CNGA4 (cyclic nucleotide gated channel subunit alpha 4) - Rat Genome Database

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Gene: CNGA4 (cyclic nucleotide gated channel subunit alpha 4) Pan paniscus
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Symbol: CNGA4
Name: cyclic nucleotide gated channel subunit alpha 4
RGD ID: 11859647
Description: ENCODES a protein that exhibits cGMP binding (ortholog); intracellularly cAMP-activated cation channel activity (ortholog); intracellularly cGMP-activated cation channel activity (ortholog); INVOLVED IN sensory perception of smell (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH genetic disease (ortholog); neuronal ceroid lipofuscinosis (ortholog); FOUND IN intracellular cyclic nucleotide activated cation channel complex (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclic nucleotide gated channel alpha 4; cyclic nucleotide-gated cation channel alpha-4
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v298,673,844 - 8,686,515 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,637,699 - 8,647,964 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,368,768 - 6,378,976 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,051,091 - 6,061,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,051,091 - 6,061,550 (+)Ensemblpanpan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
CNGA4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v298,673,844 - 8,686,515 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1118,637,699 - 8,647,964 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0116,368,768 - 6,378,976 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1116,051,091 - 6,061,550 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl116,051,091 - 6,061,550 (+)Ensemblpanpan1.1panPan2
CNGA4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38116,234,793 - 6,244,976 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl116,234,765 - 6,244,479 (+)EnsemblGRCh38hg38GRCh38
GRCh37116,260,319 - 6,265,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36116,216,910 - 6,222,235 (+)NCBINCBI36Build 36hg18NCBI36
Celera116,379,405 - 6,384,782 (+)NCBICelera
Cytogenetic Map11p15.4NCBI
HuRef115,920,393 - 5,925,778 (+)NCBIHuRef
CHM1_1116,259,550 - 6,264,935 (+)NCBICHM1_1
T2T-CHM13v2.0116,293,180 - 6,303,456 (+)NCBIT2T-CHM13v2.0
Cnga4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397105,049,247 - 105,057,981 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7105,053,775 - 105,057,949 (+)EnsemblGRCm39 Ensembl
GRCm387105,400,024 - 105,408,775 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7105,404,568 - 105,408,742 (+)EnsemblGRCm38mm10GRCm38
MGSCv377112,553,082 - 112,557,252 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367105,278,389 - 105,282,559 (+)NCBIMGSCv36mm8
Celera7105,676,665 - 105,680,835 (+)NCBICelera
Cytogenetic Map7E3NCBI
cM Map755.85NCBI
Cnga4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81169,134,332 - 169,168,317 (+)NCBIGRCr8
mRatBN7.21159,752,357 - 159,756,369 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1159,752,357 - 159,756,375 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1167,773,767 - 167,777,745 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01174,959,758 - 174,963,736 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01167,855,020 - 167,858,998 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01170,238,959 - 170,246,858 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1170,242,846 - 170,246,858 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01177,245,757 - 177,253,787 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41163,137,544 - 163,141,556 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11163,233,020 - 163,237,158 (+)NCBI
Celera1157,687,159 - 157,691,171 (+)NCBICelera
Cytogenetic Map1q32NCBI
Cnga4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541421,977,996 - 21,986,441 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541421,977,996 - 21,986,349 (+)NCBIChiLan1.0ChiLan1.0
CNGA4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12129,575,140 - 29,581,721 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2129,575,578 - 29,580,616 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2129,273,213 - 29,293,243 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02130,397,346 - 30,417,377 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2130,402,030 - 30,407,489 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12129,722,659 - 29,738,374 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02129,884,350 - 29,904,367 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02130,078,976 - 30,098,988 (+)NCBIUU_Cfam_GSD_1.0
Cnga4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494756,360,294 - 56,369,005 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936842310,741 - 314,754 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936842310,741 - 314,754 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CNGA4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl93,431,340 - 3,442,426 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.193,430,995 - 3,438,411 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.294,133,006 - 4,138,939 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CNGA4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1158,581,702 - 58,592,733 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl158,582,175 - 58,588,376 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038156,418,620 - 156,428,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cnga4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248177,719,332 - 7,737,336 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248177,716,951 - 7,732,177 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSPPAT00000043813   ⟹   ENSPPAP00000021014
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl116,051,091 - 6,061,550 (+)Ensembl
RefSeq Acc Id: XM_034932033   ⟹   XP_034787924
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,674,203 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,638,057 - 8,647,964 (+)NCBI
Mhudiblu_PPA_v0116,369,022 - 6,378,976 (+)NCBI
RefSeq Acc Id: XM_034932035   ⟹   XP_034787926
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,673,844 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,637,699 - 8,647,964 (+)NCBI
Mhudiblu_PPA_v0116,368,768 - 6,378,976 (+)NCBI
RefSeq Acc Id: XM_055094048   ⟹   XP_054950023
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,674,203 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,638,057 - 8,647,964 (+)NCBI
RefSeq Acc Id: XM_055094049   ⟹   XP_054950024
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,673,921 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,637,776 - 8,647,964 (+)NCBI
RefSeq Acc Id: XM_055094050   ⟹   XP_054950025
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,673,927 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,637,782 - 8,647,964 (+)NCBI
RefSeq Acc Id: XM_055094051   ⟹   XP_054950026
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,673,931 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,637,786 - 8,647,964 (+)NCBI
RefSeq Acc Id: XM_055094052   ⟹   XP_054950027
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,674,199 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,638,054 - 8,647,964 (+)NCBI
RefSeq Acc Id: XM_055094053   ⟹   XP_054950028
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,674,218 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,638,073 - 8,647,964 (+)NCBI
RefSeq Acc Id: XM_055094054   ⟹   XP_054950029
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,673,937 - 8,686,515 (+)NCBI
NHGRI_mPanPan1118,637,792 - 8,647,964 (+)NCBI
RefSeq Acc Id: XM_063608080   ⟹   XP_063464150
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v298,674,078 - 8,686,515 (+)NCBI
RefSeq Acc Id: XP_034787926   ⟸   XM_034932035
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034787924   ⟸   XM_034932033
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000021014   ⟸   ENSPPAT00000043813
RefSeq Acc Id: XP_054950024   ⟸   XM_055094049
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B0U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054950025   ⟸   XM_055094050
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B0U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054950026   ⟸   XM_055094051
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B0U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054950029   ⟸   XM_055094054
- Peptide Label: isoform X4
RefSeq Acc Id: XP_054950027   ⟸   XM_055094052
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B0U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_054950023   ⟸   XM_055094048
- Peptide Label: isoform X2
RefSeq Acc Id: XP_054950028   ⟸   XM_055094053
- Peptide Label: isoform X3
- UniProtKB: A0A2R9B0U6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063464150   ⟸   XM_063608080
- Peptide Label: isoform X4
Protein Domains
Cyclic nucleotide-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000033731 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000043813.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  1.20.5.170 UniProtKB/TrEMBL
  2.60.120.10 UniProtKB/TrEMBL
  Helix hairpin bin UniProtKB/TrEMBL
InterPro CLZ_dom UniProtKB/TrEMBL
  cNMP-bd-like UniProtKB/TrEMBL
  cNMP-bd_CS UniProtKB/TrEMBL
  cNMP-bd_dom UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  RmlC-like_jellyroll UniProtKB/TrEMBL
KEGG Report pps:100992084 UniProtKB/TrEMBL
NCBI Gene CNGA4 ENTREZGENE
PANTHER CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-4 UniProtKB/TrEMBL
  CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A UniProtKB/TrEMBL
Pfam CLZ UniProtKB/TrEMBL
  cNMP_binding UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
PROSITE CNMP_BINDING_1 UniProtKB/TrEMBL
  CNMP_BINDING_2 UniProtKB/TrEMBL
  CNMP_BINDING_3 UniProtKB/TrEMBL
SMART cNMP UniProtKB/TrEMBL
Superfamily-SCOP SSF51206 UniProtKB/TrEMBL
  Voltage-gated potassium channels UniProtKB/TrEMBL
UniProt A0A2R9B0U6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-06-25 CNGA4  cyclic nucleotide gated channel subunit alpha 4  CNGA4  cyclic nucleotide gated channel alpha 4  Symbol and/or name change 5135510 APPROVED