VANGL2 (VANGL planar cell polarity protein 2) - Rat Genome Database
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Pathways
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Gene: VANGL2 (VANGL planar cell polarity protein 2) Pan paniscus
Analyze
Symbol: VANGL2
Name: VANGL planar cell polarity protein 2
RGD ID: 11861786
Description: INVOLVED IN anterior/posterior pattern specification (ortholog); apical protein localization (ortholog); cell migration involved in kidney development (ortholog); PARTICIPATES IN Wnt signaling, the planar cell polarity pathway; ASSOCIATED WITH Kidney Neoplasms (ortholog); neural tube defect (ortholog); spina bifida (ortholog); FOUND IN apical cytoplasm (ortholog); apical plasma membrane (ortholog); basolateral plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: vang-like 2 (van gogh, Drosophila); vang-like protein 2
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,676,595 - 139,704,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,683,745 - 139,704,281 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,754,897 - 135,783,031 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anterior/posterior pattern specification  (ISO)
apical protein localization  (ISO)
cell migration involved in kidney development  (ISO)
cochlea development  (ISO)
cochlea morphogenesis  (ISO)
convergent extension involved in axis elongation  (ISO)
convergent extension involved in neural plate elongation  (ISO)
convergent extension involved in organogenesis  (ISO)
digestive tract morphogenesis  (ISO)
dopaminergic neuron axon guidance  (ISO)
establishment of body hair planar orientation  (ISO)
establishment of planar polarity  (ISO)
establishment of planar polarity involved in neural tube closure  (ISO)
establishment or maintenance of epithelial cell apical/basal polarity  (ISO)
glomerulus development  (ISO)
hair follicle development  (ISO)
heart looping  (ISO)
heparan sulfate proteoglycan biosynthetic process  (ISO)
inner ear receptor cell development  (ISO)
inner ear receptor cell stereocilium organization  (ISO)
kidney morphogenesis  (ISO)
lateral sprouting involved in lung morphogenesis  (ISO)
membranous septum morphogenesis  (ISO)
muscular septum morphogenesis  (ISO)
neural tube closure  (ISO)
non-canonical Wnt signaling pathway  (ISO)
non-motile cilium assembly  (ISO)
orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis  (ISO)
planar cell polarity pathway involved in axis elongation  (ISO)
planar cell polarity pathway involved in axon guidance  (ISO)
planar cell polarity pathway involved in heart morphogenesis  (ISO)
planar cell polarity pathway involved in neural tube closure  (ISO)
planar dichotomous subdivision of terminal units involved in lung branching morphogenesis  (ISO)
positive regulation of JUN kinase activity  (ISO)
post-anal tail morphogenesis  (ISO)
regulation of actin cytoskeleton organization  (ISO)
regulation of establishment of planar polarity  (ISO)
regulation of Wnt signaling pathway  (ISO)
Rho protein signal transduction  (ISO)
serotonergic neuron axon guidance  (ISO)
somatic stem cell division  (ISO)
somatic stem cell population maintenance  (ISO)
Wnt signaling pathway, planar cell polarity pathway  (ISO)
wound healing  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
VANGL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11139,676,595 - 139,704,281 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1139,683,745 - 139,704,281 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01135,754,897 - 135,783,031 (+)NCBIMhudiblu_PPA_v0panPan3
VANGL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1160,400,564 - 160,428,670 (+)EnsemblGRCh38hg38GRCh38
GRCh381160,400,564 - 160,428,674 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371160,370,354 - 160,398,460 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,636,988 - 158,665,088 (+)NCBINCBI36hg18NCBI36
Build 341157,198,538 - 157,211,533NCBI
Celera1133,439,094 - 133,467,201 (+)NCBI
Cytogenetic Map1q23.2NCBI
HuRef1131,726,520 - 131,754,628 (+)NCBIHuRef
CHM1_11161,765,749 - 161,793,853 (+)NCBICHM1_1
Vangl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391171,828,527 - 171,856,532 (-)NCBIGRCm39mm39
GRCm39 Ensembl1171,828,527 - 171,856,011 (-)Ensembl
GRCm381172,000,960 - 172,027,318 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,000,960 - 172,028,444 (-)EnsemblGRCm38mm10GRCm38
MGSCv371173,934,502 - 173,957,399 (-)NCBIGRCm37mm9NCBIm37
MGSCv361173,841,046 - 173,863,943 (-)NCBImm8
Celera1174,856,349 - 174,879,265 (-)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.54NCBI
Vangl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21384,462,731 - 84,489,404 (-)NCBI
Rnor_6.0 Ensembl1390,380,632 - 90,405,591 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01390,379,203 - 90,405,627 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01394,902,313 - 94,928,719 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41387,964,426 - 87,988,364 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11388,152,106 - 88,178,412 (-)NCBI
Celera1384,077,622 - 84,101,482 (-)NCBICelera
Cytogenetic Map13q24NCBI
Vangl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546812,161,843 - 12,189,547 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495546812,162,084 - 12,189,322 (+)NCBIChiLan1.0ChiLan1.0
VANGL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13821,822,873 - 21,824,537 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Vangl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936740228,377 - 242,318 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
VANGL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl490,053,380 - 90,080,656 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1490,051,994 - 90,080,701 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2497,945,552 - 97,971,014 (-)NCBISscrofa10.2Sscrofa10.2susScr3
VANGL2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,521,066 - 3,549,301 (-)NCBI
ChlSab1.1 Ensembl203,521,060 - 3,548,718 (-)Ensembl
Vangl2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624794841,302 - 867,717 (-)NCBI


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000020223   ⟹   ENSPPAP00000004390
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1139,683,745 - 139,704,281 (+)Ensembl
RefSeq Acc Id: XM_008964270   ⟹   XP_008962518
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11139,676,640 - 139,704,281 (+)NCBI
Mhudiblu_PPA_v01135,755,290 - 135,783,031 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034938495   ⟹   XP_034794386
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01135,754,897 - 135,783,031 (+)NCBI
Protein Sequences
Protein RefSeqs XP_008962518 (Get FASTA)   NCBI Sequence Viewer  
  XP_034794386 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008962518   ⟸   XM_008964270
- Sequence:
RefSeq Acc Id: XP_034794386   ⟸   XM_034938495
RefSeq Acc Id: ENSPPAP00000004390   ⟸   ENSPPAT00000020223


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000018476 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000004390 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000020223 UniProtKB/TrEMBL
InterPro VANGL UniProtKB/TrEMBL
KEGG Report pps:100992381 UniProtKB/TrEMBL
NCBI Gene VANGL2 ENTREZGENE
PANTHER PTHR20886 UniProtKB/TrEMBL
Pfam Strabismus UniProtKB/TrEMBL
PIRSF Strabismus UniProtKB/TrEMBL
UniProt A0A2R8ZHE0_PANPA UniProtKB/TrEMBL