior  (ISO)
learning  (ISO)
multicellular organism growth  (ISO)
negative regulation of cell-cell adhesion  (ISO)
negative regulation of endothelial cell apoptotic process  (ISO)
negative regulation of Rho protein signal transduction  (ISO)
neural tube closure  (ISO)
neuroepithelial cell differentiation  (ISO)
neuromuscular process controlling balance  (ISO)
neuron differentiation  (ISO)
neuron remodeling  (ISO)
peptidyl-tyrosine phosphorylation  (IEA)
phagocytosis  (ISO)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IEA,ISO)
phosphorylation  (IEA)
platelet-derived growth factor receptor signaling pathway  (ISO)
positive regulation of canonical NF-kappaB signal transduction  (ISO)
positive regulation of cytosolic calcium ion concentration  (IEA,ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of establishment of T cell polarity  (ISO)
positive regulation of interleukin-2 production  (ISO)
positive regulation of neuron projection development  (IEA,ISO)
positive regulation of oxidoreductase activity  (IEA)
positive regulation of T cell migration  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of Wnt signaling pathway, planar cell polarity pathway  (ISO)
post-embryonic development  (ISO)
protein localization  (ISO)
protein phosphorylation  (IEA)
regulation of apoptotic process  (IEA)
regulation of cellular component organization  (IEA)
regulation of extracellular matrix organization  (ISO)
Rho protein signal transduction  (ISO)
signaling  (IEA)
substrate-dependent cell migration, cell extension  (ISO)
synapse maturation  (ISO)
visual learning  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
ABL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2170,530,839 - 70,660,797 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1170,195,232 - 70,322,490 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01154,586,423 - 154,711,621 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11158,275,334 - 158,313,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1158,280,994 - 158,313,915 (-)Ensemblpanpan1.1panPan2
ABL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381179,099,330 - 179,229,677 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1179,099,330 - 179,229,684 (-)EnsemblGRCh38hg38GRCh38
GRCh371179,068,465 - 179,198,812 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361177,335,085 - 177,465,390 (-)NCBINCBI36Build 36hg18NCBI36
Build 341175,808,413 - 175,930,393NCBI
Celera1152,177,312 - 152,307,714 (-)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1150,296,029 - 150,426,165 (-)NCBIHuRef
CHM1_11180,492,111 - 180,622,356 (-)NCBICHM1_1
T2T-CHM13v2.01178,454,335 - 178,584,699 (-)NCBIT2T-CHM13v2.0
Abl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391156,386,160 - 156,477,189 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1156,386,356 - 156,477,138 (+)EnsemblGRCm39 Ensembl
GRCm381156,558,590 - 156,649,619 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1156,558,786 - 156,649,568 (+)EnsemblGRCm38mm10GRCm38
MGSCv371158,488,918 - 158,579,750 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361158,395,726 - 158,479,393 (+)NCBIMGSCv36mm8
Celera1158,949,003 - 159,040,041 (+)NCBICelera
Cytogenetic Map1G3NCBI
cM Map167.71NCBI
Abl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81371,223,902 - 71,319,770 (+)NCBIGRCr8
mRatBN7.21368,673,702 - 68,770,846 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1368,673,722 - 68,839,742 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1371,260,527 - 71,356,363 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01372,580,546 - 72,675,673 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01369,842,041 - 69,937,159 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01374,154,533 - 74,333,244 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1374,154,835 - 74,333,244 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01379,074,821 - 79,253,783 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41371,546,918 - 71,915,301 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1368,537,724 - 68,702,946 (+)NCBICelera
Cytogenetic Map13q22NCBI
Abl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540618,437,672 - 18,527,698 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540618,435,984 - 18,527,967 (-)NCBIChiLan1.0ChiLan1.0
ABL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1720,696,659 - 20,735,362 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl720,700,144 - 20,727,410 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha720,144,587 - 20,259,861 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0720,356,575 - 20,471,864 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl720,356,795 - 20,463,911 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1720,263,283 - 20,379,080 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0720,371,214 - 20,487,250 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0720,506,417 - 20,622,140 (+)NCBIUU_Cfam_GSD_1.0
Abl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934491,923,100 - 92,008,043 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364819,824,392 - 9,847,104 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364819,823,790 - 9,847,291 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ABL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9120,892,952 - 120,984,695 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19120,888,891 - 120,984,724 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29132,663,636 - 132,782,743 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ABL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12550,106,621 - 50,244,002 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2550,216,483 - 50,241,621 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605551,607,771 - 51,778,370 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Abl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247713,160,224 - 3,278,787 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247713,160,528 - 3,280,860 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Sequence


Ensembl Acc Id: ENSPPAT00000065398   ⟹   ENSPPAP00000042468
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1158,280,994 - 158,313,915 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000065399   ⟹   ENSPPAP00000042469
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1158,280,994 - 158,313,915 (-)Ensembl
Ensembl Acc Id: ENSPPAT00000065403   ⟹   ENSPPAP00000042473
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1158,280,994 - 158,306,738 (-)Ensembl
RefSeq Acc Id: XM_003824703   ⟹   XP_003824751
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,619,233 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,283,691 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,623,242 (-)NCBI
PanPan1.11158,275,334 - 158,313,941 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008978369   ⟹   XP_008976617
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,619,251 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,283,691 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,623,241 (-)NCBI
PanPan1.11158,275,334 - 158,313,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008978370   ⟹   XP_008976618
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,619,233 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,283,655 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,623,240 (-)NCBI
PanPan1.11158,275,334 - 158,313,954 (-)NCBI
Sequence:
RefSeq Acc Id: XM_024929901   ⟹   XP_024785669
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,619,212 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,283,691 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,623,242 (-)NCBI
PanPan1.11158,280,994 - 158,313,943 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034941460   ⟹   XP_034797351
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,547,337 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,211,721 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,690,884 (-)NCBI
RefSeq Acc Id: XM_034941466   ⟹   XP_034797357
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,530,839 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,195,232 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,711,621 (-)NCBI
RefSeq Acc Id: XM_034941480   ⟹   XP_034797371
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,530,839 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,195,232 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,711,621 (-)NCBI
RefSeq Acc Id: XM_034941496   ⟹   XP_034797387
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,530,839 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,195,232 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,711,621 (-)NCBI
RefSeq Acc Id: XM_034941505   ⟹   XP_034797396
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2170,530,839 - 70,660,797 (+)NCBI
NHGRI_mPanPan1170,195,232 - 70,322,490 (+)NCBI
Mhudiblu_PPA_v01154,586,423 - 154,711,621 (-)NCBI
RefSeq Acc Id: XP_008976618   ⟸   XM_008978370
- Peptide Label: isoform X6
- UniProtKB: A0A2R9CMY8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008976617   ⟸   XM_008978369
- Peptide Label: isoform X8
- UniProtKB: A0A2R9CKH6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_003824751   ⟸   XM_003824703
- Peptide Label: isoform X2
- UniProtKB: A0A2R9CMZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_024785669   ⟸   XM_024929901
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CMZ1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034797396   ⟸   XM_034941505
- Peptide Label: isoform X7
- UniProtKB: A0A2R9CKH6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034797371   ⟸   XM_034941480
- Peptide Label: isoform X3
- UniProtKB: A0A2R9CMZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034797387   ⟸   XM_034941496
- Peptide Label: isoform X5
- UniProtKB: A0A2R9CMY8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034797357   ⟸   XM_034941466
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CMZ1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_034797351   ⟸   XM_034941460
- Peptide Label: isoform X9
Ensembl Acc Id: ENSPPAP00000042469   ⟸   ENSPPAT00000065399
Ensembl Acc Id: ENSPPAP00000042468   ⟸   ENSPPAT00000065398
Ensembl Acc Id: ENSPPAP00000042473   ⟸   ENSPPAT00000065403
Protein Domains
Protein kinase   SH2   SH3


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043803 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000065398.1 UniProtKB/TrEMBL
  ENSPPAT00000065399.1 UniProtKB/TrEMBL
  ENSPPAT00000065403.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/TrEMBL
  Nucleotidyltransferases domain 2 UniProtKB/TrEMBL
  SH3 Domains UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro ABL_SH2 UniProtKB/TrEMBL
  F-actin-binding UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Non-receptor_tyrosine_kinases UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/TrEMBL
  SH3_domain UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
NCBI Gene ABL2 ENTREZGENE
PANTHER TYROSINE-PROTEIN KINASE UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE ABL2 UniProtKB/TrEMBL
Pfam F_actin_bind UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3_1 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
SMART FABD UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH3 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP SSF50044 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A2R9CKH6 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CMY8 ENTREZGENE, UniProtKB/TrEMBL
  A0A2R9CMZ1 ENTREZGENE, UniProtKB/TrEMBL