TERF2 (telomeric repeat binding factor 2) - Rat Genome Database

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Gene: TERF2 (telomeric repeat binding factor 2) Pan paniscus
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Symbol: TERF2
Name: telomeric repeat binding factor 2
RGD ID: 11866182
Description: ENCODES a protein that exhibits telomerase activity (ortholog); INVOLVED IN axonal transport of messenger ribonucleoprotein complex (ortholog); in utero embryonic development (ortholog); positive regulation of telomere maintenance (ortholog); ASSOCIATED WITH adult T-cell leukemia/lymphoma (ortholog); autosomal dominant dyskeratosis congenita 6 (ortholog); genetic disease (ortholog); FOUND IN chromosome, telomeric region (ortholog); shelterin complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: telomeric repeat-binding factor 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,900,039 - 78,933,141 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,811,673 - 84,844,776 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,729,906 - 49,763,002 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11669,115,208 - 69,148,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1669,116,539 - 69,148,423 (-)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
TERF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21878,900,039 - 78,933,141 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11684,811,673 - 84,844,776 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01649,729,906 - 49,763,002 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11669,115,208 - 69,148,175 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1669,116,539 - 69,148,423 (-)Ensemblpanpan1.1panPan2
TERF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381669,355,567 - 69,386,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1669,355,567 - 69,408,571 (-)EnsemblGRCh38hg38GRCh38
GRCh371669,389,470 - 69,419,910 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361667,947,032 - 67,977,374 (-)NCBINCBI36Build 36hg18NCBI36
Build 341667,947,035 - 67,977,374NCBI
Celera1653,904,070 - 53,934,402 (-)NCBICelera
Cytogenetic Map16q22.1NCBI
HuRef1655,267,237 - 55,298,105 (-)NCBIHuRef
CHM1_11670,797,479 - 70,827,880 (-)NCBICHM1_1
T2T-CHM13v2.01675,157,261 - 75,188,141 (-)NCBIT2T-CHM13v2.0
Terf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398107,796,032 - 107,823,180 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl8107,796,032 - 107,823,179 (-)EnsemblGRCm39 Ensembl
GRCm388107,069,400 - 107,096,548 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8107,069,400 - 107,096,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv378109,593,302 - 109,620,445 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv368109,959,033 - 109,985,558 (-)NCBIMGSCv36mm8
Celera8111,295,694 - 111,322,833 (-)NCBICelera
Cytogenetic Map8D3NCBI
cM Map853.59NCBI
Terf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81951,887,221 - 51,915,756 (-)NCBIGRCr8
mRatBN7.21934,976,963 - 35,005,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1934,977,471 - 35,005,819 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1941,792,949 - 41,821,176 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01942,446,296 - 42,474,523 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01944,745,934 - 44,774,149 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01939,271,992 - 39,301,506 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1939,272,499 - 39,300,893 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01950,136,319 - 50,165,159 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41936,930,490 - 36,958,589 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11936,935,821 - 36,963,550 (-)NCBI
Celera1934,401,104 - 34,429,331 (-)NCBICelera
Cytogenetic Map19q12NCBI
Terf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554847,318,860 - 7,347,430 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554847,318,813 - 7,344,221 (+)NCBIChiLan1.0ChiLan1.0
TERF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1580,278,224 - 80,305,315 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl580,277,505 - 80,306,342 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha580,268,753 - 80,295,630 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0580,712,130 - 80,739,229 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl580,711,877 - 80,739,196 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1580,539,324 - 80,566,375 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0580,222,161 - 80,249,209 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0580,861,710 - 80,888,804 (+)NCBIUU_Cfam_GSD_1.0
Terf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934940,090,640 - 40,119,506 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647519,468,702 - 19,498,793 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647519,469,501 - 19,498,494 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TERF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl617,605,763 - 17,631,721 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1617,605,748 - 17,631,795 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2616,552,399 - 16,578,508 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TERF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1558,019,422 - 58,051,819 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl558,019,468 - 58,050,802 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604720,749,467 - 20,781,837 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Terf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474616,992,110 - 17,019,857 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474616,992,049 - 17,020,809 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000064626   ⟹   ENSPPAP00000041700
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1669,116,539 - 69,148,423 (-)Ensembl
RefSeq Acc Id: XM_014341797   ⟹   XP_014197283
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21878,900,039 - 78,933,141 (-)NCBI
NHGRI_mPanPan11684,811,673 - 84,844,776 (-)NCBI
Mhudiblu_PPA_v01649,729,906 - 49,763,002 (-)NCBI
PanPan1.11669,115,208 - 69,148,175 (-)NCBI
Sequence:
RefSeq Acc Id: XM_034940567   ⟹   XP_034796458
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21878,900,039 - 78,933,126 (-)NCBI
NHGRI_mPanPan11684,811,673 - 84,844,756 (-)NCBI
Mhudiblu_PPA_v01649,731,046 - 49,762,989 (-)NCBI
RefSeq Acc Id: XM_055100399   ⟹   XP_054956374
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21878,900,039 - 78,933,126 (-)NCBI
NHGRI_mPanPan11684,811,673 - 84,844,757 (-)NCBI
RefSeq Acc Id: XM_055100400   ⟹   XP_054956375
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v21878,901,990 - 78,933,128 (-)NCBI
NHGRI_mPanPan11684,813,625 - 84,844,758 (-)NCBI
Protein Sequences
Protein RefSeqs XP_014197283 (Get FASTA)   NCBI Sequence Viewer  
  XP_034796458 (Get FASTA)   NCBI Sequence Viewer  
  XP_054956374 (Get FASTA)   NCBI Sequence Viewer  
  XP_054956375 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSPPAP00000041700.1
RefSeq Acc Id: XP_014197283   ⟸   XM_014341797
- Peptide Label: isoform X1
- UniProtKB: A0A2R9CIE3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_034796458   ⟸   XM_034940567
- Peptide Label: isoform X4
- UniProtKB: A0A2R9CIE3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSPPAP00000041700   ⟸   ENSPPAT00000064626
RefSeq Acc Id: XP_054956374   ⟸   XM_055100399
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054956375   ⟸   XM_055100400
- Peptide Label: isoform X3
Protein Domains
HTH myb-type   Myb-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000043458 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000064626.1 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.210 UniProtKB/TrEMBL
  Homeodomain-like UniProtKB/TrEMBL
InterPro Homeobox-like_sf UniProtKB/TrEMBL
  Myb_dom UniProtKB/TrEMBL
  SANT/Myb UniProtKB/TrEMBL
  Telomere_rpt-bd_fac_dimer_dom UniProtKB/TrEMBL
  Telomere_rpt-bd_fac_dimer_sf UniProtKB/TrEMBL
  TERF1/2 UniProtKB/TrEMBL
  TERF2 UniProtKB/TrEMBL
  TERF2_RBM UniProtKB/TrEMBL
NCBI Gene TERF2 ENTREZGENE
PANTHER PTHR46833 UniProtKB/TrEMBL
  TELOMERIC REPEAT-BINDING FACTOR 2 UniProtKB/TrEMBL
Pfam Myb_DNA-binding UniProtKB/TrEMBL
  TERF2_RBM UniProtKB/TrEMBL
  TRF UniProtKB/TrEMBL
PIRSF Telomere_bd-1_Pin2 UniProtKB/TrEMBL
PROSITE HTH_MYB UniProtKB/TrEMBL
  MYB_LIKE UniProtKB/TrEMBL
SMART SANT UniProtKB/TrEMBL
Superfamily-SCOP SSF46689 UniProtKB/TrEMBL
  SSF63600 UniProtKB/TrEMBL
UniProt A0A2R9CIE3 ENTREZGENE, UniProtKB/TrEMBL