CYP4X1 (cytochrome P450 family 4 subfamily X member 1)

Gene: CYP4X1 (cytochrome P450 family 4 subfamily X member 1) Pan paniscus

Analyze

Symbol:

CYP4X1

Name:

cytochrome P450 family 4 subfamily X member 1

RGD ID:

11855780

Description:

ENCODES a protein that exhibits anandamide 14,15 epoxidase activity (inferred); heme binding (inferred); iron ion binding (inferred); ASSOCIATED WITH autism spectrum disorder (ortholog); genetic disease (ortholog); FOUND IN membrane (inferred)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

cytochrome P450 4X1; LOC100978561

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	179,761,822 - 179,789,015 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	178,903,543 - 178,930,702 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	46,322,430 - 46,349,646 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	47,676,533 - 47,703,724 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	47,676,533 - 47,703,724 (+)	Ensembl	panpan1.1		panPan2

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

genetic disease (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Cellular Component

membrane (IEA)

Molecular Function

anandamide 14,15 epoxidase activity (IEA)

heme binding (IEA)

iron ion binding (IEA)

metal ion binding (IEA)

monooxygenase activity (IEA)

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen (IEA)

References

Additional References at PubMed

PMID:22301074

Genomics

Comparative Map Data

CYP4X1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	179,761,822 - 179,789,015 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	178,903,543 - 178,930,702 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	46,322,430 - 46,349,646 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	47,676,533 - 47,703,724 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	47,676,533 - 47,703,724 (+)	Ensembl	panpan1.1		panPan2

CYP4X1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	46,961,364 - 47,055,432 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	47,023,669 - 47,050,751 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	47,427,036 - 47,516,423 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	47,261,827 - 47,289,010 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	1	47,201,259 - 47,228,442	NCBI
Celera	1	45,776,425 - 45,803,552 (+)	NCBI		Celera
Cytogenetic Map	1	p33	NCBI
HuRef	1	45,605,361 - 45,632,362 (+)	NCBI		HuRef
CHM1_1	1	47,606,010 - 47,633,192 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	1	46,838,775 - 46,932,851 (+)	NCBI		T2T-CHM13v2.0

Cyp4x1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	4	114,963,518 - 114,991,276 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	4	114,963,520 - 114,991,478 (-)	Ensembl		GRCm39 Ensembl
GRCm38	4	115,106,323 - 115,134,079 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	4	115,106,323 - 115,134,281 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	4	114,781,287 - 114,806,582 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	4	114,606,614 - 114,631,909 (-)	NCBI		MGSCv36	mm8
Celera	4	113,855,830 - 113,880,996 (-)	NCBI		Celera
Cytogenetic Map	4	D1	NCBI
cM Map	4	52.76	NCBI

Cyp4x1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	5	133,888,439 - 133,923,254 (-)	NCBI		GRCr8
mRatBN7.2	5	128,651,681 - 128,683,338 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	5	128,651,776 - 128,682,779 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	5	131,335,284 - 131,365,398 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	5	133,064,937 - 133,095,052 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	5	133,086,626 - 133,116,743 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	5	133,929,532 - 133,959,447 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	5	133,929,532 - 133,959,447 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	5	137,719,870 - 137,750,890 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	5	135,496,568 - 135,527,509 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	5	135,501,793 - 135,532,735 (-)	NCBI
Celera	5	127,291,173 - 127,321,075 (-)	NCBI		Celera
Cytogenetic Map	5	q35	NCBI

LOC102010235
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955464	11,378,980 - 11,556,544 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955464	11,373,217 - 11,415,433 (-)	NCBI	ChiLan1.0	ChiLan1.0

CYP4X1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	13,509,032 - 13,546,803 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	13,509,508 - 13,605,382 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	13,662,665 - 13,699,145 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	13,658,546 - 13,696,331 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	13,659,035 - 13,696,333 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	13,459,321 - 13,495,830 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	13,527,340 - 13,563,865 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	13,596,850 - 13,633,361 (-)	NCBI		UU_Cfam_GSD_1.0

LOC101954492
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405058	62,145,582 - 62,175,706 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936474	27,970,523 - 28,000,518 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936474	27,970,585 - 27,997,909 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LOC100627093
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	6	164,414,206 - 164,469,968 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	6	151,954,288 - 152,008,537 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

CYP4X1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	20	85,869,402 - 85,897,215 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	20	85,869,982 - 85,896,668 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666033	31,105,354 - 31,174,573 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

LOC101706848
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624859	5,669,726 - 5,686,910 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624859	5,647,610 - 5,697,885 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_003812730	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034964526	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSPPAT00000045655 ⟹ ENSPPAP00000022841

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	1	47,676,533 - 47,703,724 (+)	Ensembl

RefSeq Acc Id:

XM_003812730 ⟹ XP_003812778

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	179,761,822 - 179,789,015 (-)	NCBI
NHGRI_mPanPan1	1	178,903,543 - 178,930,702 (-)	NCBI
Mhudiblu_PPA_v0	1	46,322,430 - 46,349,646 (+)	NCBI
PanPan1.1	1	47,676,533 - 47,703,724 (+)	NCBI

Sequence:

show sequence

CAAAAGCAGTTGGGCCGAACGAAGCGTGCGCGCTTTGATAACCGGCTAGAAATCCCGCACGCGC
GCCTGCCTCCTCTCCCCAGGCCTGAGCTGCCCCTCCCACTGCCTTTCCTTCTTCCCGCGAGTCA
GAAGCTTCGCGAGGGCCCAGAGAGGCGGTGGGCTGGGCGACCCTACGCCAGCTCCGGGCGGGAG
AAAGCCCACCCTCTCCCGCGCCCCAGGAAACCGCCGGCGTTCGACGCTGCGCAGAGCCATGGAA
TTCTCCTGGCTGGAGACGCGCTGGGCGCGGCCCTTTTACCTGGCGTTCGTGTTCTGCCTGGCCC
TGGGGCTGCTGCAGGCCATTAAGCTGTACCTGCGGAGGCAGCGGCTGCTGCGGGACCTGCGCCC
CTTCCCAGCGCCCCCCACCCACTGGTTCCTTGGGCACCAGAAGTTTATTCAGGATGATAACATG
GAGAAGCTTGAGGAAATTATTGAAAAATACCCTCGTGCCTTCCCTTTCTGGATTGGGCCCTTTC
AGGCATTTTTCTATATCTACGACCCAGACTATGCAAAGACACTTCTGAGCAGAACAGATCCCAA
GTCCCAGTACCTGCAGAAATTCTCACCTCCACTTCTTGGAAAAGGACTAGCGGCTCTAGACGGA
CCCAAGTGGTTCCAGCATCGTCGCCTACTAACTCCTGGATTCCACTTTAACATCCTGAAAGCAT
ACGTTGAGGTGATGGCTCATTCTGTGAAAATGATGCTGGATAAGTGGGAGAAGATTTGCAGCAC
TCAGGACACAAGCGTGGAGGTCTATGAGCACATCAACTTGATGTCTCTGGATATAATCATGAAA
TGCGCTTTCAGCAAGGAGACCAACTGCCAGACAAACAGCACCCATGATCCTTATGCAAAAGCCA
TATTTGAACTCAGCAAAATCATATTTCACCGCTTGTACAGTTTGTTGTATCACAGTGACATAAT
TTTCAAACTCAGCCCTCAGGGCTACCGCTTCCAGAAGTTAAGCCGAGTGTTGAATCAGTACACA
GATACAATAATCCAGGAAAGAAAGAAATCCCTCCAGGCTGGGGTAAAGCAGGATAACACTCCGA
AGAGGAAGTACCAGGATTTTCTGGATATTGTGCTTTCTGCCAAGGATGAAAGTGGTAGCAGCTT
CTCAGATATTGATGTACACTCTGAAGTGAGCACGTTCTTGTTGGCAGGACATGACACCTTGGCA
GCAAGCATCTCCTGGATCCTTTACTGCCTGGCTCTGAACCCTGAGCATCAAGAGAGATGCCGGG
AGGAGGTCAGGGGCATCCTGGGGGATGGGTCTTCTATCACTTGGGACCAGCTGGGTGAGATGTC
GTACACCACAATGTGCATCAAGGAGACGTGCCGATTGATTCCTGCAGTCCCGTCCATTTCCAGA
GATCTCAGCAAGCCACTTACCTTCCCAGATGGATGCACATTGCCTGCAGGGATCACCGTGGTTC
TTAGTATTTGGGGTCTTCACCACAACCCTGCTGTCTGGAAAAACCCAAAGGTCTTTGACCCCTT
GAGGTTCTCTCAGGAGAATTCTGATCAGAGACACCCCTATGCCTACTTACCATTCTCAGCTGGA
TCAAGGAACTGCATTGGGCAGGAGTTTGCCATGATTGAGTTAAAGGTAACCATTGCCTTGATTC
TGCTCCACTTCAGAGTGACTCCAGACCCCACCAGGCCTCTTACTTTCCCCAACCATTTTATCCT
CAAGCCCAAGAATGGGATGTATTTGCACCTGAAGAAACTCTCTGAATGTTAGATCTCAGGGTAC
AATGATTAAACGTACTTTGTTTTTAAGTTAAATTTACAGCTAATGATCCAAGCAGATAGAAAGG
GATCAATGTATGGTGGGAGGATTGGAGGTTGGTGGGATAGGGGTCTCTGTGAAGCTACACATGA
TCCAAAATCATTTCTAGGTACACAGTGTGTCAGACTAGATCTGTTTCTATATAACTTTGGGAGA
CTTTCAGATCTTTTCTGTTAAACTTTCACTACTATTAATGCTGTATACACCAATAGACTTTCAT
ATATTTTCTTTTGTTTTTAAAATAGTTTTCAGAATTATGCAAGTAATAAGTGCATGTATGCTCA
CTGTCAAAAATTCCCAACACTAGAAAATCATGTAGAATAAAAATTTTAAATCTCACTTCACTTA
GCCTACATTCCATGCCCTGACTAATCCTACTGCTTTTCCTAAAAACAGAATAATTTGGTGTGCA
TTCTTTCAGACTTTTTCCTATACATTTTATATGTAGAAATATAGCAATGTATTTGTATAGATGT
GATCATTCCTATATTGTTATTGATTTTTTCACTTAATAAAAATTCGCCTTATTCCTTATCA

hide sequence

RefSeq Acc Id:

XM_034964526 ⟹ XP_034820417

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	1	179,761,822 - 179,788,770 (-)	NCBI
NHGRI_mPanPan1	1	178,903,543 - 178,930,437 (-)	NCBI
Mhudiblu_PPA_v0	1	46,322,880 - 46,349,646 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_003812778	(Get FASTA)	NCBI Sequence Viewer
	XP_034820417	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000022841.1

RefSeq Acc Id:	XP_003812778 ⟸ XM_003812730
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R9B681 (UniProtKB/TrEMBL)
- Sequence:	show sequence MEFSWLETRWARPFYLAFVFCLALGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDD NMEKLEEIIEKYPRAFPFWIGPFQAFFYIYDPDYAKTLLSRTDPKSQYLQKFSPPLLGKGLAAL DGPKWFQHRRLLTPGFHFNILKAYVEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINLMSLDII MKCAFSKETNCQTNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQ YTDTIIQERKKSLQAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDT LAASISWILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSI SRDLSKPLTFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFS AGSRNCIGQEFAMIELKVTIALILLHFRVTPDPTRPLTFPNHFILKPKNGMYLHLKKLSEC hide sequence

RefSeq Acc Id:	XP_034820417 ⟸ XM_034964526
- Peptide Label:	isoform X1

RefSeq Acc Id:

ENSPPAP00000022841 ⟸ ENSPPAT00000045655

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000034593	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000045655.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.630.10	UniProtKB/TrEMBL
InterPro	Cyt_P450	UniProtKB/TrEMBL
	Cyt_P450_CS	UniProtKB/TrEMBL
	Cyt_P450_E_grp-I	UniProtKB/TrEMBL
	Cyt_P450_sf	UniProtKB/TrEMBL
KEGG Report	pps:100978561	UniProtKB/TrEMBL
NCBI Gene	LOC100978561	ENTREZGENE
PANTHER	CYTOCHROME P450 4X1-RELATED	UniProtKB/TrEMBL
	CYTOCHROME P450 FAMILY 4	UniProtKB/TrEMBL
Pfam	p450	UniProtKB/TrEMBL
PRINTS	EP450I	UniProtKB/TrEMBL
	P450	UniProtKB/TrEMBL
PROSITE	CYTOCHROME_P450	UniProtKB/TrEMBL
Superfamily-SCOP	SSF48264	UniProtKB/TrEMBL
UniProt	A0A2R9B681	ENTREZGENE, UniProtKB/TrEMBL
VGNC ID	VGNC:83014	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2020-02-25	CYP4X1	cytochrome P450 family 4 subfamily X member 1	LOC100978561	cytochrome P450 4X1	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD